USRE45510E1 - Patch having easily detachable release sheet - Google Patents

Patch having easily detachable release sheet Download PDF

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Publication number
USRE45510E1
USRE45510E1 US13/687,376 US200613687376A USRE45510E US RE45510 E1 USRE45510 E1 US RE45510E1 US 200613687376 A US200613687376 A US 200613687376A US RE45510 E USRE45510 E US RE45510E
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United States
Prior art keywords
release sheet
patch
division zone
pattern
precut
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US13/687,376
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English (en)
Inventor
Hideaki Iwahashi
Shigeo Ota
Nobuo Tsutsumi
Takafumi Miyachika
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Hisamitsu Pharmaceutical Co Inc
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Hisamitsu Pharmaceutical Co Inc
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Priority to US13/687,376 priority Critical patent/USRE45510E1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/01—Non-adhesive bandages or dressings
    • A61F13/01021—Non-adhesive bandages or dressings characterised by the structure of the dressing
    • A61F13/01029—Non-adhesive bandages or dressings characterised by the structure of the dressing made of multiple layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0259—Adhesive bandages or dressings characterised by the release liner covering the skin adhering layer
    • A61F13/00029—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00289—Wound bandages easy removing of the protection sheet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00795—Plasters special helping devices
    • A61F2013/008—Plasters special helping devices easy removing of the protection sheet
    • A61F2013/00812—Plasters special helping devices easy removing of the protection sheet perforate or breakable zones

Definitions

  • the invention relates to a patch such as a cataplasm or a plaster. More particularly, it relates to a patch that is excellent in convenience, wherein the patch can be applied on a diseased part cleanly and simply even by an aged person without unnecessarily touching its adhesive surface and without leaving creases on the patch such as the cataplasm or the plaster.
  • a patch wherein a release sheet can easily be detached by forming with two pieces of release sheets put together at the central part of the patch and bent from the joint and by providing a pull tab part (Patent document 1)
  • a patch wherein a release sheet can easily be detached by providing a cutting line in a shape such as a wavy pattern or a zigzag pattern having a convex part and a concave part in the release sheet and by bending the entire patch, whereby said convex part becomes a catching part (Patent document 2)
  • Patent document 1 a patch, wherein a release sheet can easily be detached by providing a cutting line in a shape such as a wavy pattern or a zigzag pattern having a convex part and a concave part in the release sheet and by bending the entire patch, whereby said convex part becomes a catching part (Patent document 2)
  • it is costly to form the pull-tab part on the former patch and it is necessary to handle the patch with care because the
  • a first-aid adhesive plaster is known in a field of an adhesive plaster having a sterile pad, wherein a piece of a thin plate for detachment having a cutting with a wavy line, is used and divided into two pieces by pulling apart (Patent document 3).
  • Patent document 3 a first-aid adhesive plaster is known in a field of an adhesive plaster having a sterile pad, wherein a piece of a thin plate for detachment having a cutting with a wavy line, is used and divided into two pieces by pulling apart.
  • actions such as bending the first-aid adhesive plaster itself and shifting it from one hand to the other are needed, and therefore, it does not always exhibit excellent usability (easiness for application) (Patent document 3).
  • a patch excellent in usability is known in a field of a patch, in which only a release sheet can be divided by simply pulling apart (Patent document 4), however, since the needs of consumers, who are mainly aged persons and who seek superior usability (easiness for application), it is desired to provide an advanced patch with a simpler operation to detach the release sheet.
  • the inventors have found that, by providing one or more precut parts near the division zone on a release sheet that are opened when a patch is pulled apart, the divided release sheet is turned up cleanly; and the inventors further advanced the research, and completed the invention.
  • the invention relates to a patch comprising a stretchable support, an adhesive mass laminated substantially all over one surface of the support and a release sheet attached to the entire surface of the adhesive mass wherein only the release sheet is divided at a division zone by simply pulling apart, and wherein one or more precut parts that are opened when the patch is pulled apart are provided near the division zone.
  • the invention relates to the patch, wherein the division zone is arranged in an S-shaped pattern, a wavy pattern or a zigzag pattern.
  • the invention relates to the patch, wherein the division zone is arranged in a straight-line pattern.
