US20120245603A1 - Clip for tissue closure - Google Patents

Clip for tissue closure Download PDF

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Publication number
US20120245603A1
US20120245603A1 US13052634 US201113052634A US20120245603A1 US 20120245603 A1 US20120245603 A1 US 20120245603A1 US 13052634 US13052634 US 13052634 US 201113052634 A US201113052634 A US 201113052634A US 20120245603 A1 US20120245603 A1 US 20120245603A1
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Prior art keywords
tissue
apparatus
eversion
body
clip
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Granted
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US13052634
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US9149276B2 (en )
Inventor
Laveille Kao Voss
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Abbott Cardiovascular Systems Inc
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Abbott Cardiovascular Systems Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/08Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/10Surgical instruments, devices or methods, e.g. tourniquets for applying or removing wound clamps, e.g. containing only one clamp or staple; Wound clamp magazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/128Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for applying or removing clamps or clips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/128Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for applying or removing clamps or clips
    • A61B17/1285Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for applying or removing clamps or clips for minimally invasive surgery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00584Clips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00646Type of implements
    • A61B2017/00659Type of implements located only on one side of the opening
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00676Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect promotion of self-sealing of the puncture
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00982General structural features
    • A61B2017/00986Malecots, e.g. slotted tubes, of which the distal end is pulled to deflect side struts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/08Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
    • A61B2017/081Tissue approximator

Abstract

A tissue engaging device and a corresponding deployment apparatus. The tissue engaging device has a generally annular-shaped body disposed about a central axis. The body has a plurality of inwardly protruding members separated by corresponding intermember spaces. The body is movable between a first position where the body is substantially convex before engagement with the tissue and a second position where the body is substantially concave when the body is engaged with the tissue. The tissue engaging device may be bioabsorbable. The deployment apparatus has a sheath and a tissue eversion apparatus for everting the tissue and positioning the everted tissue within the tissue engaging device.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • [0001]
    Not Applicable.
  • BACKGROUND OF THE INVENTION
  • [0002]
    1. The Field of the Invention
  • [0003]
    The present disclosure generally relates to tissue closure apparatuses and methods.
  • [0004]
    2. The Relevant Technology
  • [0005]
    During intravascular and other related medical procedures, catheters are typically inserted through an incision or puncture in the skin and underlying tissues to access an artery or vein, typically in the groin, neck, or subclavian areas of a patient. The catheter can be inserted through a puncture in the blood vessel and guided to the desired site to perform interventional procedures such as angiography, angioplasty, stent delivery, plaque removal, and infusion of a therapeutic substance.
  • [0006]
    After the procedure is completed and the catheter is removed from the patient, however, the access hole must be closed to prevent hemorrhage. This is typically achieved by applying pressure over the blood vessel manually and then by applying a pressure bandage or a compressive weight. With conventional methods, the risk of post-puncture hemorrhage is high, which can cause considerable complications. The risk of complications is exacerbated by the concomitant use of anticoagulant medications such as heparin or warfarin and by anti-platelet drugs, which are commonly used following a procedure in order to prevent clot formation and thrombus and/or to treat vascular disease.
  • [0007]
    It is generally recognized that many currently employed vascular sealing methods and devices and other tissue closure methods and devices incompletely seal holes or wounds in vascular or other tissue. Achieving complete wound closure is particularly important in sealing arterial punctures, which are relatively high pressure systems. For example, under normal blood pressure, the arterial system has a pressure of about 120/80 mmHg or more. Failure to completely close arterial holes can result in hematoma, exsanguination, and in extreme cases, may result in catastrophic consequences, such as limb amputation and death. Moreover, many currently employed vascular devices employ methods and materials that remain on the intravascular endothelial surface or otherwise in the sealed vessel. Materials that remain intravascularly can be a nidus for thrombus or intravascular mural hyperplasia with later spontaneous and catastrophic closure of the vessel.
  • [0008]
    To overcome these shortcomings, some currently employed vascular devices seal the vessel from the outside of the vessel. However, these vascular devices are typically made of stainless steel, titanium, nickel-titanium (Nitinol) or other non-bioabsorbable material. As such, these vascular devices will permanently remain within the body unless physically removed later by a physician. With a prevalence of reaccessing patients for multiple procedures, this can lead to various problems. For example, when a physician tries to reenter the blood vessel in the same location, the prior placed vascular device will prevent the physician from doing so, and could possibly cause damage to the insertion instrument being used. Furthermore, after each procedure, an additional vascular device will be attached to the blood vessel to be left permanently in the body.
  • BRIEF SUMMARY OF THE INVENTION
  • [0009]
    The present disclosure provides methods and apparatuses that are suitable for closure of vascular punctures or other openings in bodily tissues. The devices and methods described herein are configured for wound closure on the external surface of the wound, which allows wound healing with little endothelial disruption thereby reducing the chances of intravascular thrombosis or embolism or intimal hyperplasia. In some embodiments, the devices are bioabsorbable.
  • [0010]
    In one aspect of the invention there is provided a device for engaging tissue that includes a generally annular-shaped body disposed about a central axis. The body has a plurality of inwardly protruding members separated by corresponding intermember spaces. The body is movable between a first position where the body is substantially convex before engagement with the tissue and a second position where the body is substantially concave when the body is engaged with the tissue.
  • [0011]
    In another aspect of the invention there is provided a tissue closure device for closing an opening in a tissue having an interior surface and opposing exterior surface. The tissue closure device includes a deployment apparatus and a tissue engaging device. The deployment apparatus includes an sheath having a central longitudinal axis extending between a proximal end and a spaced apart distal end. A lumen extends between the proximal and distal ends of the sheath and is bounded by a lumen surface. The deployment apparatus also includes a tissue eversion apparatus configured to form an everted tissue region. The tissue eversion apparatus is positioned within the lumen of the sheath and deployable therefrom for engaging the interior surface of the vessel wall and everting edges of the tissue to be closed. The tissue engaging device is operatively coupled to the deployment apparatus and deliverable therefrom. The tissue engaging device includes a generally annular-shaped body disposed about a central axis. The body has an aperture extending therethrough for receiving the everted edges of the tissue and closing the opening in the tissue. The body is movable between a first position where the body is substantially convex before engagement with the tissue and a second position where the body is substantially concave when the body is engaged with the tissue.
  • [0012]
    In another aspect of the invention there is provided a method of closing an opening in a body tissue. The method includes the steps of positioning a tissue engaging device over the opening in the body tissue, the tissue engaging device being substantially convex with respect to the body tissue; forming an everted tissue region around the opening in the body tissue; and passing the everted tissue region through an aperture in the tissue engaging device, thereby causing the tissue engaging device to become substantially concave with respect to the body tissue to secure the everted tissue region within the aperture and close the opening.
  • [0013]
    In another aspect of the invention there is provided a method of closing an opening extending between an interior surface and an opposing exterior surface of a body tissue. The method includes the steps of positioning a deployment apparatus adjacent the exterior surface and over the opening in the body tissue, a tissue eversion apparatus being disposed within the deployment apparatus and a tissue engaging device being associated with the deployment apparatus and positioned over the opening of the body tissue, the tissue engaging device being substantially convex with respect to the body tissue; deploying the tissue eversion apparatus from the deployment apparatus through the opening of the body tissue so that the tissue eversion apparatus engages the interior surface of the body tissue; retracting the tissue eversion apparatus back into the deployment apparatus, the engagement of the tissue eversion apparatus with the interior surface of the body tissue causing an everted tissue region to be formed around the opening as the tissue eversion apparatus is refracted, the everted tissue region being passed through an aperture in the tissue engaging device as the tissue eversion apparatus is refracted, thereby causing the tissue engaging device to become substantially concave with respect to the body tissue to secure the everted tissue region within the aperture and close the opening; and disengaging the tissue eversion apparatus from the everted tissue region, the everted tissue region remaining secured within the tissue engaging device to close the opening and the tissue engaging device remaining substantially concave with respect to the body tissue.
  • [0014]
    These and other embodiments and features of the present invention will become more fully apparent from the following description and appended claims, or may be learned by the practice of the invention as set forth hereinafter.
  • [0015]
    Embodiments of the present invention may provide several advantages over conventional designs. For example, embodiments of a closure device according to the present invention may provide an improved, more complete closure of a vessel opening than prior designs. Furthermore, embodiments of a closure device according to the present invention may be made of a bioabsorbable material so as to become absorbed into the body after a certain amount of time. This may prevent problems of reaccessing patients for multiple procedures. Other advantages may also be provided by the present invention.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0016]
    Various embodiments of the present invention will now be discussed with reference to the appended drawings. It is appreciated that these drawings depict only typical embodiments of the invention and are therefore not to be considered limiting of its scope. In the drawings, like numerals designate like elements.
  • [0017]
    FIG. 1 is a top view of a first embodiment of a tissue engaging device, in accordance with the present invention;
  • [0018]
    FIGS. 2A and 2B are top views of alternative embodiments of tissue engaging devices, in accordance with the present invention;
  • [0019]
    FIG. 3A is a perspective side view of a tissue engaging device having a substantially planar configuration;
  • [0020]
    FIGS. 3B and 3C are perspective side views of a tissue engaging device having a curved configuration, respectively showing the tissue engaging device in a convex state and a concave state;
  • [0021]
    FIG. 3D is a perspective side view of an alternative tissue engaging device in a convex state;
  • [0022]
    FIG. 4A is a cross sectional side view of a deployment apparatus having an sheath and a tissue eversion assembly, the deployment apparatus being suitable for delivering any of the tissue engaging devices shown in FIGS. 1 and 2;
  • [0023]
    FIG. 4B is a close up view of a portion of FIG. 4A;
  • [0024]
    FIG. 4C is an close up view of an alternative sheath having an inner sheath positioned therein.
  • [0025]
    FIGS. 5A and 5B are close-up perspective views of a tissue eversion apparatus of the tissue eversion assembly shown in FIG. 4A, in unexpanded and expanded states, respectively;
  • [0026]
    FIG. 6 is a close-up perspective view of an alternative embodiment of a tissue eversion apparatus in an expanded state;
  • [0027]
    FIGS. 7A-7H illustrate a method of closing an opening in a tissue wall using the deployment apparatus of FIG. 4, the tissue eversion apparatus of FIGS. 5A and 5B, and the tissue engaging device of FIG. 1;
  • [0028]
    FIGS. 8A and 8B are close-up perspective views of an alternative embodiment of a tissue eversion apparatus comprising a plurality of resilient arms in unexpanded and expanded states, respectively;
  • [0029]
    FIGS. 9A-9F illustrate a method of closing an opening in a tissue wall using the tissue eversion apparatus of FIGS. 8A and 8B; and
  • [0030]
    FIGS. 10A and 10B are close-up perspective views of an alternative embodiment of a tissue eversion apparatus comprising a barbed balloon in unexpanded and expanded states, respectively.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • [0031]
    As used in the specification and appended claims, directional terms, such as “top,” “bottom,” “up,” “down,” “upper,” “lower,” “proximal,” “distal,” and the like are used herein solely to indicate relative directions in viewing the drawings and are not intended to limit the scope of the claims in any way.
  • [0032]
    The present disclosure provides methods and apparatuses that are suitable for closure of vascular punctures or other openings in bodily tissues. The devices and methods described herein are configured for wound closure on the external surface of the wound, which allows wound healing with little endothelial disruption thereby reducing the chances of intravascular thrombosis or embolism or intimal hyperplasia. In some embodiments, the closure elements are bioabsorbable.
  • [0033]
    Generally, the apparatuses and methods described herein can be used with any type of body tissue that has sufficient strength to be held together by the tissue engaging devices described hereinafter. By way of example only, embodiments of the present invention can be used to close openings in tissues that have a wall or membrane function, e.g., pulmonary, intestinal, vascular, urethral, gastric, renal or other wall structures, or in membranes, e.g., amniotic or pericardial membranes. Openings in other types of tissues can also be closed using embodiments of the present invention. Although many types of body tissue can be closed by the methods and apparatuses disclosed herein, the description included herein refers to “vessels” for convenience.
  • [0034]
    Furthermore, the apparatuses and methods described herein can be used with large and small hole punctures or other openings in the body tissue. By way of example, the tissue engaging devices of the present invention can be sized to close holes from 5 French to 30 French or larger. It may also be possible to close holes of other sizes.
  • [0035]
    Turning now to the drawings, FIG. 1 shows a first embodiment of a tissue engaging device or clip 100 for closing an incision, puncture, or other passage through tissue, such as, e.g., communicating with a blood vessel or other body lumen. Clip 100 includes a body 102, which may be generally annular in shape, bounding an aperture 104 and surrounding a central axis 106. As used herein, an “annular-shaped body” includes any hollow body, e.g., including one or more structures surrounding an aperture, whether the body is substantially flat or curved or has a significant thickness or depth. Thus, although an annular-shaped body may be circular, it may include other noncircular shapes as well, such as elliptical or other shapes that are asymmetrical about a central axis.
  • [0036]
    Body 102 includes an outer region 108 that encircles aperture 104 and has an outer circumferential edge 110. Body 102 may include a plurality of tissue engaging members 112 that extend from outer region 108 into aperture 104 and generally towards central axis 106. Tissue engaging members 112 can comprise any structure that is designed to engage the tissue once the tissue has been positioned within aperture 104. This can include structures designed to puncture or otherwise penetrate the tissue or to structures designed to press against the tissue without penetration therein. For example, in the depicted embodiment, tissue engaging members 112 comprise tines 114 and tabs 116 extending into aperture 104. With a substantially pointed tip 118, tines 114 may penetrate the tissue or press against the tissue without penetration. Tabs 116 are designed to generally press against the tissue without penetrating the tissue, although in some embodiments, tabs may also penetrate the tissue. Other types of tissue engaging members 112 may also be used.
  • [0037]
    Each tine 114 may extend from outer region 108 to spaced apart tip 118 and may be biased to extend generally inwardly, e.g., towards one another and/or generally towards central axis 106. Tines 114 may be provided in pairs opposite from one another or may be provided otherwise symmetrically or asymmetrically with respect to central axis 106.
  • [0038]
    Tines 114 may include a variety of pointed tips, such as, e.g., a bayonet tip, and/or may include barbs for penetrating or otherwise engaging tissue. For example, to increase the penetration ability of clip 100 and/or to lower the insertion force required to penetrate tissue, each tine 114 may include a tapered edge extending towards tip 118 along one side of tine. Alternatively, each tine 114 may be provided with a tapered edge on each side of the tine extending towards tip 118.
  • [0039]
    Each 116 tab may extend from outer region 108 to a spaced apart inner circumferential edge 120 and may be biased to extend generally inwardly, e.g., towards one another and/or generally towards central axis 106. Tabs 116 may be provided in pairs opposite from one another or may be provided otherwise symmetrically or asymmetrically with respect to central axis 106.
  • [0040]
    Tissue engaging members 112 are separated by intermember spaces 122, which are portions of aperture 104 which are positioned between adjacent tissue engaging members 112. For example, tine 114A and tab 116A are separated by intermember space 122A.
  • [0041]
    Tines and tabs 114, 116 can be combined in any order. For example, tines 114 and tabs 116 can alternate with each other, as in the depicted embodiment. Other combinations can also be used. In addition, clip 100 can employ the same number of tines and tabs 114, 116 or the number of one can be more than the other. In some embodiments, more tines 114 are present than tabs 116, while in other embodiments, more tabs 116 are present.
  • [0042]
    Clip 100 can be comprised of a biocompatible material. Examples of such materials include stainless steel, titanium, and nickel titanium alloys. In addition, clip 100 can be comprised of a bioabsorbable material. Examples of such materials include PGA and magnesium alloys. Other materials are also possible. By being comprised of a bioabsorbable material, clip 100 may dissolve and become absorbed into the body after the opening in the tissue has been closed. Because clip 100 may be absorbed into the body, the surgeon in future procedures will not be prevented from reaccessing a similar area of the tissue as is the case with many conventional clips.
  • [0043]
    FIGS. 2A and 2B show alternative embodiments of clips 100′ and 100″ based on clip 100 of FIG. 1. While clip 100 incorporates a mixture of tines and tabs 114, 116, clip 100′ of FIG. 2A includes only tines 114′ with no tabs. Furthermore, while all of tines 114 of clip 100 are substantially the same length, tines 114′ of clip 100′ are of varying lengths. Conversely, clip 100″ of FIG. 2B includes only tabs 116″ with no tines, and the tabs can be of varying sizes, if so desired. Other combinations of sizes and numbers of tines and tabs can alternatively be used. Clips 100′ and 100″ as well as any derivatives thereof, can be comprised of the same types of materials as clip 100, discussed above.
  • [0044]
    Any of the clips disclosed herein can be substantially planar or have a curvature associated therewith. For example, FIG. 3A shows clip 100 having a top surface 300 and an opposing bottom surface 302 in a substantially planar configuration. Alternatively, FIGS. 3B and 3C show clip 100 in a cup-shaped configuration, with clip 100 being in a convex state in FIG. 3B with respect to the bottom surface 302 that faces the tissue and a concave state in FIG. 3C. Clip 100 can be movable between the two states shown in FIGS. 3B and 3C, as discussed below. For example, in one embodiment, clip 100 is designed to bias towards the convex state shown in FIG. 3B and be moved to and remain in the concave state shown in FIG. 3C when the everted tissue is pulled up and through clip 100.
  • [0045]
    As shown in FIGS. 3B and 3C, the tines and tabs can be configured to extend inward so as to align with the specific convex and/or concave shape of clip 100. Alternatively, one or more of the tines or tabs can be configured to extend in a different direction so as to not align with the specific convex or concave shape. For example, FIG. 3D shows an alternative embodiment of clip 100 in which an opposing pair of tines 114 extend outward and down from the rest of the clip and are thus not aligned with the convex shape of the clip. This can be advantageous in it can allow the capture of more tissue during the eversion process because the extended tine can contact the tissue earlier and further away from the body of the clip.
