US7045605B2 - Modified antibodies to prostate-specific membrane antigen and uses thereof - Google Patents

Modified antibodies to prostate-specific membrane antigen and uses thereof Download PDF

Info

Publication number
US7045605B2
US7045605B2 US10/160,505 US16050502A US7045605B2 US 7045605 B2 US7045605 B2 US 7045605B2 US 16050502 A US16050502 A US 16050502A US 7045605 B2 US7045605 B2 US 7045605B2
Authority
US
United States
Prior art keywords
antibody
binding fragment
chain variable
antigen binding
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime, expires
Application number
US10/160,505
Other languages
English (en)
Other versions
US20040213791A1 (en
Inventor
Neil Bander
Francis J. Carr
Anita Hamilton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell Research Foundation Inc
Original Assignee
Cornell Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/160,505 priority Critical patent/US7045605B2/en
Application filed by Cornell Research Foundation Inc filed Critical Cornell Research Foundation Inc
Assigned to CORNELL RESEARCH FOUNDATION, INC. reassignment CORNELL RESEARCH FOUNDATION, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BANDER, NEIL, CARR, FRANCIS J., HAMILTON, ANITA
Assigned to DARPA reassignment DARPA CONFIRMATORY LICENSE (SEE DOCUMENT FOR DETAILS). Assignors: CORNELL RESEARCH FOUNDATION, INC.
Priority to US10/449,379 priority patent/US7514078B2/en
Assigned to THE UNITED STATES GOVERNMENT SECRETARY OF THE ARMY ARMY MEDICAL RESEARCH AND MATERIEL COMMAND reassignment THE UNITED STATES GOVERNMENT SECRETARY OF THE ARMY ARMY MEDICAL RESEARCH AND MATERIEL COMMAND CONFIRMATORY LICENSE (SEE DOCUMENT FOR DETAILS). Assignors: CORNELL UNIVERSITY
Publication of US20040213791A1 publication Critical patent/US20040213791A1/en
Priority to US11/219,563 priority patent/US7666414B2/en
Publication of US7045605B2 publication Critical patent/US7045605B2/en
Application granted granted Critical
Priority to US12/371,399 priority patent/US20090280120A1/en
Priority to US12/692,757 priority patent/US20100278726A1/en
Priority to US15/182,422 priority patent/US20170037142A1/en
Priority to US15/615,631 priority patent/US20180118847A1/en
Adjusted expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1072—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from the reproductive system, e.g. ovaria, uterus, testes or prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Definitions