  • the invention relates to the patch, wherein the division zone is arranged in precut parts are provided in the form of a T-shaped pattern.
  • the invention relates to the patch, wherein the longitudinal bar of a T-shape is parallel to pulling directions of the patch and the tip of said longitudinal bar is pointed toward the division zone.
  • the invention relates to the patch, wherein the precut part is provided convexly toward the pulling directions from the division zone.
  • the invention relates to the patch, wherein the division zone is arranged in precut parts are provided in the form of a V-shaped pattern or a circular arc pattern.
  • the invention relates to the patch, wherein the release sheet is one piece of release sheet having a division zone, and only the release sheet is divided at the division zone due to the difference in a rate of elongation between the release sheet and the support by simply pulling the patch apart.
  • a release sheet is divided by simply pulling a patch apart without starting from a detachment step such as searching edges of the release sheet or a support, but the release sheet can also be picked extremely easily because the edges of the divided parts of the release sheet are favorably turned up with the presence of a precut part. Furthermore, since a part of an adhesive mass is exposed more widely as a result of a favorable turn-up, application of the patch becomes easier without shifting the patch from one hand to the other (so-called one-touch operation) by directly applying an exposed part of the adhesive mass, which is exposed more widely, to a diseased part.
  • the release sheet is divided at a division zone; simultaneously, an opening is formed at a precut part; air enters into a space between the release sheet and an adhesive mass from the precut part, and this air facilitates a turn-up.
  • FIG. 1 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 2 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 3 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 4 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 5 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 6 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 7 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 8 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 9 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 10 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 11 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 12 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 13 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 14 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 15 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 16 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • FIG. 17 shows a descriptive drawing (front view) illustrating one embodiment of a patch of the invention.
  • a division zone according to the invention is a part where a release sheet is divided when pulling a patch apart. This may be located at a desired position such as substantially central part of the release sheet or its peripheral part.
  • the division zone of the invention typically includes a thin cut part thinned without penetrating the release sheet, which is so-called a half-cut, a perforation cut part in which the release sheet is cut at a designated interval, the other called as a weakened line or the like, further, a mortise (notch) formed on the side of the release sheet in an I-shaped pattern, a V-shaped pattern and the like.
  • the release sheet is one piece of release sheet having a division zone, and by simply pulling apart only the release sheet is divided at said division zone due to the difference in a rate of elongation.
  • the release sheet consists of two pieces of completely divided release sheets, however, the release sheet is preferably one piece of release sheet having the division zone from viewpoints such as protection of the patch shape, prevention from vaporization of an efficacious ingredient, and the like.
  • the division zone in the form of a thin cut part or a cut part in a perforation pattern, it is formed across the release sheet at substantially central part, a peripheral part or the like so that the release sheet is divided, and the form of said division zone may be arranged in a pattern such as a straight pattern, an S-shaped pattern, a wavy pattern or a zigzag pattern, and further, for example, entire division zone may be arranged in a zigzag pattern, wherein each line of said zigzag may further form a zigzag-pattern, a wavy pattern or the like, or a combination of the above patterns, and may be arranged in any other patterns.
  • the S-shaped pattern, the wavy pattern, the zigzag pattern or the like which form a convex part and a concave part are preferable.
  • the distance (stroke) between one convex part and its neighboring convex part is relatively long (in a case of a small number of strokes), a section formed after division of the release sheet is large and can easily be picked.
  • the precut part according to the invention is, without limitation, provided in a form which is opened when the patch is pulled, and this open part contributes to the turn-up of the release sheet; typically, in the form of a straight pattern, a T-shaped pattern, a V-shaped pattern, a folding-fan pattern or the like.
  • the longitudinal bar of a T-shape is parallel to the pulling directions of the patch and the tip of said longitudinal bar is pointed toward a division zone and/or is provided convexly toward the pulling directions from a division zone.
  • One or more precut part are provided near the division zone, and preferably are in a closed state before use. It may be provided in any pattern as long as it is opened when pulling the patch apart, and typically, a precut penetrating the release sheet, a thin cut part of a half-cut pattern, a perforation cut part and the like.
