US3709701A - Production of mixed crystals of sodium glutamate and sodium inosinate - Google Patents

Production of mixed crystals of sodium glutamate and sodium inosinate Download PDF

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Publication number
US3709701A
US3709701A US00149791A US3709701DA US3709701A US 3709701 A US3709701 A US 3709701A US 00149791 A US00149791 A US 00149791A US 3709701D A US3709701D A US 3709701DA US 3709701 A US3709701 A US 3709701A
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United States
Prior art keywords
crystals
sodium
glutamate
inosinate
monosodium glutamate
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Expired - Lifetime
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US00149791A
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English (en)
Inventor
H Samejima
K Shimaoka
Y Aoki
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KH Neochem Co Ltd
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Kyowa Hakko Kogyo Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Definitions

  • the present invention is concerned with a process for producing mixed crystals of monosodium glutamate and disodium inosinate.
  • mixed crystals of sodium glutamate and sodium inosinate which have excellent appearance and in which disodium inosinate is dispersed in any desired ratio, can be produced without the formation of monocrystals of sodium inosinate by feeding a solution containing both sodium glutamate and sodium inosinate as an accelerator for the growth of seed crystals of sodium glutamate, even using apparatus conventionally employed for producing crystals of sodium glutamate.
  • Mixed crystals of sodium glutamate and disodium inosinate are prepared by adding a solution containing both monosodium glutamate and disodium inosinate to a monosodium glutamate mother liquor containing seed crystals of monosodium glutamate, and simultaneously evaporating the resulting mixture to grow mixed crystals of a desired size.
  • the seed crystals may be caused to be present in the original mother liquor either by evaporating a solution of monosodium glutamate until seed crystals are spontaneously formed and have grown to a size which will not pass through a mesh screen, or a suitable number of separately formed seed crystals of this size can be added to a mother liquor saturated with monosodium glutamate.
  • the solution containing both monosodium glutamate and disodium inosinate in the desired ratio with from 250-500 mg./ml. of monosodium glutamate being present is added either continuously or intermittently to mother liquor containing the seed crystals while simultaneously concentrating the resulting mixture.
  • the concentration is carried out in such a manner that no ad ditional seed crystals are formed, and the mixed crystals are grown until they reach the desired size. Ordinarily, culturing is continued for about 6-10 hours.
  • the mixed crystals formed are then harvested and they have an excellent appearance comparable to that of monocrystals of monosodium glutamate.
  • the mixed crystals are uniform from the nucleus to the surface as to the relative proportions of monosodium glutamate and disodium inosinate.
  • Seed crystals of sodium glutamate are in general obtained in a suitable crystallizer having an agitator capable of agitating at slow speed, such as e.g. a vacuum evaporation type crystallizer in which a mother liqwor of monosodium glutamate is concentrated at 35-85 C., preferably at 50-70 C., under reduced pressure to a range of 600-750 mg./ml. preferably 640 700 mg./ml., thereby to form spontaneously a suitable number of seed crystals of monosodium glutamate therein.
  • a suitable crystallizer having an agitator capable of agitating at slow speed such as e.g. a vacuum evaporation type crystallizer in which a mother liqwor of monosodium glutamate is concentrated at 35-85 C., preferably at 50-70 C., under reduced pressure to a range of 600-750 mg./ml. preferably 640 700 mg./ml., thereby to form spontaneously
  • a solution which contains about 250-500 mg./ml. of monosodium glutamate and a desired concentration of disodium inosinate, whereby both monosodium glutamate and disodium inosinate crystallize out as mixed crystals around said seed crystals or nuclei.
  • the mixed crystals thus formed contain both substances uniformly at a desired ratio and have a beautiful appearance similar to that of monosodium glutamate crystals.
  • the mixed crystals thus formed are cultured e.g. for
  • the concentration level of the mixed solution containing monosodium glutamate and disodium inosinate should be kept within the range as described above to prevent formation of seed crystals in addition to those originally present. (Furthermore, the size of the seed crystals before the addition of disodium inosinate should be such that they will not pass through a 150 mesh screen. Otherwise, various difficulties arise in the advantageous growth of seed crystals.
  • mixed crystals of monosodium glutamate and disodium inosinate which have a beautiful appearance similar to that of monosodium glutamate crystals and which also contain both substances uniformly at any desired ratio, by providing the mother liquor with a suitable number of seed crystals, continuing the concentration of the mother liquor in such a manner that no additional seed crystals might be formed spontaneously therein, adding to the mother liquor continuously or intermittently a mixed solution, which contains about 250-500 mg./ml. of monosodium glutamate and a desired concentration of disodium inosinate, thereby to form mixed crystals, and culturing the formed seed mixed crystals until desired mesh sizes can be obtained.
  • the cultivation is for example preferably continued for about 6-10 hours.
  • seed crystals having sizes larger than those of crystals which will just pass through a 150 mesh screen are added to the mother liquor, or may be formed therein and that thereafter a mixed solution containing both substances uniformly should be added to the mother liquor for the formation of mixed crystals.
  • EXAMPLE 2 In a manner similar to that described in "Example 1, 1 0,000 ml. (concentration-200 g./l.) of an original solution of monosodium glutamate is obtained by neutralizing glutamic acid with caustic soda and is decolorized with active carbon. 5,000 ml. of the original solution are concentrated to 1,500 ml. in a separable flask at 50 C. and there are added 100 grams of seed crystals of about 140 mesh size. Then, the solution is concentrated in vacuo at an evaporation rate of 700 ml./hour. 110 grams of disodium inosinate are dissolved in the remaining 5,000 ml.
  • the concentration system is fed continuously to the concentration system at a rate of 710 ml./hr. for the growth of seed crystals.
  • the concentrate is centrifuged.
  • the separated crystals are dried to give 1,444 g. of dried crystals (water content 0.14%). No difference from usual sodium glutamate crystals is observed as to appearance of form and luster.
  • the amount of monosodium glutamate in the crystals is 1,370 g. and that of disodium inosinate is 72 g.
  • the inosinate content is 5%.
  • Crystals having a size of 50-60 mesh are analyzed as to the inosinate content, and it is found that the crystals contain almost equal ratios of disodium inosinate, and that the portions of crystals, which remain after being washed slightly with warm water, also contain disodium inosinate.
  • the yields of the crystallized monosodium glutamate and disodium inosinate are both 65%.
  • a process for producing mixed crystals of monosodium glutamate and disodium inosinate comprising adding continuously or intermittently a solution containing both monosodium glutamate in an amount of about 250500 mg./ml., and disodium inosinate to a mother liquor or monosodium glutamate containing seed crystals consisting of monosodium glutamate of a size such that they will not pass through a mesh, and simultaneously evaporating said mother liquor to cause the seed crystals to grow in such a manner that no additional seed crystals or nuclei are formed therein after addition of said solution containing both monosodium glutamate and disodium inosinate is begun.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Seasonings (AREA)
  • Saccharide Compounds (AREA)
US00149791A 1966-04-07 1971-06-03 Production of mixed crystals of sodium glutamate and sodium inosinate Expired - Lifetime US3709701A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2149666 1966-04-07

