US4685907A - Dressing and a method for the manufacture thereof - Google Patents
Dressing and a method for the manufacture thereof Download PDFInfo
- Publication number
- US4685907A US4685907A US06/703,130 US70313085A US4685907A US 4685907 A US4685907 A US 4685907A US 70313085 A US70313085 A US 70313085A US 4685907 A US4685907 A US 4685907A
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- United States
- Prior art keywords
- dressing
- zinc
- sores
- zinc oxide
- incorporates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00987—Apparatus or processes for manufacturing non-adhesive dressings or bandages
- A61F13/00991—Apparatus or processes for manufacturing non-adhesive dressings or bandages for treating webs, e.g. for moisturising, coating, impregnating or applying powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/84—Accessories, not otherwise provided for, for absorbent pads
- A61F13/8405—Additives, e.g. for odour, disinfectant or pH control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00157—Wound bandages for burns or skin transplants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/00519—Plasters use for treating burn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/0091—Plasters containing means with disinfecting or anaesthetics means, e.g. anti-mycrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/15577—Apparatus or processes for manufacturing
- A61F2013/15821—Apparatus or processes for manufacturing characterized by the apparatus for manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
- A61L2300/214—Amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/428—Vitamins, e.g. tocopherol, riboflavin
Definitions
- the present invention relates to a medicated dressing containing substance for cleansing open sores and stimulating the healing thereof.
- the present invention is based on the understanding that zinc oxide has a positive healing effect on open sores and like wounds.
- Zinc-oxide tape dressings are also encumbered with disadvantages, however.
- the body temperature of the patients tends to rise quite considerably, especially when the surface area the dressing is greater than 5% of the body surface, which is assumed to be due to the fact that during the initial treatment stages the dressing is too tight to allow the requisite evaporation of body fluid to take place.
- tape dressings are not suitable for use with all types of sores, and especially not infected sores, where the tape creates occlusions, thereby providing conditions favourable to the growth of bacteria.
- biochemical theory zinc has the following effect on cells and biomembranes in vivo.
- lymphocytes are unavoidably necessary for immunoreactions, and it is undeniable that immunity plays an important part in the healing of open sores. In this context it is significant that serum protein must be present and that it should be maintained within the region of 15-45 ⁇ 10 -5 M in order for the zinc concentration to have an optimal effect.
- Zinc has an inhibiting effect on the rupturing tendencies of most cells. Among other things, histamine is released locally when mast cells rupture, which has a deleterious effect on the healing process of open sores and like wounds. According to certain hypotheses, even trophical sores are created when histamine is released locally. Zinc also has a stabilizing effect on lysosomala vacuolar membranes. The contents of these vacuoles is highly toxic to tissue. The effect of zinc on mast cell membranes does not appear particularly contingent on concentration.
- thrombus often form in the region of a wound or sore and inhibit healing processes by impairing blood circulation. Thrombus are formed by the initial aggregation of thrombocytes, from which the actual thrombus breaks away. Consequently, it is extremely important to prevent the aggregation of thrombocytes. Zinc applied locally to tissue will inhibit thrombocyte aggregation at a concentration as low as 1.0-1.5 ⁇ 10 -5 M.
- zinc has a positive healing effect on open sores, provided that the correct concentrations are observed with local application.
- the skin is made up of two layers, i.e. the upper skin layer (epidermis) and the lower skin (dermis).
- Epidermis has a thickness of about 100 ⁇ m, while the thickness of dermis varies between 3 to 5 mm, depending upon its location in the anatomy.
- the zinc concentration in epidermis is approximately six times greater than that in dermis (Reference: Molokhia mm. Portnoy B. Neutron activation analysis of trace elements in skin. Br J. Dermatol 1969; 81; 759-762). This is probably why tested ointments of high zinc concentrations are well tolerated when treating superficial skin complaints. The situation is quite different, however, in the case of ulcerated skin, where the skin deficiency also involves dermis.