  • the precut part convexly toward the pulling directions from the division zone, because it promotes turn-up of the release sheet and prevent re-sticking of the release sheet; in particular, a V-shaped pattern or a circular arc pattern is preferable.
  • the patch according to the invention comprises the support, adhesive mass and release sheet, and those conventionally used can be used as described below.
  • a plastic film which may be colorless or colored, such as a casted polypropylene (CPP), an oriented polypropylene (OPP), polyethylene terephthalate (PET), polybutylene terephthalate (PBT), polyethylene, polyester, polyurethane, polyvinyl chloride or polystyrene, silicone-treated treatment papers, which is a silicone-treated synthetic resin, synthetic paper, synthetic fiber or the like, aluminum foil, laminated paper, which is a kraft paper laminated with polyethylene or the like may be used.
  • CPP casted polypropylene
  • OPP oriented polypropylene
  • PET polyethylene terephthalate
  • PBT polybutylene terephthalate
  • silicone-treated treatment papers which is a silicone-treated synthetic resin, synthetic paper, synthetic fiber or the like, aluminum foil, laminated paper, which is a kraft paper laminated with polyethylene or the like may be used.
  • the thickness of the above release sheet is in the range of 10 ⁇ m-75 ⁇ m, preferably 12 ⁇ m-40 ⁇ m, more preferably 15 ⁇ m-35 ⁇ m. If the release sheet is too thin, the release sheet tends to be intertwined with an adhesive mass when detached, and it is difficult to pick the release sheet because the release sheet is thin and slippery, further, the release sheet is easily divided when manufacturing, which results in lower workability or the like; the release sheet is easily creased when attaching the release sheet on the adhesive mass. On the other hand, if the release sheet is too thick, the release sheet can easily be picked for detachment, however it becomes difficult to divide as well as to cut an original sheet when manufacturing, and it tends to lower workability, etc.
  • the tensile strength of the release sheet is in the range of 10 g/cm-140 g/cm, preferably 20 g/cm-100 g/cm, more preferably 30 g/cm-60 g/cm. If the tensile strength of the release sheet is too small, the release sheet is cut on the way when manufacturing and can not continuously be attached on the adhesive mass; the release sheet is easily divided when placing a patch such as a cataplasm, a plaster or the like in a package bag; further a yield tends to be decreased. In addition, if the tensile strength of the release sheet is too large, it becomes difficult to divide the release sheet, and usability tends to be worsened.
  • the tensile strength can be measured using, for example, a tensile test machine AGS-100B (manufactured by Shimadzu Corporation) in terms of a weight at the time of rupture, wherein the release sheet is held by a chuck of 50 mm width with the standard point distance of 100 mm and pulled at 100 mm/min.
  • AGS-100B manufactured by Shimadzu Corporation
  • the release sheet having the thickness of 10 ⁇ m-75 ⁇ m and the tensile strength 10 g/cm-140 g/cm is particularly preferable, because in addition to the above workability and usability, the turn-up becomes more favorable together with elasticity of the release sheet and effects of the precut part provided in the release sheet, whereby the adhesive mass can be exposed more widely.
  • an indication such as a figure including an arrow or the like, a letter, a symbol, or the like may be drawn on both parts of the release sheet, or, for example, it may be colored.
  • coloring or the like for example, by clearly indicating on the release sheet, a procedure how to pull the patch apart and how to stick on a diseased part in one-touch without shifting from one hand to the other, it is possible to use the patch while reading How To Use, and usability (sticking easiness) can be improved more.
  • the above indication may be located on the support.
  • the release sheet may further be embossed, and typically, the entire surface or a partial area of the release sheet, for example, an area where can easily be picked by the hand for tearing the division zone, an area where it can easily be picked for detaching the release sheet which is torn, or the like, is embossed.
  • a form of the embossing is not limited, as long as the release sheet can easily be picked by the hand without slipping; it may be formed, for example, in a lattice pattern, a circle pattern, an angular pattern, a star pattern, or the like, or in any other patterns.