  • [0046]
    The clips of the present invention may be delivered using various apparatuses and methods. Referring now to FIG. 4A, a tissue closure device 400 for closing an opening in a tissue according to one embodiment is depicted. Tissue closure device 400 includes a deployment apparatus 402 with clip 100 being releasably mounted thereon. Deployment apparatus 402 is used to deliver clip 100 to the tissue opening and manipulate the tissue so as to secure the tissue with the clip and thereby close the opening.
  • [0047]
    Generally, deployment apparatus 402 can include a sheath 404 having a longitudinal axis 406 and a tissue eversion assembly 408 slidably mounted therein. Sheath 404 can include a substantially rigid, semi-rigid, or substantially flexible tubular body 410 having a sidewall 412 extending longitudinally between a proximal end 414 and an opposing distal end 416. Sidewall 412 can bound a lumen 418 that extends along longitudinal axis 406 between the two ends 414, 416. Lumen 418 can have a size for inserting one or more devices therethrough, such as a catheter, guide wire, and the like (not shown). Sheath 404 may also include one or more seals (not shown), such as a hemostatic valve, within lumen 418 at or near proximal end 414 that provides a fluid-tight seal, yet accommodates inserting one or more devices into the lumen 418 without fluid passing proximally from sheath 404.
  • [0048]
    As particularly shown in FIG. 4B, at distal end 416 of sheath 404, lumen 418 is sized to receive clip 100 and to releasably retain clip 100 until the clip has been positioned over the opening and everted tissue has been received within the clip, as discussed below. When clip 100 is positioned within lumen 418, aperture 104 in the middle of clip 100 aligns with longitudinal axis 406 of lumen 418 so that everted tissue can be pulled up and into aperture 104, as discussed in more detail below.
  • [0049]
    As shown in the depicted embodiment, sidewall 412 narrows at distal end 416 so as to form an annular taper 438 thereat. As a result, an annular channel 440 is formed at distal end 416 of sheath 404 that has a larger diameter than the portion of lumen 418 proximal of taper 438. As a result, clip 100 can be positioned within channel 440, with taper 438 preventing clip 100 from moving proximally further into lumen 418.
  • [0050]
    An annular ridge 420 or similar retaining member can extend from sidewall 412 into lumen 418 to releasably retain clip 100 within the lumen. The retaining member 420 can be designed to retain clip 100 within lumen 418 until a distal force of a predetermined strength overcomes the retaining force and dislodges clip 100 from lumen 418. For example, as discussed below, a force caused by everted tissue that has been positioned within clip 100 by a tissue eversion apparatus can provide enough force to dislodge the clip. Other dislodging forces are also possible.
  • [0051]
    In an alternative embodiment, instead of having sheath 404 tapered at distal end 416 to form channel 440, an inner sheath can be used in conjunction with sheath 404 to prevent clip 100 from moving proximally into lumen 418. For example, FIG. 4C shows an alternative embodiment of a sheath 450 having an inner sheath 452 positioned within lumen 418. Sheath 450 is similar to sheath 404 except that sidewall 412 does not taper at distal end 416. Instead, inner sheath 452 is positioned at distal end 416 adjacent to the proximal side of clip 100. Inner sheath 452 prevents clip 100 from moving proximally further into lumen 418.
  • [0052]
    In some embodiments, inner sheath 452 can be slidable within lumen 418 so as to be removable therefrom. In these embodiments, unlike sheath 404, sheath 450 can allow clip 100 to be initially inserted into lumen 418 at the proximal end of sheath 450 and slid to its initial position at distal end 416. Inner sheath 452 can thereafter be slid into lumen 418 at the proximal end of sheath 450. A slidable inner sheath 452 can also be used to force clip 100 out of distal end 416 of lumen 418. After tissue has been everted into clip 100, inner sheath 452 can be pushed distally within lumen 418 against the proximal side of clip 100 with enough force to cause clip 100 to overcome the retaining force of retaining member 420 and dislodge clip 100 from lumen 418, thereby ejecting clip 100 from sheath 404.
  • [0053]
    Returning to FIG. 4A, sheath 404 may optionally include a side port 422 that communicates with lumen 418, for example, to deliver fluids into lumen 418. Alternatively, or in addition, side port 422 may be used to provide a “bleed back” indicator. An exemplary “bleed back” indicator and related methods of use are disclosed in application Ser. No. 09/680,837, filed Oct. 6, 2000 (now U.S. Pat. No. 6,626,918), entitled “Apparatus and Methods for Positioning a Vascular Sheath,” which is assigned to the assignee of the present application. The disclosure of the '837 application and any other references cited therein are fully incorporated by reference herein.
  • [0054]
    Tissue eversion assembly 408 can include a rigid, semi-rigid, or flexible tubular body 424 (such as an elongate rail) with a longitudinal axis 426. Tubular body 424 can have a proximal end region 428 and a distal end region 430 and can include a predetermined length and a predetermined outer cross-section, both of which can be of any suitable dimension that will slidably fit within lumen 418 of sheath 404. When tissue eversion assembly 408 is positioned within lumen 418, longitudinal axis 426 of tissue tubular body 424 may align with longitudinal axis 406 of sheath 404.
  • [0055]
    Proximal end region 428 of tissue eversion assembly 408 can include a handle 432 or other actuation device to extend or retract distal end region 430 into or out of distal end 416 of sheath 404. Handle 432 can also include manipulator devices to manipulate a tissue eversion apparatus, as discussed below. Distal end region 430 of tissue eversion assembly 408 can include a substantially rounded, soft, and/or flexible distal end or tip 434 to facilitate advancement and/or retraction of distal end region 430 into a blood vessel or other opening in tissue. As desired, a pigtail or J-tip (not shown) may be provided on tip 434 to further aid atraumatic advancement of distal end region 430.
  • [0056]
    Tissue eversion assembly 408 can also include a tissue eversion apparatus to facilitate the formation of an everted tissue region by engaging the interior surface of the tissue. For example, in the depicted embodiment, a tissue eversion apparatus 436 is positioned at distal end region 430 of tissue eversion assembly 408.
  • [0057]
    Turning to FIGS. 5A and 5B, tissue eversion apparatus 436 can comprise a plurality of substantially flexible members 500 selectably controllable between an unexpanded state, as shown in FIG. 5A, and an expanded state, as shown in FIG. 5B. Although four substantially flexible members 500 are depicted, it is appreciated that more or less substantially flexible members can be used.
  • [0058]
    Each substantially flexible member 500 has an inner surface 502 and an opposing outer surface 504 extending from a proximal end 506 to a spaced apart distal end 508. As shown in FIG. 5A, when tissue eversion apparatus 436 is in the unexpanded state, substantially flexible members 500 are substantially axially aligned with tubular body 424, with outer surfaces 504 facing outward from body 424. This helps to facilitate insertion of tissue eversion apparatus 436 through an opening through tissue, as discussed below.
  • [0059]
    Conversely, when tissue eversion apparatus 436 is in the expanded state, substantially flexible members 500 are flexed outward, as shown in FIG. 5B. In this expanded state, a portion of each substantially flexible member 500 forms a loop 510 with a portion 512 of the outer surface 504 of loop 510 facing proximally. In the expanded state, tissue eversion apparatus 436 is capable of engaging tissue positioned about an opening after tissue eversion apparatus 436 has been positioned through the opening, as discussed in detail below. Substantially flexible members 500 can be made of a material that allows substantially flexible members 500 to move easily between the unexpanded and expanded states. For example, substantially flexible members 500 can be made of stainless steel, nickel, titanium or the like. Other materials can also be used.
  • [0060]
    A control member (not shown), such as a rod, wire, or other elongate member, may be moveably disposed within a lumen (not shown) formed by tubular body 424 and extending substantially between proximal end region 428 and distal end region 430. The control member may extend from handle 432 (See FIG. 4A) to a distal end region of the control member coupled with distal end region 430 of body 424 and/or the movable end regions of substantially flexible members 500. By moving tubular body 424 axially relative to the control member, distal end region 430 and/or substantially flexible members 500, can be selectively transitioned between the unexpanded and expanded states. An exemplary control member and related methods of use are disclosed in copending U.S. application Ser. No. 12/135,858 filed on Jun. 9, 2008 and entitled “Antimicrobial Closure Element and Closure Element Applier,” which is assigned to the assignee of the present application. The disclosures of the '858 application and any references cited therein are expressly incorporated herein by reference.
  • [0061]
    One or more tissue engaging members can be integrally formed with or otherwise attached to each substantially flexible member 500 so as to engage the tissue when tissue eversion apparatus 436 comes into contact with the tissue while in the expanded state, as discussed below. For example, in the depicted embodiment, the tissue engaging members comprise one or more barbs 520 extending from the outer surface 504 of each substantially flexible member 500. Barbs 520 can be positioned on the portion 512 of outer surface 504 that faces proximally in the expanded state, as shown in FIG. 5B. Barbs 520 can be made of metal, plastic, or other suitable rigid or semi-rigid material. Alternatively, barbs 520 can be integrally formed with flexible member 500 and thus made of the same material. Any desired number of barbs 520 can be included on each substantially flexible member 500. Other types of tissue engaging members can also be used, such as needles, hooks, anchors, temporary adhesives or the like.
  • [0062]
    FIG. 6 shows an alternative embodiment 600 of a tissue eversion apparatus. Tissue eversion apparatus 600 is similar to tissue eversion apparatus 436 except that instead of tissue engaging members 520 being positioned on outer surface 504 of loop 510 of each substantially flexible member 500, the tissue engaging members 520 of tissue eversion apparatus 600 extend from the inner surface 502 of loop 510. To facilitate tissue engaging members 500 engaging the tissue, a window 602 is formed in the substantially flexible member for the tissue engaging members to extend through.
  • [0063]
    As shown in FIG. 6, tissue engaging members 520 are formed with or otherwise attached to the proximal facing portion of inner surface 502 of each loop 510 formed on substantially flexible members 500 when the tissue eversion apparatus 600 is in the expanded state. Window 602 is formed on the portion of loop 510 opposing tissue engaging members 520 so that tissue engaging members 520 can project through window 602 when tissue eversion apparatus 600 is in the expanded state. To facilitate this, tissue engaging members 520 are typically longer than the width of substantially flexible member 500 so that tissue engaging members 520 can extend beyond window 602 and engage tissue.
  • [0064]
    Because tissue engaging members 500 are disposed on inner surface 502 of substantially flexible members 500, tissue engaging members 520 face inward (i.e., toward longitudinal axis 426) when substantially flexible member 500 is in the unexpanded state. This can help to prevent tissue engaging members 520 from inadvertently snagging or otherwise contacting the tissue while tissue eversion apparatus 600 is passed through an opening in the tissue while in the unexpanded state.
  • [0065]
    Turning to FIGS. 7A-7H, a method of sealing and/or closing a passage through tissue, such as an opening 700 communicating with a blood vessel or other body lumen 702 through a wall 704 thereof, using tissue closure device 400 will now be discussed. Applicant notes that all of the disclosed methods herein are exemplary only and that other methods of sealing and/or closing a passage through tissue using tissue closure device 400 can also be performed.
  • [0066]
    Initially, tissue closure device 400 is assembled. To do this, clip 100 is removably secured within lumen 418 at distal end 416 of sheath 404, as discussed above, so as to be positioned as shown in FIG. 7A. In the depicted embodiment, a cup-shaped clip is used, although a substantially planar clip, such as that shown in FIG. 3A, can alternatively be used. Clip 100 is positioned within lumen 418 to be convex with respect to the tissue in the biased position of the clip. In this position, ridge 420 (see FIG. 4B) secures clip 100 within lumen 418, as discussed above.
  • [0067]
    To complete the assembly of tissue closure device 400, distal end region 430 of tissue eversion assembly 408 is slidably received within lumen 418 of sheath 404 at proximal end 414 (see FIG. 4A). Tissue eversion assembly 408 is then slid toward distal end 416 of sheath 404 so as to be positioned within lumen 418 as shown in FIG. 7A. Substantially flexible members 500 are in the unexpanded state as tissue closure device is assembled. Tissue eversion assembly 408 can be positioned within lumen 418 before or after clip 100 has been positioned within lumen 418. When both tissue eversion assembly 408 and clip 100 have been positioned within lumen 418, distal end region 430 of tissue eversion assembly 408 (including tip 434, if used) is disposed adjacent clip 100 at distal end 416 of sheath 404, as shown in FIG. 7A.
  • [0068]
    Tissue closure device 400 is inserted into the body so that distal end 416 of sheath 404 abuts the outer surface 706 of vessel wall 704 and is positioned directly over opening 700 as shown in FIG. 7A. This can be done either before or after tissue eversion assembly 408 has been inserted into lumen 418. A guide wire can be used to aid in positioning tissue closure device, as is known in the art, either by receiving the guide wire within lumen 418 or a lumen formed in tissue eversion assembly 408. A bleed back lumen or other indicating method or apparatus known in the art can also be used to indicate when tissue closure device 400 is in position.
  • [0069]
    As shown in FIG. 7B, once tissue closure device 400 is in position above opening 700, an external deploying force, denoted by arrow 708, is then applied to tissue eversion assembly 408 by pushing distally on handle 432 (See FIG. 4A) or other actuating device. The deploying force 708 causes distal end region 430 of tissue eversion assembly 408 to extend through opening 700 and into vessel lumen 702.
  • [0070]
    Once distal end region 430 of tissue eversion assembly 408 has been extended into body lumen 702, the control member and/or tubular body 424 are axially moved relative to each other so as to cause substantially flexible members 500 to transition to the expanded state, as shown in FIG. 7C. Tissue engaging members 520 in the form of barbs are positioned on outer surface 504 of each substantially flexible member 500 so as to face proximally (i.e., toward vessel wall 704 adjacent to opening 700) when substantially flexible members 500 are in the expanded state.
  • [0071]
    An external retracting force, denoted by arrow 710 in FIG. 7D, is then applied to tissue eversion assembly 408 by pulling proximally on handle 432 (See FIG. 4A) or other actuating device. This causes the expanded substantially flexible members 500 to move proximally toward opening 700 in vessel wall 704. Substantially flexible members 500 continue moving proximally until outer surfaces 504 thereof contact the inner surface 712 of vessel wall 704 surrounding opening 700, as shown in FIG. 7D. As substantially flexible members 500 move toward vessel wall 704, barbs 520 engage inner surface 712 of vessel wall 704 and extend into the wall.
  • [0072]
    As external retracting force 710 is maintained on tissue eversion assembly 408, substantially flexible members 500 continue moving proximally. As they do so, vessel wall 704 surrounding opening 700 begin to evert and form an everted tissue region 714 as a result of the engagement with barbs 520, as shown in FIG. 7E. As a result, the engaged tissue may begin to exert a resistive force on substantially flexible members 500, causing substantially flexible members 500 to begin to bend distally. As a result, loops 510 begin to move inward, thereby causing the everted tissue region 714 to also be pulled inward, as shown in FIG. 7E.
  • [0073]
    As external retracting force 710 continues, everted tissue region 714 is pulled proximally and inward into lumen 418 and through clip 100 by substantially flexible members 500, as shown in FIG. 7F. As everted tissue region 714 is pulled proximally through clip 100, the everted tissue begins to contact and exert a proximal force on tines 114 and/or tabs 116 (see FIG. 1) of clip 100. This proximal force causes clip 100 to transition or invert from the convex shape to a concave shape with respect to vessel wall 704, as shown in FIG. 7F. The tines and/or tabs also cause the edges of the everted tissue region 714 to constrict inward so as to begin to press tightly together.
  • [0074]
    At some point, because of the retaining force of the clip the force exerted by clip 100 on the tissue eversion region 714 causes the tissue in the tissue eversion region 714 to pull away and disengage from barbs 520, as shown in FIG. 7G. Once this occurs, substantially flexible members 500 are pulled proximally away from everted tissue region 714. With substantially flexible members 500 no longer engaged to the inner surface of everted tissue region 714, the everted tissue presses tightly together due to the tines and/or tabs of clip 100, thereby completely closing opening 700. Everted tissue region 714 is now secured within clip 100, thereby keeping opening 700 closed. Furthermore, the constricted everted tissue region 714 disposed between the tines and/or tabs prevents clip 100 from reverting back to the original convex shape.
  • [0075]
    Once barbs 520 have disengaged from the everted tissue, tissue eversion assembly 408 and sheath 404 can be removed from the body. As sheath 404 is removed, a retaining force is exerted on clip 100 by its engagement with tissue eversion region 714. This force is larger than the retaining force caused by the ridge 420 (see FIG. 4B) within lumen. As such, as sheath 404 is removed from the body, clip 100 remains within the body, secured to vessel wall 704 as shown in FIG. 7H. Because clip 100 is biased toward the convex shape, the tines and/or tabs of clip 100 will continue to exert a distal force when clip 100 is in the concave shape to attempt to cause clip 100 to return to the convex shape. However, as noted above, as a result of the constricted everted tissue 714 disposed through clip 100, clip 100 will remain in the concave shape. Because of this, an added closing force is continuously exerted on everted tissue region 714 by the tines and/or tabs of clip 100 as the tines and/or tabs attempt to return clip 100 to the convex shape. This added force helps to maintain the secure nature of the closure of opening 700.
  • [0076]
    If clip 100 is made of a bioabsorbable material, clip 100 will dissolve and be absorbed into the body after the tissue has grown together over opening 700. This can aid the surgeon in future procedures by allowing the surgeon to reaccess a similar area of the tissue without having to remove or avoid the clip.
  • [0077]
    As noted above, a planar tissue engaging device can be used instead of an inverting curved tissue engaging device. If a planar tissue engaging device is used, such as clip 100 shown in FIG. 3A, the same method of sealing and/or closing a passage through tissue can be used as discussed above with reference to FIGS. 7A-7H. However, unlike the inverting clip, as the everted tissue region is pulled through the planar clip by the barbs, the clip will not invert from a convex shape to a concave shape. Instead, the planar clip may remain planar during the sealing/closing method. As a result, when the sheath has been removed, the tines and/or tabs of the planar clip may not impose an added closing force. Alternatively, the everted tissue region may cause the tines and/or tabs of the planar clip to rise above the plane of the clip due to the force of the everted tissue.