- zinc ointments and zinc tape are suitable only for certain kinds of sores, as beforementioned, strenuous efforts have been made to find a suitable method of applying zinc oxide locally to an open sore.
- zinc oxide has been applied to open sores in an absorbent air-permeable bandage, such as a dressing. It has been found difficult, however, to bind the zinc oxide to the dressing in a satisfactory manner, while at the same time, dispensing suitable amounts of zinc oxide from the dressing to the sore.
- Tests have also been carried out with zinc oxide slurried in water, the dressings being saturated with the slurry and then dried. The tests did not show a good result. The zinc oxide did not bind firmly to the dressing material, but quickly departed therefrom in the form of dust. Dressings saturated in zinc oxide suspensions also became very stiff and inflexible, since the suspension remained mostly in the outer layers of the dressing, thereby resulting in an inhomogenous impregnation of the dressing. In order to achieve successful treatment it is imperative that the dressing is pliable and conforming, with good contact with the sore and therewith optimal effect. In addition it is important that zinc is continuously dispensed to the sore in the correct dosages over an extended period of time, so-called slow release dosing.
- a dressing according to the invention containing substance for cleansing sores and stimulating the healing thereof is characterized in that the substance comprises zinc oxide in an amount of 1-10% by weight calculated on the dry weight of the dressing, the zinc oxide being bound in the structure of the dressing blank or preform, adhered in homogenous distribution on the individual fibres by means of a tissue-compatible, preferably water-soluble polymer for so-called slow release dosing when applied to open sores.
- the method according to the invention for preparing dressings containing substance for cleansing sores and stimulating the healing thereof is characterized by feeding a web of dressing-blank material through a press nip, preferably a gauze web; transferring to the dressing blank upstream of the roll nip a suspension containing said substance in the form of zinc oxide; causing the zinc-oxide particles to be present into the structure of the dressing blank and bound to the individual fibres of said blank during its passage through the roll nip, the zinc-oxide particles being bound by means of a tissue-compatible, preferably water-soluble polymer present in the suspension; and by drying the dressing-blank web and converting the same to dressings.
- FIG. 1 illustrates schematically the method of applying zinc oxide to the dressing blank
- FIG. 2 is an enlarged view of a gauze fibre or filament of a dressing according to the invention.
- FIG. 3 is an enlarged view of individual gauze fibres according to FIG. 2;
- FIG. 4 illustrates diagrammatically differences in the healing effect of dressings provided with zinc oxide according to the invention and dressings which lack zinc oxide.
- a gauze web 1 is fed continuously from a storage reel 2 through the press nip of a pair of rolls 3,4, to which a zinc-oxide suspension is supplied continuously from a nozzle 5.
- the press nip is sealed off and the supply of suspension through the nozzle is controlled by a level meter (not shown) in a manner to sustain the requisite amount of suspension above the roll nip.
- the suspension is thus dispensed to the gauze web as the web is fed between the rolls 3,4.
- the gauze web passes through the roll nip, the zinc-oxide particles are pressed into the structure of the gauze and adhere to the individual fibres thereof.
- the suspension also contains polyvinyl pyrrolidone, this substance being added in order to bind or fix the zinc-oxide particles on the gauze fibres.
- the gauze web now saturated with said suspension, is fed from the rolls to a drying oven 6. When dry, the gauze web can be converted to dressings in a conventional manner (not illustrated).
- the zinc oxide and polyvinyl pyrrolidone (PVP), for example of the kind retailed under the trade name KOLLIDON®, is found homogenously distributed in the finished dressing and the dressing cannot be distinguished from an untreated dressing.
- FIGS. 2 and 3 illustrate fibres to which zinc oxide has been bound in the aforedescribed manner.
- the reproduced pictures were taken with a scanning electronmicroscope.
- a gauze fibre has been enlarged 440 times
- FIG. 3 shows individual fibres in FIG. 2 enlarged 2000 times.
- the homogenous distribution of zinc oxide in the dressing can clearly be seen from FIGS. 2 and 3.