  • the embossed release sheet has partially different strength, and therefore, promotes the turn-up; further, if the cut part is provided, ruggedness of the embossing and the cut part together give a favorable, variable turn-up; an adhesive mass surface becomes more exposed, resulting in further improvement in convenience when picking the release sheet. Further, owing to the turn-up that is not planar, there is a merit that the release sheet hardly sticks again to the adhesive mass.
  • the support for the patch of the invention may be any support that is not divided when the release sheet is divided by pulling the patch apart.
  • the difference in a rate of elongation between the release sheet and the above support so that only the release sheet is divided at division part when pulling said patch apart, while for a favorable turn-up of the release sheet when dividing, the difference is preferably not less than 0.3%.
  • stretch materials such as woven fabric, knitted fabric, non-woven fabric and non-woven paper.
  • natural fibers such as bast fibers like paper, cotton, hemp and jute, cellulose fibers such as vein fiber like Manila hemp, animal hair fibers like wool, and protein fibers like silk fiber and feather fiber, regenerated fibers such as regenerated cellulose fibers like rayon and cupra, and regenerated protein fiber, semi-synthetic fibers such as cellulose acetate and promix, nylon aramid fiber, polyethylene terephthalate fiber, polyester fiber, acryl fiber, polyolefin fibers like polyethylene and polypropylene, polyvinyl alcohol fiber, polyvinyl chloride fiber, polyvinylidene chloride fiber, polyvinyl chloride type fiber, polyurethane fiber, polyoxymethylene fiber, polytetrafluoroethylene fiber, polyparaphenylene benzbisthiazole (PBT) fiber, polyimide fiber, and the like may be used.
  • natural fibers such as bast fibers
  • the above fibers are appropriately selected according to physical properties such as the thickness, stretching, tensile strength and workability, feeling when applying, covering for a diseased part, the transfer of a drug to the support, and the like.
  • the adhesive mass for the patch of the invention comprises a drug, which is contained in or disposed on a base, so that the patch such as a cataplasm and a plaster is effectively used.
  • the adhesive mass is formed to hold water for sufficiently efficacious effects to the skin, while also to have adhesiveness and appropriate cohesiveness without giving excessive softness at an ambient temperature or higher and without leaving the adhesive mass on the skin.
  • the adhesive mass is prepared from a thickener, a moistening agent and the like, while as the thickener, it is desirable to be able to stably hold water in 30%-80% and to have a water-holding property.
  • aqueous polymers including natural polymers such as those of plant origins like guar gum, locust bean gum, carrageenan, alginic acid, sodium alginate, agar, gum arabic, tragacanth gum, karaya gum, pectin and starch, those of microorganism origins like xanthan gum and acacia gum, and those of animal origins like gelatin and collagen, semi-synthetic polymers such as celluloses like methyl cellulose, ethyl cellulose, hydroxyethyl cellulose and sodium carboxymethyl cellulose, and starches like soluble starch, carboxymethyl starch and dialdehyde starch, synthetic polymers such as vinyls like polyvinyl alcohol, polyvinyl
  • Sodium polyacrylate is particularly preferable because it has high gel strength and excellent in a water-holding property. Further, sodium polyacrylate of average polymerization degree 20000-70000 is preferable. If the average polymerization degree is smaller than 20000, a thickening effect is poor, and there is a tendency that a sufficient gel strength cannot be obtained. On the other hand, if the average polymerization degree is larger than 70000, the thickening effect is too strong, and workability tends to be reduced. In addition, by using a combination of two or more of the above aqueous polymers, for example, a polymer complex with a strong ionic polymer of sodium polyacrylate is formed, and an elastic gel with higher gel strength can be obtained.
  • polyvalent alcohols such as glycerin, propylene glycol and sorbitol, and as a filler, kaolin, talc, titanium, bentonite, aluminum silicate, titanium oxide, zinc oxide, aluminum metasilicate, calcium sulfate, calcium phosphate and the like may be added.
  • solubilizer or an absorption enhancer propylene carbonate, crotamiton, 1-menthol, mentha oil, limonene, diisopropyl adipate or the like, and as an adjuvant, methyl salicylate, glycol salicylate, 1-menthol, thymol, mentha oil, vanillic amide nonylate, red pepper extract and the like may be added. Further, if necessary, a stabilizing agent, an antioxidant, an emulsifying agent, and the like may be added.