  • [0078]
    FIGS. 8A and 8B show an alternative embodiment 800 of a tissue eversion apparatus. Tissue eversion apparatus 800 comprises a plurality of resilient arms 802 that are movable between an unexpanded state, shown in FIG. 8A, and an expanded state, shown in FIG. 8B. Although four resilient arms 802 are depicted, it is appreciated that more or less resilient arms 802 can be used.
  • [0079]
    Each resilient arm 802 extends from a proximal end 804 that is attached to or otherwise formed at distal end region 430 of tubular body 424 to a distal end 806. One or more barbs 520 or other tissue engaging members similar to those discussed previously can be integrally formed with or otherwise attached to distal end 806 of each resilient arm 802 so as to engage tissue when tissue eversion apparatus 800 comes into contact with the tissue while in the expanded state. When tissue eversion apparatus 800 is in the unexpanded state, resilient arms 802 extend substantially longitudinally from tubular body 424 so as to abut each other in a retracted position as shown in FIG. 8A. Conversely, when tissue eversion apparatus 800 is in the expanded state, resilient arms 802 extend laterally from tubular body 424 so as to be spread apart from each other in a deployed position, as shown in FIG. 8B.
  • [0080]
    Resilient arms 802 can be designed to be biased toward the deployed position. That is, when resilient arms 802 are not in the deployed position, a resilient force can act on resilient arms 802 to force distal ends 806 of resilient arms 802 to spread apart and thereby move to the deployed position. This can be accomplished by using a shape-memory type of material for the resilient arms, such as a nickel-titanium alloy (e.g., Nitinol), or other known shape-memory type of material.
  • [0081]
    A control sheath 808 having a bore 810 can be used with tissue eversion apparatus 800 to control when resilient arms 802 move between the retracted and deployed positions. When proximal ends 804 of resilient arms 802 are positioned within bore 810, control sheath 808 keeps resilient arms 802 together in the retracted position as shown in FIG. 8A and prevents resilient arms 802 from moving to the deployed position. Conversely, when proximal ends 804 of resilient arms 802 extend out of distal end 812 of bore 810, the resilient force causes resilient arms 802 to remain in the deployed position, as shown in FIG. 8B. Accordingly, control sheath 808 can be used to cause resilient arms 802 to move between the two positions.
  • [0082]
    For example, when tissue eversion apparatus 800 is in the unexpanded state of FIG. 8A, resilient arms 802 are in the retracted position abutting each other. An external force can be used to move resilient arms 802 distally with respect to control sheath 808. This can be accomplished, e.g., by applying a distal force to tubular body 424 or a proximal force to control sheath 808. Resilient arms 802 can continue to move distally with respect to control sheath 808 until the proximal ends 804 of resilient arms 802 move out of distal end 812 of control sheath bore 810. Once outside of bore 810, resilient arms 802 can spring out to the deployed position by virtue of the resilient force, thereby causing tissue eversion apparatus 800 to be in the expanded state shown in FIG. 8B.
  • [0083]
    In a similar but opposite manner, when tissue eversion apparatus 800 is in the expanded state of FIG. 8B, resilient arms 802 can be moved proximally with respect to control sheath 808. This causes resilient arms 802 to retract back into the control sheath bore 810. As proximal ends 804 of resilient arms 802 move into bore 810, the bore wall at distal end 812 exerts an inward force on resilient arms 802, overcoming the resilient force and causing distal ends 806 of resilient arms 802 to move inward. As resilient arms 802 retreat further into bore 810, resilient arms 802 move inward until the arms abut each other in the retracted position, thereby causing tissue eversion apparatus 800 to be in the unexpanded state shown in FIG. 8A.
  • [0084]
    Turning to FIGS. 9A-9F, a method of sealing and/or closing a passage through tissue using tissue eversion apparatus 800 will now be discussed. The method of sealing and/or closing using tissue eversion apparatus 800 is similar to the method discussed above using tissue eversion apparatus 436 with some variations. For example, similar to the previously described method, tissue eversion apparatus 800 is positioned within lumen 418 of sheath 404. However, as shown in FIG. 9A, control sheath 808 is also received within lumen 418 and tissue eversion apparatus 800 is positioned within control sheath 808 so as to be in the unexpanded state, as discussed above. Tissue eversion apparatus 800 can be positioned within control sheath 808 either before or after control sheath 808 has been received within lumen 418. Furthermore, control sheath 808 can be positioned within lumen 418 before or after clip 100 has been positioned within lumen 418. When control sheath 808 and clip 100 have been positioned within lumen 418, distal end 806 of tissue eversion apparatus 800 is disposed adjacent clip 100 at distal end 416 of sheath 404, as shown in FIG. 9A.
  • [0085]
    Similar to the previously discussed method, once clip 100 has been positioned above opening 700, external deploying force 708 is applied to tubular body 424 which causes the distal end 806 of tissue eversion apparatus 800 to extend through opening 700 and into vessel lumen 702. The same or similar deploying force 900 is simultaneously applied to control sheath 808 so that control sheath 808 moves distally with tissue eversion apparatus 800 to also extend through opening 700 and into vessel lumen 702, as shown in FIG. 9B. Because resilient arms 802 remain within control sheath 808, tissue eversion apparatus 800 remains in the unexpanded state.
  • [0086]
    The external deploying force 708 continues to be applied to tubular body 424 while the deploying force 900 applied to the control sheath 808 is removed. As a result, tissue eversion apparatus 800 further extends into vessel lumen 702 while control sheath 808 does not. Consequently, resilient arms 802 move out of bore 810 at distal end 812 of control sheath 808. Once outside of bore 810, resilient arms 802 spring out to the deployed position as shown in FIG. 9C and as discussed above. The positioning of distal end 812 of control sheath 808 prevents resilient arms 802 from springing out to the deployed position too soon; without control sheath 808, resilient arms 802 could spring out too soon, causing barbs 520 to snag on the tissue surrounding vessel wall opening 700 instead of the inner surface 712 of the tissue wall 704.
  • [0087]
    As shown in FIG. 9D, once tissue eversion apparatus 800 is in the expanded state, external retracting force 710 is applied to tubular body 410 to cause tissue eversion apparatus 800 to move proximally and contact inner surface 712 of vessel wall 704, similar to the previously discussed method. The same or similar refracting force 902 is simultaneously applied to control sheath 808 so that control sheath 808 will also move proximally with resilient arms 802. As a result, resilient arms 802 remain in the deployed position and barbs 520 engage inner surface 712 of vessel wall 704.
  • [0088]
    Similar to the previously discussed method, retracting force 710 is maintained on tubular body 424 to pull everted tissue region 714 upward through clip 100, as shown in FIG. 9E. Retracting force 902 is also maintained so that control sheath 808 moves proximally with resilient arms 802. At a predefined point, retracting force 902 is removed from control sheath 808, so that retracting force 710 on tubular body 424 causes resilient arms 802 to retract into control sheath 808. As resilient arms 802 retract into control sheath 808, resilient arms 802 move inward to the retracted position as discussed above and shown in FIG. 9E. As a result, the everted tissue 714 comes together through clip 100.
  • [0089]
    Similar to the previously discussed method, once a desired amount of everted tissue has been pulled proximally through clip 100, barbs 520 disengage from the everted tissue as shown in FIG. 9F. Tissue eversion apparatus 800, control sheath 808, and sheath 404 can then be removed from the body and clip 100 will remain secured to the vessel wall 704 in a similar manner as discussed previously.
  • [0090]
    FIGS. 10A and 10B show another alternative embodiment 1000 of a tissue eversion apparatus. Tissue eversion apparatus 1000 comprises a balloon 1002 that is inflatable between an unexpanded state, shown in FIG. 10A, and an expanded state, shown in FIG. 10B.
  • [0091]
    Balloon 1002 extends distally from distal end region 430 of tubular body 424. Balloon 1002 comprises a thin wall 1004 having an inner surface 1006 and an opposing outer surface 1008. Inner surface 1006 bounds an inflatable chamber 1010. Balloon 1002 is made of an expandable material that is capable of being expanded with air or other type of gas or liquid. For example, balloon 1002 can be made of polyvinyl chloride, nylon, or pebax. Other materials can also be used.
  • [0092]
    A lumen 1012 can extend through body 424 so as to fluidly communicate with chamber 1010 of balloon 1002. When tissue eversion apparatus 1000 is in the unexpanded state, balloon 1002 is deflated such that the balloon extends longitudinally away from tubular body 424, as shown in FIG. 10A, Conversely, when tissue eversion apparatus 1000 is in the expanded state, balloon 1002 is inflated so as to extend laterally from tubular body 424, as shown in FIG. 10B.
  • [0093]
    One or more barbs 520 or other tissue engaging members similar to those discussed previously can be integrally formed with or otherwise attached to outer surface 1008 of balloon 1002 so as to engage the tissue when balloon 1002 comes into contact with the tissue while in the expanded state.
  • [0094]
    During use, the deflated balloon 1002 is inserted through the opening in the tissue similar to the other tissue eversion apparatuses previously discussed. Once inserted, balloon 1002 can be inflated by passing air or other inflating component through lumen 1012 within body 424 and into chamber 1010 of balloon 1003. Balloon 1002 is then retracted back through the opening, similar to previously discussed methods, such that barbs 520 contact and evert tissue around the opening. As balloon 1002 retracts back through clip 100, balloon 1002 can be controllably deflated by selectively releasing air from chamber 1010 and through lumen 1012 of body 424. Similar to previously discussed methods, this causes the everted tissue to come together through clip 100.
  • [0095]
    Similar to previously discussed methods, once a desired amount of everted tissue has been pulled proximally through clip 100, the barbs 520 disengage from the everted tissue and tissue eversion apparatus 1000 and sheath 404 can be removed from the body and clip 100 will remain secured to the vessel wall.
  • [0096]
    Although the present invention has been described in considerable detail with reference to certain embodiments, it is contemplated that one skilled in the art may make modifications to the device herein without departing from the scope of the invention. Therefore, the scope of the appended claims should not be considered limited to the embodiments described herein

Claims (29)

  1. 1. A device for engaging tissue, comprising:
    a generally annular-shaped body disposed about a central axis, the body having a plurality of inwardly protruding members separated by corresponding intermember spaces, the body being movable between a first position where the body is substantially convex before engagement with the tissue and a second position where the body is substantially concave when the body is engaged with the tissue.
  2. 2. The device for engaging tissue according to claim 1, wherein the device is bioabsorbable.
  3. 3. The device for engaging tissue according to claim 1, wherein at least one of the inwardly protruding members comprises a tine.
  4. 4. The device for engaging tissue according to claim 3, wherein the tine does not form a portion of the convex shape when the device is in the first position.
  5. 5. The device for engaging tissue according to claim 1, wherein at least one of the inwardly protruding members comprises a tab.
  6. 6. The device for engaging tissue according to claim 1, wherein the device comprises a clip.
  7. 7. The device for engaging tissue according to claim 1, wherein the body includes a top surface and an opposing bottom surface, the intermember spaces together forming an aperture extending through the body between the top and bottom surfaces.
  8. 8. The device for engaging tissue according to claim 1, wherein the body is resiliently biased toward the first position.
  9. 9. A tissue closure device for closing an opening in a tissue having an interior surface and opposing exterior surface, the tissue closure device comprising:
    a deployment apparatus comprising:
    a sheath having a central longitudinal axis extending between a proximal end and a spaced apart distal end, a lumen extending between the proximal and distal ends, the lumen being bounded by a lumen surface; and
    a tissue eversion apparatus configured to form an everted tissue region, the tissue eversion apparatus being positioned within the lumen of the sheath and deployable therefrom for engaging the interior surface of the tissue and everting edges of the tissue to be closed; and
    a tissue engaging device operatively coupled to the deployment apparatus and deliverable therefrom, the tissue engaging device comprising a generally annular-shaped body disposed about a central axis, the body having an aperture extending therethrough for receiving the everted edges of the tissue and closing the opening in the tissue, the body being movable between a first position where the body is substantially convex before engagement with the tissue and a second position where the body is substantially concave when the body is engaged with the tissue.
  10. 10. The tissue closure device according to claim 9, wherein the tissue engaging device is bioabsorbable.
  11. 11. The tissue closure device according to claim 9, wherein the tissue eversion apparatus is configured to position the everted edges of the tissue within the tissue engaging device.
  12. 12. The tissue closure device according to claim 9, wherein the tissue eversion apparatus includes one or more barbs for everting the tissue.
  13. 13. The tissue closure device according to claim 12, wherein the tissue eversion apparatus also includes an adhesive coating for everting the tissue.
  14. 14. The tissue closure device according to claim 9, wherein the aperture of the body of the tissue engaging device is aligned with the lumen of the deployment apparatus so that the tissue eversion apparatus passes through the aperture when deployed from the lumen.
  15. 15. The tissue closure device according to claim 9, wherein the tissue eversion apparatus is movable between an unexpanded state in which the tissue eversion apparatus is configured to not contact the tissue and an expanded state in which the tissue eversion apparatus is configured to contact and evert the tissue.
  16. 16. The tissue closure device according to claim 15, wherein the tissue eversion apparatus comprises one or more substantially flexible members each having one or more barbs extending therefrom, the tissue eversion apparatus being configured such that the barbs contact and evert the tissue when the tissue eversion apparatus is in the expanded state.
  17. 17. The tissue closure device according to claim 16, wherein each substantially flexible member has an outer surface and wherein the barbs extend outwardly from the outer surface.
  18. 18. The tissue closure device according to claim 16, wherein each substantially flexible member has an outer surface and an opposing inner surface, a window being formed that extends between the inner and outer surfaces, the barbs extending from the inner surface of each substantially flexible member so as to extend through the window when the tissue eversion apparatus is in the expanded state.
  19. 19. The tissue closure device according to claim 16, wherein the barbs extend inwardly when the tissue eversion apparatus is in the unexpanded state.
  20. 20. The tissue closure device according to claim 15, wherein the tissue eversion apparatus comprises a plurality of resilient arms each having one or more barbs extending therefrom, the tissue eversion apparatus being configured such that the barbs contact and evert the tissue when the tissue eversion apparatus is in the expanded state.
  21. 21. The tissue closure device according to claim 20, wherein the deployment apparatus further comprises a control sheath disposed within the lumen of the sheath, the resilient arms being positioned within the control sheath so as to abut each other when the tissue eversion apparatus is in the unexpanded state.
  22. 22. The tissue closure device according to claim 15, wherein the tissue eversion apparatus comprises an inflatable balloon having one or more barbs extending therefrom, the tissue eversion apparatus being configured such that the barbs contact and evert the tissue when the tissue eversion apparatus is in the expanded state.
  23. 23. A method of closing an opening in a body tissue, the method comprising:
    positioning a tissue engaging device over the opening in the body tissue, the tissue engaging device being substantially convex with respect to the body tissue;
    forming an everted tissue region around the opening in the body tissue; and
    passing the everted tissue region through an aperture in the tissue engaging device, thereby causing the tissue engaging device to become substantially concave with respect to the body tissue to secure the everted tissue region within the aperture and close the opening.
  24. 24. A method of closing an opening extending between an interior surface and an opposing exterior surface of a body tissue, the method comprising:
    positioning a deployment apparatus adjacent the exterior surface and over the opening in the body tissue, a tissue eversion apparatus being disposed within the deployment apparatus and a tissue engaging device being associated with the deployment apparatus and positioned over the opening of the body tissue, the tissue engaging device being substantially convex with respect to the body tissue;
    deploying the tissue eversion apparatus from the deployment apparatus through the opening of the body tissue so that the tissue eversion apparatus engages the interior surface of the body tissue;
    retracting the tissue eversion apparatus back into the deployment apparatus, the engagement of the tissue eversion apparatus with the interior surface of the body tissue causing an everted tissue region to be formed around the opening as the tissue eversion apparatus is retracted, the everted tissue region being passed through an aperture in the tissue engaging device as the tissue eversion apparatus is retracted, thereby causing the tissue engaging device to become substantially concave with respect to the body tissue to secure the everted tissue region within the aperture and close the opening; and
    disengaging the tissue eversion apparatus from the everted tissue region, the everted tissue region remaining secured within the tissue engaging device to close the opening and the tissue engaging device remaining substantially concave with respect to the body tissue.
  25. 25. The method according to claim 24, wherein deploying the tissue eversion apparatus comprises extending a plurality of substantially flexible members having tissue engaging members disposed on an outer surface thereof through the opening of the body tissue in an unexpanded state and expanding the substantially flexible members such that the tissue engaging members engage the interior surface of the body tissue.
  26. 26. The method according to claim 24, wherein deploying the tissue eversion apparatus comprises extending a plurality of substantially flexible members having tissue engaging members disposed on an inner surface thereof through the opening of the body tissue in an unexpanded state and expanding the substantially flexible members such that the tissue engaging members extend through a window formed within the substantially flexible members to engage the interior surface of the body tissue.
  27. 27. The method according to claim 24, wherein deploying the tissue eversion apparatus comprises extending a plurality of resilient arms having tissue engaging members disposed thereon through the opening of the body tissue in an unexpanded state in which distal ends of the resilient arms abut each other and expanding the resilient arms such that the tissue engaging members engage the interior surface of the body tissue.
  28. 28. The method according to claim 27, wherein the resilient arms bias toward the expanded state and a control sheath is used to control movement between the expanded and unexpanded states.
  29. 29. The method according to claim 24, wherein deploying the tissue eversion apparatus comprises extending a deflated balloon having tissue engaging members through the opening of the body tissue and inflating the balloon to cause the tissue engaging members to engage the interior surface of the body tissue.