  • the anti-PSMA antibody binds all or part of an epitope bound by an antibody described herein, e.g., a J591, E99, J415, and J533 antibody.
  • the anti-PSMA antibody can inhibit, e.g., competitively inhibit, the binding of an antibody described herein, e.g., a J591, E99, J415, and J533 antibody, to human PSMA.
  • An anti-PSMA antibody may bind to an epitope, e.g., a conformational or a linear epitope, which epitope when bound prevents binding of an antibody described herein, e.g., a J591, E99, J415, and J533 antibody.
  • the epitope can be in close proximity spatially or functionally-associated, e.g., an overlapping or adjacent epitope in linear sequence or conformational space, to the one recognized by the J591, E99, J415, or J533 antibody.
  • An antibody e.g., a modified antibody, is preferably monospecific, e.g., a monoclonal antibody, or an antigen-binding fragment thereof.
  • the antibodies, e.g., the modified antibodies can be full-length (e.g., an IgG (e.g., an IgG1, IgG2, IgG3, IgG4), IgM, IgA (e.g., IgA1, IgA2), IgD, and IgE, but preferably an IgG) or can include only an antigen-binding fragment (e.g., a Fab, F(ab′) 2 or scFv fragment, or one or more CDRs).
  • an antigen-binding fragment e.g., a Fab, F(ab′) 2 or scFv fragment, or one or more CDRs.
  • the modified antibody or antigen-binding fragment thereof can have at least one, two, and preferably three CDRs from the light or heavy chain variable region of the antibody produced by the cell line having ATCC Accession Number HB-12126 or the deimmunized J591 antibody produced by the cell line having ATCC Accession Number PTA-3709.
  • the light chain variable framework of the modified anti-PSMA antibody, or antigen-binding fragment thereof has at least one, two, three, five, seven, ten amino acid residues which differ from the framework of the non-human anti-PSMA light chain variable region (e.g., the murine J591 light chain variable region), or which is from a human light chain variable framework (e.g., a human germline, mature, or consensus framework sequence), at a position selected from the group consisting of: residue 8, 9, 10, 11, 20, 22, 60, 63, 76, 77, 78, 80, 83, 87, 103, 104 and 106 (Kabat numbering as shown in Table 2).
  • the framework of the non-human anti-PSMA light chain variable region e.g., the murine J591 light chain variable region
  • a human light chain variable framework e.g., a human germline, mature, or consensus framework sequence
  • the heavy chain variable framework of the modified anti-PSMA antibody, or antigen-binding fragment thereof has at least one, two, three, four, five amino acid residues, which differ from the framework of a non-human anti-PSMA heavy chain variable region (e.g., the murine J415 heavy chain variable region), or which is from a human heavy chain variable framework (e.g., a human mature, consensus, or germline framework), at a position selected from the group consisting of: residue 20, 87, 94, 95, and 112 (linear numbering as shown in Table 5).
  • a non-human anti-PSMA heavy chain variable region e.g., the murine J415 heavy chain variable region
  • a human heavy chain variable framework e.g., a human mature, consensus, or germline framework
  • the heavy chain variable framework has at least 60%, 65%, 70%, 80%, 82%, 85%, 90%, or 94% identity with, or differs by at least 5, 10, 20, or 30 but less than 10, 20, 30, or 40 residues from, a non-human heavy chain variable framework, e.g., the murine J591 or J415 or heavy chain variable framework shown in SEQ ID NO:7 or SEQ ID NO:35, respectively, or a heavy chain variable framework of the antibody produced by the hybridoma cell line having an ATCC Accession Number HB-12126 or 12109.
  • the non-human heavy chain variable framework is from murine J591 antibody (SEQ ID NO:7; see FIG.
  • a CDR1 having at least one, two, three, four, five, six, seven amino acids selected from the group consisting of residue 24 (lysine), 25 (alanine), 26 (serine), 29 (valine), 30 (glycine), 31 (threonine), and 33 (valine) (linear numbering as shown in FIG. 3B );
  • the invention features a method of producing an anti-PSMA antibody, e.g., a modified anti-PSMA antibody, or antigen-binding fragment thereof.
  • the method includes:
  • the modified anti-PSMA antibody or fragment thereof is coupled to a radioactive ion, e.g., indium ( 111 In), iodine ( 131 I or 125 I), yttrium ( 90 Y), lutetium ( 177 Lu), actinium ( 225 Ac), bismuth ( 212 Bi or 213 Bi), sulfur ( 35 S), carbon ( 14 C), tritium ( 3 H), rhodium ( 188 Rh), technetium ( 99 mTc), praseodymium, or phosphorous ( 32 P).
  • a radioactive ion e.g., indium ( 111 In), iodine ( 131 I or 125 I), yttrium ( 90 Y), lutetium ( 177 Lu), actinium ( 225 Ac), bismuth ( 212 Bi or 213 Bi), sulfur ( 35 S), carbon ( 14 C), tritium ( 3 H), rhodium ( 188 Rh), technetium ( 99 mTc), prase
  • the invention provides a method for determining the dose, e.g., radiation dose, that different tissues are exposed to when a subject, e.g., a human subject, is administered an anti-PSMA antibody that is conjugated to a radioactive isotope.
  • a subject e.g., a human subject
  • an anti-PSMA antibody that is conjugated to a radioactive isotope.
  • CDR1 is depicted in SEQ ID NO:4; CDR2 is depicted in SEQ ID NO:5; CDR3 is depicted in SEQ ID NO:6; framework 1 is depicted in SEQ ID NO:13; framework 2 is depicted in SEQ ID NO:14; framework 3 is depicted in SEQ ID NO:15; framework 4 is depicted in SEQ ID NO:16; the framework excluding CDR regions is depicted in SEQ ID NO:18; and the framework including CDR regions is depicted in SEQ ID NO:22.
  • FIG. 11A depicts the nucleic acid coding sequence, the amino acid sequence, and the nucleic acid reverse complement sequence of the murine E99 heavy chain variable region (SEQ ID NO:83–85, respectively). The relative locations of the CDRs and some restriction sites are indicated.
  • amino acid or nucleic acid “identity” is equivalent to amino acid or nucleic acid “homology”.
  • the percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, which need to be introduced for optimal alignment of the two sequences.
  • the temperature of the washes can be increased to 55° C. for low stringency conditions); 2) medium stringency hybridization conditions in 6 ⁇ SSC at about 45° C., followed by one or more washes in 0.2 ⁇ SSC, 0.1% SDS at 60° C.; 3) high stringency hybridization conditions in 6 ⁇ SSC at about 45° C., followed by one or more washes in 0.2 ⁇ SSC, 0.1% SDS at 65° C.; and preferably 4) very high stringency hybridization conditions are 0.5M sodium phosphate, 7% SDS at 65° C., followed by one or more washes at 0.2 ⁇ SSC, 1% SDS at 65° C. Very high stringency conditions (4) are the preferred conditions and the ones that should be used unless otherwise specified.
  • Humanized or CDR-grafted antibody molecules or immunoglobulins can be produced by CDR-grafting or CDR substitution, wherein one, two, or all CDRs of an immunoglobulin chain can be replaced. See e.g., U.S. Pat. No. 5,225,539; Jones et al. 1986 Nature 321:552–525; Verhoeyan et al. 1988 Science 239:1534; Beidler et al. 1988 J. Immunol. 141:4053–4060; Winter U.S. Pat. No. 5,225,539, the contents of all of which are hereby expressly incorporated by reference.
  • deimmunized V H and V L of murine J591 regions were constructed by mutagenesis of the murine V H and V L genes.
  • the murine J591 variable region sequences are shown in FIGS. 1A–1B .
  • Potential epitopes (identified using a peptide threading program) in murine J591 heavy chain and light chain variable regions are shown in FIGS. 3A and 3B , respectively.
  • the 13-mer peptides predicted to bind to MHC class II are indicated by the underline, the CDRs are located at residues 26 to 35, 50 to 66, and 99 to 104 of FIG. 3A and residues 24 to 34, 50 to 56, and 89 to 97 of FIG.
  • the culture medium is Dulbecco's Modification of Eagle's Medium (DMEM)(Life Technologies, Catalogue No: 31965-023) supplemented with 10% foetal bovine serum of USA origin (Life Technologies, Fetal Bovine Serum Cat No: 16000), Antibiotic/Antimycotic solution (Life Technologies, Cat No: 15240), Gentamycin (Life Technologies, catalogue No: 15710), Sodium pyruvate (Life Technologies, Catalogue No: 11360-039), 250 ⁇ g/ml xanthine (Sigma Catalogue No: X-3627, stock made up at 25 mg/ml in 0.5M NaOH), and 0.8 ⁇ g/ml mycophenolic acid (Sigma Catalogue No: M-3536, stock made up at 2.5 mg/ml in 100% ethanol).
  • DMEM Dulbecco's Modification of Eagle's Medium
  • DMEM Dulbecco's Modification of Eagle's Medium
  • DMEM Dulbecco's Modification
  • Constant regions from these species are known in the art (see e.g., Kabat, E. A., et al. (1991) Sequences of Proteins of Immunological Interest, Fifth Edition , U.S. Department of Health and Human Services, NIH Publication No. 91-3242).
  • an antibody may be derivatized with biotin, and detected through indirect measurement of avidin or streptavidin binding.
  • suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; and examples of bioluminescent materials include luciferase, luciferin, and aequorin.
  • the J591 deimmunized anti-PSMA antibody light chain variable region contains the following regions: an FR1 domain corresponding to about amino acid residues 1–23 of SEQ ID NO:22 (linear numbering; see also SEQ ID NO:13), which is encoded by about nucleotides 261–329 of SEQ ID NO:25; a CDR1 domain corresponding to about amino acid residues 24–34 of SEQ ID NO:22 (linear numbering; see also SEQ ID NO:4), which is encoded by about nucleotides 330–362 of SEQ ID NO:25; an FR2 domain corresponding to about amino acid residues 35–49 of SEQ ID NO:22 (linear numbering; see also SEQ ID NO:14), which is encoded by about nucleotides 363–407 of SEQ ID NO:25; a CDR2 domain corresponding to about amino acid residues 50–56 of SEQ ID NO:22 (linear numbering; see SEQ ID NO:5), which is encoded by about
  • the nucleotide and amino acid sequence of the modified (deimmunized) anti-PSMA J591 immunoglobulin heavy chain variable region is shown in FIG. 4A (SEQ ID NO:23 and 21, respectively).
  • the non-coding complementary sequence is also shown in FIG. 4A (SEQ ID NO:24).
  • parenteral administration and “administered parenterally” as used herein means modes of administration other than enteral and topical administration, usually by injection, and includes, without limitation, intravenous, intramuscular, intraarterial, intrathecal, intracapsular, intraorbital, intracardiac, intradermal, intraperitoneal, transtracheal, subcutaneous, subcuticular, intraarticular, subcapsular, subarachnoid, intraspinal, epidural and intrasternal injection and infusion.
  • compositions typically should be sterile and stable under the conditions of manufacture and storage.
  • the composition can be formulated as a solution, microemulsion, dispersion, liposome, or other ordered structure suitable to high antibody concentration.
  • Sterile injectable solutions can be prepared by incorporating the active compound (i.e., antibody or antibody portion) in the required amount in an appropriate solvent with one or a combination of ingredients enumerated above, as required, followed by filtered sterilization.
  • dispersions are prepared by incorporating the active compound into a sterile vehicle that contains a basic dispersion medium and the required other ingredients from those enumerated above.
  • an antibody or antibody portion of the invention may be orally administered, for example, with an inert diluent or an assimilable edible carrier.
  • the compound (and other ingredients, if desired) may also be enclosed in a hard or soft shell gelatin capsule, compressed into tablets, or incorporated directly into the subject's diet.
  • the compounds may be incorporated with excipients and used in the form of ingestible tablets, buccal tablets, troches, capsules, elixirs, suspensions, syrups, wafers, and the like.
  • To administer a compound of the invention by other than parenteral administration it may be necessary to coat the compound with, or co-administer the compound with, a material to prevent its inactivation.
  • the kit can further contain a radioprotectant.
  • a radioprotectant The radiolytic nature of isotopes, e.g., 90 Yttrium ( 90 Y) is known.
  • radioprotectants may be included, e.g., in the reaction buffer, as long as such radioprotectants are benign, meaning that they do not inhibit or otherwise adversely affect the labeling reaction, e.g., of an isotope, such as of 90 Y, to the antibody.
  • Anti-PSMA antibodies of the invention can be administered in combination with one or more of the existing modalities for treating prostate cancers, including, but not limited to: surgery (e.g., radical prostatectomy); radiation therapy (e.g., external-beam therapy which involves three dimensional, conformal radiation therapy where the field of radiation is designed to conform to the volume of tissue treated; interstitial-radiation therapy where seeds of radioactive compounds are implanted using ultrasound guidance; and a combination of external-beam therapy and interstitial-radiation therapy); hormonal therapy, which can be administered before or following radical prostatectomy or radiation (e.g., treatments which reduce serum testosterone concentrations, or inhibit testosterone activity, e.g., administering a leuteinizing hormone-releasing hormone (LHRH) analog or agonist (e.g., Lupron, Zoladex, leuprolide, buserelin, or goserelin) or antagonists (e.g., Abarelix).
  • LHRH leuteinizing hormone-releasing hormone
  • agonist e.g
  • the number of DOTA bound per antibody was determined using a saturation binding method with natural occurring isotope of Indium and 111 Indium. Multiple aliquots (minimum two) of DOTA-deJ591 were mixed with various amounts, ranging from 10 to 30 ⁇ L, of a 3.0 mM solution of InCl 3 (0.01 M HCl) spiked with a tracer amount of 111 In. The mixture was incubated at 37° C. for 16 hours and then analyzed by ITLC, using silica gel impregnated glass fiber 10 cm strip (ITLC-SG, Gelman, or equivalent) and an eluant of 1% DTPA (pH 6.0).
  • mice bearing LNCaP tumors treated with 177 Lu-DOTA-deJ591 exhibited a response similar to the 90 Y-DOTA-deJ591 treated animals.
  • mice with LNCaP tumors 300–400 mg were divided into three groups.
  • a control group received no treatment.
  • Group-2 received 200 ⁇ Ci and Group-3 received 300 ⁇ Ci of 177 Lu-DOTA-deJ591.
  • 177 Lu-DOTA-deJ591 was, in a dose dependent manner, able to reduce the mean tumor mass by 80–97% at the two dose levels.
  • the control group showed a progressive increase in tumor size, which was accompanied by a steady loss of body weight and the mice were sacrificed by fifty-three days because of low body mass.
  • deJ591 Nuclear imaging with either 111 In or 177 Lu labeled deJ591 was performed as an initial step of each trial.
  • 111 In which is a ⁇ -emitter, was used either as tracer for “naked” mAb or as a surrogate imaging agent prior to the administration of 90 Y (a pure ⁇ emitter which does not image on radionuclide scans).
  • 90 Y a pure ⁇ emitter which does not image on radionuclide scans
  • 177 Lu emits both ⁇ and ⁇ particles, allowing direct imaging, and can be used as both an imaging and a therapeutic agent.
  • the antibody scans were compared to standard imaging studies (bone, CT or MR scans) obtained on each patient to assess the underlying sensitivity, specificity, and accuracy of deJ591 targeting to metastatic sites. Bony and soft tissue metastases were evaluated independently.
  • CTC Common Toxicity Criteria
  • Biochemical (PSA) response was determined as described above.
  • Complete response is defined as complete disappearance of all measurable lesions by physical examination or imaging studies with no appearance of new lesions for >2 months.
  • Partial response is defined as a 50% or greater reduction in the sum of the products of the longest perpendicular diameters of all measurable lesions. There may be no new lesions.
  • Stable disease patients who do not meet the criteria of partial response and who are without signs of progressive disease for >2 months.
  • Progressive disease is defined as a greater than 25% increase in the sum of the products of the longest perpendicular diameters of the immeasurable lesions, the appearance of new lesions or a rise in prostate specific antigen above pre-treatment baseline.
  • PSMA is also expressed by vascular endothelial cells of numerous solid tumors, but not by normal vascular endothelium in benign tissues. As discussed above, this expression pattern of PSMA occurs in virtually all solid tumors.
  • IL-2 will be permanently discontinued for any study drug-related Grade 4 toxicity except hematologic (which can be corrected with EPO or G-CSF or blood transfusions). If at any time during the study, ALT is ⁇ 20 times the upper limit of normal, both IL-2 and mAb therapy will be permanently discontinued in that subject. Electrolyte abnormalities that can be readily corrected will not require permanent drug discontinuation.
  • IL-2 mediated immune modulation is being evaluated by flow cytometry on peripheral blood to quantify expression of lymphocyte subsets pre- and post-mAb treatment.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
US10/160,505 2001-06-01 2002-05-30 Modified antibodies to prostate-specific membrane antigen and uses thereof Expired - Lifetime US7045605B2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US10/160,505 US7045605B2 (en) 2001-06-01 2002-05-30 Modified antibodies to prostate-specific membrane antigen and uses thereof
US10/449,379 US7514078B2 (en) 2001-06-01 2003-05-30 Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
US11/219,563 US7666414B2 (en) 2001-06-01 2005-09-02 Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen
US12/371,399 US20090280120A1 (en) 2001-06-01 2009-02-13 Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
US12/692,757 US20100278726A1 (en) 2001-06-01 2010-01-25 Modified Antibodies to Prostate-Specific Membrane Antigen and Uses Thereof
US15/182,422 US20170037142A1 (en) 2001-06-01 2016-06-14 Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
US15/615,631 US20180118847A1 (en) 2001-06-01 2017-06-06 Modifield antibodies to prostate-specific membrane antigen and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29521401P 2001-06-01 2001-06-01
US32358501P 2001-09-20 2001-09-20
US36281002P 2002-03-08 2002-03-08
US10/160,505 US7045605B2 (en) 2001-06-01 2002-05-30 Modified antibodies to prostate-specific membrane antigen and uses thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US37983803A Continuation-In-Part 2001-06-01 2003-03-03
US10/449,379 Continuation-In-Part US7514078B2 (en) 2001-06-01 2003-05-30 Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies

Publications (2)

Publication Number Publication Date
US20040213791A1 US20040213791A1 (en) 2004-10-28
US7045605B2 true US7045605B2 (en) 2006-05-16

Family

ID=27404335

Family Applications (1)

Application Number Title Priority Date Filing Date
US10/160,505 Expired - Lifetime US7045605B2 (en) 2001-06-01 2002-05-30 Modified antibodies to prostate-specific membrane antigen and uses thereof

Country Status (10)

Country Link
US (1) US7045605B2 (fr)
EP (2) EP1392360B1 (fr)
JP (2) JP4619651B2 (fr)
AT (1) ATE535258T1 (fr)
AU (1) AU2002318169B2 (fr)
CA (1) CA2447695C (fr)
HK (1) HK1062915A1 (fr)
IL (3) IL158969A0 (fr)
MX (1) MXPA03010804A (fr)
WO (1) WO2002098897A2 (fr)

