US9567361B2 - Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics - Google Patents
Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics Download PDFInfo
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- US9567361B2 US9567361B2 US13/469,499 US201213469499A US9567361B2 US 9567361 B2 US9567361 B2 US 9567361B2 US 201213469499 A US201213469499 A US 201213469499A US 9567361 B2 US9567361 B2 US 9567361B2
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- purified
- growth
- probiotic bacterium
- fucosyllactose
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- A23L33/28—Substances of animal origin, e.g. gelatin or collagen
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Definitions
- Human milk glycans which comprise both unbound oligosaccharides and their glycoconjugates, play a significant role in the protection and development of the infant gastrointestinal (GI) tract.
- Milk oligosaccharides found in various mammals differ greatly, and composition in humans is unique (Hamosh M, 2001 Pediatr Clin North Am, 48:69-86; Newburg D, 2001 Adv Exp Med Biol, 501:3-10).
- glycan levels in human milk change throughout lactation and also vary widely among individuals (Morrow A et al., 2004 J Pediatr, 145:297-303; Chaturvedi P et al., 2001 Glycobiology, 11:365-372).
- Fresh fecal samples were collected from three healthy babies, identified as A, B and C, who had not received antibiotics or pre/probiotics and had no history of gastrointestinal disorder.
- Fresh human infant feces were added to phosphate-buffered sterile anaerobic saline solution (1:10 feces to saline), mixed in a blender for 60 s, homogenized and filtered through a double layer of sterile cheesecloth.
- 2 g/L 2′FL and 5 g/L HMO were dissolved for 1 hour in medium before inoculation with 10% (v/v) fecal slurry prepared as above.
- Hungate tubes containing 2′-FL or HMO were inoculated with fecal material, serving as the treatment.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pediatric Medicine (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Dairy Products (AREA)
- Preparation Of Fruits And Vegetables (AREA)
- Cereal-Derived Products (AREA)
- Non-Alcoholic Beverages (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/469,499 US9567361B2 (en) | 2011-05-13 | 2012-05-11 | Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
| US15/419,241 US10286001B2 (en) | 2011-05-13 | 2017-01-30 | Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
| US16/403,095 US20190255083A1 (en) | 2011-05-13 | 2019-05-03 | Use of purified 2'-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161485895P | 2011-05-13 | 2011-05-13 | |
| US13/469,499 US9567361B2 (en) | 2011-05-13 | 2012-05-11 | Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US15/419,241 Continuation US10286001B2 (en) | 2011-05-13 | 2017-01-30 | Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| US20120294840A1 US20120294840A1 (en) | 2012-11-22 |
| US9567361B2 true US9567361B2 (en) | 2017-02-14 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US13/469,499 Active US9567361B2 (en) | 2011-05-13 | 2012-05-11 | Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
| US15/419,241 Active US10286001B2 (en) | 2011-05-13 | 2017-01-30 | Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
| US16/403,095 Abandoned US20190255083A1 (en) | 2011-05-13 | 2019-05-03 | Use of purified 2'-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US15/419,241 Active US10286001B2 (en) | 2011-05-13 | 2017-01-30 | Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
| US16/403,095 Abandoned US20190255083A1 (en) | 2011-05-13 | 2019-05-03 | Use of purified 2'-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US9567361B2 (ja) |
| EP (1) | EP2707379A4 (ja) |
| JP (4) | JP6129821B2 (ja) |
| WO (1) | WO2012158517A1 (ja) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10286001B2 (en) | 2011-05-13 | 2019-05-14 | Glycosyn LLC | Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
| EP3583858A1 (en) | 2018-06-20 | 2019-12-25 | DuPont Nutrition Biosciences ApS | Compositions for treating or preventing gut barrier dysfunction |
| US10821124B2 (en) * | 2015-03-05 | 2020-11-03 | Societe Des Produits Nestle S.A. | Compositions for use in improving stool consistency or frequency in infants or young children |
| CN111935995A (zh) * | 2018-03-29 | 2020-11-13 | 森永乳业株式会社 | 营养组合物以及使用了该营养组合物的饮食品组合物和配方奶粉 |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5766947B2 (ja) | 2007-09-07 | 2015-08-19 | チルドレンズ ホスピタル メディカル センター | 臨床サンプルにおける分泌性のルイス抗原およびシアル化抗原のレベルの疾患リスクの予測指標としての使用 |
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| US10821124B2 (en) * | 2015-03-05 | 2020-11-03 | Societe Des Produits Nestle S.A. | Compositions for use in improving stool consistency or frequency in infants or young children |
| CN111935995A (zh) * | 2018-03-29 | 2020-11-13 | 森永乳业株式会社 | 营养组合物以及使用了该营养组合物的饮食品组合物和配方奶粉 |
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Also Published As
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| WO2012158517A1 (en) | 2012-11-22 |
| US20170136049A1 (en) | 2017-05-18 |
| JP2019031516A (ja) | 2019-02-28 |
| EP2707379A4 (en) | 2014-10-08 |
| JP6416308B2 (ja) | 2018-10-31 |
| JP2017160221A (ja) | 2017-09-14 |
| JP2014513697A (ja) | 2014-06-05 |
| US20190255083A1 (en) | 2019-08-22 |
| US20120294840A1 (en) | 2012-11-22 |
| JP2022020856A (ja) | 2022-02-01 |
| EP2707379A1 (en) | 2014-03-19 |
| JP6129821B2 (ja) | 2017-05-17 |
| US10286001B2 (en) | 2019-05-14 |
| JP6985231B2 (ja) | 2021-12-22 |
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