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Cited By (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120296374A1 (en) * 2011-05-19 2012-11-22 Abbott Cardiovascular Systems, Inc. Tissue eversion apparatus and tissue closure device and methods for use thereof
US8556930B2 (en) 2006-06-28 2013-10-15 Abbott Laboratories Vessel closure device
US8556932B2 (en) 2011-05-19 2013-10-15 Abbott Cardiovascular Systems, Inc. Collapsible plug for tissue closure
US8579932B2 (en) 2002-02-21 2013-11-12 Integrated Vascular Systems, Inc. Sheath apparatus and methods for delivering a closure device
US8585836B2 (en) 2002-12-31 2013-11-19 Integrated Vascular Systems, Inc. Methods for manufacturing a clip and clip
US8590760B2 (en) 2004-05-25 2013-11-26 Abbott Vascular Inc. Surgical stapler
US8597325B2 (en) 2000-12-07 2013-12-03 Integrated Vascular Systems, Inc. Apparatus and methods for providing tactile feedback while delivering a closure device
US8617184B2 (en) 2011-02-15 2013-12-31 Abbott Cardiovascular Systems, Inc. Vessel closure system
US8657852B2 (en) 2008-10-30 2014-02-25 Abbott Vascular Inc. Closure device
US8672953B2 (en) 2007-12-17 2014-03-18 Abbott Laboratories Tissue closure system and methods of use
US8690910B2 (en) 2000-12-07 2014-04-08 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8728119B2 (en) 2001-06-07 2014-05-20 Abbott Vascular Inc. Surgical staple
US8758400B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Closure system and methods of use
US8758396B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US8758398B2 (en) 2006-09-08 2014-06-24 Integrated Vascular Systems, Inc. Apparatus and method for delivering a closure element
US8758399B2 (en) 2010-08-02 2014-06-24 Abbott Cardiovascular Systems, Inc. Expandable bioabsorbable plug apparatus and method
US20140200409A1 (en) * 2013-01-17 2014-07-17 Abbott Cardiovascular Systems, Inc. Access device for accessing tissue
US8784447B2 (en) 2000-09-08 2014-07-22 Abbott Vascular Inc. Surgical stapler
US8808310B2 (en) 2006-04-20 2014-08-19 Integrated Vascular Systems, Inc. Resettable clip applier and reset tools
US8821534B2 (en) 2010-12-06 2014-09-02 Integrated Vascular Systems, Inc. Clip applier having improved hemostasis and methods of use
US8820602B2 (en) 2007-12-18 2014-09-02 Abbott Laboratories Modular clip applier
US20140257341A1 (en) * 2013-03-06 2014-09-11 St. Jude Medical, Cardiology Division, Inc. Pmvr clip configurations for mitral leaflet
US8858594B2 (en) 2008-12-22 2014-10-14 Abbott Laboratories Curved closure device
US8893947B2 (en) 2007-12-17 2014-11-25 Abbott Laboratories Clip applier and methods of use
US8905937B2 (en) 2009-02-26 2014-12-09 Integrated Vascular Systems, Inc. Methods and apparatus for locating a surface of a body lumen
US8920442B2 (en) 2005-08-24 2014-12-30 Abbott Vascular Inc. Vascular opening edge eversion methods and apparatuses
US8926633B2 (en) 2005-06-24 2015-01-06 Abbott Laboratories Apparatus and method for delivering a closure element
US8926656B2 (en) 2003-01-30 2015-01-06 Integated Vascular Systems, Inc. Clip applier and methods of use
US20150012006A1 (en) * 2013-07-02 2015-01-08 Cardica, Inc. Anastomosis stapling/clipping devices, systems and methods
US8932324B2 (en) 2005-08-24 2015-01-13 Abbott Vascular Inc. Redundant tissue closure methods and apparatuses
US20150038800A1 (en) * 2013-08-02 2015-02-05 Covidien Lp Devices, systems, and methods for wound closure
US8956388B2 (en) 2000-01-05 2015-02-17 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant
US20150057682A1 (en) * 2012-02-01 2015-02-26 St. Jude Medical, Inc. Clip delivery system for heart valve repair and method of use
US9050068B2 (en) 2005-07-01 2015-06-09 Abbott Laboratories Clip applier and methods of use
US9089674B2 (en) 2000-10-06 2015-07-28 Integrated Vascular Systems, Inc. Apparatus and methods for positioning a vascular sheath
US9089311B2 (en) 2009-01-09 2015-07-28 Abbott Vascular Inc. Vessel closure devices and methods
US20150250461A1 (en) * 2012-09-26 2015-09-10 Eric Berreklouw Constrictor for closing or narrowing a passage through tissue of a hollow organ
US9173644B2 (en) 2009-01-09 2015-11-03 Abbott Vascular Inc. Closure devices, systems, and methods
US9271707B2 (en) 2003-01-30 2016-03-01 Integrated Vascular Systems, Inc. Clip applier and methods of use
US9282965B2 (en) 2008-05-16 2016-03-15 Abbott Laboratories Apparatus and methods for engaging tissue
US9295469B2 (en) 2002-06-04 2016-03-29 Abbott Vascular Inc. Blood vessel closure clip and delivery device
US9320522B2 (en) 2000-12-07 2016-04-26 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
WO2016069779A1 (en) * 2014-10-28 2016-05-06 Trocare, LLC Fascia closure device and method
US9332976B2 (en) 2011-11-30 2016-05-10 Abbott Cardiovascular Systems, Inc. Tissue closure device
US9398914B2 (en) 2003-01-30 2016-07-26 Integrated Vascular Systems, Inc. Methods of use of a clip applier
US9414820B2 (en) 2009-01-09 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US9456811B2 (en) 2005-08-24 2016-10-04 Abbott Vascular Inc. Vascular closure methods and apparatuses
US9486191B2 (en) 2009-01-09 2016-11-08 Abbott Vascular, Inc. Closure devices
US9579091B2 (en) 2000-01-05 2017-02-28 Integrated Vascular Systems, Inc. Closure system and methods of use
WO2017053872A1 (en) * 2015-09-25 2017-03-30 Steven Craig Anderson Apparatus and method for adhesion
US9955960B2 (en) 2011-02-26 2018-05-01 Abbott Cardiovascular Systems, Inc. Hinged tissue support device

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9945133B2 (en) * 2011-11-15 2018-04-17 New Standards Manufacturing Co. System and method for aligning and leveling tile

Citations (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1242139A (en) * 1915-08-20 1917-10-09 Robert L Callahan Means for fastening sacks.
US1480935A (en) * 1922-04-03 1924-01-15 Dora P Gleason Barrette
US3348595A (en) * 1967-03-15 1967-10-24 Walter Landor Bag closure structure
US3357070A (en) * 1966-03-11 1967-12-12 Harriet L Soloan Accessories for hairdos and articles of apparel
US3682180A (en) * 1970-06-08 1972-08-08 Coilform Co Inc Drain clip for surgical drain
US4189808A (en) * 1978-09-20 1980-02-26 Brown Theodore G Retainer and closure for a garbage can liner bag
US4267995A (en) * 1979-10-09 1981-05-19 Mcmillan Ronald R Wire holder
US4697312A (en) * 1985-06-27 1987-10-06 Haagexport, B.V. Device for carrying and closing bags
US5404621A (en) * 1994-03-10 1995-04-11 Heinke; Richard M. Closure for plastic bags
US5669935A (en) * 1995-07-28 1997-09-23 Ethicon, Inc. One-way suture retaining device for braided sutures
US5735736A (en) * 1994-06-06 1998-04-07 Volk Enterprises, Inc. Retainer for poultry hocks
US5845657A (en) * 1997-05-29 1998-12-08 Carberry; Geoff Hair styling device
US6095155A (en) * 1997-05-16 2000-08-01 Criscuolo; Joseph Michael Paul Retaining apparatus
US6120513A (en) * 1998-01-09 2000-09-19 Bailey; Robert W. Laparoscopic surgery instrumentation and method of its use
US6161263A (en) * 1997-06-25 2000-12-19 Anderson; Paul Sock pair retention apparatus
US20010053909A1 (en) * 2000-05-26 2001-12-20 Olympus Optical Co., Ltd. Endoscope hood for mucous membrane resection
US6578585B1 (en) * 2001-02-21 2003-06-17 Barbara Stachowski Barrette
US6613060B2 (en) * 1997-06-02 2003-09-02 Scimed Life Systems, Inc. Textured ligating band
US6676685B2 (en) * 1999-02-22 2004-01-13 Tyco Healthcare Group Lp Arterial hole closure apparatus
US6695867B2 (en) * 2002-02-21 2004-02-24 Integrated Vascular Systems, Inc. Plunger apparatus and methods for delivering a closure device
US6736822B2 (en) * 2002-02-20 2004-05-18 Mcclellan Scott B. Device and method for internal ligation of tubular structures
US6849078B2 (en) * 1999-11-18 2005-02-01 Ovesco Endoscopy, Gmbh Apparatus and method for compressing body tissue
US6904647B2 (en) * 1999-02-10 2005-06-14 James H. Byers, Jr. Clamping devices
US6942674B2 (en) * 2000-01-05 2005-09-13 Integrated Vascular Systems, Inc. Apparatus and methods for delivering a closure device
US6984238B2 (en) * 1995-02-24 2006-01-10 Gifford Iii Hanson S Devices and methods for performing avascular anastomosis
US20060058844A1 (en) * 2004-09-13 2006-03-16 St. Jude Medical Puerto Rico B.V. Vascular sealing device with locking system
US20070049968A1 (en) * 2005-08-24 2007-03-01 Sibbitt Wilmer L Jr Vascular opening edge eversion methods and apparatuses
US20070060951A1 (en) * 2005-09-15 2007-03-15 Shannon Francis L Atrial tissue fixation device
US20070123936A1 (en) * 2005-11-15 2007-05-31 Aoi Medical, Inc. Arterial Closure Button
US20070213747A1 (en) * 2006-03-09 2007-09-13 Leonid Monassevitch Surgical compression clips
US20080004636A1 (en) * 2005-07-01 2008-01-03 Abbott Laboratories Clip applier and methods of use
US20080065152A1 (en) * 2006-09-08 2008-03-13 Abbott Laboratories Apparatus and method for delivering a closure element
US20080287988A1 (en) * 2007-05-17 2008-11-20 Smith Paul J Tissue aperture securing and sealing apparatuses and related methods of use
US20090105728A1 (en) * 2007-10-23 2009-04-23 Minos Medical Devices and methods for securing tissue
US20090157101A1 (en) * 2007-12-17 2009-06-18 Abbott Laboratories Tissue closure system and methods of use
US20090306681A1 (en) * 2006-01-30 2009-12-10 Del Nido Pedro J Tissue tack
US7645285B2 (en) * 2004-05-26 2010-01-12 Idx Medical, Ltd Apparatus and methods for occluding a hollow anatomical structure
US20100130965A1 (en) * 2005-08-24 2010-05-27 Abbott Vascular Inc. Redundant Tissue Closure Methods and Apparatuses
US7799042B2 (en) * 2004-05-13 2010-09-21 The Cleveland Clinic Foundation Skin lesion exciser and skin-closure device therefor
US20110066163A1 (en) * 2009-09-14 2011-03-17 National Cancer Center Hemostatic Clip and Hemostatic Clip Operation Apparatus Using the Same
US8226666B2 (en) * 2003-03-14 2012-07-24 Edwards Lifesciences Corporation Mitral valve repair system and method for use

Family Cites Families (894)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US287046A (en) 1883-10-23 Combined cork and screw nozzle
US438400A (en) 1890-10-14 Connector for electric conductors
US556082A (en) 1896-03-10 Julius boeddinghaus
US1088393A (en) 1913-09-20 1914-02-24 Oscar E Backus Button.
US1331401A (en) 1919-09-12 1920-02-17 Summers Henry Clay Button-fastening
US1596004A (en) 1923-04-04 1926-08-17 Bengoa Miguel Becerro De Hypodermic syringe
US1647958A (en) 1926-11-02 1927-11-01 Ariberto E Ciarlante Hair-curling material and method of preparing the same
US1880569A (en) 1930-09-27 1932-10-04 John P Weis Surgical clip applying instrument
US2087074A (en) 1936-08-17 1937-07-13 Tucker Ralph Button
US2108206A (en) 1937-03-09 1938-02-15 Lillian Pearl Mecker Tenaculum
US2210061A (en) 1939-01-24 1940-08-06 Aircraft Screw Prod Co Inserting tool
US2254620A (en) 1939-11-14 1941-09-02 George I Miller Clip
US2371978A (en) 1941-12-13 1945-03-20 Roy G Perham Clamp for retaining the edges of a wound in apposition
US2316297A (en) 1943-01-15 1943-04-13 Beverly A Southerland Surgical instrument
US2453227A (en) 1946-09-21 1948-11-09 George Martin Button staple anchor and shield
US2583625A (en) 1946-10-29 1952-01-29 Thomas & Betts Corp Method of and tool for crimping tubes
US2610631A (en) 1949-11-02 1952-09-16 David J Calicchio Ligator
US2910067A (en) 1952-10-13 1959-10-27 Technical Oil Tool Corp Wound clip and extractor therefor
US2684070A (en) 1953-03-23 1954-07-20 Walter L Kelsey Surgical clip
US2755699A (en) 1953-07-16 1956-07-24 Heli Coil Corp Wire coil screw thread insert with grip end having an angular configuration
US2951482A (en) 1955-09-22 1960-09-06 Gregory B Sullivan Surgical saw
US3113379A (en) 1956-02-28 1963-12-10 Joseph J Frank Closure fastening
US2944311A (en) 1956-10-20 1960-07-12 Schneckenberger Adolf Detachable fastening device
US2969887A (en) 1959-04-08 1961-01-31 American Thermos Products Comp Threaded pouring lip stopper combination for vacuum bottle
US3015403A (en) 1959-04-08 1962-01-02 American Thermos Products Comp Threaded stopper expanding pouring lip combination for vacuum bottle
US3120230A (en) 1960-10-24 1964-02-04 Jack H Sanders Surgical clamp
US3209754A (en) 1961-08-10 1965-10-05 Ernest C Wood Surgical clip
US3142878A (en) 1963-04-10 1964-08-04 James V Santora Staple button fastener
US3494533A (en) 1966-10-10 1970-02-10 United States Surgical Corp Surgical stapler for stitching body organs
US3482428A (en) 1967-07-12 1969-12-09 Nikolai Nikolaevich Kapitanov Surgical apparatus for suturing tissues with metal staples
US3523351A (en) 1967-10-20 1970-08-11 Sargent & Co Locator and holder in a crimping tool for an electrical connector
US3586002A (en) 1968-01-08 1971-06-22 Ernest C Wood Surgical skin clip
US3510923A (en) 1968-06-20 1970-05-12 American Hospital Supply Corp Parallel jaw ratchet clip and retractor
US3604425A (en) 1969-04-11 1971-09-14 New Research And Dev Lab Inc Hemostatic clip
US3618447A (en) 1969-09-15 1971-11-09 Phillips Petroleum Co Deterioration fasteners
US3985138A (en) 1972-08-25 1976-10-12 Jarvik Robert K Preformed ligatures for bleeders and methods of applying such ligatures
DE2157911C2 (en) 1970-12-11 1982-02-04 Marc Edmond Jean Van Bruxelles Be Hoorn
US3757629A (en) 1971-05-10 1973-09-11 R Schneider Resilient plastic staple
DE2133304B2 (en) 1971-07-05 1977-03-24 Transvenous unipolar pacemaker electrode assembly
BE789131A (en) 1971-09-24 1973-03-22 Extracorporeal Med Spec surgical needle for performing medical operations
US3856018A (en) 1973-02-26 1974-12-24 P Perisse Process for ligating sectioned blood vessels
US3856016A (en) 1972-11-03 1974-12-24 H Davis Method for mechanically applying an occlusion clip to an anatomical tubular structure
US3823719A (en) 1972-11-14 1974-07-16 Acme United Corp Finger operated forceps type surgical instrument
GB1358466A (en) 1972-11-22 1974-07-03 Vnii Ispytatel Med Tech Surgical instrument for stitching tissue with suture wire
US3874388A (en) 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US3828791A (en) 1973-03-21 1974-08-13 M Santos Surgical instruments
US3805337A (en) 1973-04-23 1974-04-23 Raymond Lee Organization Inc Spring wire hose clamp
GB1413191A (en) 1973-07-04 1975-11-12 Vnii Khirurgicheskoi Apparatur Device for the eversion of hollow organs and vascular stapling instrument incorporating same
US4018229A (en) 1974-09-13 1977-04-19 Olympus Optical Co., Ltd. Apparatus for ligation of affected part in coeloma
NL7403762A (en) 1974-03-20 1975-09-23 Leer Koninklijke Emballage Plug of plastics or the like material, provided with external screw thread.