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030003101A1 (en) * 1996-05-06 2003-01-02 Cornell Research Foundation, Inc. Treatment and diagnosis of prostate cancer
US20050260234A1 (en) * 2001-03-07 2005-11-24 Simard John J L Anti-neovasculature preparations for cancer
US20060062793A1 (en) * 2004-03-03 2006-03-23 Webb Iain J Modified antibodies to prostate-specific membrane antigen and uses thereof
US20060182750A1 (en) * 2005-02-11 2006-08-17 Immunogen, Inc. Process for preparing stable drug conjugates
US20070048314A1 (en) * 2005-08-24 2007-03-01 Immunogen, Inc. Process for preparing purified drug conjugates
US20080025981A1 (en) * 2002-03-04 2008-01-31 Young Paul E Cancer-linked genes as targets for chemotherapy
US20080286284A1 (en) * 2001-10-23 2008-11-20 Psma Development Company, Llc Compositions of PSMA antibodies
US20090238755A1 (en) * 1996-05-06 2009-09-24 Bander Neil H Treatment and Diagnosis of Cancer
US20090274620A1 (en) * 2001-02-07 2009-11-05 Wilex Ag Hybridoma Cell Line G250 and its use for Producing Monoclonal Antibodies
US20090280120A1 (en) * 2001-06-01 2009-11-12 Bander Neil H Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
US20100008888A1 (en) * 2002-07-01 2010-01-14 Wilex Ag Co-administration of cg250 and il-2 or ifn-alpha for treating cancer such as renal cell carcinomas
WO2010096486A1 (fr) 2009-02-17 2010-08-26 Cornell Research Foundation, Inc. Procédés et kits pour le diagnostic d'un cancer et la prédiction d'une valeur thérapeutique
US20100291113A1 (en) * 2007-10-03 2010-11-18 Cornell University Treatment of Proliferative Disorders Using Antibodies to PSMA
US20110166319A1 (en) * 2005-02-11 2011-07-07 Immunogen, Inc. Process for preparing purified drug conjugates
US20110165081A1 (en) * 2001-10-23 2011-07-07 Psma Development Company, Llc Psma antibodies and uses thereof
USRE43586E1 (en) 1992-11-05 2012-08-14 Sloan-Kettering Institute For Cancer Research Antibodies to prostate-specific membrane antigen
US20130028896A1 (en) * 2009-04-01 2013-01-31 The University Of British Columbia Semaphorin 3C (Sema3C) Inhibitor Therapeutics, Methods, and Uses
WO2013185117A1 (fr) 2012-06-07 2013-12-12 Ambrx, Inc. Conjugués anticorps-médicament d'antigène membranaire spécifique à la prostate
WO2013188740A1 (fr) 2012-06-14 2013-12-19 Ambrx, Inc. Anticorps anti-psma conjugués à des polypeptides de ligand de récepteur nucléaire
US8772459B2 (en) 2009-12-02 2014-07-08 Imaginab, Inc. J591 minibodies and Cys-diabodies for targeting human prostate specific membrane antigen (PSMA) and methods for their use
US8795673B2 (en) 2011-03-29 2014-08-05 Immunogen, Inc. Preparation of maytansinoid antibody conjugates by a one-step process
US20150110814A1 (en) * 2013-10-18 2015-04-23 Psma Development Company, Llc Combination therapies with psma ligand conjugates
US9238878B2 (en) 2009-02-17 2016-01-19 Redwood Bioscience, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
US9242012B2 (en) 2008-09-08 2016-01-26 Psma Development Company, Llc Methods for killing PSMA-expressing, taxane-resistant cancer cells
US9376500B2 (en) 2009-06-03 2016-06-28 Immunogen, Inc. Conjugation methods
US9540438B2 (en) 2011-01-14 2017-01-10 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
US10035817B2 (en) 2012-10-04 2018-07-31 Immunogen, Inc. Method of purifying cell-binding agent-cytotoxic agent conjugates with a PVDF membrane
US10179819B2 (en) 2015-07-31 2019-01-15 Regeneron Pharmaceuticals, Inc. Anti-PSMA antibodies, bispecific antigen-binding molecules that bind PSMA and CD3, and uses thereof
US10398791B2 (en) 2013-10-18 2019-09-03 Deutsches Krebsforschungszentrum Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
US10906987B2 (en) 2016-03-01 2021-02-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Antibodies specific to human poliovirus receptor (PVR)
US11208632B2 (en) 2016-04-26 2021-12-28 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
US11254744B2 (en) 2015-08-07 2022-02-22 Imaginab, Inc. Antigen binding constructs to target molecules
US11266745B2 (en) 2017-02-08 2022-03-08 Imaginab, Inc. Extension sequences for diabodies
AU2020203191B2 (en) * 2013-10-18 2023-03-09 Psma Development Company, Llc Combination therapies with psma ligand conjugates
EP4282434A2 (fr) 2016-06-06 2023-11-29 Abzena (UK) Limited Anticorps, leurs utilisations et leurs conjugués
WO2024182569A2 (fr) 2023-02-28 2024-09-06 Eisai R&D Management Co., Ltd. Anticorps anti-psma, conjugués et procédés d'utilisation

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7070782B1 (en) 1992-11-05 2006-07-04 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen
US6953668B1 (en) 1992-11-05 2005-10-11 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen
US6569432B1 (en) 1995-02-24 2003-05-27 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen and uses thereof
US20040253246A1 (en) * 1996-02-23 2004-12-16 Israeli Ron S. Prostate-specific membrane antigen and uses thereof
DE10060729A1 (de) * 2000-12-07 2002-06-20 Messer Griesheim Gmbh Schmelzofen
US7666414B2 (en) 2001-06-01 2010-02-23 Cornell Research Foundation, Inc. Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen
WO2003057163A2 (fr) * 2002-01-03 2003-07-17 Smithkline Beecham Corporation Preparation d'immunoconjugues
US7651689B2 (en) * 2002-11-15 2010-01-26 Albert Einstein College Of Medicine Of Yeshiva University Methods of applying ionization radiation for therapy of infections
WO2004078137A2 (fr) * 2003-03-04 2004-09-16 Greenville Hospital System Agents antitumoraux comprenant une partie de ciblage et une partie de declenchement de reponse immunitaire
EP1755686A2 (fr) * 2004-06-02 2007-02-28 Sidney Kimmel Cancer Center Imagerie et ciblage d'agents therapeutiques de proteines exprimees sur la surface d'une cellule endotheliale
US20070237712A1 (en) * 2004-06-14 2007-10-11 Rajasekaran Ayyappan K Methods of Redistributing Apical Target Antigens to Detect and Treat Cellular Proliferative Disease
EP1726650A1 (fr) * 2005-05-27 2006-11-29 Universitätsklinikum Freiburg Anticorps monoclonaux et fragments d'anticorps monocaténaires contre l'antigène spécifique de surface membranaire de la prostate
NZ595386A (en) * 2005-08-11 2013-08-30 Arpi Matossian Rogers Peptides for treatment and diagnosis of autoimmune disease
AU2012227185B2 (en) * 2005-08-24 2015-07-02 Immunogen, Inc. Process for preparing maytansinoid antibody conjugates
BRPI0617546A2 (pt) * 2005-09-26 2011-07-26 Medarex Inc conjugado de fÁrmaco-anticorpo, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula de tumor, mÉtodo para retardar ou interromper o crescimento de um tumor em um sujeito mamÍfero e composto
US9862770B2 (en) * 2005-10-19 2018-01-09 Ibc Pharmaceuticals, Inc. Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
CN101680896A (zh) 2007-03-27 2010-03-24 伊缪诺维亚公司 检测腺癌的蛋白标志/标记
CA2691539C (fr) * 2007-06-21 2014-08-26 Angelica Therapeutics, Inc. Toxines modifiees
CA2695382A1 (fr) * 2007-08-01 2009-02-05 The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health Of Human Services, National Institutes Of Immunotoxine de la toxine diphterique d'un dianticorps de repliement et ses procedes d'utilisation
US9193763B2 (en) 2007-08-17 2015-11-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
JOP20090061B1 (ar) * 2008-02-11 2021-08-17 Ferring Int Center Sa طريقة معالجة سرطان البروستاتا بمضادات الهرمونات التناسلية GnRH
WO2009110944A1 (fr) * 2008-02-29 2009-09-11 Angelica Therapeutics, Inc. Toxines modifiées
CN107337734A (zh) * 2009-12-04 2017-11-10 弗·哈夫曼-拉罗切有限公司 多特异性抗体、抗体类似物、组合物和方法
US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
WO2012145714A2 (fr) 2011-04-22 2012-10-26 Emergent Product Development Seattle, Llc Protéines de liaison à un antigène membranaire spécifique de la prostate et compositions et procédés associés
US20130064811A1 (en) * 2011-09-09 2013-03-14 International Business Machines Corporation Methods to Enhance Cancer Treatment
CA2853669C (fr) * 2011-10-28 2019-03-12 Fredax Ab Agents therapeutiques et utilisations de ceux-ci
CN108424456B (zh) 2011-11-23 2022-04-26 医学免疫有限责任公司 特异于her3的结合分子及其用途
CA2865282A1 (fr) * 2012-02-24 2013-08-29 Cornell University Psma eleve identifie des cancers letaux de la prostate
KR101986404B1 (ko) * 2012-10-12 2019-06-07 에이디씨 테라퓨틱스 에스에이 피롤로벤조디아제핀-항체 컨주게이트
AU2013328580B2 (en) 2012-10-12 2016-01-21 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
EA201890915A1 (ru) 2012-11-15 2018-09-28 Эндосайт, Инк. Конъюгаты для доставки лекарственных средств и способы лечения заболеваний, вызванных клетками, экспрессирующими psma
EP3508215A3 (fr) * 2012-12-03 2019-10-02 Bristol-Myers Squibb Company Amélioration de l'activité anticancéreuse de protéines de fusion fc immunomodulatrices
WO2014128258A1 (fr) * 2013-02-22 2014-08-28 Wilex Ag Traitement du cancer basé sur une stratification caix
GB201303576D0 (en) * 2013-02-28 2013-04-10 Singapore Volition Pte Ltd Method for predicting therapy efficacy using nucleosome structure biomarkers
AU2014230735B2 (en) 2013-03-13 2018-03-15 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
CA2902905A1 (fr) 2013-03-15 2014-09-25 Claude Geoffrey Davis Toxines modifiees
EP2784510A1 (fr) * 2013-03-25 2014-10-01 Universität Zu Köln Procédés de diagnostic et de différenciation d'oncocytome et de carcinome rénal malin, produits et utilisations associés
US11305012B2 (en) * 2013-09-24 2022-04-19 Medimmune, Llc Binding molecules specific for HER3 and uses thereof
WO2015052532A1 (fr) * 2013-10-11 2015-04-16 Spirogen Sàrl Conjugués anticorps-pyrrolobenzodiazépines
CN112898431B (zh) 2013-11-19 2024-05-28 弗雷达克斯有限责任公司 人源化抗激肽释放酶-2抗体
US10745490B2 (en) 2014-04-11 2020-08-18 Celldex Therapeutics, Inc. Anti-ErbB antibodies and methods of use thereof
LT3151865T (lt) 2014-05-22 2021-10-25 Byondis B.V. Prijungiamų vaistų vietai specifinis konjugavimas su antikūnais ir to pasekoje gaunami avk
US9903871B2 (en) * 2014-07-15 2018-02-27 Temple University Of The Commonwealth System Of Higher Education Stabilized peptide fragments from nucleoredoxin X1 and uses thereof
EP3193940A1 (fr) 2014-09-10 2017-07-26 Medimmune Limited Pyrrolobenzodiazépines et leurs conjugués
GB201419976D0 (en) * 2014-11-10 2014-12-24 Univ Newcastle Biomarkers for disease progression in melanoma
MX2017006201A (es) * 2014-11-14 2017-07-31 Genentech Inc Respuesta de prediccion a un antagonista de vegf.
KR102654033B1 (ko) * 2014-12-08 2024-04-02 1글로브 바이오메디칼 씨오., 엘티디. 가용성 유니버셜 adcc 증강 합성 융합 유전자 및 펩티드 기술 및 그 용도
US10188759B2 (en) 2015-01-07 2019-01-29 Endocyte, Inc. Conjugates for imaging
CN108368169A (zh) * 2015-03-18 2018-08-03 约翰霍普金斯大学 靶向钾通道kcnk9的新的单克隆抗体抑制剂
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
SG10202002577XA (en) 2015-09-21 2020-04-29 Aptevo Res & Development Llc Cd3 binding polypeptides
TWI752012B (zh) * 2016-03-04 2022-01-11 美商Ｊｎ生物科學有限責任公司 針對tigit之抗體
KR101796277B1 (ko) * 2016-04-12 2017-11-13 앱클론(주) 안정성이 개선된 ｈｅｒ２에 특이적으로 결합하는 항체
EP3507308A4 (fr) * 2016-09-04 2020-03-18 TargImmune Therapeutics AG Protéines chimériques pour cibler l'arn double brin
CN109862919A (zh) 2016-10-11 2019-06-07 免疫医疗有限公司 抗体-药物缀合物联合免疫介导的治疗剂
US11773182B2 (en) 2017-01-05 2023-10-03 The Johns Hopkins University Development of new monoclonal antibodies recognizing human prostate-specific membrane antigen (PSMA)
EP3366703B1 (fr) * 2017-02-28 2019-04-03 Ralf Kleef Thérapie ciblant les points de contrôle immunitaires avec hyperthermie
BR112019021880A2 (pt) 2017-04-20 2020-06-02 Adc Therapeutics Sa Terapia de combinação com conjugado anticorpo anti-axl-droga
US11491247B2 (en) 2017-05-02 2022-11-08 Cornell University Methods and reagents for tumor targeting with greater efficacy and less toxicity
MA52235A (fr) 2018-03-05 2021-02-17 Janssen Pharmaceutica Nv Anticorps anti-phf-tau et leurs utilisations
CN112119157A (zh) * 2018-03-06 2020-12-22 宾夕法尼亚大学董事会 前列腺特异性膜抗原car及其使用方法
EP3796942A1 (fr) 2018-05-23 2021-03-31 ADC Therapeutics SA Adjuvant moléculaire
EP4063387A4 (fr) * 2019-11-22 2023-08-02 Nantong Yichen Biopharma. Co. Ltd. Anticorps psma et son utilisation
JP2023513752A (ja) 2020-02-14 2023-04-03 ベイジン ヨンタイ ルイケ バイオテクノロジー カンパニー リミテッド 外部から導入された細胞シグナル伝達調節因子を過剰発現する免疫細胞及びその使用
CR20220535A (es) * 2020-03-26 2022-12-15 Ramirez Fort Marigdalia Kaleth Tratamientos con radiación ultravioleta
AU2021284273A1 (en) 2020-06-02 2022-12-15 Arcus Biosciences, Inc. Antibodies to TIGIT
GB202010970D0 (en) 2020-07-16 2020-09-02 Immunovia Ab Methods, arrays and uses thereof
US20230372528A1 (en) 2020-10-16 2023-11-23 University Of Georgia Research Foundation, Inc. Glycoconjugates
GB202102396D0 (en) 2021-02-19 2021-04-07 Adc Therapeutics Sa Molecular adjuvant
CN113773401B (zh) * 2021-09-15 2023-06-20 宜明昂科生物医药技术（上海）股份有限公司 靶向cd47和pd-l1的重组融合蛋白及其制备和用途
WO2023222557A1 (fr) 2022-05-17 2023-11-23 Bayer Aktiengesellschaft Complexes radiopharmaceutiques ciblant l'antigène membranaire spécifique de la prostate et leurs combinaisons
EP4279092A1 (fr) 2022-05-17 2023-11-22 Bayer AG Complexes radiopharmaceutiques
WO2024109792A1 (fr) 2022-11-24 2024-05-30 Wuxi Biologics (Shanghai) Co., Ltd. Anticorps psma et leurs utilisations

