US4685907A - Dressing and a method for the manufacture thereof - Google Patents

Dressing and a method for the manufacture thereof Download PDF

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Publication number
US4685907A
US4685907A US06/703,130 US70313085A US4685907A US 4685907 A US4685907 A US 4685907A US 70313085 A US70313085 A US 70313085A US 4685907 A US4685907 A US 4685907A
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dressing
zinc
sores
zinc oxide
incorporates
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Magnus Agren
Percy Nordqvist, deceased
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Essity Hygiene and Health AB
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Molnlycke Vafveri AB
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Assigned to MOLNLYCKE AB reassignment MOLNLYCKE AB ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: NORDQVIST, PATRICK, AGREN, MAGNUS, NORDQVIST PATRICK, HEIRS OF THE ESTATE OF PERCY NORDQUIST, DEC'D., NORDQVIST, PER, NORDQVIST, ULLA
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/44Medicaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/00051Accessories for dressings
    • A61F13/00063Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/00987Apparatus or processes for manufacturing non-adhesive dressings or bandages
    • A61F13/00991Apparatus or processes for manufacturing non-adhesive dressings or bandages for treating webs, e.g. for moisturising, coating, impregnating or applying powder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/84Accessories, not otherwise provided for, for absorbent pads
    • A61F13/8405Additives, e.g. for odour, disinfectant or pH control
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00089Wound bandages
    • A61F2013/00157Wound bandages for burns or skin transplants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00365Plasters use
    • A61F2013/00519Plasters use for treating burn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00902Plasters containing means
    • A61F2013/0091Plasters containing means with disinfecting or anaesthetics means, e.g. anti-mycrobic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/15577Apparatus or processes for manufacturing
    • A61F2013/15821Apparatus or processes for manufacturing characterized by the apparatus for manufacturing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/21Acids
    • A61L2300/214Amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402Anaestetics, analgesics, e.g. lidocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/428Vitamins, e.g. tocopherol, riboflavin

