MXPA99004408A - Preparation consisting of a surface-adhering, film-like or wafer-like administration form - Google Patents

Abstract

A preparation consisting of surface-adhering, film-like or wafer-like administration form having a coding comprising characters and/or graphic symbols or models to identify gustatory or odorous and/or preventive or healing substances that are released during application is characterized in that the coding is formed by surface sections having a different thickness.

Description

PREPARATION BASED ON A FLAT SUBMISSION FORMAT BY MOVIE OR OBJECT MODE DESCRIPTION OF THE INVENTION The invention relates to a preparation based on a form of flat administration as a film or wafer with a coding by alphabetic characters and / or graphics or drawings for the identification of sapid or aromatic and / or curative substances that are released during the application. Pharmaceutical manufacturers are increasingly forced to identify not only the primary packaging but also the product itself. This relates especially to medicaments in the form of administration with the aim of a controlled release of their active substances. In the current level of the technique, the coding of buildings in the form of tablets, tablets or products in the form of a sheet or film is usually carried out a work operation complementary to manufacturing -properly said, reprinting or stamping symbols or special drawings . In addition to the work that this demands with the corresponding increase -of the manufacturing costs it can not be left aside to discuss for example that when printing by means of the contribution of a printing medium, for example of a printing ink, which is thereby produced or the risk of allergy is unnecessarily increased in some cases. The invention aims to indicate for a preparation of the category designated in the general concept forming the category, a coding using alphabetic characters and / or graphics or drawings, which avoids REF .: 30029 the aforementioned drawbacks, in. particular the application of a foreign substance such as printing ink, thus avoiding the risk of allergy and reducing the corresponding expense corresponding to the creation of a subsequent coding. In a preparation of the kind cited in the general concept of claim 1, the problem with the invention is solved by the fact that the coding is formed by areas of the surface with different thickness. By means of the configuration of zones of the surface of different thickness for the purpose of coding, the application of a logo mediajíte printing with food dyes is avoided, as well as the inconvenient drawbacks in this respect. Instead, it is created according to the invention and by means of differences in the layer thickness of the presentation form in the form of a film or a wafer forming a pattern, a perceptible logo for the view in the area of the surface of the the preparation, whose effect - equates approximately to a water mark in paper-like dispersions. The invention therefore represents an advantageous alternative for the application of product identifications with respect to printing with foreign substances. Although the formation of "watermarks" on drying out dispersions on structured substrates is also based on the formation of variations in the thickness of the surface paper dispersions, it had never been proposed to apply this kind of identification with rel_a. tion to forms of presentation of curative substances in the form of a film, a pebble or a wafer. One of the versions of the preparation foresees that the zones of different thickness will be obtained conditioned by the same manufacturing process, avoiding differences of density or compaction. In another version of the preparation, it is foreseen that the zones of gross thickness have different densities (compaction). The process object of the invention for the manufacture of the preparation provides that the application of the characters or drawings of the coding takes place by an irreversible deformation during the plastically defor able state. One of the manufacturing methods of the subject preparation of the invention provides that codes or coding patterns are formed in the course of manufacturing without intervention of pressure (compaction). Another method object of the invention for the manufacture of the invention provides that the characters or drawings of the coding are applied by the action of pressure (compaction). One of the executions foresees that the thickness differences are obtained by means of the recirculation of a suT-Btract that presents a series of sva-aars and / or recesses corresponding to the coding. These elevations or recesses can be applied, for example, to a substrate similar to a printing plan., through the application of etching to etching or chemical engraving. According to another proposal object of the invention, the differences in thickness can be obtained by applying local temperature differences during drying to the preparation. According to another process which is the subject of the invention for the manufacture of the invention, the differences in thickness are applied continuously, for example by means of a structured stamping cylinder or intermittent-form, for example by means of a punch. Next, the production of codified flat administration forms is described by means of the following exemplary embodiments. These provide for a sequence of working operations as follows: Preparation of the dough: Combination, dissolution or controlled mixing of the different components. As the solvent, water or an ethanol / water mixture is used. Coating: Application device: Cylinders, smoothing box, nozzles Continuous coating. on: I. structured substrate (for example Teflon, stainless steel) II. Non-stick material (eg paper sheet) with flat surface or III. as in II Drying: With respect to I: By means of hot air With respect to II: By means of hot air, being necessary that there are "hotter and colder" zones. In this way, a strip-like band having different thicknesses is obtained. In hotter areas, the material is thicker, and in colder areas it is thinner. These areas are obtained by a) an openwork surface, for example a perforated structure with a grid in the substrate in the form of a strip, b) the use of materials with different thermal conductivity during the manufacture of the conveyor belt c) material with non-stick finish in which segments with different thermoconductive properties are implanted. With respect to III: By means of hot air as in I, and also employing a structured cylinder-stamper. Confection 1. Longitudinal cut to form narrow rolls. 2. Singularize by means of die-cutting or cross-section (in the case of II, the paper or the sheet is previously removed). 3. Packaging. Further details, characteristics and advantages of the invention can be deduced from that of the following description of two exemplary embodiments represented schematically in the drawings. There they can be seen: Figure I, a schematic representation in section with the preparation of the coding on a substrate that presents differences in thickness. Figure II, in section, the fabrication of a coding when applying local temperature differences to the preparation.