Citations (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4454106A (en) 1982-06-07 1984-06-12 Gansow Otto A Use of metal chelate conjugated monoclonal antibodies
US4472509A (en) 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
WO1986006384A1 (fr) 1985-04-26 1986-11-06 Gansow Otto A Procede de formation d'un conjugue de proteines chelatees metalliques
WO1988002635A1 (fr) 1986-10-17 1988-04-21 Cytogen Corporation Procede de preparation de compositions d'ions metalliques-chelatant-proteine appropriees a une injection
EP0299795A2 (fr) 1987-07-16 1989-01-18 Nycomed As Acides aminopolycarboxyliques et leurs dérivés
US4814275A (en) 1985-05-13 1989-03-21 E.I. Dupont De Nemours And Company Monoclonal hybridoma antibody specific for a human epithelial antigen
US4855353A (en) 1986-02-14 1989-08-08 Nihon Medi-Physics Co., Ltd. High molecular compounds having amino groups, and their utilization
WO1989006979A1 (fr) 1988-01-26 1989-08-10 Cockbain, Julian, Roderick, Michaelson Composes paramagnetiques
US4863854A (en) 1985-08-12 1989-09-05 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies to mucin-like human differentiation antigens
US4863851A (en) 1986-10-20 1989-09-05 The Upjohn Company Monoclonal antibody to prostate secretory protein
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
EP0392423A2 (fr) 1989-04-11 1990-10-17 Hoechst Aktiengesellschaft 1,4-7-10-Tétraazacyclotridécanes substitués, leur procédé de préparation et leur utilisation pour marquer des matières avec des radionucléides
US5013645A (en) 1987-04-14 1991-05-07 Abbott Laboratories Immunological methods and materials for detection of tumor associated antigens
EP0279397B1 (fr) 1987-02-16 1991-06-12 Sumitomo Chemical Company, Limited Base solide, procédé pour la préparer et son utilisation dans la préparation d'oléfines à double liaison interne
EP0232751B1 (fr) 1986-01-23 1991-09-11 E.R. Squibb & Sons, Inc. 4,7,10-Triscarboxyméthyl-1,4,7,10-tétraazacyclododécane substitué en position 1 et analogues
US5053503A (en) 1989-02-17 1991-10-01 Centocor Chelating agents
US5057302A (en) 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
WO1991015466A2 (fr) 1990-04-09 1991-10-17 Cockbain, Julian, Roderick, Michaelson Agents chelateurs
US5118611A (en) 1988-07-25 1992-06-02 Adeza Biomedical Corporation Adenocarcinoma antigen binding methods and reagents
US5130118A (en) 1987-11-06 1992-07-14 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
US5162504A (en) 1988-06-03 1992-11-10 Cytogen Corporation Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients
US5217704A (en) 1987-11-06 1993-06-08 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
US5227471A (en) 1992-01-30 1993-07-13 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Monoclonal antibody PD41 that binds to a prostate mucin antigen that is expressed in human prostatic carcinoma
US5229289A (en) 1988-03-11 1993-07-20 The Biomembrane Institute Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with animal and human and with synthetic carbohydrate-carrier conjugates
WO1993017715A1 (fr) 1992-03-05 1993-09-16 Board Of Regents, The University Of Texas System Agents diagnostiques et/ou therapeutiques cibles sur des cellules endotheliales neovasculaires
WO1993019668A1 (fr) 1992-04-07 1993-10-14 Immunomedics, Inc. Procede et kit destines a l'imagerie et au traitement d'organes et de tissus
WO1994004702A2 (fr) 1992-08-21 1994-03-03 Immunomedics, Inc. Procede ameliore de detection et de therapie de lesions au moyen de conjugues de biotine ou d'avidine
WO1994009820A1 (fr) 1992-11-05 1994-05-11 Sloan-Kettering Institute For Cancer Research Antigene de membrane specifique a la prostate
EP0315188B1 (fr) 1987-11-06 1994-06-01 Abbott Laboratories Méthode et matériaux de préparation de solutions d'anticorps marqués avec des métaux
US5342924A (en) 1987-12-31 1994-08-30 Tanox Biosystems, Inc. Extracellular segments of human ε immunoglobulin anchoring peptides and antibodies specific therefor
WO1994026297A1 (fr) 1993-05-17 1994-11-24 Immunomedics, Inc. Detection et therapie ameliorees de lesions au moyen de conjugues de biotine/avidine et d'une proteine chelatant un ion metal
EP0208531B1 (fr) 1985-07-05 1995-04-12 Immunomedics, Inc. Matériaux pour Lymphographie et pour obtenir l'Image des Organes et Kit
WO1995026206A1 (fr) 1994-03-28 1995-10-05 The Regents Of The University Of California Procede d'elaboration de complexes agent de chelation-ligand etiquetes par radionucleide
WO1995031444A1 (fr) 1994-05-11 1995-11-23 Bracco International B.V. Composes monomeres et multimeres a relaxivite accrue
US5474756A (en) 1986-01-23 1995-12-12 Bracco International B.V. Method for imaging mammalian tissue using 1-substituted-1,4,7-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
EP0382583B1 (fr) 1989-02-10 1996-01-17 Celltech Therapeutics Limited Azamacrocycles et procédé pour leur préparation
US5489525A (en) 1992-10-08 1996-02-06 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibodies to prostate cells
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5531978A (en) 1987-07-16 1996-07-02 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
WO1996026272A1 (fr) 1995-02-24 1996-08-29 Sloan-Kettering Institute For Cancer Research Antigene membranaire specifique de la prostate et ses utilisations
EP0495878B1 (fr) 1989-10-11 1996-11-27 Akzo Nobel N.V. Procede de purification de composes conjugues chelateurs
WO1996039185A1 (fr) 1995-06-05 1996-12-12 Cornell Research Foundation, Inc. Traitement et diagnostic du cancer de la prostate
WO1996040245A1 (fr) 1995-06-07 1996-12-19 Immunomedics, Inc. Apport ameliore d'agents diagnostiques ou therapeutiques a un site cible
US5599677A (en) 1993-12-29 1997-02-04 Abbott Laboratories Immunoassays for prostate specific antigen
US5621001A (en) 1992-08-03 1997-04-15 Bristol-Myers Squibb Company Methods for administration of taxol
US5639879A (en) 1993-04-02 1997-06-17 Associated Universities, Inc. Macrocyclic polyaminocarboxylates for stable radiometal antibody conjugates for therapy, spect and pet imaging
US5660827A (en) 1992-03-05 1997-08-26 Board Of Regents, The University Of Texas System Antibodies that bind to endoglin
CA2261018A1 (fr) 1996-07-18 1998-01-29 Cornell Research Foundation, Inc. Traitement et diagnostic du cancer
US5804602A (en) 1996-06-17 1998-09-08 Guilford Pharmaceuticals Inc. Methods of cancer treatment using naaladase inhibitors
EP0882454A2 (fr) 1997-04-18 1998-12-09 BRACCO S.p.A. Procédé pour la conjugaison de chélates avec des molécules contenants des groups amino
US5863538A (en) 1992-03-05 1999-01-26 Board Of Regents, The University Of Texas System Compositions for targeting the vasculature of solid tumors
US5877289A (en) 1992-03-05 1999-03-02 The Scripps Research Institute Tissue factor compositions and ligands for the specific coagulation of vasculature
US5935818A (en) 1995-02-24 1999-08-10 Sloan-Kettering Institute For Cancer Research Isolated nucleic acid molecule encoding alternatively spliced prostate-specific membrane antigen and uses thereof
US5958474A (en) 1996-08-21 1999-09-28 Nestec S.A. Process for preparing food flavor precursors
US6004555A (en) 1992-03-05 1999-12-21 Board Of Regents, The University Of Texas System Methods for the specific coagulation of vasculature
EP0594739B1 (fr) 1991-07-12 2000-03-01 Antisoma Research Limited Traitement du cancer
US6036955A (en) 1992-03-05 2000-03-14 The Scripps Research Institute Kits and methods for the specific coagulation of vasculature
US6093399A (en) 1992-03-05 2000-07-25 Board Of Regents, The University Of Texas System Methods and compositions for the specific coagulation of vasculature
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US6150508A (en) 1996-03-25 2000-11-21 Northwest Biotherapeutics, Inc. Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen
US6200765B1 (en) 1998-05-04 2001-03-13 Pacific Northwest Cancer Foundation Non-invasive methods to detect prostate cancer
US6340701B1 (en) * 1999-11-24 2002-01-22 Immunogen Inc Cytotoxic agents comprising taxanes and their therapeutic use
US6342219B1 (en) * 1999-04-28 2002-01-29 Board Of Regents, The University Of Texas System Antibody compositions for selectively inhibiting VEGF
CA2452288A1 (fr) 2001-09-20 2003-03-27 Cornell Research Foundation, Inc. Methodes et compositions de traitement ou de prevention de troubles cutanes au moyen d'agents de liaison specifiques pour un antigene membranaire specifique de la prostate
US6824780B1 (en) 1999-10-29 2004-11-30 Genentech, Inc. Anti-tumor antibody compositions and methods of use

