UY34603A - Anticuerpos anti-asic-1 y usos de los mismos - Google Patents

Anticuerpos anti-asic-1 y usos de los mismos

Info

Publication number
UY34603A
UY34603A UY34603A UY34603A UY34603A UY 34603 A UY34603 A UY 34603A UY 34603 A UY34603 A UY 34603A UY 34603 A UY34603 A UY 34603A UY 34603 A UY34603 A UY 34603A
Authority
UY
Uruguay
Prior art keywords
asic
antibodies
same
figura
hay
Prior art date
Application number
UY34603A
Other languages
English (en)
Inventor
Mcdonald Lynn
Gao Min
Marc R Morra
Nicole M Alessandri Haber
Michael L Lacroix-Fralish
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47666522&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY34603(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of UY34603A publication Critical patent/UY34603A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención proporciona anticuerpos y fragmentos de unión a antígeno de los mismos que se unen específicamente a células que expresan el canal iónico sensible al ácido de tipo 1 (ASIC1). De acuerdo con ciertas realizaciones de la invención, los anticuerpos inhiben las corrientes iónicas mediadas por ASIC1, inducidas por ácido en células que expresan ASIC1 humana. Los anticuerpos de la invención son útiles para el tratamiento del dolor, incluyendo el dolor asociado con intervenciones q uirúrgicas y diversas enfermedades y trastornos.
UY34603A 2012-01-31 2013-01-31 Anticuerpos anti-asic-1 y usos de los mismos UY34603A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261592837P 2012-01-31 2012-01-31
US201261644038P 2012-05-08 2012-05-08
US201261692925P 2012-08-24 2012-08-24

Publications (1)

Publication Number Publication Date
UY34603A true UY34603A (es) 2013-07-31

Family

ID=47666522

Family Applications (1)

Application Number Title Priority Date Filing Date
UY34603A UY34603A (es) 2012-01-31 2013-01-31 Anticuerpos anti-asic-1 y usos de los mismos

Country Status (33)

Country Link
US (3) US9150648B2 (es)
EP (2) EP3453723B1 (es)
JP (1) JP6302844B2 (es)
KR (1) KR102111941B1 (es)
CN (1) CN104093738B (es)
AR (1) AR089852A1 (es)
AU (1) AU2013215254B2 (es)
CA (1) CA2862332C (es)
CL (1) CL2014002019A1 (es)
CO (1) CO7020877A2 (es)
CY (2) CY1121368T1 (es)
DK (2) DK3453723T3 (es)
EA (1) EA028647B1 (es)
ES (2) ES2886123T3 (es)
HR (2) HRP20211541T1 (es)
HU (2) HUE042531T2 (es)
IL (2) IL233410A0 (es)
IN (1) IN2014CN04645A (es)
JO (1) JO3547B1 (es)
LT (2) LT3453723T (es)
MX (1) MX358518B (es)
MY (1) MY168748A (es)
NZ (1) NZ626242A (es)
PH (1) PH12014501613A1 (es)
PL (2) PL3453723T3 (es)
PT (2) PT3453723T (es)
RS (2) RS58439B1 (es)
SG (1) SG11201403222UA (es)
SI (2) SI3453723T1 (es)
SM (1) SMT202100628T1 (es)
TW (1) TWI591073B (es)
UY (1) UY34603A (es)
WO (1) WO2013116296A1 (es)

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CA2862332C (en) 2012-01-31 2021-05-18 Regeneron Pharmaceuticals, Inc. Anti-asic1 antibodies and uses thereof
MA39847A (fr) 2014-04-15 2017-02-22 Sorrento Therapeutics Inc Protéines de liaison à l'antigène se liant à wisp1
IL318433A (en) 2014-05-16 2025-03-01 Ablynx Nv Improved immunoglobulin variable complexes
AU2015261536B2 (en) 2014-05-16 2020-05-07 Ablynx Nv Improved immunoglobulin variable domains
CN105233286B (zh) * 2015-09-10 2018-10-30 上海交通大学医学院 含酸敏感离子通道调控剂的制剂及其在治疗瘙痒中的用途
CN105713089B (zh) * 2016-02-26 2019-08-06 上海科技大学 一种特异性抑制酸敏感离子通道i型的全人抗体
WO2018085441A1 (en) * 2016-11-01 2018-05-11 Berg Llc Filamin b binding proteins and uses thereof
CA3089377A1 (en) * 2018-01-26 2019-08-01 Regeneron Pharmaceuticals, Inc. Anti-tmprss2 antibodies and antigen-binding fragments
WO2020243912A1 (en) * 2019-06-04 2020-12-10 Shanghaitech University AFFINITY-MATURATED ANTI-ASIC1a ANTIBODIES
PH12022550056A1 (en) * 2019-07-11 2023-04-12 Memorial Sloan Kettering Cancer Center Dll3-targeting antibodies and uses thereof
JP2022547781A (ja) * 2019-07-23 2022-11-16 シャンハイテック ユニバーシティ Ａｓｉｃ１チャネルアンタゴニスト抗体
MX2022003074A (es) * 2019-09-13 2022-06-14 Memorial Sloan Kettering Cancer Center Anticuerpos anti-cd371, y usos de los mismos.
CA3228654A1 (en) * 2021-08-09 2023-02-16 Brian Rabinovich Proteins that decouple t cell-mediated tumor cytotoxicity from release of pro-inflammatory cytokines
WO2023034566A1 (en) * 2021-09-02 2023-03-09 Memorial Sloan-Kettering Cancer Center Anti-dll3 antibodies and uses thereof
CN119331085B (zh) * 2024-10-16 2025-03-14 中国科学院合肥物质科学研究院 沙贝冠状病毒广谱中和抗体及其应用