- Tests have also been made with other polymers, such as carboxy methyl and the like, polyethylene glycols etc., from which it could be ascertained that polyvinyl pyrrolidone is the most suitable, due to its atoxic and hygroscopic properties.
- a composition which proved satisfactory from a handling aspect was also produced by varying the amount of polymer used from 0.1 to 5% by weight, calculated on the dry weight of the dressing, and the amount of zinc oxide used from 1 to 10% by weight and even values outside these limits.
- the amount of zinc oxide in the finished product is decisive in achieving good treatment results.
- Zinc dressings of this lastmentioned composition have been tested with the aid of scientific methodology.
- the zinc dressing also had a cleansing effect on necrotic tissue.
- Necrosis has previously been treated with medicinal preparations containing proteolytic enzymes, for example Varidase® and Trypure®, which are intended to be applied directly to a sore, in gel or solution form.
- proteolytic enzymes for example Varidase® and Trypure®, which are intended to be applied directly to a sore, in gel or solution form.
- the use of proteolytic enzymes is both troublesome and time consuming.
- a further disadvantage with medicinal preparations of the aforesaid kind is that they are suitable only for the treatment of necrosis.
- the zinc dresslng according to the invention have been found to have an extremely good cleansing effect, comparable with that achieved with known medicinal preparations contaning proteolytic enzymes.
- the dressing according to the invention was compared with an established method of treatment, Varidase®.
- Varidase® was applied to a sore dressing twice a day.
- the investigation was planned as an open, random study, the result of which was judged by a non-resident, impartial physician.
- the zinc content in serum was also measured in all patients. No patient had serum zinc values above 15 ⁇ mol/l. Since the average age of the patients was 78 years, the result of the serum assays was expected. It could therefore be established that the patients had a zinc deficiency, which is considered a prerequisite for successful zinc therapy, at least in tablet form.
- sores were washed with common salt solutions prior to applying the dressings. This was done once a day. If the sore seeped excessively, the dressing was changed more than once a day, although one daily dressing sufficed as a rule.
- the zinc dressing according to the invention was found to produce a very good result with all of the aforementioned types of sore. No secondary effects were observed, despite the fact that in the case of certain sores, extremely difficult to heal, treatment was continued for four months. Neither were the dressings found to adhere to the sores during treatment, due probably to the water-binding property of PVP.
- the zinc dressing according to the invention can therefore be used over a broad spectrum, since it can be applied with good effect both for cleansing necrotic tissue and for healing sores.
- dispensing of zinc oxide to the sore can be controlled by the amount of zinc allocated to a particular dressing and/or by the polymer selected and its percent by weight ratio in the dressing.
- the dressing material may also be other than gauze, for example a non-woven material, where the selection of material also governs the dispensing of zinc ions.
- the dressing may also include one or more further active substances in addition to zinc oxide.
- Suitable additives are antiseptic agents, such as iodine, antibiotica, vitamines, amino acids, proteins, pain killing substances, such as XYLOCAIN®, and vessel-expanding substances such as nitroglycerine, either per se or in combination.