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940475A (en) 1970-06-11 1976-02-24 Biological Developments, Inc. Radioimmune method of assaying quantitatively for a hapten
US4289747A (en) 1978-12-26 1981-09-15 E-Y Laboratories, Inc. Immunological determination using lectin
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
DE3307869A1 (de) 1983-03-05 1984-09-06 Dragoco Gerberding & Co Gmbh, 3450 Holzminden Methylsubstituierte 1-((3-methylthio)-1-oxo-butyl)-cyclohex-2-ene, verfahren zu deren herstellung und deren verwendung als riech- und aromastoffe
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0170697B1 (fr) 1984-02-08 1991-10-23 Cetus Oncology Corporation Conjugues de toxines
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (fr) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Récepteurs chimériques par liaison et expression de l'ADN
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US4970198A (en) 1985-10-17 1990-11-13 American Cyanamid Company Antitumor antibiotics (LL-E33288 complex)
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・２・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
GB8905669D0 (en) 1989-03-13 1989-04-26 Celltech Ltd Modified antibodies
WO1991000906A1 (fr) 1989-07-12 1991-01-24 Genetics Institute, Inc. Animaux chimeriques et transgeniques pouvant produire des anticorps humains
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
US5612205A (en) 1990-08-29 1997-03-18 Genpharm International, Incorporated Homologous recombination in mammalian cells
DK0814159T3 (da) 1990-08-29 2005-10-24 Genpharm Int Transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
US5264586A (en) 1991-07-17 1993-11-23 The Scripps Research Institute Analogs of calicheamicin gamma1I, method of making and using the same
ES2149768T3 (es) 1992-03-25 2000-11-16 Immunogen Inc Conjugados de agentes enlazantes de celulas derivados de cc-1065.
US5550246A (en) 1994-09-07 1996-08-27 The Scripps Research Institute Calicheamicin mimics
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US5714586A (en) 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
ES2260788T3 (es) 1996-03-25 2006-11-01 Medarex, Inc. Anticuerpos monoclonales especificos para el dominio estracelular de antigeno de membrana especifico de la prostata.
DE69833755T2 (de) 1997-05-21 2006-12-28 Biovation Ltd. Verfahren zur herstellung von nicht-immunogenen proteinen
JP2002534959A (ja) 1998-12-08 2002-10-22 バイオベーション リミテッド 免疫原性タンパク質の改変方法
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
IT1395574B1 (it) 2009-09-14 2012-10-16 Guala Dispensing Spa Dispositivo di erogazione