DE2513868C2 (en) 1974-04-01 1982-11-04 Olympus Optical Co., Ltd., Tokyo, Jp
US3939820A (en) 1974-10-29 1976-02-24 Datascope Corporation Single-chamber, multi-section balloon for cardiac assistance
US3926194A (en) 1974-11-20 1975-12-16 Ethicon Inc Sutures with reduced diameter at suture tip
US4018228A (en) 1975-02-24 1977-04-19 Goosen Carl C Surgical punch apparatus
US3960147A (en) 1975-03-10 1976-06-01 Murray William M Compression bone staples and methods of compressing bone segments
GB1486351A (en) 1975-06-06 1977-09-21 Rocket Of London Ltd Surgical clip applicator
US4014492A (en) 1975-06-11 1977-03-29 Senco Products, Inc. Surgical staple
US4007743A (en) 1975-10-20 1977-02-15 American Hospital Supply Corporation Opening mechanism for umbrella-like intravascular shunt defect closure device
US4359052A (en) 1976-01-26 1982-11-16 Concept Inc. Removable tip cautery
GB1526186A (en) 1976-04-28 1978-09-27 Kendall & Co Device for testing whether a tip of a hollow needle inserted in a patient's body is in a region of sub-or supra-atmospheric pressure
DE2730691C2 (en) 1976-07-16 1982-12-16 Maruho Co. Ltd., Osaka, Jp
US4047533A (en) 1976-09-20 1977-09-13 American Cyanamid Company Absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant
US4112944A (en) 1976-12-13 1978-09-12 Williams Gayland M Tube clamp and piercing device
DE2658478C2 (en) 1976-12-23 1978-11-30 Aesculap-Werke Ag Vormals Jetter & Scheerer, 7200 Tuttlingen
US4204541A (en) 1977-01-24 1980-05-27 Kapitanov Nikolai N Surgical instrument for stitching up soft tissues with lengths of spiked suture material
US4153321A (en) 1977-03-17 1979-05-08 Kravex Manufacturing Company Battery booster cable
US4217902A (en) 1977-05-02 1980-08-19 March Alfred L Hemostatic clip
US4169476A (en) 1977-08-12 1979-10-02 Wolf Medical Instruments Corporation Applicator for surgical clip
US4201215A (en) 1977-09-06 1980-05-06 Crossett E S Apparatus and method for closing a severed sternum
US4345606A (en) 1977-12-13 1982-08-24 Littleford Philip O Split sleeve introducers for pacemaker electrodes and the like
US4215699A (en) 1978-04-03 1980-08-05 The Kendall Company Position indicating device
US4207870A (en) 1978-06-15 1980-06-17 Becton, Dickinson And Company Blood sampling assembly having porous vent means vein entry indicator
US4273129A (en) 1978-06-29 1981-06-16 Richard Wolf Gmbh Forceps for applying clips to fallopian tubes
USRE31855F1 (en) 1978-12-01 1986-08-19 Tear apart cannula
US4355751A (en) 1978-12-08 1982-10-26 Kapitanov Nikolai N Surgical instrument for suturing cutaneous tissue
US4214587A (en) 1979-02-12 1980-07-29 Sakura Chester Y Jr Anastomosis device and method
US4440170A (en) 1979-03-06 1984-04-03 Ethicon, Inc. Surgical clip applying instrument
US4278091A (en) 1980-02-01 1981-07-14 Howmedica, Inc. Soft tissue retainer for use with bone implants, especially bone staples
US4396139A (en) 1980-02-15 1983-08-02 Technalytics, Inc. Surgical stapling system, apparatus and staple
US4317451A (en) 1980-02-19 1982-03-02 Ethicon, Inc. Plastic surgical staple
US4317445A (en) 1980-03-31 1982-03-02 Baxter Travenol Laboratories, Inc. Catheter insertion unit with separate flashback indication for the cannula
US4318401A (en) 1980-04-24 1982-03-09 President And Fellows Of Harvard College Percutaneous vascular access portal and catheter
US4428376A (en) 1980-05-02 1984-01-31 Ethicon Inc. Plastic surgical staple
FR2481594B1 (en) 1980-05-02 1985-01-04 Ethicon Inc
US4327485A (en) 1980-05-21 1982-05-04 Amp Incorporated Pistol grip tool
US4407286A (en) 1980-08-25 1983-10-04 United States Surgical Corporation Surgical staples
US4505274A (en) 1980-10-17 1985-03-19 Propper Manufacturing Co., Inc. Suture clip
US4368736A (en) 1980-11-17 1983-01-18 Kaster Robert L Anastomotic fitting
US4526174A (en) 1981-03-27 1985-07-02 Minnesota Mining And Manufacturing Company Staple and cartridge for use in a tissue stapling device and a tissue closing method
US4412832A (en) 1981-04-30 1983-11-01 Baxter Travenol Laboratories, Inc. Peelable catheter introduction device
US4411654A (en) 1981-04-30 1983-10-25 Baxter Travenol Laboratories, Inc. Peelable catheter with securing ring and suture sleeve
US4485816A (en) 1981-06-25 1984-12-04 Alchemia Shape-memory surgical staple apparatus and method for use in surgical suturing
US4449531A (en) 1981-08-27 1984-05-22 Ethicon, Inc. Non-metallic, bio-compatible hemostatic clips with interlocking latch means
US4480356A (en) 1981-10-07 1984-11-06 Martin Donald A Double-grip clip
US4724840A (en) 1982-02-03 1988-02-16 Ethicon, Inc. Surgical fastener applier with rotatable front housing and laterally extending curved needle for guiding a flexible pusher
DE3204532C2 (en) 1982-02-10 1983-12-08 B. Braun Melsungen Ag, 3508 Melsungen, De
DE3204522C2 (en) 1982-02-10 1988-08-25 B. Braun Melsungen Ag, 3508 Melsungen, De
US4475544A (en) 1982-02-23 1984-10-09 Reis Norman I Bone gripping forceps
US4860746A (en) 1982-04-20 1989-08-29 Inbae Yoon Elastic surgical ring clip and ring loader
US4664305A (en) 1982-05-04 1987-05-12 Blake Joseph W Iii Surgical stapler
JPS58181006U (en) 1982-05-28 1983-12-03
US4501276A (en) 1982-07-16 1985-02-26 Illinois Tool Works Inc. Fetal electrode apparatus
US4934364A (en) 1982-09-30 1990-06-19 United States Surgical Corporation Surgical clip applying apparatus having fixed jams
US4523591A (en) 1982-10-22 1985-06-18 Kaplan Donald S Polymers for injection molding of absorbable surgical devices
US4525157A (en) 1983-07-28 1985-06-25 Manresa, Inc. Closed system catheter with guide wire
US4665906A (en) 1983-10-14 1987-05-19 Raychem Corporation Medical devices incorporating sim alloy elements
US4586503A (en) 1983-12-01 1986-05-06 University Of New Mexico Surgical microclip
US4929240A (en) 1983-12-01 1990-05-29 University Of New Mexico Surgical clip and applier
US5104399A (en) 1986-12-10 1992-04-14 Endovascular Technologies, Inc. Artificial graft and implantation method
US6221102B1 (en) 1983-12-09 2001-04-24 Endovascular Technologies, Inc. Intraluminal grafting system
US4917087A (en) 1984-04-10 1990-04-17 Walsh Manufacturing (Mississuaga) Limited Anastomosis devices, kits and method
US4607638A (en) 1984-04-20 1986-08-26 Design Standards Corporation Surgical staples
DE3420455C1 (en) 1984-06-01 1985-05-15 Peter Dr-Ing Osypka Separating means for Einfuehrungshuelse
US4610252A (en) 1984-10-15 1986-09-09 Catalano J Denis Dual muscle clamp
US4651737A (en) 1984-10-15 1987-03-24 American Cyanamid Company Nonmetallic surgical clip
US4596559A (en) 1984-11-02 1986-06-24 Fleischhacker John J Break-away handle for a catheter introducer set
US4610251A (en) 1985-04-19 1986-09-09 Kumar Sarbjeet S Surgical staple
US4635634A (en) 1985-07-12 1987-01-13 Santos Manuel V Surgical clip applicator system
CN85106639B (en) 1985-09-03 1988-08-03 第三军医大学野战外科研究所 Instrument for blood vessel anastomosis
DE3533423C2 (en) 1985-09-19 1990-02-22 Richard Wolf Gmbh, 7134 Knittlingen, De
US4834757A (en) 1987-01-22 1989-05-30 Brantigan John W Prosthetic implant
US4693249A (en) 1986-01-10 1987-09-15 Schenck Robert R Anastomosis device and method
JPH0522551B2 (en) 1986-04-09 1993-03-29 Terumo Corp
US4777950A (en) 1986-04-11 1988-10-18 Kees Surgical Specialty Co. Vascular clip
US4967949A (en) 1986-07-11 1990-11-06 Vastech Medical Products Inc. Apparatus for effecting occlusion of the vas deferens
US4874122A (en) 1986-07-14 1989-10-17 Minnesota Mining And Manufacturing Company Bent back box staple and staple closing mechanism with split actuator
DE3630210C2 (en) 1986-09-04 1989-10-05 Wisap Gesellschaft Fuer Wissenschaftlichen Apparatebau Mbh, 8029 Sauerlach, De
US4738658A (en) 1986-09-19 1988-04-19 Aries Medical Incorporated Tapered hemostatic device for use in conjunction with a catheter for alleviating blood leakage and method for using same
US4789090A (en) 1986-11-03 1988-12-06 Blake Joseph W Iii Surgical stapler
US4771782A (en) 1986-11-14 1988-09-20 Millar Instruments, Inc. Method and assembly for introducing multiple catheters into a biological vessel
US4744364A (en) 1987-02-17 1988-05-17 Intravascular Surgical Instruments, Inc. Device for sealing percutaneous puncture in a vessel
US4852568A (en) 1987-02-17 1989-08-01 Kensey Nash Corporation Method and apparatus for sealing an opening in tissue of a living being
US4719917A (en) 1987-02-17 1988-01-19 Minnesota Mining And Manufacturing Company Surgical staple
US4890612A (en) 1987-02-17 1990-01-02 Kensey Nash Corporation Device for sealing percutaneous puncture in a vessel
USRE34866E (en) 1987-02-17 1995-02-21 Kensey Nash Corporation Device for sealing percutaneous puncture in a vessel
US4865026A (en) 1987-04-23 1989-09-12 Barrett David M Sealing wound closure device
US4772266A (en) 1987-05-04 1988-09-20 Catheter Technology Corp. Catheter dilator/sheath assembly and method
US5478353A (en) 1987-05-14 1995-12-26 Yoon; Inbae Suture tie device system and method for suturing anatomical tissue proximate an opening
US5100418A (en) 1987-05-14 1992-03-31 Inbae Yoon Suture tie device system and applicator therefor
US5171250A (en) 1987-05-14 1992-12-15 Inbae Yoon Surgical clips and surgical clip applicator and cutting and transection device
US5366459A (en) 1987-05-14 1994-11-22 Inbae Yoon Surgical clip and clip application procedures
US4836204A (en) 1987-07-06 1989-06-06 Landymore Roderick W Method for effecting closure of a perforation in the septum of the heart
JPH0579336B2 (en) 1987-07-14 1993-11-02 Bikutoru Arekuseebich Ripatofu
US4887601A (en) 1987-11-06 1989-12-19 Ophthalmic Ventures Limited Partnership Adjustable surgical staple and method of using the same
US5030226A (en) 1988-01-15 1991-07-09 United States Surgical Corporation Surgical clip applicator
JP2561853B2 (en) 1988-01-28 1996-12-11 株式会社ジェイ・エム・エス Compacts and methods of use thereof with a shape memory
US5114065A (en) 1988-05-23 1992-05-19 Technalytics, Inc. Surgical stapler
US5254105A (en) 1988-05-26 1993-10-19 Haaga John R Sheath for wound closure caused by a medical tubular device
US5330445A (en) 1988-05-26 1994-07-19 Haaga John R Sheath for wound closure caused by a medical tubular device
CA2004658C (en) 1988-06-03 1995-10-10 Michael A. Oberlander Arthroscopic clip and insertion tool
US5002562A (en) 1988-06-03 1991-03-26 Oberlander Michael A Surgical clip
US5015247A (en) 1988-06-13 1991-05-14 Michelson Gary K Threaded spinal implant
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4885003A (en) 1988-07-25 1989-12-05 Cordis Corporation Double mesh balloon catheter device
US4917089A (en) 1988-08-29 1990-04-17 Sideris Eleftherios B Buttoned device for the transvenous occlusion of intracardiac defects
CA2000360A1 (en) 1988-10-11 1990-04-11 Stephen J. Failla Ophthalmic staple and instruments for implementing use
US5047047A (en) 1988-10-26 1991-09-10 Inbae Yoon Wound closing device
US4961729A (en) 1988-12-13 1990-10-09 Vaillancourt Vincent L Catheter insertion assembly
US4976721A (en) 1988-12-14 1990-12-11 The Research Foundation Of State University Of New York Surgical clamping device
US4886067A (en) 1989-01-03 1989-12-12 C. R. Bard, Inc. Steerable guidewire with soft adjustable tip
FR2641692B1 (en) 1989-01-17 1995-05-12 Nippon Zeon Co
US4997439A (en) 1989-01-26 1991-03-05 Chen Fusen H Surgical closure or anastomotic device
JPH07103457B2 (en) 1989-02-10 1995-11-08 トミー株式会社 Form method of applying shape memory alloy orthodontic wire
US4983176A (en) 1989-03-06 1991-01-08 University Of New Mexico Deformable plastic surgical clip
US5053047A (en) 1989-05-16 1991-10-01 Inbae Yoon Suture devices particularly useful in endoscopic surgery and methods of suturing
US5100422A (en) 1989-05-26 1992-03-31 Impra, Inc. Blood vessel patch
US5620461A (en) 1989-05-29 1997-04-15 Muijs Van De Moer; Wouter M. Sealing device
US6764500B1 (en) 1989-05-29 2004-07-20 Kensey Nash Corporation Sealing device
US5007921A (en) 1989-10-26 1991-04-16 Brown Alan W Surgical staple
US5026390A (en) 1989-10-26 1991-06-25 Brown Alan W Surgical staple
US5059201A (en) 1989-11-03 1991-10-22 Asnis Stanley E Suture threading, stitching and wrapping device for use in open and closed surgical procedures
GB8924806D0 (en) 1989-11-03 1989-12-20 Neoligaments Ltd Prosthectic ligament system
US5122122A (en) 1989-11-22 1992-06-16 Dexide, Incorporated Locking trocar sleeve
US5061274A (en) 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
WO1993007813A1 (en) 1989-12-04 1993-04-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5797958A (en) 1989-12-05 1998-08-25 Yoon; Inbae Endoscopic grasping instrument with scissors
US5226908A (en) 1989-12-05 1993-07-13 Inbae Yoon Multi-functional instruments and stretchable ligating and occluding devices
US5421832A (en) 1989-12-13 1995-06-06 Lefebvre; Jean-Marie Filter-catheter and method of manufacturing same
US5156609A (en) 1989-12-26 1992-10-20 Nakao Naomi L Endoscopic stapling device and method
US5891088A (en) 1990-02-02 1999-04-06 Ep Technologies, Inc. Catheter steering assembly providing asymmetric left and right curve configurations
US5035692A (en) 1990-02-13 1991-07-30 Nicholas Herbert Hemostasis clip applicator
US5197971A (en) 1990-03-02 1993-03-30 Bonutti Peter M Arthroscopic retractor and method of using the same
US5032127A (en) 1990-03-07 1991-07-16 Frazee John G Hemostatic clip and applicator therefor
US5167643A (en) 1990-04-27 1992-12-01 Lynn Lawrence A Needle protection station
US5021059A (en) 1990-05-07 1991-06-04 Kensey Nash Corporation Plug device with pulley for sealing punctures in tissue and methods of use
DE4014653A1 (en) 1990-05-08 1991-11-14 Beiersdorf Ag surgical clamp
US5116349A (en) 1990-05-23 1992-05-26 United States Surgical Corporation Surgical fastener apparatus
US5078731A (en) 1990-06-05 1992-01-07 Hayhurst John O Suture clip
US5041129A (en) 1990-07-02 1991-08-20 Acufex Microsurgical, Inc. Slotted suture anchor and method of anchoring a suture
US5193533A (en) 1990-07-09 1993-03-16 Brigham And Women's Hospital High-pressure jet ventilation catheter
US5176691A (en) 1990-09-11 1993-01-05 Pierce Instruments, Inc. Knot pusher
US5391183A (en) 1990-09-21 1995-02-21 Datascope Investment Corp Device and method sealing puncture wounds
US7008439B1 (en) 1990-09-21 2006-03-07 Datascope Investments Corp. Device and method for sealing puncture wounds
US5108421A (en) 1990-10-01 1992-04-28 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5192300A (en) 1990-10-01 1993-03-09 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
CA2027427A1 (en) 1990-10-12 1992-04-13 William S. Laidlaw Plug for sealing wood preservative in wood structures
FR2668361B1 (en) 1990-10-30 1995-04-21 Christian Mai