Definitions

  • the present invention relates to a medicated dressing containing substance for cleansing open sores and stimulating the healing thereof.
  • the present invention is based on the understanding that zinc oxide has a positive healing effect on open sores and like wounds.
  • Zinc-oxide tape dressings are also encumbered with disadvantages, however.
  • the body temperature of the patients tends to rise quite considerably, especially when the surface area the dressing is greater than 5% of the body surface, which is assumed to be due to the fact that during the initial treatment stages the dressing is too tight to allow the requisite evaporation of body fluid to take place.
  • tape dressings are not suitable for use with all types of sores, and especially not infected sores, where the tape creates occlusions, thereby providing conditions favourable to the growth of bacteria.
  • biochemical theory zinc has the following effect on cells and biomembranes in vivo.
  • lymphocytes are unavoidably necessary for immunoreactions, and it is undeniable that immunity plays an important part in the healing of open sores. In this context it is significant that serum protein must be present and that it should be maintained within the region of 15-45 ⁇ 10 -5 M in order for the zinc concentration to have an optimal effect.
  • Zinc has an inhibiting effect on the rupturing tendencies of most cells. Among other things, histamine is released locally when mast cells rupture, which has a deleterious effect on the healing process of open sores and like wounds. According to certain hypotheses, even trophical sores are created when histamine is released locally. Zinc also has a stabilizing effect on lysosomala vacuolar membranes. The contents of these vacuoles is highly toxic to tissue. The effect of zinc on mast cell membranes does not appear particularly contingent on concentration.
  • thrombus often form in the region of a wound or sore and inhibit healing processes by impairing blood circulation. Thrombus are formed by the initial aggregation of thrombocytes, from which the actual thrombus breaks away. Consequently, it is extremely important to prevent the aggregation of thrombocytes. Zinc applied locally to tissue will inhibit thrombocyte aggregation at a concentration as low as 1.0-1.5 ⁇ 10 -5 M.
  • zinc has a positive healing effect on open sores, provided that the correct concentrations are observed with local application.
  • the skin is made up of two layers, i.e. the upper skin layer (epidermis) and the lower skin (dermis).
  • Epidermis has a thickness of about 100 ⁇ m, while the thickness of dermis varies between 3 to 5 mm, depending upon its location in the anatomy.
  • the zinc concentration in epidermis is approximately six times greater than that in dermis (Reference: Molokhia mm. Portnoy B. Neutron activation analysis of trace elements in skin. Br J. Dermatol 1969; 81; 759-762). This is probably why tested ointments of high zinc concentrations are well tolerated when treating superficial skin complaints. The situation is quite different, however, in the case of ulcerated skin, where the skin deficiency also involves dermis.
  • zinc ointments and zinc tape are suitable only for certain kinds of sores, as beforementioned, strenuous efforts have been made to find a suitable method of applying zinc oxide locally to an open sore.
  • zinc oxide has been applied to open sores in an absorbent air-permeable bandage, such as a dressing. It has been found difficult, however, to bind the zinc oxide to the dressing in a satisfactory manner, while at the same time, dispensing suitable amounts of zinc oxide from the dressing to the sore.
  • Tests have also been carried out with zinc oxide slurried in water, the dressings being saturated with the slurry and then dried. The tests did not show a good result. The zinc oxide did not bind firmly to the dressing material, but quickly departed therefrom in the form of dust. Dressings saturated in zinc oxide suspensions also became very stiff and inflexible, since the suspension remained mostly in the outer layers of the dressing, thereby resulting in an inhomogenous impregnation of the dressing. In order to achieve successful treatment it is imperative that the dressing is pliable and conforming, with good contact with the sore and therewith optimal effect. In addition it is important that zinc is continuously dispensed to the sore in the correct dosages over an extended period of time, so-called slow release dosing.
  • a dressing according to the invention containing substance for cleansing sores and stimulating the healing thereof is characterized in that the substance comprises zinc oxide in an amount of 1-10% by weight calculated on the dry weight of the dressing, the zinc oxide being bound in the structure of the dressing blank or preform, adhered in homogenous distribution on the individual fibres by means of a tissue-compatible, preferably water-soluble polymer for so-called slow release dosing when applied to open sores.
  • the method according to the invention for preparing dressings containing substance for cleansing sores and stimulating the healing thereof is characterized by feeding a web of dressing-blank material through a press nip, preferably a gauze web; transferring to the dressing blank upstream of the roll nip a suspension containing said substance in the form of zinc oxide; causing the zinc-oxide particles to be present into the structure of the dressing blank and bound to the individual fibres of said blank during its passage through the roll nip, the zinc-oxide particles being bound by means of a tissue-compatible, preferably water-soluble polymer present in the suspension; and by drying the dressing-blank web and converting the same to dressings.
  • FIG. 1 illustrates schematically the method of applying zinc oxide to the dressing blank
  • FIG. 2 is an enlarged view of a gauze fibre or filament of a dressing according to the invention.
  • FIG. 3 is an enlarged view of individual gauze fibres according to FIG. 2;
  • FIG. 4 illustrates diagrammatically differences in the healing effect of dressings provided with zinc oxide according to the invention and dressings which lack zinc oxide.