Patent Citations (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4454106A (en) 1982-06-07 1984-06-12 Gansow Otto A Use of metal chelate conjugated monoclonal antibodies
US4472509A (en) 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
WO1986006384A1 (fr) 1985-04-26 1986-11-06 Gansow Otto A Procede de formation d'un conjugue de proteines chelatees metalliques
US4814275A (en) 1985-05-13 1989-03-21 E.I. Dupont De Nemours And Company Monoclonal hybridoma antibody specific for a human epithelial antigen
US6331175B1 (en) 1985-07-05 2001-12-18 Immunomedics, Inc. Method and kit for imaging and treating organs and tissues
EP0208531B1 (fr) 1985-07-05 1995-04-12 Immunomedics, Inc. Matériaux pour Lymphographie et pour obtenir l'Image des Organes et Kit
US5697902A (en) 1985-07-05 1997-12-16 Immunomedics, Inc. Method for imaging and treating organs and tissues
US4863854A (en) 1985-08-12 1989-09-05 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies to mucin-like human differentiation antigens
US5674470A (en) 1986-01-23 1997-10-07 Bracco Diagnostics Inc. Method for imaging mammalian tissue using 1-substituted- 4,7,10-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5474756A (en) 1986-01-23 1995-12-12 Bracco International B.V. Method for imaging mammalian tissue using 1-substituted-1,4,7-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US6143274A (en) 1986-01-23 2000-11-07 Tweedle; Michael F. Method for imaging and radiopharmaceutical therapy using 1-substituted-4,7,10-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5846519A (en) 1986-01-23 1998-12-08 Bracco Diagnostics Inc. Method for imaging mammalian tissue using 1-substituted-1,4,7-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
EP0232751B1 (fr) 1986-01-23 1991-09-11 E.R. Squibb & Sons, Inc. 4,7,10-Triscarboxyméthyl-1,4,7,10-tétraazacyclododécane substitué en position 1 et analogues
US4855353A (en) 1986-02-14 1989-08-08 Nihon Medi-Physics Co., Ltd. High molecular compounds having amino groups, and their utilization
EP0233619B1 (fr) 1986-02-14 1992-12-30 Nihon Medi-Physics Co., Ltd. Composés aminés de haut poids moléculaire et leur utilisation
WO1988002635A1 (fr) 1986-10-17 1988-04-21 Cytogen Corporation Procede de preparation de compositions d'ions metalliques-chelatant-proteine appropriees a une injection
US4863851A (en) 1986-10-20 1989-09-05 The Upjohn Company Monoclonal antibody to prostate secretory protein
US5057302A (en) 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
EP0279397B1 (fr) 1987-02-16 1991-06-12 Sumitomo Chemical Company, Limited Base solide, procédé pour la préparer et son utilisation dans la préparation d'oléfines à double liaison interne
US5013645A (en) 1987-04-14 1991-05-07 Abbott Laboratories Immunological methods and materials for detection of tumor associated antigens
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
EP0292689B1 (fr) 1987-04-24 1996-07-31 Bracco International B.V. 1,4,7-Triscarboxyméthyl-1,4,7,10-tétraazacyclododécane substitué et analogues
EP0466200A1 (fr) 1987-07-16 1992-01-15 Nycomed Imaging As Acides aminocarboxyliques et dérivés
US5419893A (en) 1987-07-16 1995-05-30 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof for magnetic resonance imaging
US5198208A (en) 1987-07-16 1993-03-30 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
WO1989000557A1 (fr) 1987-07-16 1989-01-26 Cockbain, Julian, Roderick, Michaelson Acides aminopolycarboxyliques et leurs derives
US5531978A (en) 1987-07-16 1996-07-02 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
EP0299795A2 (fr) 1987-07-16 1989-01-18 Nycomed As Acides aminopolycarboxyliques et leurs dérivés
US5130118A (en) 1987-11-06 1992-07-14 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
US5217704A (en) 1987-11-06 1993-06-08 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
EP0315188B1 (fr) 1987-11-06 1994-06-01 Abbott Laboratories Méthode et matériaux de préparation de solutions d'anticorps marqués avec des métaux
US5342924A (en) 1987-12-31 1994-08-30 Tanox Biosystems, Inc. Extracellular segments of human ε immunoglobulin anchoring peptides and antibodies specific therefor
WO1989006979A1 (fr) 1988-01-26 1989-08-10 Cockbain, Julian, Roderick, Michaelson Composes paramagnetiques
US5208324A (en) 1988-01-26 1993-05-04 Nycomed Imaging As Paramagnetic compounds
US5229289A (en) 1988-03-11 1993-07-20 The Biomembrane Institute Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with animal and human and with synthetic carbohydrate-carrier conjugates
US5162504A (en) 1988-06-03 1992-11-10 Cytogen Corporation Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients
US5578484A (en) 1988-06-03 1996-11-26 Cytogen Corporation Hybridoma and monoclonal antibody 9H10-A4 specific to an antigen of LNCaP cells
US5763202A (en) 1988-06-03 1998-06-09 Cytogen Corporation Methods of detecting prostate carcinoma using a monoclonal antibody to a new antigenic marker in epithelial prostatic cells alone or with a monoclonal antibody to an antigen of LNCaP cells
US5118611A (en) 1988-07-25 1992-06-02 Adeza Biomedical Corporation Adenocarcinoma antigen binding methods and reagents
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5565562A (en) 1989-02-10 1996-10-15 Celltech Therapeutics Limited Triaza macrocycles
EP0382583B1 (fr) 1989-02-10 1996-01-17 Celltech Therapeutics Limited Azamacrocycles et procédé pour leur préparation
US5053503A (en) 1989-02-17 1991-10-01 Centocor Chelating agents
EP0392423A2 (fr) 1989-04-11 1990-10-17 Hoechst Aktiengesellschaft 1,4-7-10-Tétraazacyclotridécanes substitués, leur procédé de préparation et leur utilisation pour marquer des matières avec des radionucléides
EP0495878B1 (fr) 1989-10-11 1996-11-27 Akzo Nobel N.V. Procede de purification de composes conjugues chelateurs
WO1991015466A2 (fr) 1990-04-09 1991-10-17 Cockbain, Julian, Roderick, Michaelson Agents chelateurs
EP0594739B1 (fr) 1991-07-12 2000-03-01 Antisoma Research Limited Traitement du cancer
US5227471A (en) 1992-01-30 1993-07-13 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Monoclonal antibody PD41 that binds to a prostate mucin antigen that is expressed in human prostatic carcinoma
US5314996A (en) 1992-01-30 1994-05-24 Eastern Virginia Medical School Of Medical College Of Hampton Roads Isolated nucleotide sequences encoding an: antigen binding site of monoclonal antibody PD41; and antigen associated with prostate adenocarcinomas
US6036955A (en) 1992-03-05 2000-03-14 The Scripps Research Institute Kits and methods for the specific coagulation of vasculature
US5877289A (en) 1992-03-05 1999-03-02 The Scripps Research Institute Tissue factor compositions and ligands for the specific coagulation of vasculature
US6004555A (en) 1992-03-05 1999-12-21 Board Of Regents, The University Of Texas System Methods for the specific coagulation of vasculature
US6261535B1 (en) 1992-03-05 2001-07-17 The University Of Texas System Board Of Regents Diagnostic methods for targeting the vasculature of solid tumors
US6004554A (en) 1992-03-05 1999-12-21 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US5863538A (en) 1992-03-05 1999-01-26 Board Of Regents, The University Of Texas System Compositions for targeting the vasculature of solid tumors
US5855866A (en) 1992-03-05 1999-01-05 Board Of Regenis, The University Of Texas System Methods for treating the vasculature of solid tumors
US5660827A (en) 1992-03-05 1997-08-26 Board Of Regents, The University Of Texas System Antibodies that bind to endoglin
US6051230A (en) 1992-03-05 2000-04-18 Board Of Regents, The University Of Texas System Compositions for targeting the vasculature of solid tumors
WO1993017715A1 (fr) 1992-03-05 1993-09-16 Board Of Regents, The University Of Texas System Agents diagnostiques et/ou therapeutiques cibles sur des cellules endotheliales neovasculaires
US6093399A (en) 1992-03-05 2000-07-25 Board Of Regents, The University Of Texas System Methods and compositions for the specific coagulation of vasculature
US5776427A (en) 1992-03-05 1998-07-07 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
WO1993019668A1 (fr) 1992-04-07 1993-10-14 Immunomedics, Inc. Procede et kit destines a l'imagerie et au traitement d'organes et de tissus
US5621001A (en) 1992-08-03 1997-04-15 Bristol-Myers Squibb Company Methods for administration of taxol
WO1994004702A2 (fr) 1992-08-21 1994-03-03 Immunomedics, Inc. Procede ameliore de detection et de therapie de lesions au moyen de conjugues de biotine ou d'avidine
US5489525A (en) 1992-10-08 1996-02-06 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibodies to prostate cells
US5538866A (en) 1992-11-05 1996-07-23 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen
WO1994009820A1 (fr) 1992-11-05 1994-05-11 Sloan-Kettering Institute For Cancer Research Antigene de membrane specifique a la prostate
US5639879A (en) 1993-04-02 1997-06-17 Associated Universities, Inc. Macrocyclic polyaminocarboxylates for stable radiometal antibody conjugates for therapy, spect and pet imaging
WO1994026297A1 (fr) 1993-05-17 1994-11-24 Immunomedics, Inc. Detection et therapie ameliorees de lesions au moyen de conjugues de biotine/avidine et d'une proteine chelatant un ion metal
US5599677A (en) 1993-12-29 1997-02-04 Abbott Laboratories Immunoassays for prostate specific antigen
WO1995026206A1 (fr) 1994-03-28 1995-10-05 The Regents Of The University Of California Procede d'elaboration de complexes agent de chelation-ligand etiquetes par radionucleide
WO1995031444A1 (fr) 1994-05-11 1995-11-23 Bracco International B.V. Composes monomeres et multimeres a relaxivite accrue
US5935818A (en) 1995-02-24 1999-08-10 Sloan-Kettering Institute For Cancer Research Isolated nucleic acid molecule encoding alternatively spliced prostate-specific membrane antigen and uses thereof
WO1996026272A1 (fr) 1995-02-24 1996-08-29 Sloan-Kettering Institute For Cancer Research Antigene membranaire specifique de la prostate et ses utilisations
WO1996039185A1 (fr) 1995-06-05 1996-12-12 Cornell Research Foundation, Inc. Traitement et diagnostic du cancer de la prostate
WO1996040245A1 (fr) 1995-06-07 1996-12-19 Immunomedics, Inc. Apport ameliore d'agents diagnostiques ou therapeutiques a un site cible
US6150508A (en) 1996-03-25 2000-11-21 Northwest Biotherapeutics, Inc. Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen
US20030003101A1 (en) 1996-05-06 2003-01-02 Cornell Research Foundation, Inc. Treatment and diagnosis of prostate cancer
US20030031673A1 (en) 1996-05-06 2003-02-13 Bander Neil H. Treatment and diagnosis of cancer
US6649163B1 (en) 1996-05-06 2003-11-18 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US6770450B1 (en) 1996-05-06 2004-08-03 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US6107090A (en) 1996-05-06 2000-08-22 Cornell Research Foundation, Inc. Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US5804602A (en) 1996-06-17 1998-09-08 Guilford Pharmaceuticals Inc. Methods of cancer treatment using naaladase inhibitors
BR9710487A (pt) 1996-07-18 1999-08-17 Cornell Res Foundation Inc Processos para remover por abla-Æo ou exterminal c-lulas cancerosas e c-lulas epiteliais de prÄstata normais hiperpl sticas benignas e cancerosas para detectar tecido canceroso em uma amostra biolÄgica e c-lulas epiteliais de prÄstata normais hiperpl sticas benignas e cancerosas ou uma por-Æo das mesmas em uma amostra biolÄgica agente biolÄgico isolado composi-Æo kit para detectar c-ncer e linhagem de c-lula de hidridoma
AU733544B2 (en) 1996-07-18 2001-05-17 Cornell Research Foundation Inc. Treatment and diagnosis of cancer
NZ524036A (en) 1996-07-18 2004-12-24 Cornell Res Foundation Inc Treatment and diagnosis of cancer
NZ333683A (en) 1996-07-18 2001-09-28 Cornell Res Foundation Inc Treatment and diagnosis of cancer
CN1244921A (zh) 1996-07-18 2000-02-16 康乃尔研究基金会有限公司 癌症的治疗和诊断
CA2261018A1 (fr) 1996-07-18 1998-01-29 Cornell Research Foundation, Inc. Traitement et diagnostic du cancer
EA004634B1 (ru) 1996-07-18 2004-06-24 Корнелл Рисерч Фаундейшн, Инк Лечение и диагностика рака
JP2002513378A (ja) 1996-07-18 2002-05-08 コーネル・リサーチ・ファンデーション・インコーポレイテッド 癌の治療および診断
US5958474A (en) 1996-08-21 1999-09-28 Nestec S.A. Process for preparing food flavor precursors
US6022524A (en) 1997-04-18 2000-02-08 Dibra S.P.A. Process for the conjugation of chelants with molecules containing amino groups
EP0882454A2 (fr) 1997-04-18 1998-12-09 BRACCO S.p.A. Procédé pour la conjugaison de chélates avec des molécules contenants des groups amino
US6200765B1 (en) 1998-05-04 2001-03-13 Pacific Northwest Cancer Foundation Non-invasive methods to detect prostate cancer
US6342219B1 (en) * 1999-04-28 2002-01-29 Board Of Regents, The University Of Texas System Antibody compositions for selectively inhibiting VEGF
US6824780B1 (en) 1999-10-29 2004-11-30 Genentech, Inc. Anti-tumor antibody compositions and methods of use
US6340701B1 (en) * 1999-11-24 2002-01-22 Immunogen Inc Cytotoxic agents comprising taxanes and their therapeutic use
CA2452288A1 (fr) 2001-09-20 2003-03-27 Cornell Research Foundation, Inc. Methodes et compositions de traitement ou de prevention de troubles cutanes au moyen d'agents de liaison specifiques pour un antigene membranaire specifique de la prostate
US20030161832A1 (en) 2001-09-20 2003-08-28 Neil Bander Methods and compositions for treating or preventing skin disorders using binding agents specific for prostate specific membrane antigen

Non-Patent Citations (71)