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CA2862332C (en) 2012-01-31 2021-05-18 Regeneron Pharmaceuticals, Inc. Anti-asic1 antibodies and uses thereof
US9371383B2 (en) 2012-01-31 2016-06-21 Regeneron Pharmaceuticals, Inc. Anti-ASIC1 antibodies and uses thereof

Also Published As

Publication number Publication date
US20180222976A1 (en) 2018-08-09
SG11201403222UA (en) 2014-07-30
PT3453723T (pt) 2021-09-07
EP2809681B1 (en) 2018-12-05
DK3453723T3 (da) 2021-09-13
CN104093738A (zh) 2014-10-08
PT2809681T (pt) 2019-02-18
CL2014002019A1 (es) 2015-01-16
HUE056335T2 (hu) 2022-02-28
CO7020877A2 (es) 2014-08-11
EA028647B1 (ru) 2017-12-29
LT3453723T (lt) 2021-09-10
KR20140125363A (ko) 2014-10-28
IL254416B (en) 2018-03-29
AR089852A1 (es) 2014-09-24
CA2862332A1 (en) 2013-08-08
ES2707599T3 (es) 2019-04-04
JO3547B1 (ar) 2020-07-05
ES2886123T3 (es) 2021-12-16
RS62454B1 (sr) 2021-11-30
DK2809681T3 (en) 2019-03-11
SMT202100628T1 (it) 2022-01-10
NZ626242A (en) 2017-02-24
CN104093738B (zh) 2018-05-18
US20160002332A1 (en) 2016-01-07
HUE042531T2 (hu) 2019-07-29
MX2014008541A (es) 2014-10-24
IL233410A0 (en) 2014-08-31
IL254416A0 (en) 2017-11-30
PL3453723T3 (pl) 2022-01-03
PL2809681T3 (pl) 2019-05-31
IN2014CN04645A (es) 2015-09-18
MX358518B (es) 2018-08-24
CY1124778T1 (el) 2022-11-25
EP3453723A2 (en) 2019-03-13
CY1121368T1 (el) 2020-05-29
PH12014501613B1 (en) 2014-10-13
HK1199269A1 (en) 2015-06-26
HRP20211541T1 (hr) 2021-12-24
TW201335182A (zh) 2013-09-01
EP2809681A1 (en) 2014-12-10
US9150648B2 (en) 2015-10-06
PH12014501613A1 (en) 2014-10-13
HRP20190358T1 (hr) 2019-04-05
EA201491452A1 (ru) 2014-11-28
TWI591073B (zh) 2017-07-11
US10513557B2 (en) 2019-12-24
AU2013215254B2 (en) 2017-08-31
JP2015508063A (ja) 2015-03-16
US20130195878A1 (en) 2013-08-01
MY168748A (en) 2018-11-30
JP6302844B2 (ja) 2018-03-28
SI2809681T1 (sl) 2019-04-30
WO2013116296A1 (en) 2013-08-08
RS58439B1 (sr) 2019-04-30
EP3453723B1 (en) 2021-08-11
AU2013215254A1 (en) 2014-07-03
CA2862332C (en) 2021-05-18
SI3453723T1 (sl) 2021-11-30
KR102111941B1 (ko) 2020-05-18
EP3453723A3 (en) 2019-04-10
LT2809681T (lt) 2019-02-11
BR112014018651A2 (pt) 2017-07-04

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