  • a gauze web 1 is fed continuously from a storage reel 2 through the press nip of a pair of rolls 3,4, to which a zinc-oxide suspension is supplied continuously from a nozzle 5.
  • the press nip is sealed off and the supply of suspension through the nozzle is controlled by a level meter (not shown) in a manner to sustain the requisite amount of suspension above the roll nip.
  • the suspension is thus dispensed to the gauze web as the web is fed between the rolls 3,4.
  • the gauze web passes through the roll nip, the zinc-oxide particles are pressed into the structure of the gauze and adhere to the individual fibres thereof.
  • the suspension also contains polyvinyl pyrrolidone, this substance being added in order to bind or fix the zinc-oxide particles on the gauze fibres.
  • the gauze web now saturated with said suspension, is fed from the rolls to a drying oven 6. When dry, the gauze web can be converted to dressings in a conventional manner (not illustrated).
  • the zinc oxide and polyvinyl pyrrolidone (PVP), for example of the kind retailed under the trade name KOLLIDON®, is found homogenously distributed in the finished dressing and the dressing cannot be distinguished from an untreated dressing.
  • FIGS. 2 and 3 illustrate fibres to which zinc oxide has been bound in the aforedescribed manner.
  • the reproduced pictures were taken with a scanning electronmicroscope.
  • a gauze fibre has been enlarged 440 times
  • FIG. 3 shows individual fibres in FIG. 2 enlarged 2000 times.
  • the homogenous distribution of zinc oxide in the dressing can clearly be seen from FIGS. 2 and 3.
  • Tests have also been made with other polymers, such as carboxy methyl and the like, polyethylene glycols etc., from which it could be ascertained that polyvinyl pyrrolidone is the most suitable, due to its atoxic and hygroscopic properties.
  • a composition which proved satisfactory from a handling aspect was also produced by varying the amount of polymer used from 0.1 to 5% by weight, calculated on the dry weight of the dressing, and the amount of zinc oxide used from 1 to 10% by weight and even values outside these limits.
  • the amount of zinc oxide in the finished product is decisive in achieving good treatment results.
  • Zinc dressings of this lastmentioned composition have been tested with the aid of scientific methodology.
  • the zinc dressing also had a cleansing effect on necrotic tissue.
  • Necrosis has previously been treated with medicinal preparations containing proteolytic enzymes, for example Varidase® and Trypure®, which are intended to be applied directly to a sore, in gel or solution form.
  • proteolytic enzymes for example Varidase® and Trypure®, which are intended to be applied directly to a sore, in gel or solution form.
  • the use of proteolytic enzymes is both troublesome and time consuming.
  • a further disadvantage with medicinal preparations of the aforesaid kind is that they are suitable only for the treatment of necrosis.
  • the zinc dresslng according to the invention have been found to have an extremely good cleansing effect, comparable with that achieved with known medicinal preparations contaning proteolytic enzymes.
  • the dressing according to the invention was compared with an established method of treatment, Varidase®.
  • Varidase® was applied to a sore dressing twice a day.
  • the investigation was planned as an open, random study, the result of which was judged by a non-resident, impartial physician.
  • the zinc content in serum was also measured in all patients. No patient had serum zinc values above 15 ⁇ mol/l. Since the average age of the patients was 78 years, the result of the serum assays was expected. It could therefore be established that the patients had a zinc deficiency, which is considered a prerequisite for successful zinc therapy, at least in tablet form.
  • sores were washed with common salt solutions prior to applying the dressings. This was done once a day. If the sore seeped excessively, the dressing was changed more than once a day, although one daily dressing sufficed as a rule.
  • the zinc dressing according to the invention was found to produce a very good result with all of the aforementioned types of sore. No secondary effects were observed, despite the fact that in the case of certain sores, extremely difficult to heal, treatment was continued for four months. Neither were the dressings found to adhere to the sores during treatment, due probably to the water-binding property of PVP.
  • the zinc dressing according to the invention can therefore be used over a broad spectrum, since it can be applied with good effect both for cleansing necrotic tissue and for healing sores.
  • dispensing of zinc oxide to the sore can be controlled by the amount of zinc allocated to a particular dressing and/or by the polymer selected and its percent by weight ratio in the dressing.
  • the dressing material may also be other than gauze, for example a non-woven material, where the selection of material also governs the dispensing of zinc ions.
  • the dressing may also include one or more further active substances in addition to zinc oxide.
  • Suitable additives are antiseptic agents, such as iodine, antibiotica, vitamines, amino acids, proteins, pain killing substances, such as XYLOCAIN®, and vessel-expanding substances such as nitroglycerine, either per se or in combination.
  • antiseptic agents such as iodine, antibiotica, vitamines, amino acids, proteins, pain killing substances, such as XYLOCAIN®, and vessel-expanding substances such as nitroglycerine, either per se or in combination.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Press Drives And Press Lines (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Detergent Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Reduction Or Emphasis Of Bandwidth Of Signals (AREA)
US06/703,130 1984-02-17 1985-02-19 Dressing and a method for the manufacture thereof Expired - Lifetime US4685907A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8400855 1984-02-17
SE8400855A SE451669C (sv) 1984-02-17 1984-02-17 Kompress innehaallande zinkoxid