* Cited by examiner, † Cited by third party
Title
Bander et al., "Phase I clinical trial targeting a monoclonal antibody (mAb) to the extracellular domain of prostate specific membrane antigen (PSMAext) in hormone-independent patients", J. Urol. vol. 163, No. 4 Suppl., p. 160, 2000.
Bander, AACR Meeting Presentation: "mAb Therapy of Prostate Cancer Targeting PSMAext", Apr. 9, 2002.
Bander, ASCO Meeting Presentation: "Phase I Radioimmunotherapy Trials of mAb J591 to the Extracellular Domain of Prostate Specific Membrane Antigen (PSMAext) Radiolabeled with 90Y or 177Lu in Advanced Prostate Cancer", May 18-21, 2002.
Bander, CaPCURE Board Presentation: "Antibody Treatment of Prostate Cancer", Nov. 1999.
Bander, CaPCURE Board Presentation: "Monolconal Antibody Therapy of Prostate Cancer", 2001.
Bander, Oral Presentation: "mAb anti-PSMAext Therapy of Prostate Cancer", Oct. 1999.
Barren et al. (1997), "Monoclonal Antibody 7E11.C5 Staining of Viable LNCaP Cells", Prostate 30(1):65-8.
Carter et al. (1996), "Prostate-specific Membrane Antigen is a Hydrolase with Substrate and Pharmacologic Characteristics of a Neuropeptidase", Proc. Natl. Acad. Sci. U.S.A. 93:749-751.
Chang et al. (1999), "Five Different Anti-Prostate-specific Membrane Antigen (PSMA) Antibodies Confirm PSMA Expression in Tumor-associated Neovasculature", Cancer Research, 59(13):3192-3198.
Chang et al., "Comparison of anti-prostate-specific membrane antigen antibodies and other immunomarkers in metastatic prostate carcinoma", Urology 57 (6):1179-1183 (2001).
Chang et al., "Prostate-specific Membrane Antigen Is Produced in Tumor-associated Neovasculature", Clinical Cancer Research 674(5):2674-2681 (1999).
Chang et al., "Prostate-Specific Membrane Antigen: Much More Than a Prostrate Cancer Marker", Molecular Urology 3(3):313-321 (1999).
Chang et al., "The clinical role of prostate-specific membrane antigen (PSMA)", Urologic Oncology 7:7-12 (2002).
Consent Form for Clinical Investigation by the New York Hospital-Cornell Medical Center.
Diamond et al. (1997), "Monoclonal Antibody 225 Blockade of Prostate Specific Membrane Antigen (PSM) Expression: Potential Novel Therapy for Prostate Cancer", Journal of Urology 157(4 suppl):226 (Abstract 884).
Dillman et al. (1988), "Toxicities Associated with Monoclonal Antibody Infusions in Cancer Patients", Mol. Biother. 1(2):81-85.
Dillman et al. (1994), "Human Anti-Mouse Antibody Response in Cancer Patients Following Single Low-Dose Injections of Radiolabeled Murine Monoclonal Antibodies", Cancer Biotherapy 9(1):17-28.
Fair et al. (1997), "Prostate Specific Membrane Antigen", Prostate 32(2):140-8.
Fracasso et al., "Anti-tumor Effects of Toxins Targeted to the Prostate Specific Membrane Antigen", The Prostate 53:9-23 (2002).
Fundamental Immunology 242, William E. Paul, M.D. ed., 3d ed. 1993. *
Ghosh et al. Journal of Cellular Biochemistry, 91(3):528-539, 2004. *
Goldsmith and Bander, "Monoclonal Antibody Therapy", Nuclear Oncology: Diagnosis and Therapy. Chapter 32: Prostate Carcinoma. pp. 433-439. Lippincott Williams and Wilkins, Philadelphia, 2001.
Goldsmith et al., "Evaluation of Anti-PSMA Antibody, . . . " J. of Nuclear Med. 41(5):80P, 2000 (Abstract).
Gong et al., "Overview of Evolving Strategies Incorporating Prostate-Specific Membrane Antigen as Target for Therapy", Molecular Urology 4(3):217-223 (2000).
Gong et al., "Prostate-specific membrane antigen (PSMA)-specific monoclonal antibodies in the treatment of prostate and other cancers", Cancer and Metastasis Reviews 18:483-490 (1999).
Grauer et al., "Identification, Purification, and Subcellular Localization of Prostate-specific Membrane Antigen PSM' Protein in the LNCaP Prostatis Carcinoma Cell Line", Cancer Rearch 58:4787-4789 (1998).
Hamilton et al. (1998), "A novel humanized antibody against Prostate Specific Membrane Antigen (PSMA) for in vivo targeting and therapy", Proc. Amer. Assoc. Cancer Res. 39:440, Abstract #2997.
Harlow and Lane (1988), "Antibodies: A laboratory manual", Cold Spring Harbor Laboratory, p. 139-243.
Heston (1997), "Characterization and Glutamyl Preferring Carboxypeptidase Function of Prostate Specific Membrane Antigen: A Novel Folate Hydrolase", Urology 49(3A):104-112.
Hinman et al. Cancer Research 53:3336-23342, 1993. *
Holmes (2001), "PSMA specific antibodies and their diagnostic and therapeutic use", Exp. Opin. Invest. Drugs 10(3):511-19.
Horoszewicz et al. (1987), "Monoclonal Antibodies to a New Antigenic Marker in Epithelial Prostatic Cells and Serum of Prostatic Cancer Patients", Anticancer Research 7(5B):927-936.
Israeli et al. (1993), "Molecular Cloning of a Complementary DNA Encoding a Prostate-Specific Membrane Antigen", Cancer Research 53(2):227-230.
Israeli et al. (1994), "Expression of the Prostate-Specific Membrane Antigen", Cancer Research 54(7):1807-1811.
Israeli et al. (1997), "Prostate Specific Membrane Antigen and Other Prostatic Tumor Markers on the Horizon", Urological Clinics of North America 24(2):439-50.
Jain, R.K. (1990), "Vacular and interstitial barriers to delivery of therapeutic agents in tumors", Cancer and Metastasis Reviews 9(3):253-266.
Leek et al. (1995), "Prostate-Specific Membrane Antigen: Evidence for the Existence of a Second Related Human Gene", British Journal of Cancer 72:583-588.
Leung et al. (1986), "Selection of a Monoclonal Antibody to a New Prostate Cancer Marker for In Vivo Clinical Trials", 6<SUP>th </SUP>International Congress of Immunology, p. 516 (Abstract 4.15.19).
Li et al. Bioconjugate Chemistry 5(2):101-104, 1994. *
Liu et al. (1997), "Monoclonal Antibodies to the Extracellular Domain of Prostate-specific Membrane Antigen also React with Tumor Vascular Endothelium", Cancer Research 57(18):3629-3634.
Liu et al. (1998), "mAbs to the Extracellular Domain of Prostate Specific Membrane Antigen (PSMA)", 11<SUP>th </SUP>International Conference on Monoclonal Antibodies for Cancer, Mar. 19-21, Abstract 2.
Liu et al. Proc. Natl. Acad. Sci. USA 93:8618-8623, 1996. *
Liu, et al. (1998), "Constitutive and Antibody-Induced Internalization of Prostate-Specific Membrane Antigen", Cancer Research 58(18):4055-4060.
Murphy et al. (1995), "Comparison of Prostate Specific Antigen, Prostate Specific Membrane Antigen, and LNCaP-Based Enzyme-Linked Immunosorbent Assays in Prostatic Cancer Patients and Patients With Benign Prostatic Enlargement", The Prostate 26:164-168.
Murphy et al. (1995), "Comparison of Prostate Specific Membrane Antigen, and Prostate Specific Antigen Levels in Prostatic Cancer Patients", Anticancer Res. 15:1473-1480.
Murphy et al. (1996), "Measurement of Prostate-Specific Membrane Antigen in the Serum With a New Antibody", The Prostate 28(4):266-271.
Murphy et al., "Current Evaluation of the Tissue Localization and . . . "Cancer 83(11):2259-2269, 1998.
Pinto et al. (1996), "Prostate-Specific Membrane Antigen: A Novel Folate Hydrolase in Human Prostatic Carcinoma Cells", Clincal Cancer Research 2(9):1445-51.
Proceedings of American Society of Clinical Oncology vol. 20, May 12-15, 2001, San Francisco, CA.
Richstone et al. Proceedings of the American Society of Clinical Oncology, vol. 19, abstract 1329, May 20, 2000. *
Rochon et al. (1994), "Western Blot Assay for Prostate-Specific Membrane Antigen in Serum of Prostate Cancer Patients", The Prostate 25(4):219-223.
Rudikoff et al. Proc. Natl. Acad. Sci. USA 1982 vol. 79 pp. 1979-1983. *
Schlom (1991), "Monoclonal antibodies: They're more and less than you think", Molecular Foundations of Oncology, ed. Broder, Williams & Wilkins, p. 95-134.
Silver et al. (1997), "Prostate-specific Membrane Antigen Expression in Normal and Malignant Human Tissues", Clinical Cancer Research 3:81-85.
Smith (2001), "Technology evaluation: C242-DM1, ImmunoGen Inc.", Current Opin. In Mol Therapeutics 3(2):198-203.
Smith-Jones et al., "In Vitro Characterization of Radiolabeled Monoclonal Antibodies Specific for the Extracellular Domain of Prostrate-specific Membrane Antigen", Cancer Research 60:5237-5243 (2000).
Smith-Jones et al., "Monoclonal Antibodies (MAB) Specific to Extracellular . . . " J. of Nuclear Med. 40(5):226P, 1999 (Abstract).
Smith-Jones et al., "Preclinical Studies with <SUP>131</SUP>I and <SUP>111</SUP>In labeled Monoclonal Antibodies . . . " J of Labeled Compounds and Radiopharm. 42(1):S701-S703, 1999.
Sokoloff et al., "A Dual-Monoclonal Sandwich Assay for Prostate-specific Membrane Antigen: Levels in Tissues, Seminal Fluid and Urine", The Prostate 43:150-157 (2000).
Su et al. (1995), "Alternatively Spliced Variants of Prostate-specific Membrane Antigen RNA: Ratio of Expression as a Potential Measurement of Progression", Cancer Research 55:1441-1443.
Troyer et al. (1994), "Subcellular Localization of the 7E11-C5 Prostate Specific Antigen", Proc. Am. Assoc. Cancer Research 35:283 (Abstract 1688).
Troyer et al. (1995), "Biochemical Characterization and Mapping of the 7E11-C5.3 Epitope of the Prostate-Specific Membrane Antigen", Urol Oncol 1:29-37.
Troyer et al. (1995), "Detection and Characterization of the Prostate-Specific Membrane Antigen (PSMA) in Tissue Extracts and Body Fluids", International Journal of Cancer 62(5):552-558.
Troyer et al. (1997), "Location of prostate-specific membrane antigen in the LNCaP prostate carcinoma cell line", Prostate 30(4):232-242.
Uria et al. (1997), "Prostate Specific Membrane Antigen in Breast Carcinoma", The Lancet 349(9065):1601.
US 6,290,956, 09/2001, Bander (withdrawn)
Wang et al. (1988), "Monoclonal Antibody Assays for Prostatic Tumor", Immunol Ser 39:195-219.
Wang et al., "Identification of Prostate Specific Membrane Antigen (PSMA) as the Target of Monoclonal Antibody 107-1A4 by Proteinchip(R); Array, Surface-enhanced Laser Desorption/ionization (SELDI) Technology", Int. J. Cancer 92:871-876 (2001).
Wright (1990), "Characterization of a New Prostate Carcinoma-Associated Marker: 7E11-C5", Antibody Immunoconjugates and RadioPharmaceuticals 3:Abstract 193.
Wright et al. (1995), "Expression of Prostate-Specific Membrane Antigen in Normal, Benign, and Malignant Prostate Tissues", Urol Oncol, 1:18-28.
Yang et al. (1998), "Alpha particle emitter therapy of micrometastases: <SUP>213</SUP>Bi-J5 (anti-PSMA) treatment of LNCaP spheroids", Proceedings of the American Association for Cancer Research 39:440 (Abstract #2996).