- antiseptic agents such as iodine, antibiotica, vitamines, amino acids, proteins, pain killing substances, such as XYLOCAIN®, and vessel-expanding substances such as nitroglycerine, either per se or in combination.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Press Drives And Press Lines (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Jellies, Jams, And Syrups (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Detergent Compositions (AREA)
- Medicinal Preparation (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Reduction Or Emphasis Of Bandwidth Of Signals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8400855 | 1984-02-17 | ||
SE8400855A SE451669C (sv) | 1984-02-17 | 1984-02-17 | Kompress innehaallande zinkoxid |
Publications (1)
Publication Number | Publication Date |
---|---|
US4685907A true US4685907A (en) | 1987-08-11 |
Family
ID=20354776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US06/703,130 Expired - Lifetime US4685907A (en) | 1984-02-17 | 1985-02-19 | Dressing and a method for the manufacture thereof |
Country Status (10)
Country | Link |
---|---|
US (1) | US4685907A (de) |
EP (1) | EP0153915B1 (de) |
AT (1) | ATE80030T1 (de) |
CA (1) | CA1242973A (de) |
DE (2) | DE3586569T2 (de) |
DK (1) | DK160352C (de) |
ES (1) | ES8700570A1 (de) |
FI (1) | FI85107C (de) |
NO (1) | NO162894C (de) |
SE (1) | SE451669C (de) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5405314A (en) * | 1992-11-02 | 1995-04-11 | Sunfive Company Ltd. | Wound protecting member including chitin |
US5421291A (en) * | 1994-03-28 | 1995-06-06 | Church & Dwight Co., Inc. | Animal litter containing a water-swellable clay, carboxymethylcellulose, and siliceous coated bicarbonate particles |
WO2001037888A1 (en) * | 1999-11-24 | 2001-05-31 | The Boots Company Plc | Medicated dressings |
US6254294B1 (en) * | 1999-08-09 | 2001-07-03 | Sigrid G. Muhar | Pharmaceutical kit |
US20060153904A1 (en) * | 2002-04-04 | 2006-07-13 | Smith Daniel H | Non-woven fiber assemblies |
US20060246798A1 (en) * | 2002-04-04 | 2006-11-02 | Reneker Darrell H | Mechanically strong absorbent non-woven fibrous mats |
US9283174B2 (en) | 2011-05-10 | 2016-03-15 | Tatsuya Mori | Non-aqueous patch |
US9925264B2 (en) | 2011-05-10 | 2018-03-27 | Itochu Chemical Frontier Corporation | Non-aqueous patch |
US10765640B2 (en) | 2011-09-27 | 2020-09-08 | Itochu Chemical Frontier Corporation | Non-aqueous patch |
US11786455B2 (en) | 2011-05-10 | 2023-10-17 | Itochu Chemical Frontier Corporation | Non-aqueous patch |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2649318A1 (fr) * | 1989-07-07 | 1991-01-11 | Tisnes Paul | Formes galeniques deshydratees pour l'usage dermatologique et cosmetique |
SE502495C2 (sv) * | 1990-04-24 | 1995-10-30 | Abigo Medical Ab | Antimikrobiellt, antiallergent och detoxifierande medel och användningen därav i hud- eller slemhinnebehandlingsprodukt, byggmaterial, papper och ytbehandlingsmaterial |
US5415865A (en) * | 1990-04-24 | 1995-05-16 | Molnlycke Ab | Means having microbial effect and little or completely abolished tendency to develop contact allergic reactions or toxic effects and use thereof in e.g. skin and wound treatment products |
DE102020207985A1 (de) | 2020-06-28 | 2021-12-30 | Innomotion AG | Sterile Vorrichtung zur Bedeckung der menschlichen Haut und Verfahren zur Herstellung einer sterilen Vorrichtung |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2063218A (en) * | 1932-07-26 | 1936-12-08 | Zisserman Leon | Antiseptic or medicated dressing or material and the manufacture thereof |