Publications (1)

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US3709701A true US3709701A (en) 1973-01-09

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US00149791A Expired - Lifetime US3709701A (en) 1966-04-07 1971-06-03 Production of mixed crystals of sodium glutamate and sodium inosinate

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US (1) US3709701A (forum.php)
BE (1) BE696756A (forum.php)
CH (1) CH483204A (forum.php)
DE (1) DE1593919A1 (forum.php)
FR (1) FR1605380A (forum.php)
GB (1) GB1178905A (forum.php)
NL (1) NL6704980A (forum.php)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806370A (en) * 1987-07-08 1989-02-21 Takeda Chemical Industries, Ltd. 5'-nucleotide seasoning composition and production thereof
US4842881A (en) * 1986-04-22 1989-06-27 Takeda Chemical Industries, Ltd. Coating 5'-nucleotide

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4842881A (en) * 1986-04-22 1989-06-27 Takeda Chemical Industries, Ltd. Coating 5'-nucleotide
US4806370A (en) * 1987-07-08 1989-02-21 Takeda Chemical Industries, Ltd. 5'-nucleotide seasoning composition and production thereof

Also Published As

Publication number Publication date
GB1178905A (en) 1970-01-21
CH483204A (de) 1969-12-31
FR1605380A (forum.php) 1975-02-28
BE696756A (forum.php) 1967-09-18
DE1593919A1 (de) 1972-02-03
NL6704980A (forum.php) 1967-10-09

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