Cited By (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43586E1 (en) 1992-11-05 2012-08-14 Sloan-Kettering Institute For Cancer Research Antibodies to prostate-specific membrane antigen
US8951737B2 (en) 1996-05-06 2015-02-10 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US20030003101A1 (en) * 1996-05-06 2003-01-02 Cornell Research Foundation, Inc. Treatment and diagnosis of prostate cancer
US7666425B1 (en) 1996-05-06 2010-02-23 Cornell Research Foundation, Inc. Treatment and diagnosis of prostate cancer
US20090238755A1 (en) * 1996-05-06 2009-09-24 Bander Neil H Treatment and Diagnosis of Cancer
US20090274620A1 (en) * 2001-02-07 2009-11-05 Wilex Ag Hybridoma Cell Line G250 and its use for Producing Monoclonal Antibodies
US9605075B2 (en) 2001-02-07 2017-03-28 Wilex Ag Hybridoma cell line G250 and its use for producing monoclonal antibodies
US20050260234A1 (en) * 2001-03-07 2005-11-24 Simard John J L Anti-neovasculature preparations for cancer
US20090208537A1 (en) * 2001-03-07 2009-08-20 Mannkind Corporation Anti-Neovasculature Preparations for Cancer
US20090280120A1 (en) * 2001-06-01 2009-11-12 Bander Neil H Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
US8470330B2 (en) 2001-10-23 2013-06-25 Psma Development Company, Llc PSMA antibodies and uses thereof
US20080286284A1 (en) * 2001-10-23 2008-11-20 Psma Development Company, Llc Compositions of PSMA antibodies
US9695248B2 (en) 2001-10-23 2017-07-04 Psma Development Company, Llc PSMA antibodies and uses thereof
US20110165081A1 (en) * 2001-10-23 2011-07-07 Psma Development Company, Llc Psma antibodies and uses thereof
US8114965B2 (en) * 2001-10-23 2012-02-14 Psma Development Company, Llc Compositions of PSMA antibodies
US20080025981A1 (en) * 2002-03-04 2008-01-31 Young Paul E Cancer-linked genes as targets for chemotherapy
US20100008888A1 (en) * 2002-07-01 2010-01-14 Wilex Ag Co-administration of cg250 and il-2 or ifn-alpha for treating cancer such as renal cell carcinomas
US8828381B2 (en) * 2002-07-01 2014-09-09 Wilex Ag Co-administration of CG250 and IL-2 or IFN-alpha for treating cancer such as renal cell carcinomas
US20060062793A1 (en) * 2004-03-03 2006-03-23 Webb Iain J Modified antibodies to prostate-specific membrane antigen and uses thereof
US20060182750A1 (en) * 2005-02-11 2006-08-17 Immunogen, Inc. Process for preparing stable drug conjugates
US20110166319A1 (en) * 2005-02-11 2011-07-07 Immunogen, Inc. Process for preparing purified drug conjugates
US8383122B2 (en) 2005-08-24 2013-02-26 Immunogen, Inc. Process for preparing purified drug conjugates
US8933205B2 (en) 2005-08-24 2015-01-13 Immunogen, Inc. Process for preparing purified drug conjugates
US9789204B2 (en) 2005-08-24 2017-10-17 Immunogen, Inc. Process for preparing purified drug conjugates
US20070048314A1 (en) * 2005-08-24 2007-03-01 Immunogen, Inc. Process for preparing purified drug conjugates
US11471536B2 (en) 2005-08-24 2022-10-18 Immunogen, Inc. Process for preparing purified drug conjugates
US7811572B2 (en) 2005-08-24 2010-10-12 Immunogen, Inc. Process for preparing purified drug conjugates
US20110021744A1 (en) * 2005-08-24 2011-01-27 Immunogen, Inc. Process for preparing purified drug conjugates
EP3714906A1 (fr) 2007-10-03 2020-09-30 Cornell University Traitement de troubles prolifératifs utilisant des anticorps psma radiomarqués
US20100291113A1 (en) * 2007-10-03 2010-11-18 Cornell University Treatment of Proliferative Disorders Using Antibodies to PSMA
US9242012B2 (en) 2008-09-08 2016-01-26 Psma Development Company, Llc Methods for killing PSMA-expressing, taxane-resistant cancer cells
US9879249B2 (en) 2009-02-17 2018-01-30 Redwood Bioscience, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
US9238878B2 (en) 2009-02-17 2016-01-19 Redwood Bioscience, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
EP3495000A1 (fr) 2009-02-17 2019-06-12 Cornell Research Foundation, Inc. Procédés et kits pour le diagnostic du cancer et la prédiction d'une valeur thérapeutique
WO2010096486A1 (fr) 2009-02-17 2010-08-26 Cornell Research Foundation, Inc. Procédés et kits pour le diagnostic d'un cancer et la prédiction d'une valeur thérapeutique
US10517969B2 (en) 2009-02-17 2019-12-31 Cornell University Methods and kits for diagnosis of cancer and prediction of therapeutic value
US20130028896A1 (en) * 2009-04-01 2013-01-31 The University Of British Columbia Semaphorin 3C (Sema3C) Inhibitor Therapeutics, Methods, and Uses
US8808693B2 (en) * 2009-04-01 2014-08-19 The University Of British Columbia Semaphorin 3C (Sema3C) inhibitor therapeutics, methods, and uses
US9771432B2 (en) 2009-06-03 2017-09-26 Immunogen, Inc. Conjugation methods
US9376500B2 (en) 2009-06-03 2016-06-28 Immunogen, Inc. Conjugation methods
US11498979B2 (en) 2009-06-03 2022-11-15 Immunogen, Inc. Methods for preparing a purified maytansinoid conjugate in a solution
US10815309B2 (en) 2009-06-03 2020-10-27 Immunogen, Inc. Methods for preparing antibody-drug conjugates
US10233257B2 (en) 2009-06-03 2019-03-19 Immunogen, Inc. Methods for preparing antibody-drug conjugates
EP3135302A1 (fr) 2009-12-02 2017-03-01 Imaginab, Inc. Minicorps j591 et cys-diacorps pour cibler l'antigène membranaire spécifique de la prostate humaine (psma) et procédés pour leur utilisation
US8772459B2 (en) 2009-12-02 2014-07-08 Imaginab, Inc. J591 minibodies and Cys-diabodies for targeting human prostate specific membrane antigen (PSMA) and methods for their use
US11180570B2 (en) 2009-12-02 2021-11-23 Imaginab, Inc. J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (PSMA) and methods for their use
EP3511023A1 (fr) 2009-12-02 2019-07-17 Imaginab, Inc. Minicorps j591 et cys-diacorps pour cibler l'antigène membranaire spécifique de la prostate humaine (psma) et leurs procédés d'utilisation
US9540438B2 (en) 2011-01-14 2017-01-10 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
US10183998B2 (en) 2011-01-14 2019-01-22 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
US11090390B2 (en) 2011-03-29 2021-08-17 Immunogen, Inc. Preparation of maytansinoid antibody conjugates by a one-step process
US11744900B2 (en) 2011-03-29 2023-09-05 Immunogen, Inc. Preparation of maytansinoid antibody conjugates by a one-step process
US10435432B2 (en) 2011-03-29 2019-10-08 Immunogen, Inc. Preparation of maytansinoid antibody conjugates by a one-step process
US8795673B2 (en) 2011-03-29 2014-08-05 Immunogen, Inc. Preparation of maytansinoid antibody conjugates by a one-step process
US9914748B2 (en) 2011-03-29 2018-03-13 Immunogen, Inc. Preparation of maytansinoid antibody conjugates by a one-step process
US9428543B2 (en) 2011-03-29 2016-08-30 Immunogen, Inc. Preparation of maytansinoid antibody conjugates by a one-step process
WO2013185117A1 (fr) 2012-06-07 2013-12-12 Ambrx, Inc. Conjugués anticorps-médicament d'antigène membranaire spécifique à la prostate
EP3536700A1 (fr) 2012-06-07 2019-09-11 Ambrx, Inc. Conjugués anticorps-médicament d'antigène membranaire spécifique à la prostate
WO2013188740A1 (fr) 2012-06-14 2013-12-19 Ambrx, Inc. Anticorps anti-psma conjugués à des polypeptides de ligand de récepteur nucléaire
US10035817B2 (en) 2012-10-04 2018-07-31 Immunogen, Inc. Method of purifying cell-binding agent-cytotoxic agent conjugates with a PVDF membrane
US10398791B2 (en) 2013-10-18 2019-09-03 Deutsches Krebsforschungszentrum Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
AU2020203191B2 (en) * 2013-10-18 2023-03-09 Psma Development Company, Llc Combination therapies with psma ligand conjugates
US11951190B2 (en) 2013-10-18 2024-04-09 Novartis Ag Use of labeled inhibitors of prostate specific membrane antigen (PSMA), as agents for the treatment of prostate cancer
US10471160B2 (en) 2013-10-18 2019-11-12 Deutsches Krebsforschungszentrum Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
US11045564B2 (en) 2013-10-18 2021-06-29 Deutsches Krebsforschungszentrum Labeled inhibitors of prostate specific membrane antigen (PSMA) as agents for the treatment of prostate cancer
US11931430B2 (en) 2013-10-18 2024-03-19 Novartis Ag Labeled inhibitors of prostate specific membrane antigen (PSMA) as agents for the treatment of prostate cancer
US20150110814A1 (en) * 2013-10-18 2015-04-23 Psma Development Company, Llc Combination therapies with psma ligand conjugates
US10179819B2 (en) 2015-07-31 2019-01-15 Regeneron Pharmaceuticals, Inc. Anti-PSMA antibodies, bispecific antigen-binding molecules that bind PSMA and CD3, and uses thereof
US11155633B2 (en) 2015-07-31 2021-10-26 Regeneran Pharmaceuticals, Inc. Anti-PSMA antibodies, bispecific antigen-binding molecules that bind PSMA and CD3, and uses thereof
US11254744B2 (en) 2015-08-07 2022-02-22 Imaginab, Inc. Antigen binding constructs to target molecules
US10906987B2 (en) 2016-03-01 2021-02-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Antibodies specific to human poliovirus receptor (PVR)
US11208632B2 (en) 2016-04-26 2021-12-28 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
US11788066B2 (en) 2016-04-26 2023-10-17 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
EP4282434A2 (fr) 2016-06-06 2023-11-29 Abzena (UK) Limited Anticorps, leurs utilisations et leurs conjugués
US11266745B2 (en) 2017-02-08 2022-03-08 Imaginab, Inc. Extension sequences for diabodies
WO2024182569A2 (fr) 2023-02-28 2024-09-06 Eisai R&D Management Co., Ltd. Anticorps anti-psma, conjugués et procédés d'utilisation

Also Published As

Publication number Publication date
EP1392360A4 (fr) 2005-07-20
CA2447695C (fr) 2015-02-24
AU2002318169B2 (en) 2007-10-18
JP2004532639A (ja) 2004-10-28
EP2277542A1 (fr) 2011-01-26
IL158969A (en) 2010-11-30
JP4619651B2 (ja) 2011-01-26
EP1392360B1 (fr) 2011-11-30
US20040213791A1 (en) 2004-10-28
WO2002098897A2 (fr) 2002-12-12
EP1392360A2 (fr) 2004-03-03
ATE535258T1 (de) 2011-12-15
IL201274A (en) 2015-04-30
HK1062915A1 (en) 2004-12-03
MXPA03010804A (es) 2004-11-22
JP2010017189A (ja) 2010-01-28
WO2002098897A3 (fr) 2003-05-01
IL158969A0 (en) 2004-05-12
EP2277542B1 (fr) 2014-04-16
IL201274A0 (en) 2011-07-31
CA2447695A1 (fr) 2002-12-12

Similar Documents

Publication Publication Date Title
US7045605B2 (en) Modified antibodies to prostate-specific membrane antigen and uses thereof
US20180118847A1 (en) Modifield antibodies to prostate-specific membrane antigen and uses thereof
US7514078B2 (en) Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
AU2002318169A1 (en) Modified antibodies to prostate-specific membrane antigen and uses thereof
US20060062793A1 (en) Modified antibodies to prostate-specific membrane antigen and uses thereof
JP5703447B2 (ja) Ｐｓｍａ抗体およびタンパク質マルチマー
EP2384767B1 (fr) Anticorps se liant à l&#39;OV064 et leurs procédés d&#39;utilisation
US9926378B2 (en) Antibodies that bind OV064 and methods of use therefor

Legal Events

Date Code Title Description
AS Assignment

Owner name: CORNELL RESEARCH FOUNDATION, INC., NEW YORK

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BANDER, NEIL;CARR, FRANCIS J.;HAMILTON, ANITA;REEL/FRAME:013176/0409;SIGNING DATES FROM 20020722 TO 20020729

AS Assignment

Owner name: DARPA, VIRGINIA

Free format text: CONFIRMATORY LICENSE;ASSIGNOR:CORNELL RESEARCH FOUNDATION, INC.;REEL/FRAME:013241/0489

Effective date: 20020828

AS Assignment

Owner name: THE UNITED STATES GOVERNMENT SECRETARY OF THE ARMY

Free format text: CONFIRMATORY LICENSE;ASSIGNOR:CORNELL UNIVERSITY;REEL/FRAME:015233/0123

Effective date: 20030729

STCF Information on status: patent grant

Free format text: PATENTED CASE

FEPP Fee payment procedure

Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY

FEPP Fee payment procedure

Free format text: PAT HOLDER CLAIMS SMALL ENTITY STATUS, ENTITY STATUS SET TO SMALL (ORIGINAL EVENT CODE: LTOS); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY

FPAY Fee payment

Year of fee payment: 4

FPAY Fee payment

Year of fee payment: 8

MAFP Maintenance fee payment

Free format text: PAYMENT OF MAINTENANCE FEE, 12TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2553)

Year of fee payment: 12