US6106930A - Preparation consisting of a surface-adhering, film-like or wafer-like administration form - Google Patents

Preparation consisting of a surface-adhering, film-like or wafer-like administration form Download PDF

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Publication number
US6106930A
US6106930A US09/002,976 US297698D US6106930A US 6106930 A US6106930 A US 6106930A US 297698 D US297698 D US 297698D US 6106930 A US6106930 A US 6106930A
Authority
US
United States
Prior art keywords
pharmaceutical preparation
areas
coding
producing
thickness
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US09/002,976
Other languages
English (en)
Inventor
Karin Ludwig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Assigned to LTS LOHMANN THERAPIE-SYSTEME GMBH reassignment LTS LOHMANN THERAPIE-SYSTEME GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LUDWIG, KARIN
Application granted granted Critical
Publication of US6106930A publication Critical patent/US6106930A/en
Assigned to LTS LOHMANN THERAPIE-SYSTEME AG reassignment LTS LOHMANN THERAPIE-SYSTEME AG CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: LTS LOHMANN THERAPIE-SYSTEME GMBH
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/007—Marking tablets or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24479—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24628—Nonplanar uniform thickness material
    • Y10T428/24736—Ornamental design or indicia

Definitions

  • the invention relates to a preparation, consisting of a sheet-like, film-like or wafer-like administration form with a coding in the form of characters and/or graphic symbols or patterns for identifying the substances affecting flavour or odour and/or the therapeutic or curative substances which can be released therefrom during use.
  • medicaments in the form of pills, tablets and foil-like or film-like products are usually coded in an operation which is additional to the actual manufacture, by printing or punching of special characters or patterns.
  • the introduction of a printing medium, a printing ink, in the printing process, for example is not uncontroversial, because at least in some cases this creates or unnecessarily increases the risk of allergization.
  • the object on which the invention is based is to make available, for a preparation of the generic type specified in the preamble, a coding in the form of characters and/or graphic symbols or patterns which avoids the abovementioned disadvantages, in particular the application of a foreign substance such as printing ink, and which consequently avoids the risk of allergization and reduces the corresponding outlay for a coding subordinate to production.
  • the object is successfully achieved according to the invention, in a preparation of the type mentioned in the preamble of claim 1, by virtue of the fact that the coding is formed by surface areas of differing thickness.
  • the areas of differing thickness are formed under the production conditions while avoiding different density or compression.
  • the areas of differing thickness have a different density (compression).
  • the method according to the invention for producing the preparation involves the symbols or patterns of the coding being introduced by means of an irreversible deformation in the plastically deformable state.
  • One method according to the invention for producing the preparation involves the symbols or patterns of the coding being formed in the course of production without the action of pressure (compression).
  • a further method according to the invention for producing the preparation involves the symbols or patterns of the coding being applied under the action of pressure (compression).
  • the thickness differences are produced by coating of a support which has a sequence of elevations and/or depressions corresponding to the coding.
  • elevations and depressions can be arranged, for example, on a support similar to a pressure plate by grinding or etching.
  • the thickness differences can be produced by subjecting the preparation to local temperature differences during drying.
  • the thickness differences are introduced continuously, for example with a structured embossing roller, or intermittently, for example with a stamp.
  • the solvent used is water or an ethanol/water mixture.
  • Application device rollers, coating box, nozzles
  • I. structured support e.g. Teflon, special steel
  • dehesively treated material e.g. paper or foil
  • an open-worked surface e.g. lattice hole structure of the band-shaped support
  • FIG. I is a diagrammatic representation, in cross section, with production of the coding on a support exhibiting thickness differences
  • FIG. II shows, in cross section, the production of a coding by means of subjecting the preparation to local temperature differences.
  • FIG. I shows the preparation (1) on a structured support (2) which has a sequence of elevations (3) and depressions (4).
  • depressions (13) develop reciprocally in the preparation (1) opposite the elevations (3)
  • elevations (14) develop opposite the depressions (4) within the preparation layer.
  • Heat is delivered in a heat stream (9) which can involve both radiation and also convection.
  • FIG. II shows a manufacturing method in which the thickness differences (13, 14) in the layer (1) of the preparation are produced using local temperature differences during drying.
  • the preparation layer (1) lies on a foil-like carrier (5), for example silicone paper, aluminium foil, plastic foil or the like.
  • a conveyor belt is designated by (6), which has a lattice or hole structure consisting of bridges (7) and openings (8).
  • bridges (7) and openings (8) By means of heat delivered to the bridges in accordance with the arrows (10), these form warmer areas in contact with the carrier foil (5) and colder areas in the region of the openings (8). In the area of the warmer zones, the material turns out thicker on drying, while it is thinner in the colder areas.
  • the drying can also be assisted from above, for example, likewise by a stream (9) of heated air.
  • the temperature differences of the conveyor belt (6) can be generated, for example, by inductive heating of the bridges (7) of the lattice structure or by radiation or contact heating, while the openings (8), for example, are cooled by convection with air.
  • the invention is uncomplicated and optimally satisfies the object set out in the introduction.

