HUE042531T2 - ASIC1-ellenes antitestek és alkalmazásaik - Google Patents

ASIC1-ellenes antitestek és alkalmazásaik

Info

Publication number
HUE042531T2
HUE042531T2 HUE13702876A HUE13702876A HUE042531T2 HU E042531 T2 HUE042531 T2 HU E042531T2 HU E13702876 A HUE13702876 A HU E13702876A HU E13702876 A HUE13702876 A HU E13702876A HU E042531 T2 HUE042531 T2 HU E042531T2
Authority
HU
Hungary
Prior art keywords
applications
asic1 antibodies
asic1
antibodies
Prior art date
Application number
HUE13702876A
Other languages
English (en)
Hungarian (hu)
Inventor
Lynn Macdonald
Min Gao
Marc Morra
Nicole Alessandri-Haber
Michael LaCroix-Fralish
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47666522&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE042531(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of HUE042531T2 publication Critical patent/HUE042531T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HUE13702876A 2012-01-31 2013-01-30 ASIC1-ellenes antitestek és alkalmazásaik HUE042531T2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261592837P 2012-01-31 2012-01-31
US201261644038P 2012-05-08 2012-05-08
US201261692925P 2012-08-24 2012-08-24

Publications (1)

Publication Number Publication Date
HUE042531T2 true HUE042531T2 (hu) 2019-07-29

Family

ID=47666522

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE13702876A HUE042531T2 (hu) 2012-01-31 2013-01-30 ASIC1-ellenes antitestek és alkalmazásaik
HUE18201823A HUE056335T2 (hu) 2012-01-31 2013-01-30 ASIC1-ellenes antitestek és alkalmazásaik

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE18201823A HUE056335T2 (hu) 2012-01-31 2013-01-30 ASIC1-ellenes antitestek és alkalmazásaik

Country Status (33)

Country Link
US (3) US9150648B2 (enExample)
EP (2) EP2809681B1 (enExample)
JP (1) JP6302844B2 (enExample)
KR (1) KR102111941B1 (enExample)
CN (1) CN104093738B (enExample)
AR (1) AR089852A1 (enExample)
AU (1) AU2013215254B2 (enExample)
CA (1) CA2862332C (enExample)
CL (1) CL2014002019A1 (enExample)
CO (1) CO7020877A2 (enExample)
CY (2) CY1121368T1 (enExample)
DK (2) DK2809681T3 (enExample)
EA (1) EA028647B1 (enExample)
ES (2) ES2886123T3 (enExample)
HR (2) HRP20190358T1 (enExample)
HU (2) HUE042531T2 (enExample)
IL (2) IL233410A0 (enExample)
IN (1) IN2014CN04645A (enExample)
JO (1) JO3547B1 (enExample)
LT (2) LT2809681T (enExample)
MX (1) MX358518B (enExample)
MY (1) MY168748A (enExample)
NZ (1) NZ626242A (enExample)
PH (1) PH12014501613B1 (enExample)
PL (2) PL3453723T3 (enExample)
PT (2) PT2809681T (enExample)
RS (2) RS58439B1 (enExample)
SG (1) SG11201403222UA (enExample)
SI (2) SI3453723T1 (enExample)
SM (1) SMT202100628T1 (enExample)
TW (1) TWI591073B (enExample)
UY (1) UY34603A (enExample)
WO (1) WO2013116296A1 (enExample)

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PT3248986T (pt) 2014-05-16 2022-04-05 Ablynx Nv Domínios variáveis de imunoglobulina
KR20250099289A (ko) 2014-05-16 2025-07-01 아블린쓰 엔.브이. 개선된 면역글로불린 가변 도메인
CN105233286B (zh) * 2015-09-10 2018-10-30 上海交通大学医学院 含酸敏感离子通道调控剂的制剂及其在治疗瘙痒中的用途
CN105713089B (zh) * 2016-02-26 2019-08-06 上海科技大学 一种特异性抑制酸敏感离子通道i型的全人抗体
WO2018085441A1 (en) * 2016-11-01 2018-05-11 Berg Llc Filamin b binding proteins and uses thereof
IL276164B2 (en) * 2018-01-26 2024-11-01 Regeneron Pharma Anti-tmprss2 antibodies and antigen-binding fragments
KR20220016891A (ko) * 2019-06-04 2022-02-10 상하이테크 유니버시티 친화성-성숙된 항-ASIC1a 항체
PH12022550056A1 (en) * 2019-07-11 2023-04-12 Memorial Sloan Kettering Cancer Center Dll3-targeting antibodies and uses thereof
WO2021012176A1 (en) * 2019-07-23 2021-01-28 Shanghaitech University Asic1 channel antagonist antibody
AU2020346886A1 (en) * 2019-09-13 2022-04-14 Memorial Hospital For Cancer And Allied Diseases Anti-CD371 antibodies and uses thereof
CA3228654A1 (en) * 2021-08-09 2023-02-16 Brian Rabinovich Proteins that decouple t cell-mediated tumor cytotoxicity from release of pro-inflammatory cytokines
CN118159558A (zh) * 2021-09-02 2024-06-07 纪念斯隆-凯特琳癌症中心 抗dll3抗体和其用途
CN119331085B (zh) * 2024-10-16 2025-03-14 中国科学院合肥物质科学研究院 沙贝冠状病毒广谱中和抗体及其应用