US5053008A (en) 1990-11-21 1991-10-01 Sandeep Bajaj Intracardiac catheter
US5366458A (en) 1990-12-13 1994-11-22 United States Surgical Corporation Latchless surgical clip
US5122156A (en) 1990-12-14 1992-06-16 United States Surgical Corporation Apparatus for securement and attachment of body organs
CA2055985A1 (en) 1990-12-20 1992-06-21 Daniel Shichman Fascia clip
US5425489A (en) 1990-12-20 1995-06-20 United States Surgical Corporation Fascia clip and instrument
US5419765A (en) 1990-12-27 1995-05-30 Novoste Corporation Wound treating device and method for treating wounds
US5250058A (en) 1991-01-17 1993-10-05 Ethicon, Inc. Absorbable anastomosic fastener means
US5131379A (en) 1991-01-29 1992-07-21 Sewell Jr Frank K Device and method for inserting a cannula into a duct
US5108420A (en) 1991-02-01 1992-04-28 Temple University Aperture occlusion device
CA2060040A1 (en) 1991-02-08 1992-08-10 Miguel A. Velez Surgical staple and endoscopic stapler
US5133360A (en) 1991-03-07 1992-07-28 Spears Colin P Spears retriever
US5470010A (en) 1991-04-04 1995-11-28 Ethicon, Inc. Multiple fire endoscopic stapling mechanism
US5171249A (en) 1991-04-04 1992-12-15 Ethicon, Inc. Endoscopic multiple ligating clip applier
US5192287A (en) 1991-04-05 1993-03-09 American Cyanamid Company Suture knot tying device
US5192602A (en) 1991-05-14 1993-03-09 Spencer Victor V Louvered filter and paint arrestor
US5217471A (en) 1991-05-30 1993-06-08 Burkhart Stephen S Endoscopic suture knotting instrument
US5243857A (en) 1991-06-14 1993-09-14 Molex Incorporated Fixture for testing electrical terminations
US5207697A (en) 1991-06-27 1993-05-04 Stryker Corporation Battery powered surgical handpiece
US5236435A (en) 1991-07-22 1993-08-17 Sewell Jr Frank Laparoscopic surgical staple system
US5167634A (en) 1991-08-22 1992-12-01 Datascope Investment Corp. Peelable sheath with hub connector
US5449359A (en) 1991-09-05 1995-09-12 Groiso; Jorge A. Elastic clip for osteosynthesis
US5246156A (en) 1991-09-12 1993-09-21 Ethicon, Inc. Multiple fire endoscopic stapling mechanism
CA2078530A1 (en) 1991-09-23 1993-03-24 Jay Erlebacher Percutaneous arterial puncture seal device and insertion tool therefore
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5289963A (en) 1991-10-18 1994-03-01 United States Surgical Corporation Apparatus and method for applying surgical staples to attach an object to body tissue
US5497933A (en) 1991-10-18 1996-03-12 United States Surgical Corporation Apparatus and method for applying surgical staples to attach an object to body tissue
US5141520A (en) 1991-10-29 1992-08-25 Marlowe Goble E Harpoon suture anchor
US5290310A (en) 1991-10-30 1994-03-01 Howmedica, Inc. Hemostatic implant introducer
EP0545091B1 (en) 1991-11-05 1999-07-07 The Children's Medical Center Corporation Occluder for repair of cardiac and vascular defects
US5282827A (en) 1991-11-08 1994-02-01 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US5676689A (en) 1991-11-08 1997-10-14 Kensey Nash Corporation Hemostatic puncture closure system including vessel location device and method of use
US5411520A (en) 1991-11-08 1995-05-02 Kensey Nash Corporation Hemostatic vessel puncture closure system utilizing a plug located within the puncture tract spaced from the vessel, and method of use
US5222974A (en) 1991-11-08 1993-06-29 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US5242456A (en) 1991-11-21 1993-09-07 Kensey Nash Corporation Apparatus and methods for clamping tissue and reflecting the same
US5176648A (en) 1991-12-13 1993-01-05 Unisurge, Inc. Introducer assembly and instrument for use therewith
US6056768A (en) 1992-01-07 2000-05-02 Cates; Christopher U. Blood vessel sealing system
DE4200255A1 (en) 1992-01-08 1993-07-15 Sueddeutsche Feinmechanik Spaltkanuele and methods for producing such
US5433721A (en) 1992-01-17 1995-07-18 Ethicon, Inc. Endoscopic instrument having a torsionally stiff drive shaft for applying fasteners to tissue
JP3393383B2 (en) 1992-01-21 2003-04-07 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Septal defect closure device
US5237996A (en) 1992-02-11 1993-08-24 Waldman Lewis K Endocardial electrical mapping catheter
US5163343A (en) 1992-02-21 1992-11-17 Gish Donald A System for fastening plies of fabric
US5509900A (en) 1992-03-02 1996-04-23 Kirkman; Thomas R. Apparatus and method for retaining a catheter in a blood vessel in a fixed position
US6059825A (en) 1992-03-05 2000-05-09 Angiodynamics, Inc. Clot filter
CA2090980C (en) 1992-03-06 2004-11-30 David Stefanchik Ligating clip applier
WO1993018711A1 (en) 1992-03-18 1993-09-30 Izi Corporation Post-surgical gross pathology specimen marker
US5304183A (en) 1992-03-23 1994-04-19 Laparomed Corporation Tethered clamp retractor
US5217024A (en) 1992-03-27 1993-06-08 Dorsey Denis P Tissue sampling device with visual and tactile indicator
WO1993020768A1 (en) 1992-04-13 1993-10-28 Ep Technologies, Inc. Steerable microwave antenna systems for cardiac ablation
US5236440A (en) 1992-04-14 1993-08-17 American Cyanamid Company Surgical fastener
US6063085A (en) 1992-04-23 2000-05-16 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
WO1993021844A1 (en) 1992-04-23 1993-11-11 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
US5290284A (en) 1992-05-01 1994-03-01 Adair Edwin Lloyd Laparoscopic surgical ligation and electrosurgical coagulation and cutting device
US5540712A (en) 1992-05-01 1996-07-30 Nitinol Medical Technologies, Inc. Stent and method and apparatus for forming and delivering the same
US5336231A (en) 1992-05-01 1994-08-09 Adair Edwin Lloyd Parallel channel fixation, repair and ligation suture device
US5242457A (en) 1992-05-08 1993-09-07 Ethicon, Inc. Surgical instrument and staples for applying purse string sutures
DE4215449C1 (en) 1992-05-11 1993-09-02 Ethicon Gmbh & Co Kg, 2000 Norderstedt, De
US5766246A (en) 1992-05-20 1998-06-16 C. R. Bard, Inc. Implantable prosthesis and method and apparatus for loading and delivering an implantable prothesis
US5192288A (en) 1992-05-26 1993-03-09 Origin Medsystems, Inc. Surgical clip applier
US5269792A (en) 1992-05-26 1993-12-14 Origin Medsystems, Inc. Surgical clip
US5431667A (en) 1992-05-26 1995-07-11 Origin Medsystems, Inc. Gas-sealed instruments for use in laparoscopic surgery
US5255679A (en) 1992-06-02 1993-10-26 Cardiac Pathways Corporation Endocardial catheter for mapping and/or ablation with an expandable basket structure having means for providing selective reinforcement and pressure sensing mechanism for use therewith, and method
US5797931A (en) 1992-06-04 1998-08-25 Olympus Optical Co., Ltd. Tissue-fixing surgical instrument, tissue-fixing device, and method of fixing tissues
JPH0647050A (en) 1992-06-04 1994-02-22 Olympus Optical Co Ltd Tissue suture and ligature device
CA2098896C (en) 1992-06-30 2005-03-29 H. Jonathan Tovey Specimen retrieval pouch and method for use
US5242459A (en) 1992-07-10 1993-09-07 Laparomed Corporation Device and method for applying a ligating loop
US5290243A (en) 1992-07-16 1994-03-01 Technalytics, Inc. Trocar system
US5413571A (en) 1992-07-16 1995-05-09 Sherwood Medical Company Device for sealing hemostatic incisions
US5403330A (en) 1992-07-17 1995-04-04 Tuason; Leo B. Suture knot pusher
US5443481A (en) 1992-07-27 1995-08-22 Lee; Benjamin I. Methods and device for percutaneous sealing of arterial puncture sites
US5292332A (en) 1992-07-27 1994-03-08 Lee Benjamin I Methods and device for percutanceous sealing of arterial puncture sites
US5334199A (en) 1992-08-17 1994-08-02 Inbae Yoon Ligating instrument and methods of ligating tissue in endoscopic operative procedures
US5342393A (en) 1992-08-27 1994-08-30 Duke University Method and device for vascular repair
US5364408A (en) 1992-09-04 1994-11-15 Laurus Medical Corporation Endoscopic suture system
US5471982A (en) 1992-09-29 1995-12-05 Ep Technologies, Inc. Cardiac mapping and ablation systems
US5306254A (en) 1992-10-01 1994-04-26 Kensey Nash Corporation Vessel position locating device and method of use
US5300078A (en) 1992-10-09 1994-04-05 Laparomed Corporation Device and method for applying large-diameter ligating loop
US5489288A (en) 1992-10-09 1996-02-06 Advanced Surgical, Inc. Device and method for applying large-diameter ligating loop
US5383905A (en) 1992-10-09 1995-01-24 United States Surgical Corporation Suture loop locking device
US5304184A (en) 1992-10-19 1994-04-19 Indiana University Foundation Apparatus and method for positive closure of an internal tissue membrane opening
US5383897A (en) 1992-10-19 1995-01-24 Shadyside Hospital Method and apparatus for closing blood vessel punctures
DE4235506A1 (en) 1992-10-21 1994-04-28 Bavaria Med Tech Catheter for injection of drugs
US5309927A (en) 1992-10-22 1994-05-10 Ethicon, Inc. Circular stapler tissue retention spring method
US5676974A (en) 1992-10-23 1997-10-14 Santiago H. Valdes Pharmaceutical compositions containing giroxina and phospholipase A2 and methods of increasing a patient's CD4 count using the pharmaceutical compositions
US5344439A (en) 1992-10-30 1994-09-06 Medtronic, Inc. Catheter with retractable anchor mechanism
FR2700464B1 (en) 1992-11-13 1995-04-14 Maurice Bertholet connecting piece for bony elements.
US5972000A (en) 1992-11-13 1999-10-26 Influence Medical Technologies, Ltd. Non-linear anchor inserter device and bone anchors
US5522840A (en) 1992-11-23 1996-06-04 Krajicek; Milan Device for the non-surgical seal of the interstice in the wall of a vessel
US5334216A (en) 1992-12-10 1994-08-02 Howmedica Inc. Hemostatic plug
US5417699A (en) 1992-12-10 1995-05-23 Perclose Incorporated Device and method for the percutaneous suturing of a vascular puncture site
US5653690A (en) * 1992-12-30 1997-08-05 Medtronic, Inc. Catheter having a balloon with retention enhancement
US5327908A (en) 1993-01-08 1994-07-12 United States Surgical Corporation Surgical apparatus for measuring body tissue
US5292309A (en) 1993-01-22 1994-03-08 Schneider (Usa) Inc. Surgical depth measuring instrument and method
US5304204A (en) 1993-02-09 1994-04-19 Ethicon, Inc. Receiverless surgical fasteners
US5425705A (en) 1993-02-22 1995-06-20 Stanford Surgical Technologies, Inc. Thoracoscopic devices and methods for arresting the heart
US5797960A (en) 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US5814058A (en) 1993-03-05 1998-09-29 Innerdyne, Inc. Method and apparatus employing conformable sleeve for providing percutaneous access
US5403331A (en) 1993-03-12 1995-04-04 United States Surgical Corporation Looped suture ligating device containing a heat-shrinkable element
US5320639A (en) 1993-03-12 1994-06-14 Meadox Medicals, Inc. Vascular plug delivery system
US5456400A (en) 1993-04-22 1995-10-10 United States Surgical Corporation Apparatus and clip for fastening body tissue
US5843167A (en) 1993-04-22 1998-12-01 C. R. Bard, Inc. Method and apparatus for recapture of hooked endoprosthesis
FR2704132B1 (en) 1993-04-23 1995-07-13 Ethnor System ligation and / or suture for endoscopic surgery.
DK0621032T3 (en) 1993-04-23 2000-10-23 Novartis Ag Pharmaceutical form with controlled release
US5335680A (en) 1993-04-26 1994-08-09 Moore Pamela K Hair clip
US5613975A (en) 1993-04-28 1997-03-25 Christy; William J. Endoscopic suturing device and method
US5447265A (en) 1993-04-30 1995-09-05 Minnesota Mining And Manufacturing Company Laparoscopic surgical instrument with a mechanism for preventing its entry into the abdominal cavity once it is depleted and removed from the abdominal cavity
US5352229A (en) 1993-05-12 1994-10-04 Marlowe Goble E Arbor press staple and washer and method for its use
US5383896A (en) 1993-05-25 1995-01-24 Gershony; Gary Vascular sealing device
US5478354A (en) 1993-07-14 1995-12-26 United States Surgical Corporation Wound closing apparatus and method
US5486195A (en) 1993-07-26 1996-01-23 Myers; Gene Method and apparatus for arteriotomy closure
US5507755A (en) 1993-08-03 1996-04-16 Origin Medsystems, Inc. Apparatus and method for closing puncture wounds
US5462561A (en) 1993-08-05 1995-10-31 Voda; Jan K. Suture device
US5830125A (en) 1993-08-12 1998-11-03 Scribner-Browne Medical Design Incorporated Catheter introducer with suture capability
US5431639A (en) 1993-08-12 1995-07-11 Boston Scientific Corporation Treating wounds caused by medical procedures
FR2710254B1 (en) 1993-09-21 1995-10-27 Mai Christian Clip multi-branches autorétentive dynamic compression osteosynthesis.
US5607436A (en) 1993-10-08 1997-03-04 United States Surgical Corporation Apparatus for applying surgical clips
US5560532A (en) 1993-10-08 1996-10-01 United States Surgical Corporation Apparatus and method for applying surgical staples to body tissue
US5725554A (en) 1993-10-08 1998-03-10 Richard-Allan Medical Industries, Inc. Surgical staple and stapler
CA2173990A1 (en) 1993-10-12 1995-04-20 Narasinga Rao A library of glyco-peptides useful for identification of cell adhesion inhibitors
US5776147A (en) 1993-10-20 1998-07-07 Applied Medical Resources Corporation Laparoscopic surgical clamp
US5423857A (en) 1993-11-02 1995-06-13 Ethicon, Inc. Three piece surgical staple
US5672174A (en) 1995-08-15 1997-09-30 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US5980517A (en) 1995-08-15 1999-11-09 Rita Medical Systems, Inc. Cell necrosis apparatus
US5951547A (en) 1995-08-15 1999-09-14 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US5728143A (en) 1995-08-15 1998-03-17 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US5527322A (en) 1993-11-08 1996-06-18 Perclose, Inc. Device and method for suturing of internal puncture sites
US5536267A (en) 1993-11-08 1996-07-16 Zomed International Multiple electrode ablation apparatus
US6569159B1 (en) 1993-11-08 2003-05-27 Rita Medical Systems, Inc. Cell necrosis apparatus
US5464413A (en) 1993-11-15 1995-11-07 Siska, Jr.; William Nose clip
US5476505A (en) 1993-11-18 1995-12-19 Advanced Cardiovascular Systems, Inc. Coiled stent and delivery system
NL194533C (en) 1993-12-08 2002-07-02 Benedict Marie Doorschodt Biopsy needle assembly.
US5609597A (en) 1993-12-09 1997-03-11 Lehrer; Theodor Apparatus and method of extracorporeally applying and locking laparoscopic suture and loop ligatures
WO1995016407A1 (en) 1993-12-13 1995-06-22 Brigham And Women's Hospital Aortic valve supporting device
US5492119A (en) 1993-12-22 1996-02-20 Heart Rhythm Technologies, Inc. Catheter tip stabilizing apparatus
CA2139979A1 (en) 1994-01-13 1995-07-14 Daniel C. Rosenman Spiral surgical tack
US5728122A (en) 1994-01-18 1998-03-17 Datascope Investment Corp. Guide wire with releaseable barb anchor
FR2715290B1 (en) 1994-01-25 1996-04-05 Newpact Eurl surgical clip ligaments.