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
US09/002,976 1996-11-13 1997-11-04 Preparation consisting of a surface-adhering, film-like or wafer-like administration form Expired - Lifetime US6106930A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19646836 1996-11-13
DE19646836A DE19646836B4 (de) 1996-11-13 1996-11-13 Zubereitung, bestehend aus einer flächenhaften, film- oder oblatenartigen Darreichungsform
PCT/EP1997/006082 WO1998020859A1 (de) 1996-11-13 1997-11-04 Zubereitung, bestehend aus einer flächenhaften, film- oder oblatenartigen darreichungsform

Publications (1)

Publication Number Publication Date
US6106930A true US6106930A (en) 2000-08-22

Family

ID=7811507

Family Applications (1)

Application Number Title Priority Date Filing Date
US09/002,976 Expired - Lifetime US6106930A (en) 1996-11-13 1997-11-04 Preparation consisting of a surface-adhering, film-like or wafer-like administration form

Country Status (14)

Country Link
US (1) US6106930A (ja)
EP (1) EP0949908B1 (ja)
JP (1) JP4163753B2 (ja)
KR (1) KR100475707B1 (ja)
AT (1) ATE212542T1 (ja)
AU (1) AU725089B2 (ja)
CA (1) CA2269076C (ja)
DE (2) DE19646836B4 (ja)
DK (1) DK0949908T3 (ja)
ES (1) ES2172020T3 (ja)
NO (1) NO325851B1 (ja)
PT (1) PT949908E (ja)
SI (1) SI0949908T1 (ja)
WO (1) WO1998020859A1 (ja)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002011664A1 (en) * 2000-08-03 2002-02-14 Novo Nordisk A/S Coding on medical device
WO2002064123A2 (de) * 2001-02-14 2002-08-22 Lts Lohmann Therapie-Systeme Ag Verfahren und vorrichtung zur herstellung dünner plättchen aus einem wirkstofffilm
US20030225381A1 (en) * 2002-05-30 2003-12-04 Van Dalen Johan T.W. Apparatus and method for delivering controlled quantities of one or more agents to the eye
US6913766B1 (en) * 1999-11-12 2005-07-05 Lts Lohmann Therapie-Systeme Ag Preparation consisting of a film, sheet or wafer-shaped form of administration with a two-layered structure and an integrated identification marking
US20060104910A1 (en) * 2004-11-15 2006-05-18 Keith Lerner Over dosage indicating medicated film strip
US20070092719A1 (en) * 2002-03-13 2007-04-26 Tesa Ag Coated transparent plastic film and method for the production thereof
US20100178254A1 (en) * 2009-01-13 2010-07-15 Monosol Rx Llc Unit assembly for multiple film dosages, apparatus, and methods
WO2011150302A1 (en) * 2010-05-27 2011-12-01 Monosol Rx, Llc Oral film dosage form having indicia thereon
US8652378B1 (en) 2001-10-12 2014-02-18 Monosol Rx Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US8906277B2 (en) 2001-10-12 2014-12-09 Monosol Rx, Llc Process for manufacturing a resulting pharmaceutical film
US9108340B2 (en) 2001-10-12 2015-08-18 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US20180311179A1 (en) * 2015-10-28 2018-11-01 Lts Lohmann Therapie-Systeme Ag Method of Marking Film-Like Dosage Forms
US10272607B2 (en) 2010-10-22 2019-04-30 Aquestive Therapeutics, Inc. Manufacturing of small film strips
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US10821074B2 (en) 2009-08-07 2020-11-03 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US11077068B2 (en) 2001-10-12 2021-08-03 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US11191737B2 (en) 2016-05-05 2021-12-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR1009992B (el) 2019-12-17 2021-05-06 Αριστοτελειο Πανεπιστημιο Θεσσαλονικης-Ειδικος Λογαριασμος Κονδυλιων Ερευνας Πολυστρωματικη φαρμακομορφη χορηγουμενη παρειακα και μεθοδος για την παραγωγη της