Figure I shows the preparation (1) on a structured substrate (2), which has a series of elevations (3) and recesses (4). In reciprocal correspondence, in the preparation (1) in front of the elevations (3) there are formed -the recesses (13), and in front of the recesses (4) elevations (14), inside the preparation layer. The contribution of heat is effected by means of a heat jet (9), which can be either radiation or convection. Figure II shows a manufacturing process in which the thickness differences (13), 14) in the layer 1 of the preparation are obtained by drying with local temperature differences. In this case, the layer of the preparation (1) is placed on a sheet-like support (5), for example, a silicone sheet, an aluminum sheet, a plastic sheet or the like. Reference (d) refers to a conveyor belt having a grid structure or holes based on bridges (7) and perforations (8). By supporting heat in the bridges according to the arrows (10), these produce hotter areas in contact with the support sheet (5), and in the area of the holes (8) colder zones. In the part of the hottest areas, the material becomes thicker when drying, while in the colder zones it will be thinner. The drying can be reinforced from above, for example by means of a jet 9 of hot air. The temperature differences of the conveyor belt (6) can be obtained by, for example, inductively heating the bridges (7), the grid structure or by radiation or contact heating, while the holes (8) are cooled by example convective by air. The invention does not present complications and fulfills an optimal task initially proposed. It is noted that in relation to this date, the best method known by the applicant to carry out the said invention, is that which is clear from the present description of the invention.

Claims (10)

1. R E I V I N D I C A C I O N E S.
2. Having described the invention as above, it is claimed as property contained in the following claims: 1. Preparation based on a form of administration flat to film or wafer mode with a coding by alphabetic characters and / or graphics or drawings for the identification of the rapid or aromatic and / or curative substances that arise from the preparation when applied, -characterized because the coding is formed by zones of the surface of different thicknesses. 2.- Preparation according to claim 1, characterized in that the zones of different thickness are formed by the manufacturing process avoiding differences in density or compaction.
3. 3. Preparation according to claim 1, characterized in that the zones of different thickness have different density.
4. 4. Process for manufacturing the preparation according to one of claims 1 or 3, characterized in that the zones of different thickness are formed by the action of pressure.
5. 5. Process for manufacturing the preparation according to one of claims 1 or 2, characterized in that the zones of different thickness are formed without pressure action.
6. 6. Method according to claims 4 or 5, characterized in that the thickness differences are obtained by coating a substrate having a sequence of elevations and / or recesses corresponding to the coding.
7. 7. - Process according to claims 4 or 5, characterized in that the differences in thickness are obtained by applying some local temperature differences during drying to the preparation.
8. 8. Method according to claims 4 or 5, characterized in that the characters or drawings are applied intermittently.
9. 9. Method according to claims 4 or 5, characterized in that the characters or drawings are applied continuously.
10. 10. Process for manufacturing the preparation according to claim 1, characterized in that the coding of the areas of the surface takes place when the preparation is in a state - plastically deformable.