  • a cross-linking agent, a polymerizing agent and the like may be added, which can strengthen the adhesive mass as well as improve a water-holding property.
  • the cross-linking agent and the polymerizing agent are appropriately selected according to types of the thickener and the like.
  • polyacrylic acid or polyacrylate is selected as the thickener
  • a compound having at least two epoxy groups in the molecule polyvalent metal compounds such as inorganic salts like a hydrochloride, sulfate, phosphate and carbonate and organic salts like a citrate, tartarate, gluconate and stearate of Ca, Mg, Al or the like, oxides like zinc oxide and silica, and hydroxides like aluminum hydroxide and magnesium hydroxide are preferably used.
  • polyvinyl alcohol is selected as the thickener
  • complexes of adipic acid, thioglycolic acid, an epoxy compound (epichlorhydrin), aldehydes, an N-methylol compound, and a compound of Al, Ti, Zr, Sn, V, Cu, B, Cr or the like are preferably used.
  • polyvinyl pyrrolidone is selected as the thickener
  • methylvinyl ether-maleic anhydride copolymer a polyacid compound or alkaline salts thereof (poly acrylic acid, tannic acid and derivatives thereof) and the like are preferably used.
  • polyethylene oxide is selected as the thickener, a peroxide, a polysulfone azide and the like are preferably used.
  • methylvinyl ether-maleic anhydride copolymer is selected as the thickener
  • a polyfunctional hydroxyl compound polyamine, iodine, gelatin, polyvinyl pyrrolidone, iron, mercury and lead salts, and the like are preferably used.
  • gelatin is selected as the thickener, aldehydes such as formaldehyde, glutar aldehyde, dialdehyde starch and glyoxal, diepoxides such as butadiene oxide, diketones such as divinyl ketone, diisocyanates and the like are preferably used.
  • polyvalent metal salts such as lithium hydroxide, zinc hydroxide, aluminum hydroxide, and sodium borate are preferably added as a cross-linking agent.
  • the zinc salt and aluminum salt are preferable.
  • a cross-linking reaction is accelerated.
  • the concentration of the polyvalent metal salts added as the cross-linking agent is preferably 0.5-1.5 equivalent weight per 1 equivalent weight of the thickener (or the aqueous polymer). If the concentration of the polyvalent metal salt is too low, the reaction is too slow, and a gel strength tends to be lower; if the concentration of the polyvalent metal salt is too high, the reaction is too rapid and gelation tends to be inhomogeneous and to lower workability.
  • the adhesive mass is preferably made as follows: the thickener is 5 wt. %-20 wt. %, preferably 10 wt. %-15 wt. %; the moistening agent is 5 wt.
  • the filler is 20 wt. % or less; water is 10 wt. %-80 wt. %; the solubilizer is 0 wt. %-8 wt. %; the drug is 5 wt. % or less, preferably 0.5 wt. %-5 wt. %.
  • an acrylic copolymer, an A-B-A type block copolymer, alicyclic petroleum resin, or one having a softening agent is suitably used as the base.
  • elastic agents with thermo-plasticity such as an A-B type block copolymer, polybutene, silicone rubber, natural rubber, styrene-butadiene copolymer, NBR polyisobutylene, polyalkyl acrylate and synthetic isoprene, tackifiers such as terpene resin, petroleum resin, rosin, hydrogenated rosin and rosin-hydrogenated rosin ester, adhesiveness- or holding-modifiers such as animal and plant oils like liquid paraffin, olive oil, soya oil, beef tallow, lard, etc., polybutene, liquid polyisobutylene, lower isoprene and wax, fillers such as titanium oxide, zinc oxide, aluminum metasilicate, calcium sulfate and calcium phosphat
  • A-B-A type block copolymer a block copolymer of monovinyl-substituted aromatic compound A and conjugated diolefin copolymer B are preferably used.
  • Specific examples are: Califlex TR-1101, Califlex TR-1107, Califlex TR-1111 and the like which are manufactured by Shell Chemicals, Solprene 418, Solprene 311 and the like which are manufactured by Phillips Petroleum Company, while the mix amount is 10-40 weight parts in an adhesive mass composition, preferably 15-30 weight parts.