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US4685907A true US4685907A (en) 1987-08-11

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US (1) US4685907A (de)
EP (1) EP0153915B1 (de)
AT (1) ATE80030T1 (de)
CA (1) CA1242973A (de)
DE (2) DE3586569T2 (de)
DK (1) DK160352C (de)
ES (1) ES8700570A1 (de)
FI (1) FI85107C (de)
NO (1) NO162894C (de)
SE (1) SE451669C (de)

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US5405314A (en) * 1992-11-02 1995-04-11 Sunfive Company Ltd. Wound protecting member including chitin
US5421291A (en) * 1994-03-28 1995-06-06 Church & Dwight Co., Inc. Animal litter containing a water-swellable clay, carboxymethylcellulose, and siliceous coated bicarbonate particles
WO2001037888A1 (en) * 1999-11-24 2001-05-31 The Boots Company Plc Medicated dressings
US6254294B1 (en) * 1999-08-09 2001-07-03 Sigrid G. Muhar Pharmaceutical kit
US20060153904A1 (en) * 2002-04-04 2006-07-13 Smith Daniel H Non-woven fiber assemblies
US20060246798A1 (en) * 2002-04-04 2006-11-02 Reneker Darrell H Mechanically strong absorbent non-woven fibrous mats
US9283174B2 (en) 2011-05-10 2016-03-15 Tatsuya Mori Non-aqueous patch
US9925264B2 (en) 2011-05-10 2018-03-27 Itochu Chemical Frontier Corporation Non-aqueous patch
US10765640B2 (en) 2011-09-27 2020-09-08 Itochu Chemical Frontier Corporation Non-aqueous patch
US11786455B2 (en) 2011-05-10 2023-10-17 Itochu Chemical Frontier Corporation Non-aqueous patch

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2649318A1 (fr) * 1989-07-07 1991-01-11 Tisnes Paul Formes galeniques deshydratees pour l'usage dermatologique et cosmetique
SE502495C2 (sv) * 1990-04-24 1995-10-30 Abigo Medical Ab Antimikrobiellt, antiallergent och detoxifierande medel och användningen därav i hud- eller slemhinnebehandlingsprodukt, byggmaterial, papper och ytbehandlingsmaterial
US5415865A (en) * 1990-04-24 1995-05-16 Molnlycke Ab Means having microbial effect and little or completely abolished tendency to develop contact allergic reactions or toxic effects and use thereof in e.g. skin and wound treatment products
DE102020207985A1 (de) 2020-06-28 2021-12-30 Innomotion AG Sterile Vorrichtung zur Bedeckung der menschlichen Haut und Verfahren zur Herstellung einer sterilen Vorrichtung

Citations (12)

* Cited by examiner, † Cited by third party
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US2063218A (en) * 1932-07-26 1936-12-08 Zisserman Leon Antiseptic or medicated dressing or material and the manufacture thereof
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US3872862A (en) * 1973-10-23 1975-03-25 Michael Hume Dressing and support combination for the treatment of indolent ulcers
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US2063218A (en) * 1932-07-26 1936-12-08 Zisserman Leon Antiseptic or medicated dressing or material and the manufacture thereof
DE1282228B (de) * 1959-03-23 1968-11-07 William M Scholl Dr Streichmasse fuer die Herstellung von Gipsbinden
SE399822B (sv) * 1971-05-06 1978-03-06 Bunzl & Biach Ag Forbandsmaterial, bestaende av ett en- eller flerlagrigt cellstoffskikt, overdraget med ett vidheftningshindrande, icke sammanhengande akrylhartsskikt, samt forfarande for dess framstellning
US3872862A (en) * 1973-10-23 1975-03-25 Michael Hume Dressing and support combination for the treatment of indolent ulcers
US4049802A (en) * 1975-03-19 1977-09-20 Research Corporation Zinc sulfadiazine and its use in the treatment of burns
US4307717A (en) * 1977-11-07 1981-12-29 Lectec Corporation Sterile improved bandage containing a medicament
WO1979000871A1 (en) * 1978-04-03 1979-11-01 Moelnlycke Ab A compress for treatment of wounds
US4214582A (en) * 1979-02-07 1980-07-29 The Kendall Company Surgical dressing
US4401651A (en) * 1979-04-18 1983-08-30 Knutson Richard A Wound-healing compositions containing povidone-iodine
US4310509A (en) * 1979-07-31 1982-01-12 Minnesota Mining And Manufacturing Company Pressure-sensitive adhesive having a broad spectrum antimicrobial therein
US4486488A (en) * 1980-05-17 1984-12-04 Beiersdorf Aktiengesellschaft Composition for the production of bandages, bandages produced therewith and method for the production thereof
DE3033606A1 (de) * 1980-09-06 1982-04-08 B. Braun Melsungen Ag, 3508 Melsungen Antiadhaesiver, antimikrobieller wundverband und verfahren zu dessen herstellung