DE1282228B (de) * | 1959-03-23 | 1968-11-07 | William M Scholl Dr | Streichmasse fuer die Herstellung von Gipsbinden |
US3872862A (en) * | 1973-10-23 | 1975-03-25 | Michael Hume | Dressing and support combination for the treatment of indolent ulcers |
US4049802A (en) * | 1975-03-19 | 1977-09-20 | Research Corporation | Zinc sulfadiazine and its use in the treatment of burns |
SE399822B (sv) * | 1971-05-06 | 1978-03-06 | Bunzl & Biach Ag | Forbandsmaterial, bestaende av ett en- eller flerlagrigt cellstoffskikt, overdraget med ett vidheftningshindrande, icke sammanhengande akrylhartsskikt, samt forfarande for dess framstellning |
WO1979000871A1 (en) * | 1978-04-03 | 1979-11-01 | Moelnlycke Ab | A compress for treatment of wounds |
US4214582A (en) * | 1979-02-07 | 1980-07-29 | The Kendall Company | Surgical dressing |
US4307717A (en) * | 1977-11-07 | 1981-12-29 | Lectec Corporation | Sterile improved bandage containing a medicament |
US4310509A (en) * | 1979-07-31 | 1982-01-12 | Minnesota Mining And Manufacturing Company | Pressure-sensitive adhesive having a broad spectrum antimicrobial therein |
DE3033606A1 (de) * | 1980-09-06 | 1982-04-08 | B. Braun Melsungen Ag, 3508 Melsungen | Antiadhaesiver, antimikrobieller wundverband und verfahren zu dessen herstellung |
US4401651A (en) * | 1979-04-18 | 1983-08-30 | Knutson Richard A | Wound-healing compositions containing povidone-iodine |
US4486488A (en) * | 1980-05-17 | 1984-12-04 | Beiersdorf Aktiengesellschaft | Composition for the production of bandages, bandages produced therewith and method for the production thereof |
-
1984
- 1984-02-17 SE SE8400855A patent/SE451669C/sv not_active IP Right Cessation
-
1985
- 1985-02-14 EP EP85850053A patent/EP0153915B1/de not_active Expired
- 1985-02-14 AT AT85850053T patent/ATE80030T1/de not_active IP Right Cessation
- 1985-02-14 DE DE8585850053T patent/DE3586569T2/de not_active Expired - Lifetime
- 1985-02-14 DE DE198585850053T patent/DE153915T1/de active Pending
- 1985-02-15 CA CA000474372A patent/CA1242973A/en not_active Expired
- 1985-02-15 NO NO850605A patent/NO162894C/no not_active IP Right Cessation
- 1985-02-15 FI FI850649A patent/FI85107C/fi not_active IP Right Cessation
- 1985-02-15 ES ES540447A patent/ES8700570A1/es not_active Expired
- 1985-02-15 DK DK070785A patent/DK160352C/da not_active IP Right Cessation
- 1985-02-19 US US06/703,130 patent/US4685907A/en not_active Expired - Lifetime
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US2063218A (en) * | 1932-07-26 | 1936-12-08 | Zisserman Leon | Antiseptic or medicated dressing or material and the manufacture thereof |
DE1282228B (de) * | 1959-03-23 | 1968-11-07 | William M Scholl Dr | Streichmasse fuer die Herstellung von Gipsbinden |
SE399822B (sv) * | 1971-05-06 | 1978-03-06 | Bunzl & Biach Ag | Forbandsmaterial, bestaende av ett en- eller flerlagrigt cellstoffskikt, overdraget med ett vidheftningshindrande, icke sammanhengande akrylhartsskikt, samt forfarande for dess framstellning |
US3872862A (en) * | 1973-10-23 | 1975-03-25 | Michael Hume | Dressing and support combination for the treatment of indolent ulcers |
US4049802A (en) * | 1975-03-19 | 1977-09-20 | Research Corporation | Zinc sulfadiazine and its use in the treatment of burns |
US4307717A (en) * | 1977-11-07 | 1981-12-29 | Lectec Corporation | Sterile improved bandage containing a medicament |
WO1979000871A1 (en) * | 1978-04-03 | 1979-11-01 | Moelnlycke Ab | A compress for treatment of wounds |