  • examples are, without limitation, at least one kind of non-steroidal anti-inflammatory agent selected from methyl salicylate, glycol salicylate, 1-menthol, red pepper extract, vanillic amide nonylate, mentha oil, diclofenac, ibuprofen, indometacin, ketoprofen, loxoprofen, sulindac, tolmetin, lobenzarit, penicillamine, fenbufen, flurbiprofen, naproxen, pranoprofen, tiaprofenic acid, suprofen, felbinac, ketololac, oxaprozin, etodolac, zaltoprofen, piroxicam, pentazocine, buprenorphine hydrochloride, butorphanol tartarate, etc., and ester derivatives thereof or salts thereof, steroidal anti-inflammatory agents such as prednisolone
  • the drugs may be used in a combination of two or more kinds as needed.
  • these drugs if necessary, may be contained in or disposed on the adhesive mass as a compound which may be derived in an ester form, a compound which may be derived an amide form, a compound which may be derived in an acetal form, or in a form of medically acceptable inorganic or organic salts.
  • the amount of the drug is appropriately selected according to the type, the use, etc. of patches such as the cataplasm, plaster and the like in order to be able to apply an efficacious predetermined amount to a diseased part when applying to a patient.
  • the patch of the invention as a cold compress or the like, which contains no drug.
  • the patch of the invention is typically as shown in FIG. 1 .
  • the patch 1 comprises the stretchable support 2 , the adhesive mass 3 laminated substantially all over one surface of the above support 2 and the release sheet 4 attached to the entire surface of the above adhesive mass 3 , wherein only the above release sheet 4 is divided at the division zone 10 by simply pulling apart, and wherein plural precut parts 20 are provided near the above division zone 10 .
  • the division zone 10 is arranged in the perforation zigzag pattern and is placed in substantially central part of the patch 1 , whereby the number of strokes is 3.5.
  • a part of the precut part 20 is hooked on a part that becomes the section 5 .
  • the precut part 20 is provided in the T-shaped pattern, whereby the longitudinal bar of said T-shape is parallel to the pulling directions (the lateral directions in FIG. 1 ) of the patch 1 and the tip of said longitudinal bar is pointed toward the division zone 10 .
  • the release sheet 4 can be divided at the division zone 10 by holding both ends of the patch 1 and pulling the release sheet 4 apart together with the support 2 .
  • the precut part 20 formed near the division zone 10 is opened, while air enters into a space between the release sheet 4 and the adhesive mass 3 from said open part, so that this air facilitates detachment of the release sheet 4 from the adhesive mass 3 .
  • the precut part 20 which is torn, makes bending extremely easy.
  • the patch 1 is applied to a diseased part by applying this exposed adhesive mass 3 to the diseased part and picking the section 5 to detach the turned-up release sheet 4 . This enables the adhesive mass 3 to be exposed more widely than that of the conventional patches, the release sheet 4 to easily be detached and the patch 1 to be applied to a diseased part, without unnecessarily touching the adhesive mass 3 and creasing the patch 1 .
  • the patch of the invention includes various embodiments shown in FIGS. 2-8 .
  • the T-shaped precut part 20 is provided such that the longitudinal bar of the T-shape is parallel to the pulling directions of the patch and the tip of said longitudinal bar is pointed toward the division zone; however, it is different in that one entire precut part 20 is provided inside (in the width between two tips of zigzag pattern) one section 5 .
  • the straight precut part 20 is provided near the base of the triangle in the section 5 , and is vertically provided in the pulling directions in the patch.
  • the division zone is arrange in the half-cut wavy pattern, and the precut part 20 of T-shaped pattern is provided in a similar way to that of FIG. 1 .
  • the division zone is arranged in the half-cut S-shaped pattern (inverted S-shaped pattern) ( FIG. 5 ) or zigzag pattern ( FIG. 6 ), while the T-shaped precut part 20 is provided such that the longitudinal bar of the T-shape is parallel to the pulling directions of the patch and the tip of said longitudinal bar is pointed toward the division zone.
  • the division zone is arranged in the combination of the straight-line pattern and the curved line, and the T-shaped precut part 20 is provided.