US5443477A (en) 1994-02-10 1995-08-22 Stentco, Inc. Apparatus and method for deployment of radially expandable stents by a mechanical linkage
US5453090A (en) 1994-03-01 1995-09-26 Cordis Corporation Method of stent delivery through an elongate softenable sheath
DE4408108A1 (en) 1994-03-10 1995-09-14 Bavaria Med Tech A catheter for injecting a fluid or a Arneimittelns
US6117157A (en) 1994-03-18 2000-09-12 Cook Incorporated Helical embolization coil
WO1995026683A1 (en) 1994-03-31 1995-10-12 Boston Scientific Corporation Vascular plug with vessel locator
US5715987A (en) 1994-04-05 1998-02-10 Tracor Incorporated Constant width, adjustable grip, staple apparatus and method
US5695524A (en) 1994-04-05 1997-12-09 Tracor Aerospace, Inc. Constant width, adjustable grip, staple apparatus and method
US5416584A (en) 1994-04-25 1995-05-16 Honeywell Inc. Sinusoidal noise injection into the dither of a ring laser gyroscope
US5425740A (en) 1994-05-17 1995-06-20 Hutchinson, Jr.; William B. Endoscopic hernia repair clip and method
US5478309A (en) 1994-05-27 1995-12-26 William P. Sweezer, Jr. Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery
WO1995032669A1 (en) 1994-06-01 1995-12-07 Perclose, Inc. Apparatus and method for advancing surgical knots
US5732872A (en) 1994-06-17 1998-03-31 Heartport, Inc. Surgical stapling instrument
US6302898B1 (en) 1994-06-24 2001-10-16 Advanced Closure Systems, Inc. Devices for sealing punctures in body vessels
US6009877A (en) 1994-06-24 2000-01-04 Edwards; Stuart D. Method for treating a sphincter
US6056744A (en) 1994-06-24 2000-05-02 Conway Stuart Medical, Inc. Sphincter treatment apparatus
US5725552A (en) 1994-07-08 1998-03-10 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US5573540A (en) 1994-07-18 1996-11-12 Yoon; Inbae Apparatus and method for suturing an opening in anatomical tissue
US5544802A (en) 1994-07-27 1996-08-13 Crainich; Lawrence Surgical staple and stapler device therefor
FR2722975A1 (en) 1994-07-28 1996-02-02 Dynamique Sante Sarl Surgical implant for fastening ligament against bone surface
US5582616A (en) 1994-08-05 1996-12-10 Origin Medsystems, Inc. Surgical helical fastener with applicator
US5549633A (en) 1994-08-24 1996-08-27 Kensey Nash Corporation Apparatus and methods of use for preventing blood seepage at a percutaneous puncture site
US5562684A (en) 1994-10-11 1996-10-08 Ethicon, Inc. Surgical knot pusher device and improved method of forming knots
CA2163824C (en) 1994-11-28 2000-06-20 Advanced Cardiovascular Systems, Inc. Method and apparatus for direct laser cutting of metal stents
WO1996018352A1 (en) 1994-12-14 1996-06-20 Influence, Inc. Staple and thread assembly particularly for use in power-driven staplers for medical suturing
US6171329B1 (en) 1994-12-19 2001-01-09 Gore Enterprise Holdings, Inc. Self-expanding defect closure device and method of making and using
US5620452A (en) 1994-12-22 1997-04-15 Yoon; Inbae Surgical clip with ductile tissue penetrating members
US5720755A (en) 1995-01-18 1998-02-24 Dakov; Pepi Tubular suturing device and methods of use
US6896687B2 (en) 1997-05-19 2005-05-24 Pepi Dakov Connectors for hollow anatomical structures and methods of use
JP3798838B2 (en) 1995-01-20 2006-07-19 オリンパス株式会社 Ligating apparatus
US5634936A (en) 1995-02-06 1997-06-03 Scimed Life Systems, Inc. Device for closing a septal defect
WO1996024291A1 (en) 1995-02-07 1996-08-15 Cardiovascular Ventures, Inc. Puncture sealing system
US5649959A (en) 1995-02-10 1997-07-22 Sherwood Medical Company Assembly for sealing a puncture in a vessel
US5695504A (en) 1995-02-24 1997-12-09 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US5695505A (en) 1995-03-09 1997-12-09 Yoon; Inbae Multifunctional spring clips and cartridges and applicators therefor
RU2086192C1 (en) 1995-03-17 1997-08-10 Ялмар Яковлевич Татти Surgical suture appliance
US5868740A (en) 1995-03-24 1999-02-09 Board Of Regents-Univ Of Nebraska Method for volumetric tissue ablation
US5575771A (en) 1995-04-24 1996-11-19 Walinsky; Paul Balloon catheter with external guidewire
FR2733413B1 (en) 1995-04-27 1997-10-17 Jbs Sa A cervical cage intended for the production of an intersomatic arthrodesis
US5681280A (en) 1995-05-02 1997-10-28 Heart Rhythm Technologies, Inc. Catheter control system
US5634911A (en) 1995-05-19 1997-06-03 General Surgical Innovations, Inc. Screw-type skin seal with inflatable membrane
FR2734147B1 (en) 1995-05-19 1997-10-10 Klein Jean Michel An implantable osteosynthesis
US5709224A (en) 1995-06-07 1998-01-20 Radiotherapeutics Corporation Method and device for permanent vessel occlusion
US6132438A (en) 1995-06-07 2000-10-17 Ep Technologies, Inc. Devices for installing stasis reducing means in body tissue
WO1996039946A1 (en) 1995-06-07 1996-12-19 Raychem Corporation Wound closure device
US5645565A (en) 1995-06-13 1997-07-08 Ethicon Endo-Surgery, Inc. Surgical plug
US5814052A (en) 1995-06-29 1998-09-29 Nakao; Naomi L. Surgical cauterization snare with ligating suture
US6013084A (en) 1995-06-30 2000-01-11 Target Therapeutics, Inc. Stretch resistant vaso-occlusive coils (II)
US5700273A (en) 1995-07-14 1997-12-23 C.R. Bard, Inc. Wound closure apparatus and method
US5810846A (en) 1995-08-03 1998-09-22 United States Surgical Corporation Vascular hole closure
US6117144A (en) 1995-08-24 2000-09-12 Sutura, Inc. Suturing device and method for sealing an opening in a blood vessel or other biological structure
WO1997007741A1 (en) 1995-08-24 1997-03-06 Inbae Yoon Suture tie device system and method for suturing anatomical tissue proximate an opening
US5683405A (en) 1995-08-25 1997-11-04 Research Medical Inc. Vascular occluder
US6071300A (en) 1995-09-15 2000-06-06 Sub-Q Inc. Apparatus and method for percutaneous sealing of blood vessel punctures
US5645566A (en) 1995-09-15 1997-07-08 Sub Q Inc. Apparatus and method for percutaneous sealing of blood vessel punctures
US5704943A (en) 1995-09-25 1998-01-06 Yoon; Inbae Ligating instrument with multiple loop ligature supply and methods therefor
WO1998016161A1 (en) 1996-10-11 1998-04-23 Transvascular, Inc. Methods and apparatus for bypassing arterial obstructions and/or performing other transvascular procedures
US5674231A (en) 1995-10-20 1997-10-07 United States Surgical Corporation Apparatus and method for vascular hole closure
US5700270A (en) 1995-10-20 1997-12-23 United States Surgical Corporation Surgical clip applier
WO1997016122A1 (en) 1995-10-31 1997-05-09 Oticon A/S Method and anastomotic instrument for use when performing an end-to-side anastomosis
US5827298A (en) 1995-11-17 1998-10-27 Innovasive Devices, Inc. Surgical fastening system and method for using the same
EP0874591B1 (en) 1995-12-07 2011-04-06 Loma Linda University Medical Center Vascular wound closure device
US6425901B1 (en) 1995-12-07 2002-07-30 Loma Linda University Medical Center Vascular wound closure system
US6287322B1 (en) 1995-12-07 2001-09-11 Loma Linda University Medical Center Tissue opening locator and everter and method
US5626614A (en) 1995-12-22 1997-05-06 Applied Medical Resources Corporation T-anchor suturing device and method for using same
US5792151A (en) 1996-01-24 1998-08-11 The Ohio State University Method and apparatus for ligating a blood vessel, tissue or other bodily duct
DE69716779D1 (en) 1996-01-30 2002-12-05 Medtronic Inc Products and methods for production of dilators
CN1216930A (en) 1996-02-02 1999-05-19 血管转换公司 Device, system and method for interstitial transvascular intervention
DE19604817C2 (en) 1996-02-09 2003-06-12 Pfm Prod Fuer Die Med Ag Device for closure of defect openings in the human or animal body
US5810776A (en) 1996-02-13 1998-09-22 Imagyn Medical, Inc. Method and apparatus for performing laparoscopy
US5769870A (en) 1996-02-20 1998-06-23 Cardiothoracic Systems, Inc. Perfusion device for maintaining blood flow in a vessel while isolating an anastomosis
US5693061A (en) 1996-02-23 1997-12-02 Pierce; Javin C. Knot puller instrument for use with surgical suture in tying surgical knots
US5782917A (en) 1996-02-26 1998-07-21 Sunmed, Inc. Intramedullary bone plug
US5951575A (en) 1996-03-01 1999-09-14 Heartport, Inc. Apparatus and methods for rotationally deploying needles
US5782844A (en) 1996-03-05 1998-07-21 Inbae Yoon Suture spring device applicator
US5810851A (en) 1996-03-05 1998-09-22 Yoon; Inbae Suture spring device
US5853422A (en) 1996-03-22 1998-12-29 Scimed Life Systems, Inc. Apparatus and method for closing a septal defect
US5728132A (en) 1996-04-08 1998-03-17 Tricardia, L.L.C. Self-sealing vascular access device
US6010517A (en) 1996-04-10 2000-01-04 Baccaro; Jorge Alberto Device for occluding abnormal vessel communications
US6149660A (en) 1996-04-22 2000-11-21 Vnus Medical Technologies, Inc. Method and apparatus for delivery of an appliance in a vessel
US6117125A (en) 1996-05-02 2000-09-12 Cook Incorporated Method for predetermining uniform flow rate of a fluid from a tubular body and device therefrom
US5855585A (en) 1996-06-11 1999-01-05 X-Site, L.L.C. Device and method for suturing blood vessels and the like
US5690674A (en) 1996-07-02 1997-11-25 Cordis Corporation Wound closure with plug
US5728133A (en) 1996-07-09 1998-03-17 Cardiologics, L.L.C. Anchoring device and method for sealing percutaneous punctures in vessels
US5957900A (en) 1996-07-10 1999-09-28 Asahi Kogaku Kogyo Kabushiki Kaisha Treatment accessory for endoscope
US5797933A (en) 1996-07-16 1998-08-25 Heartport, Inc. Coronary shunt and method of use
US7169158B2 (en) 1996-07-23 2007-01-30 Tyco Healthcare Group Lp Anastomosis instrument and method for performing same
US5833698A (en) 1996-07-23 1998-11-10 United States Surgical Corporation Anastomosis instrument and method
US5855312A (en) 1996-07-25 1999-01-05 Toledano; Haviv Flexible annular stapler for closed surgery of hollow organs
US5820631A (en) 1996-08-01 1998-10-13 Nr Medical, Inc. Device and method for suturing tissue adjacent to a blood vessel
US5902310A (en) 1996-08-12 1999-05-11 Ethicon Endo-Surgery, Inc. Apparatus and method for marking tissue
US6482224B1 (en) 1996-08-22 2002-11-19 The Trustees Of Columbia University In The City Of New York Endovascular flexible stapling device
ES2208974T3 (en) 1996-08-23 2004-06-16 Cook Biotech, Inc. Prosthetic grafts, materials and methods.
US5730758A (en) 1996-09-12 1998-03-24 Allgeyer; Dean O. Staple and staple applicator for use in skin fixation of catheters
US6488692B1 (en) 1996-09-16 2002-12-03 Origin Medsystems, Inc. Access and cannulation device and method for rapidly placing same and for rapidly closing same in minimally invasive surgery
US5868763A (en) 1996-09-16 1999-02-09 Guidant Corporation Means and methods for performing an anastomosis
US5830221A (en) 1996-09-20 1998-11-03 United States Surgical Corporation Coil fastener applier
US6152936A (en) 1996-09-23 2000-11-28 Esd Medical, Llc Surgical loop delivery device
US5766217A (en) 1996-09-23 1998-06-16 Christy; William J. Surgical loop delivery device and method
US5948001A (en) 1996-10-03 1999-09-07 United States Surgical Corporation System for suture anchor placement
US5755778A (en) 1996-10-16 1998-05-26 Nitinol Medical Technologies, Inc. Anastomosis device
GB9621622D0 (en) 1996-10-17 1996-12-11 Gleeson Malachy Device and method for percutaneous closure of a vascular puncture site
US5861003A (en) 1996-10-23 1999-01-19 The Cleveland Clinic Foundation Apparatus and method for occluding a defect or aperture within body surface
WO1998018389A1 (en) 1996-10-25 1998-05-07 University Of Massachusetts Surgical vessel clips and methods for closing vessels
US5749826A (en) 1996-11-06 1998-05-12 Faulkner; James W. Urinary incontinence control device
DE69737208T2 (en) 1996-11-15 2007-11-08 Cook Inc., Bloomington The stent delivery device having a separable case
US5947999A (en) 1996-12-03 1999-09-07 Groiso; Jorge A. Surgical clip and method
US6004341A (en) 1996-12-05 1999-12-21 Loma Linda University Medical Center Vascular wound closure device
US5735873A (en) 1996-12-19 1998-04-07 Maclean; David S. Surgical tool handle
US5879366A (en) 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US5782861A (en) 1996-12-23 1998-07-21 Sub Q Inc. Percutaneous hemostasis device
US5868755A (en) 1997-01-16 1999-02-09 Atrion Medical Products, Inc. Sheath retractor mechanism and method
US5957938A (en) 1997-02-05 1999-09-28 United States Surgical Corporation Tissue everting needle
US6056770A (en) 1997-02-11 2000-05-02 Biointerventional Corporation Expansile device for use in blood vessels and tracts in the body and method
US5782860A (en) 1997-02-11 1998-07-21 Biointerventional Corporation Closure device for percutaneous occlusion of puncture sites and tracts in the human body and method
US6146385A (en) 1997-02-11 2000-11-14 Smith & Nephew, Inc. Repairing cartilage
US6056769A (en) 1997-02-11 2000-05-02 Biointerventional Corporation Expansile device for use in blood vessels and tracts in the body and tension application device for use therewith and method
US6045570A (en) 1997-02-11 2000-04-04 Biointerventional Corporation Biological sealant mixture and system for use in percutaneous occlusion of puncture sites and tracts in the human body and method
US5861005A (en) 1997-02-11 1999-01-19 X-Site, L.L.C. Arterial stapling device
US5951589A (en) 1997-02-11 1999-09-14 Biointerventional Corporation Expansile device for use in blood vessels and tracts in the body and tension application device for use therewith and method
EP0858776A3 (en) 1997-02-14 2000-01-12 Tricardia, L.L.C. Hemostatic agent delivery device having built-in pressure sensor
US5759189A (en) 1997-02-25 1998-06-02 Smith & Nephew Inc. Knot pusher
WO1998039053A1 (en) 1997-03-06 1998-09-11 Scimed Life Systems, Inc. Distal protection device and method
US5752966A (en) 1997-03-07 1998-05-19 Chang; David W. Exovascular anastomotic device
DE29723736U1 (en) 1997-03-18 1999-02-18 Wurster Helmut Dipl Ing Surgical staplers for connecting tissue parts
DE19711288B4 (en) 1997-03-18 2004-11-04 Helmut Dipl.-Ing. Wurster Applicator for receiving and closing a surgical clip
US5749898A (en) 1997-04-08 1998-05-12 Ethicon Endo-Surgery, Inc. Suture cartridge assembly for a surgical knot
US5984948A (en) 1997-04-14 1999-11-16 Hasson; Harrith M. Device for closing an opening in tissue and method of closing a tissue opening using the device
US5897487A (en) 1997-04-15 1999-04-27 Asahi Kogaku Kogyo Kabushiki Kaisha Front end hood for endoscope
EP1011532B1 (en) 1997-04-23 2014-05-07 Ethicon Endo-Surgery, Inc. Bifurcated stent and distal protection system
US6038472A (en) 1997-04-29 2000-03-14 Medtronic, Inc. Implantable defibrillator and lead system
US5957936A (en) 1997-05-01 1999-09-28 Inbae Yoon Instrument assemblies for performing anatomical tissue ligation
US6409739B1 (en) 1997-05-19 2002-06-25 Cardio Medical Solutions, Inc. Device and method for assisting end-to side anastomosis
US5993466A (en) 1997-06-17 1999-11-30 Yoon; Inbae Suturing instrument with multiple rotatably mounted spreadable needle holders
US6706051B2 (en) 1998-04-08 2004-03-16 Bhk Holding, Ltd. Hemostatic system for body cavities
US6443158B1 (en) 1997-06-19 2002-09-03 Scimed Life Systems, Inc. Percutaneous coronary artery bypass through a venous vessel
US6001110A (en) 1997-06-20 1999-12-14 Boston Scientific Corporation Hemostatic clips
US5957940A (en) 1997-06-30 1999-09-28 Eva Corporation Fasteners for use in the surgical repair of aneurysms
US5972034A (en) 1997-07-29 1999-10-26 Joint Enterprises, L.C. A Limited Corporation Self-venting intramedullary cement restrictor
EP0895753A1 (en) 1997-07-31 1999-02-10 Academisch Ziekenhuis Utrecht Temporary vascular seal for anastomosis
EP1003422B1 (en) 1997-08-05 2006-06-14 Boston Scientific Limited Detachable aneurysm neck bridge
US6059719A (en) 1997-08-06 2000-05-09 Olympus Optical Co., Ltd. Endoscope system
US6174322B1 (en) 1997-08-08 2001-01-16 Cardia, Inc. Occlusion device for the closure of a physical anomaly such as a vascular aperture or an aperture in a septum
US6024750A (en) 1997-08-14 2000-02-15 United States Surgical Ultrasonic curved blade
US6397110B1 (en) 1998-08-26 2002-05-28 Advanced Bionics Corporation Cochlear electrode system including detachable flexible positioner
US6063114A (en) 1997-09-04 2000-05-16 Kensey Nash Corporation Connector system for vessels, ducts, lumens or hollow organs and methods of use
US6059800A (en) 1997-09-10 2000-05-09 Applied Medical Resources Corporation Suturing apparatus and method
FR2768324B1 (en) 1997-09-12 1999-12-10 Jacques Seguin A surgical instrument for percutaneously, fixing one to the other two zones of soft tissue, usually spaced apart
US5858082A (en) 1997-09-15 1999-01-12 Cruz; Hector Gonzalo Self-interlocking reinforcement fibers
US5964782A (en) 1997-09-18 1999-10-12 Scimed Life Systems, Inc. Closure device and method
US5928251A (en) 1997-09-18 1999-07-27 United States Surgical Corporation Occlusion clamp and occlusion clamp applicator
US5868762A (en) 1997-09-25 1999-02-09 Sub-Q, Inc. Percutaneous hemostatic suturing device and method
US6015815A (en) 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
US6030364A (en) 1997-10-03 2000-02-29 Boston Scientific Corporation Apparatus and method for percutaneous placement of gastro-intestinal tubes
US5984949A (en) 1997-10-06 1999-11-16 Levin; John M. Tissue hooks and tools for applying same
US5984934A (en) 1997-10-10 1999-11-16 Applied Medical Resources Corporation Low-profile surgical clip
US6117148A (en) 1997-10-17 2000-09-12 Ravo; Biagio Intraluminal anastomotic device
NL1007349C2 (en) 1997-10-24 1999-04-27 Suyker Wilhelmus Joseph Leonardus System for mechanical production of anastomoses between hollow structures; as well as device and applicator for use therewith.