US4214582A (en) * | 1979-02-07 | 1980-07-29 | The Kendall Company | Surgical dressing |
US4401651A (en) * | 1979-04-18 | 1983-08-30 | Knutson Richard A | Wound-healing compositions containing povidone-iodine |
US4310509A (en) * | 1979-07-31 | 1982-01-12 | Minnesota Mining And Manufacturing Company | Pressure-sensitive adhesive having a broad spectrum antimicrobial therein |
US4486488A (en) * | 1980-05-17 | 1984-12-04 | Beiersdorf Aktiengesellschaft | Composition for the production of bandages, bandages produced therewith and method for the production thereof |
DE3033606A1 (de) * | 1980-09-06 | 1982-04-08 | B. Braun Melsungen Ag, 3508 Melsungen | Antiadhaesiver, antimikrobieller wundverband und verfahren zu dessen herstellung |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5405314A (en) * | 1992-11-02 | 1995-04-11 | Sunfive Company Ltd. | Wound protecting member including chitin |
US5421291A (en) * | 1994-03-28 | 1995-06-06 | Church & Dwight Co., Inc. | Animal litter containing a water-swellable clay, carboxymethylcellulose, and siliceous coated bicarbonate particles |
US6254294B1 (en) * | 1999-08-09 | 2001-07-03 | Sigrid G. Muhar | Pharmaceutical kit |
WO2001037888A1 (en) * | 1999-11-24 | 2001-05-31 | The Boots Company Plc | Medicated dressings |
US10920346B2 (en) | 2002-04-04 | 2021-02-16 | The University Of Akron | Mechanically strong absorbent non-woven fibrous mats |
US20060153904A1 (en) * | 2002-04-04 | 2006-07-13 | Smith Daniel H | Non-woven fiber assemblies |
US20060246798A1 (en) * | 2002-04-04 | 2006-11-02 | Reneker Darrell H | Mechanically strong absorbent non-woven fibrous mats |
US7765647B2 (en) | 2002-04-04 | 2010-08-03 | The University Of Akron | Non-woven fiber assemblies |
US8367570B2 (en) * | 2002-04-04 | 2013-02-05 | The University Of Akron | Mechanically strong absorbent non-woven fibrous mats |
US9283174B2 (en) | 2011-05-10 | 2016-03-15 | Tatsuya Mori | Non-aqueous patch |
US9931403B2 (en) | 2011-05-10 | 2018-04-03 | Itochu Chemical Frontier Corporation | Non-aqueous patch |
US10765749B2 (en) | 2011-05-10 | 2020-09-08 | Itochu Chemical Frontier Corporation | Non-aqueous patch |
US9925264B2 (en) | 2011-05-10 | 2018-03-27 | Itochu Chemical Frontier Corporation | Non-aqueous patch |
US11278623B2 (en) | 2011-05-10 | 2022-03-22 | Itochu Chemical Frontier Corporation | Non-aqueous patch |
US11786455B2 (en) | 2011-05-10 | 2023-10-17 | Itochu Chemical Frontier Corporation | Non-aqueous patch |
US10765640B2 (en) | 2011-09-27 | 2020-09-08 | Itochu Chemical Frontier Corporation | Non-aqueous patch |
US11793766B2 (en) | 2011-09-27 | 2023-10-24 | ITOCHU CHEMICAL FRONTIER Corporation; | Non-aqueous patch for the relief of pain |
Also Published As
Publication number | Publication date |
---|---|
DE3586569D1 (de) | 1992-10-08 |
DK160352C (da) | 1991-08-12 |
DK160352B (da) | 1991-03-04 |
FI850649L (fi) | 1985-08-18 |
SE8400855D0 (sv) | 1984-02-17 |
FI85107B (fi) | 1991-11-29 |
FI85107C (fi) | 1992-03-10 |
SE451669B (sv) | 1987-10-26 |
SE451669C (sv) | 1989-08-14 |
CA1242973A (en) | 1988-10-11 |
DE153915T1 (de) | 1986-01-02 |
ATE80030T1 (de) | 1992-09-15 |
SE8400855L (sv) | 1985-08-18 |
EP0153915B1 (de) | 1992-09-02 |
FI850649A0 (fi) | 1985-02-15 |
DK70785A (da) | 1985-08-18 |
EP0153915A3 (en) | 1989-10-18 |
NO162894C (no) | 1990-03-07 |
NO162894B (no) | 1989-11-27 |
ES8700570A1 (es) | 1986-10-16 |
ES540447A0 (es) | 1986-10-16 |
DE3586569T2 (de) | 1993-02-04 |
DK70785D0 (da) | 1985-02-15 |
NO850605L (no) | 1985-08-19 |
EP0153915A2 (de) | 1985-09-04 |
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