  • the division zone is arranged in the combination of the straight pattern and the zigzag pattern, and the T-shaped precut part 20 is provided.
  • FIGS. 9-12 illustrate further embodiments.
  • the angle of the convex part of the division part 10 is large, while the precut part 20 is provided in one line along the central line of the division zone 10 , and another line is additionally provided in the section 5 .
  • the angle of the convex part of the division part 10 is about 70°-90°, while the precut part 20 comprising two lines parallel and one line vertical to the central line of the division zone 10 is provided in the convex part.
  • FIGS. 11 and 12 the precut part 20 comprising three lines parallel to the central line of the division zone 10 is provided in the convex part, wherein the embodiment ( FIG. 11 ) has two connections in one ridgeline of the convex part, whereas the embodiment ( FIG. 12 ) has one connection.
  • the patches shown in FIGS. 13-17 illustrate further embodiments, wherein all or a part of the precut part 20 are provided in the convex pattern toward the outer side (apart directions).
  • the tip of the precut part 20 of convex pattern is pulled so as to be caught by the adhesive mass 3 , and therefore, the turn-up of the release sheet 4 and exposure of the adhesive mass surface are facilitated, and convenience is further increased.
  • the circular arc precut part 20 is provided in both sides of the division zone 10 in straight line pattern; in FIG. 14 , the precut part 20 is further provided in the circular arc, and in FIG. 15 , it is provided side by side with the circular arc. In FIG. 16 , the circular arc precut part is provided in two lines on one side in the embodiment described in FIG. 14 . The length of the circular arc precut part and the radius of its curvature can appropriately be changed.
  • FIG. 17 shows one embodiment, wherein on both sides of the division zone 10 arranged in straight-line pattern, the V-shaped precut part 20 is provided in the convex pattern toward the pulling directions from the division zone.
  • V-shaped precut part it is preferable to make the V-shaped precut part about 3-10 mm away from the division zone, the angle of the V-shape about 40°-70°, the height of the convex of V-shaped pattern about 5-20 mm, and the distance between the V-shapes about 10-30 mm.
  • FIG. 1 Comparative FIG. 1 FIG. 2 FIG. 3 example Easiness to pick release sheet 2.9 2.7 2.5 1* Easiness to stick 3.0 3.0 2.9 1* *The comparative example was evaluated as 1. Marks: Easiness to pick release sheet 3: very easy to pick compared with the comparative example 2: easy to pick compared with the comparative example 1: the same degree as the comparative example Easiness to stick 3: very easy to stick compared with the comparative example 2: easy to stick compared whit the comparative example 1: the same degree as the comparative example
  • the precut part was formed as described in FIG. 17 , and the patch was pulled apart to ascertain the turn-up after dividing the release sheet.
  • the V-shaped precut part 20 was provided at about 5 mm from the division zone 10 in a repetitive pattern.
  • the angle of the V-shape was made 55°; the height of the V-shaped pattern was made 10 mm, and the distance between the V-shapes was made 20 mm.
  • the turn-up of the release sheet when pulling the patch apart was extremely favorable compared with one without the precut. Further, when the patch is released, the turn-up state was easily maintained.