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JO3672B1 (ar) * 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
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ES2886123T3 (es) 2012-01-31 2021-12-16 Regeneron Pharma Anticuerpos anti-asic1 y usos de los mismos
US9371383B2 (en) 2012-01-31 2016-06-21 Regeneron Pharmaceuticals, Inc. Anti-ASIC1 antibodies and uses thereof

Also Published As

Publication number Publication date
CN104093738A (zh) 2014-10-08
IL233410A0 (en) 2014-08-31
EP2809681B1 (en) 2018-12-05
CN104093738B (zh) 2018-05-18
KR20140125363A (ko) 2014-10-28
HUE056335T2 (hu) 2022-02-28
JP2015508063A (ja) 2015-03-16
DK2809681T3 (en) 2019-03-11
PL3453723T3 (pl) 2022-01-03
AR089852A1 (es) 2014-09-24
BR112014018651A2 (pt) 2017-07-04
MX358518B (es) 2018-08-24
IL254416A0 (en) 2017-11-30
PH12014501613A1 (en) 2014-10-13
HRP20211541T1 (hr) 2021-12-24
LT3453723T (lt) 2021-09-10
MY168748A (en) 2018-11-30
TWI591073B (zh) 2017-07-11
US20180222976A1 (en) 2018-08-09
US20130195878A1 (en) 2013-08-01
US9150648B2 (en) 2015-10-06
HRP20190358T1 (hr) 2019-04-05
EP3453723B1 (en) 2021-08-11
IL254416B (en) 2018-03-29
PT2809681T (pt) 2019-02-18
ES2707599T3 (es) 2019-04-04
JO3547B1 (ar) 2020-07-05
SI2809681T1 (sl) 2019-04-30
IN2014CN04645A (enExample) 2015-09-18
EP3453723A3 (en) 2019-04-10
JP6302844B2 (ja) 2018-03-28
SMT202100628T1 (it) 2022-01-10
KR102111941B1 (ko) 2020-05-18
HK1199269A1 (en) 2015-06-26
EP3453723A2 (en) 2019-03-13
AU2013215254A1 (en) 2014-07-03
CL2014002019A1 (es) 2015-01-16
CA2862332C (en) 2021-05-18
EP2809681A1 (en) 2014-12-10
MX2014008541A (es) 2014-10-24
SI3453723T1 (sl) 2021-11-30
CO7020877A2 (es) 2014-08-11
EA028647B1 (ru) 2017-12-29
TW201335182A (zh) 2013-09-01
WO2013116296A1 (en) 2013-08-08
PL2809681T3 (pl) 2019-05-31
DK3453723T3 (da) 2021-09-13
PT3453723T (pt) 2021-09-07
US20160002332A1 (en) 2016-01-07
RS58439B1 (sr) 2019-04-30
ES2886123T3 (es) 2021-12-16
CY1121368T1 (el) 2020-05-29
US10513557B2 (en) 2019-12-24
RS62454B1 (sr) 2021-11-30
AU2013215254B2 (en) 2017-08-31
PH12014501613B1 (en) 2014-10-13
NZ626242A (en) 2017-02-24
SG11201403222UA (en) 2014-07-30
UY34603A (es) 2013-07-31
EA201491452A1 (ru) 2014-11-28
CY1124778T1 (el) 2022-11-25
CA2862332A1 (en) 2013-08-08
LT2809681T (lt) 2019-02-11

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