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456639A (en) * 1982-06-07 1984-06-26 Sealtran Corporation Laminating film of thermoset polyester resin with external layer of embossable thermoplastic resin
US4717615A (en) * 1985-07-31 1988-01-05 Leonard Kurz GmbH & Co Multi-layer foil and process for the production thereof
US4895257A (en) * 1989-01-23 1990-01-23 Winslow Phillip H Container system for dispensing pharmaceutical prescription to visually or medically impaired users
US4945215A (en) * 1986-10-15 1990-07-31 Kyodo Printing Co., Ltd. Optical recording card having hologram contained therein and method of producing the same
EP0398229A2 (en) * 1989-05-15 1990-11-22 Lip-Prints Inc. Cosmetic sample applicator and method of construction
CN1091003A (zh) * 1993-02-17 1994-08-24 杨吉田 药物非平面膜剂及其制备工艺
WO1995009608A1 (en) * 1993-10-01 1995-04-13 R.P. Scherer Corporation Method of applying an indicia to a fast-dissolving dosage form

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69211157T2 (de) * 1991-12-20 1996-10-02 Pfizer Poröse geformte abgabevorrichtung und verfahren zur herstellung derselbe

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456639A (en) * 1982-06-07 1984-06-26 Sealtran Corporation Laminating film of thermoset polyester resin with external layer of embossable thermoplastic resin
US4717615A (en) * 1985-07-31 1988-01-05 Leonard Kurz GmbH & Co Multi-layer foil and process for the production thereof
US4945215A (en) * 1986-10-15 1990-07-31 Kyodo Printing Co., Ltd. Optical recording card having hologram contained therein and method of producing the same
US4895257A (en) * 1989-01-23 1990-01-23 Winslow Phillip H Container system for dispensing pharmaceutical prescription to visually or medically impaired users
EP0398229A2 (en) * 1989-05-15 1990-11-22 Lip-Prints Inc. Cosmetic sample applicator and method of construction
US4995408A (en) * 1989-05-15 1991-02-26 Lip-Prints, Inc. Cosmetic sample applicator and method of construction
CN1091003A (zh) * 1993-02-17 1994-08-24 杨吉田 药物非平面膜剂及其制备工艺
WO1995009608A1 (en) * 1993-10-01 1995-04-13 R.P. Scherer Corporation Method of applying an indicia to a fast-dissolving dosage form

Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6913766B1 (en) * 1999-11-12 2005-07-05 Lts Lohmann Therapie-Systeme Ag Preparation consisting of a film, sheet or wafer-shaped form of administration with a two-layered structure and an integrated identification marking
WO2002011664A1 (en) * 2000-08-03 2002-02-14 Novo Nordisk A/S Coding on medical device
US7749417B2 (en) 2001-02-14 2010-07-06 Lts Lohmann Therapie-Systeme Ag Method and device for producing thin wafers from a film of active ingredients
WO2002064123A2 (de) * 2001-02-14 2002-08-22 Lts Lohmann Therapie-Systeme Ag Verfahren und vorrichtung zur herstellung dünner plättchen aus einem wirkstofffilm
WO2002064123A3 (de) * 2001-02-14 2003-02-27 Lohmann Therapie Syst Lts Verfahren und vorrichtung zur herstellung dünner plättchen aus einem wirkstofffilm
US20040076799A1 (en) * 2001-02-14 2004-04-22 Wolfgang Schafer Method and device for producing thin wafers from a film of active ingredients
US8291798B2 (en) 2001-02-14 2012-10-23 Lts Lohmann Therapie-Systeme Ag Method and device for producing small, thin sheets from an active-ingredient film
US20100224042A1 (en) * 2001-02-14 2010-09-09 Schaefer Wolfgang Method and device for producing small, thin sheets from an active-ingredient film
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US9931305B2 (en) 2001-10-12 2018-04-03 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US11077068B2 (en) 2001-10-12 2021-08-03 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US10888499B2 (en) 2001-10-12 2021-01-12 Aquestive Therapeutics, Inc. Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US9855221B2 (en) 2001-10-12 2018-01-02 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US9108340B2 (en) 2001-10-12 2015-08-18 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US8906277B2 (en) 2001-10-12 2014-12-09 Monosol Rx, Llc Process for manufacturing a resulting pharmaceutical film
US8652378B1 (en) 2001-10-12 2014-02-18 Monosol Rx Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US20070092719A1 (en) * 2002-03-13 2007-04-26 Tesa Ag Coated transparent plastic film and method for the production thereof
US10111810B2 (en) 2002-04-11 2018-10-30 Aquestive Therapeutics, Inc. Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US7018646B2 (en) 2002-05-30 2006-03-28 Van Dalen Johan T W Apparatus and method for delivering controlled quantities of one or more agents to the eye
US20030225381A1 (en) * 2002-05-30 2003-12-04 Van Dalen Johan T.W. Apparatus and method for delivering controlled quantities of one or more agents to the eye
US20060104910A1 (en) * 2004-11-15 2006-05-18 Keith Lerner Over dosage indicating medicated film strip
WO2006051406A3 (en) * 2004-11-15 2006-08-24 Warner Lambert Co Over dosage indicating medicated film strip
WO2006051406A2 (en) * 2004-11-15 2006-05-18 Warner-Lambert Company Llc Over dosage indicating medicated film strip
US20100178254A1 (en) * 2009-01-13 2010-07-15 Monosol Rx Llc Unit assembly for multiple film dosages, apparatus, and methods
US10821074B2 (en) 2009-08-07 2020-11-03 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
WO2011150302A1 (en) * 2010-05-27 2011-12-01 Monosol Rx, Llc Oral film dosage form having indicia thereon
US10272607B2 (en) 2010-10-22 2019-04-30 Aquestive Therapeutics, Inc. Manufacturing of small film strips
US10940626B2 (en) 2010-10-22 2021-03-09 Aquestive Therapeutics, Inc. Manufacturing of small film strips
US20180311179A1 (en) * 2015-10-28 2018-11-01 Lts Lohmann Therapie-Systeme Ag Method of Marking Film-Like Dosage Forms
US11925711B2 (en) * 2015-10-28 2024-03-12 Lts Lohmann Therapie-Systems Ag Method of marking film-like dosage forms
US11191737B2 (en) 2016-05-05 2021-12-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
US12023309B2 (en) 2016-05-05 2024-07-02 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions

Also Published As

Publication number Publication date
KR100475707B1 (ko) 2005-03-10
KR20000053204A (ko) 2000-08-25
NO992287L (no) 1999-05-11
CA2269076C (en) 2003-07-08
ES2172020T3 (es) 2002-09-16
DE19646836A1 (de) 1998-05-14
PT949908E (pt) 2002-07-31
AU7178098A (en) 1998-06-03
WO1998020859A1 (de) 1998-05-22
SI0949908T1 (en) 2002-08-31
CA2269076A1 (en) 1998-05-22
DK0949908T3 (da) 2002-05-13
JP2001503761A (ja) 2001-03-21
DE19646836B4 (de) 2006-06-14
DE59706271D1 (de) 2002-03-14
AU725089B2 (en) 2000-10-05
EP0949908B1 (de) 2002-01-30
JP4163753B2 (ja) 2008-10-08
EP0949908A1 (de) 1999-10-20
NO325851B1 (no) 2008-08-04
NO992287D0 (no) 1999-05-11
ATE212542T1 (de) 2002-02-15

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