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US5405314A (en) * 1992-11-02 1995-04-11 Sunfive Company Ltd. Wound protecting member including chitin
US5421291A (en) * 1994-03-28 1995-06-06 Church & Dwight Co., Inc. Animal litter containing a water-swellable clay, carboxymethylcellulose, and siliceous coated bicarbonate particles
US6254294B1 (en) * 1999-08-09 2001-07-03 Sigrid G. Muhar Pharmaceutical kit
WO2001037888A1 (en) * 1999-11-24 2001-05-31 The Boots Company Plc Medicated dressings
US10920346B2 (en) 2002-04-04 2021-02-16 The University Of Akron Mechanically strong absorbent non-woven fibrous mats
US20060153904A1 (en) * 2002-04-04 2006-07-13 Smith Daniel H Non-woven fiber assemblies
US20060246798A1 (en) * 2002-04-04 2006-11-02 Reneker Darrell H Mechanically strong absorbent non-woven fibrous mats
US7765647B2 (en) 2002-04-04 2010-08-03 The University Of Akron Non-woven fiber assemblies
US8367570B2 (en) * 2002-04-04 2013-02-05 The University Of Akron Mechanically strong absorbent non-woven fibrous mats
US9283174B2 (en) 2011-05-10 2016-03-15 Tatsuya Mori Non-aqueous patch
US9931403B2 (en) 2011-05-10 2018-04-03 Itochu Chemical Frontier Corporation Non-aqueous patch
US10765749B2 (en) 2011-05-10 2020-09-08 Itochu Chemical Frontier Corporation Non-aqueous patch
US9925264B2 (en) 2011-05-10 2018-03-27 Itochu Chemical Frontier Corporation Non-aqueous patch
US11278623B2 (en) 2011-05-10 2022-03-22 Itochu Chemical Frontier Corporation Non-aqueous patch
US11786455B2 (en) 2011-05-10 2023-10-17 Itochu Chemical Frontier Corporation Non-aqueous patch
US10765640B2 (en) 2011-09-27 2020-09-08 Itochu Chemical Frontier Corporation Non-aqueous patch
US11793766B2 (en) 2011-09-27 2023-10-24 ITOCHU CHEMICAL FRONTIER Corporation; Non-aqueous patch for the relief of pain

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DE3586569D1 (de) 1992-10-08
DK160352C (da) 1991-08-12
DK160352B (da) 1991-03-04
FI850649L (fi) 1985-08-18
SE8400855D0 (sv) 1984-02-17
FI85107B (fi) 1991-11-29
FI85107C (fi) 1992-03-10
SE451669B (sv) 1987-10-26
SE451669C (sv) 1989-08-14
CA1242973A (en) 1988-10-11
DE153915T1 (de) 1986-01-02
ATE80030T1 (de) 1992-09-15
SE8400855L (sv) 1985-08-18
EP0153915B1 (de) 1992-09-02
FI850649A0 (fi) 1985-02-15
DK70785A (da) 1985-08-18
EP0153915A3 (en) 1989-10-18
NO162894C (no) 1990-03-07
NO162894B (no) 1989-11-27
ES8700570A1 (es) 1986-10-16
ES540447A0 (es) 1986-10-16
DE3586569T2 (de) 1993-02-04
DK70785D0 (da) 1985-02-15
NO850605L (no) 1985-08-19
EP0153915A2 (de) 1985-09-04

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