  • the invention relates to a patch such as a cataplasm or a plaster and can provide the patch such as the cataplasm or the plaster that are low in cost and apt to mass production, wherein it is possible to easily divide a release sheet by simply pulling the patch such as the cataplasm or the plaster apart, and by simply applying the exposed part of the release sheet to a diseased part, even an aged person can stick it cleanly without unnecessarily touching an adhesive mass and without leaving creases.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Materials For Medical Uses (AREA)
US13/687,376 2005-08-17 2006-08-17 Patch having easily detachable release sheet Active 2027-01-06 USRE45510E1 (en)

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US13/687,376 USRE45510E1 (en) 2005-08-17 2006-08-17 Patch having easily detachable release sheet

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JP2005-236748 2005-08-17
JP2005236748 2005-08-17
PCT/JP2006/316180 WO2007020980A1 (ja) 2005-08-17 2006-08-17 簡易剥離可能な剥離シートを備えた貼付剤
US13/687,376 USRE45510E1 (en) 2005-08-17 2006-08-17 Patch having easily detachable release sheet
US12/063,688 US7910792B2 (en) 2005-08-17 2006-08-17 Patch having easily detachable release sheet

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US10398802B2 (en) 2004-02-18 2019-09-03 Ethicon, Inc. Adhesive-containing wound closure device and method
US10398800B2 (en) 2004-07-12 2019-09-03 Ethicon, Inc. Adhesive-containing wound closure device and method
US10470934B2 (en) 2016-09-29 2019-11-12 Ethicon, Inc. Methods and devices for skin closure
US10470935B2 (en) 2017-03-23 2019-11-12 Ethicon, Inc. Skin closure systems and devices of improved flexibility and stretchability for bendable joints
US10687986B2 (en) 2016-09-29 2020-06-23 Ethicon, Inc. Methods and devices for skin closure
US10792024B2 (en) 2016-09-28 2020-10-06 Ethicon, Inc. Scaffolds with channels for joining layers of tissue at discrete points
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US10398802B2 (en) 2004-02-18 2019-09-03 Ethicon, Inc. Adhesive-containing wound closure device and method
US10434211B2 (en) 2004-02-18 2019-10-08 Ethicon, Inc. Adhesive-containing wound closure device and method
US11413370B2 (en) 2004-02-18 2022-08-16 Ethicon, Inc. Adhesive-containing wound closure device and method
US10398800B2 (en) 2004-07-12 2019-09-03 Ethicon, Inc. Adhesive-containing wound closure device and method
US11446407B2 (en) 2004-07-12 2022-09-20 Ethicon, Inc. Adhesive-containing wound closure device and method
USD809665S1 (en) * 2015-03-10 2018-02-06 Johnson & Johnson Consumer Inc. Bandage release liner having a decorative parting line
US10792024B2 (en) 2016-09-28 2020-10-06 Ethicon, Inc. Scaffolds with channels for joining layers of tissue at discrete points
USD907217S1 (en) 2016-09-29 2021-01-05 Ethicon, Inc. Release paper for wound treatment devices
US10687986B2 (en) 2016-09-29 2020-06-23 Ethicon, Inc. Methods and devices for skin closure
US10470934B2 (en) 2016-09-29 2019-11-12 Ethicon, Inc. Methods and devices for skin closure
USD979768S1 (en) 2016-09-29 2023-02-28 Ethicon, Inc. Release paper for wound treatment devices
US11679034B2 (en) 2016-09-29 2023-06-20 Ethicon, Inc. Methods and devices for skin closure
US10470935B2 (en) 2017-03-23 2019-11-12 Ethicon, Inc. Skin closure systems and devices of improved flexibility and stretchability for bendable joints
US11883264B2 (en) 2017-03-23 2024-01-30 Ethicon, Inc. Skin closure systems and devices of improved flexibility and stretchability for bendable joints
US11980354B2 (en) 2017-03-23 2024-05-14 Ethicon, Inc. Scaffolds for joining layers of tissue at discrete points
US11504446B2 (en) 2017-04-25 2022-11-22 Ethicon, Inc. Skin closure devices with self-forming exudate drainage channels
US10993708B2 (en) 2018-07-31 2021-05-04 Ethicon, Inc. Skin closure devices with interrupted closure
US11974734B2 (en) 2018-07-31 2024-05-07 Ethicon, Inc. Skin closure devices with interrupted closure

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EP1915976A1 (en) 2008-04-30
BRPI0614991B1 (pt) 2018-03-20
BRPI0614991A2 (pt) 2011-04-26
KR20080036613A (ko) 2008-04-28
TW200726446A (en) 2007-07-16
WO2007020980A1 (ja) 2007-02-22
ES2530201T3 (es) 2015-02-27
US7910792B2 (en) 2011-03-22
CN101242794A (zh) 2008-08-13
TWI374027B (zh) 2012-10-11
US20090281471A1 (en) 2009-11-12
BRPI0614991B8 (pt) 2021-06-22
CN101242794B (zh) 2012-04-11
KR101280608B1 (ko) 2013-06-28
EP1915976B1 (en) 2014-12-17
EP1915976A4 (en) 2011-05-25

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