US5951518A (en) 1997-10-31 1999-09-14 Teleflex, Incorporated Introducing device with flared sheath end
US5968056A (en) 1997-11-13 1999-10-19 Boston Scientific Corporation Device and method for severing lesions
US6171277B1 (en) 1997-12-01 2001-01-09 Cordis Webster, Inc. Bi-directional control handle for steerable catheter
US5906631A (en) 1997-12-05 1999-05-25 Surface Genesis, Inc. Method and device for sealing vascular puncture wounds
US6254642B1 (en) 1997-12-09 2001-07-03 Thomas V. Taylor Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof
US6036720A (en) 1997-12-15 2000-03-14 Target Therapeutics, Inc. Sheet metal aneurysm neck bridge
US5976174A (en) 1997-12-15 1999-11-02 Ruiz; Carlos E. Medical hole closure device and methods of use
US6626919B1 (en) 1997-12-29 2003-09-30 Lee L. Swanstrom Method and apparatus for attaching or locking an implant to an anatomic vessel or hollow organ wall
US5976161A (en) 1998-01-07 1999-11-02 University Of New Mexico Tissue everting apparatus and method
US6033427A (en) 1998-01-07 2000-03-07 Lee; Benjamin I. Method and device for percutaneous sealing of internal puncture sites
US6193734B1 (en) 1998-01-23 2001-02-27 Heartport, Inc. System for performing vascular anastomoses
DE69833882D1 (en) 1998-01-30 2006-05-11 St Jude Medical Atg Inc Medical graft connector or plug as well as process for their production
US6036703A (en) 1998-02-06 2000-03-14 Ethicon Endo-Surgery Inc. Method and apparatus for establishing anastomotic passageways
EP1054628A1 (en) 1998-02-10 2000-11-29 Jump, Jeffrey Surgical device for occlusion of defects
US6280460B1 (en) 1998-02-13 2001-08-28 Heartport, Inc. Devices and methods for performing vascular anastomosis
JP4157183B2 (en) 1998-02-17 2008-09-24 オリンパス株式会社 Endoscopic treatment tool
US5951576A (en) 1998-03-02 1999-09-14 Wakabayashi; Akio End-to-side vascular anastomosing stapling device
US6517498B1 (en) 1998-03-03 2003-02-11 Senorx, Inc. Apparatus and method for tissue capture
WO1999048427A1 (en) 1998-03-20 1999-09-30 Sumit Roy Method and device for suturless anastomosis
JP2002510525A (en) 1998-04-02 2002-04-09 サルヴィアック・リミテッド Delivery catheter
US5972009A (en) 1998-04-07 1999-10-26 Boston Scientific Corporation Ligating band with rounded edges and method of use of same
JPH11299725A (en) 1998-04-21 1999-11-02 Olympus Optical Co Ltd Hood for endoscope
US5944728A (en) 1998-04-23 1999-08-31 Boston Scientific Corporation Surgical retrieval basket with the ability to capture and release material
JP2003510104A (en) 1998-05-11 2003-03-18 サージカル・コネクションズ・インコーポレイテッド Apparatus and methods for treating stress urinary incontinence e.g.
US7083588B1 (en) 1998-05-26 2006-08-01 Medtronic Vascular, Inc. Apparatus for providing coronary retroperfusion and methods of use
US7063711B1 (en) 1998-05-29 2006-06-20 By-Pass, Inc. Vascular surgery
WO2000056227A1 (en) 1999-03-19 2000-09-28 By-Pass, Inc. Advanced closure device
US7060084B1 (en) 1998-05-29 2006-06-13 By-Pass, Inc. Vascular closure device
WO1999062415A1 (en) 1998-05-29 1999-12-09 By-Pass, Inc. Methods and devices for vascular surgery
US7396359B1 (en) 1998-05-29 2008-07-08 Bypass, Inc. Vascular port device
US6726704B1 (en) 1998-05-29 2004-04-27 By-Pass, Inc. Advanced closure device
WO2000056226A1 (en) 1999-03-19 2000-09-28 By-Pass, Inc. Vascular surgery
US20050283188A1 (en) 1998-05-29 2005-12-22 By-Pass, Inc. Vascular closure device
US5919207A (en) 1998-06-02 1999-07-06 Taheri; Syde A. Percutaneous arterial closure with staples
US5910155A (en) 1998-06-05 1999-06-08 United States Surgical Corporation Vascular wound closure system
US6599311B1 (en) 1998-06-05 2003-07-29 Broncus Technologies, Inc. Method and assembly for lung volume reduction
US5941890A (en) 1998-06-26 1999-08-24 Ethicon Endo-Surgery, Inc. Implantable surgical marker
JP2000014634A (en) 1998-07-02 2000-01-18 Olympus Optical Co Ltd Endoscope system
US6228098B1 (en) 1998-07-10 2001-05-08 General Surgical Innovations, Inc. Apparatus and method for surgical fastening
US6048358A (en) 1998-07-13 2000-04-11 Barak; Shlomo Method and apparatus for hemostasis following arterial catheterization
WO2000007640A9 (en) 1998-07-22 2001-11-15 Angiolink Corp Vascular suction cannula, dilator and surgical stapler
WO2000007505A1 (en) 1998-08-04 2000-02-17 Fusion Medical Technologies, Inc. Percutaneous tissue track closure assembly and method
US6334865B1 (en) 1998-08-04 2002-01-01 Fusion Medical Technologies, Inc. Percutaneous tissue track closure assembly and method
DE19859950C2 (en) 1998-08-11 2003-08-21 S & T Ag Neuhausen Am Rheinfal A surgical stapler and apparatus for their application
US6206913B1 (en) 1998-08-12 2001-03-27 Vascular Innovations, Inc. Method and system for attaching a graft to a blood vessel
US6198974B1 (en) 1998-08-14 2001-03-06 Cordis Webster, Inc. Bi-directional steerable catheter
US6605294B2 (en) 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US7790192B2 (en) 1998-08-14 2010-09-07 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US6143004A (en) 1998-08-18 2000-11-07 Atrion Medical Products, Inc. Suturing device
US6179860B1 (en) 1998-08-19 2001-01-30 Artemis Medical, Inc. Target tissue localization device and method
DE19839188C2 (en) 1998-08-28 2003-08-21 Storz Endoskop Gmbh Schaffhaus endoscope
US6200329B1 (en) 1998-08-31 2001-03-13 Smith & Nephew, Inc. Suture collet
US6093194A (en) 1998-09-14 2000-07-25 Endocare, Inc. Insertion device for stents and methods for use
WO2000016701A1 (en) 1998-09-18 2000-03-30 United States Surgical Corporation Endovascular fastener applicator
US6296657B1 (en) 1998-10-07 2001-10-02 Gregory G. Brucker Vascular sealing device and method
US6019779A (en) 1998-10-09 2000-02-01 Intratherapeutics Inc. Multi-filar coil medical stent
US6220248B1 (en) 1998-10-21 2001-04-24 Ethicon Endo-Surgery, Inc. Method for implanting a biopsy marker
JP4164235B2 (en) 1998-10-23 2008-10-15 コビディエン アクチェンゲゼルシャフト Endoscopic bipolar electrosurgical forceps
US6152937A (en) 1998-11-06 2000-11-28 St. Jude Medical Cardiovascular Group, Inc. Medical graft connector and methods of making and installing same
US6113612A (en) 1998-11-06 2000-09-05 St. Jude Medical Cardiovascular Group, Inc. Medical anastomosis apparatus
US6152144A (en) 1998-11-06 2000-11-28 Appriva Medical, Inc. Method and device for left atrial appendage occlusion
US6102271A (en) 1998-11-23 2000-08-15 Ethicon Endo-Surgery, Inc. Circular stapler for hemorrhoidal surgery
US6200330B1 (en) 1998-11-23 2001-03-13 Theodore V. Benderev Systems for securing sutures, grafts and soft tissue to bone and periosteum
US6080183A (en) 1998-11-24 2000-06-27 Embol-X, Inc. Sutureless vessel plug and methods of use
US6210407B1 (en) 1998-12-03 2001-04-03 Cordis Webster, Inc. Bi-directional electrode catheter
US20020188275A1 (en) 1998-12-09 2002-12-12 Mcguckin James F. Multi Directional infusion needle
US6126675A (en) 1999-01-11 2000-10-03 Ethicon, Inc. Bioabsorbable device and method for sealing vascular punctures
US6221084B1 (en) 1999-01-15 2001-04-24 Pare Surgical, Inc. Knot tying apparatus having a notched thread cover and method for using same
US6120524A (en) 1999-02-16 2000-09-19 Taheri; Syde A. Device for closing an arterial puncture and method
US6083242A (en) 1999-02-17 2000-07-04 Holobeam, Inc. Surgical staples with deformation zones of non-uniform cross section
US7252666B2 (en) 2000-02-14 2007-08-07 Sherwood Services Ag Arterial hole closure apparatus
US6613059B2 (en) 1999-03-01 2003-09-02 Coalescent Surgical, Inc. Tissue connector apparatus and methods
US7001400B1 (en) 1999-03-04 2006-02-21 Abbott Laboratories Articulating suturing device and method
US6136010A (en) 1999-03-04 2000-10-24 Perclose, Inc. Articulating suturing device and method
US7235087B2 (en) 1999-03-04 2007-06-26 Abbott Park Articulating suturing device and method
US6964668B2 (en) 1999-03-04 2005-11-15 Abbott Laboratories Articulating suturing device and method
US20040092964A1 (en) 1999-03-04 2004-05-13 Modesitt D. Bruce Articulating suturing device and method
WO2000053104A8 (en) 1999-03-09 2001-01-25 St Jude Medical Cardiovascular Medical grafting methods and apparatus
WO2000055932A1 (en) 1999-03-15 2000-09-21 Bolder Technologies Corporation Tin-clad substrates for use as current collectors, batteries comprised thereof and methods for preparing same
US20040087985A1 (en) 1999-03-19 2004-05-06 Amir Loshakove Graft and connector delivery
WO2000056228A1 (en) 1999-03-19 2000-09-28 By-Pass, Inc. Low profile anastomosis connector
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US7563267B2 (en) 1999-04-09 2009-07-21 Evalve, Inc. Fixation device and methods for engaging tissue
US6632197B2 (en) 1999-04-16 2003-10-14 Thomas R. Lyon Clear view cannula
US6626921B2 (en) 1999-04-16 2003-09-30 Integrated Vascular Interventional Technologies, L.C. Externally positioned anvil apparatus for cutting anastomosis
US6375671B1 (en) 1999-04-19 2002-04-23 Nipro Corporation Closure device for transcatheter operations
US6261258B1 (en) 1999-05-03 2001-07-17 Marius Saines Hemostatic device for angioplasty
US6712836B1 (en) 1999-05-13 2004-03-30 St. Jude Medical Atg, Inc. Apparatus and methods for closing septal defects and occluding blood flow
WO2000069364A3 (en) 1999-05-18 2001-02-01 Vascular Innovations Inc Implantable medical device such as an anastomosis device
US6699256B1 (en) 1999-06-04 2004-03-02 St. Jude Medical Atg, Inc. Medical grafting apparatus and methods
US6179849B1 (en) 1999-06-10 2001-01-30 Vascular Innovations, Inc. Sutureless closure for connecting a bypass graft to a target vessel
US6165204A (en) 1999-06-11 2000-12-26 Scion International, Inc. Shaped suture clip, appliance and method therefor
US6860895B1 (en) 1999-06-18 2005-03-01 Radi Medical Systems Ab Tool, a sealing device, a system and a method for closing a wound
US6626899B2 (en) 1999-06-25 2003-09-30 Nidus Medical, Llc Apparatus and methods for treating tissue
US6206895B1 (en) 1999-07-13 2001-03-27 Scion Cardio-Vascular, Inc. Suture with toggle and delivery system
US6267773B1 (en) 1999-07-15 2001-07-31 Donald L. Gadberry Low profile surgical clip
JP3917332B2 (en) 1999-08-04 2007-05-23 ペンタックス株式会社 Operating wire connecting portion of the endoscope treatment tool
US6110184A (en) 1999-08-04 2000-08-29 Weadock; Kevin S. Introducer with vascular sealing mechanism
US6203553B1 (en) 1999-09-08 2001-03-20 United States Surgical Stapling apparatus and method for heart valve replacement
US7267679B2 (en) 1999-09-13 2007-09-11 Rex Medical, L.P Vascular hole closure device
US7341595B2 (en) 1999-09-13 2008-03-11 Rex Medical, L.P Vascular hole closure device
ES2283316T3 (en) 1999-09-13 2007-11-01 Rex Medical, Lp vascular closure.
US6358258B1 (en) 1999-09-14 2002-03-19 Abbott Laboratories Device and method for performing end-to-side anastomosis
US6421899B1 (en) 1999-09-15 2002-07-23 Emhart Llc Extraction and adjustment tool for tangless inserts
US6231561B1 (en) 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
US6984219B2 (en) 1999-09-23 2006-01-10 Mark Ashby Depth and puncture control for blood vessel hemostasis system
JP4759194B2 (en) 1999-09-23 2011-08-31 サブ−キュー・インコーポレーテッド Device for determining the depth of the incision
US6319258B1 (en) 1999-09-29 2001-11-20 Ethicon, Inc. Absorbable rivet/pin applier for use in surgical procedures
US6312447B1 (en) 1999-10-13 2001-11-06 The General Hospital Corporation Devices and methods for percutaneous mitral valve repair
US6626930B1 (en) 1999-10-21 2003-09-30 Edwards Lifesciences Corporation Minimally invasive mitral valve repair method and apparatus
US6409753B1 (en) 1999-10-26 2002-06-25 Scimed Life Systems, Inc. Flexible stent
US6689150B1 (en) 1999-10-27 2004-02-10 Atritech, Inc. Filter apparatus for ostium of left atrial appendage
WO2001034035A1 (en) 1999-11-05 2001-05-17 Onux Medical, Inc. Apparatus and method for approximating and closing the walls of a hole or puncture in a physiological shell structure
US6273903B1 (en) 1999-11-08 2001-08-14 Peter J. Wilk Endoscopic stapling device and related staple
US6695854B1 (en) 1999-11-29 2004-02-24 General Surgical Innovations, Inc. Blood vessel clip and applicator
US6602263B1 (en) 1999-11-30 2003-08-05 St. Jude Medical Atg, Inc. Medical grafting methods and apparatus
US6569173B1 (en) 1999-12-14 2003-05-27 Integrated Vascular Interventional Technologies, L.C. Compression plate anastomosis apparatus
US6790218B2 (en) 1999-12-23 2004-09-14 Swaminathan Jayaraman Occlusive coil manufacture and delivery
US20050187564A1 (en) 1999-12-23 2005-08-25 Swaminathan Jayaraman Occlusive coil manufacturing and delivery
EP1110510B1 (en) 1999-12-23 2002-03-27 Karl Storz GmbH & Co. KG Screw driven non-centrally
GB9930654D0 (en) 1999-12-23 2000-02-16 Halpin Richard M B Device for controlling extra-vascular haemorrhage
US6461364B1 (en) 2000-01-05 2002-10-08 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US6197042B1 (en) 2000-01-05 2001-03-06 Medical Technology Group, Inc. Vascular sheath with puncture site closure apparatus and methods of use
US8758400B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Closure system and methods of use
US9579091B2 (en) 2000-01-05 2017-02-28 Integrated Vascular Systems, Inc. Closure system and methods of use
US7842068B2 (en) 2000-12-07 2010-11-30 Integrated Vascular Systems, Inc. Apparatus and methods for providing tactile feedback while delivering a closure device
US6391048B1 (en) 2000-01-05 2002-05-21 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
JP4399141B2 (en) 2000-01-05 2010-01-13 インテグレイテッド・バスキュラー・システムズ・インコーポレイテッドIntegrated Vascular Systems, Inc. Apparatus for closing the tissue puncture
US6780197B2 (en) 2000-01-05 2004-08-24 Integrated Vascular Systems, Inc. Apparatus and methods for delivering a vascular closure device to a body lumen
JP4347486B2 (en) 2000-01-24 2009-10-21 株式会社ハイレックスコーポレーション Indwelling catheter
US6547806B1 (en) 2000-02-04 2003-04-15 Ni Ding Vascular sealing device and method of use
GB0002970D0 (en) 2000-02-09 2000-03-29 Anson Medical Ltd Fixator for the repair of articles
JP3742542B2 (en) 2000-03-10 2006-02-08 ペンタックス株式会社 Endoscopic foreign body recovery tool
JP3844661B2 (en) 2000-04-19 2006-11-15 ラディ・メディカル・システムズ・アクチェボラーグ Intra-arterial emboli
US6786915B2 (en) 2000-04-19 2004-09-07 Radi Medical Systems Ab Reinforced absorbable medical sealing device
US6942691B1 (en) 2000-04-27 2005-09-13 Timothy A. M. Chuter Modular bifurcated graft for endovascular aneurysm repair
US6352543B1 (en) 2000-04-29 2002-03-05 Ventrica, Inc. Methods for forming anastomoses using magnetic force
US7361185B2 (en) 2001-05-09 2008-04-22 Canica Design, Inc. Clinical and surgical system and method for moving and stretching plastic tissue
US6305891B1 (en) 2000-05-15 2001-10-23 Mark S. Burlingame Fastening device and a spacer, and a method of using the same
WO2001091628A3 (en) 2000-05-31 2003-10-30 Origin Medsystems Inc Method and apparatus for performing end-to-end and end-to-side anastomosis with eversion of tissue edges
US6402765B1 (en) 2000-06-12 2002-06-11 Niti Alloys Technologies Ltd. Surgical clip
US6689147B1 (en) 2000-06-13 2004-02-10 J. Kenneth Koster, Jr. Anastomosis punch device and method
DE60132005D1 (en) 2000-06-23 2008-01-31 Viacor Inc Automatic circular convolution for Mitral Valve Repair
US20020022822A1 (en) 2000-07-14 2002-02-21 Cragg Andrew H. Sheath-mounted arterial plug delivery device
US6443963B1 (en) 2000-07-26 2002-09-03 Orthopaedic Biosystems, Ltd. Apparatus and method for repairing or reattaching soft tissue
DE60112945D1 (en) 2000-07-27 2005-09-29 Synthes Ag Schädelkalottenfixiereinrichtung
US6428472B1 (en) 2000-08-08 2002-08-06 Kent Haas Surgical retractor having a malleable support
US6572629B2 (en) 2000-08-17 2003-06-03 Johns Hopkins University Gastric reduction endoscopy
US7074232B2 (en) 2000-09-01 2006-07-11 Medtronic Angiolink, Inc. Advanced wound site management systems and methods
JP2004511275A (en) 2000-09-01 2004-04-15 アンジオリンク・コーポレイション Management and wound closure device of the wound site
US6755842B2 (en) 2000-09-01 2004-06-29 Angiolink Corporation Advanced wound site management systems and methods
EP1317213A2 (en) 2000-09-01 2003-06-11 Advanced Vascular Technologies LLC Multi-fastener surgical apparatus and method
US6533762B2 (en) 2000-09-01 2003-03-18 Angiolink Corporation Advanced wound site management systems and methods
US20040093024A1 (en) 2000-09-01 2004-05-13 James Lousararian Advanced wound site management systems and methods
US6767356B2 (en) 2000-09-01 2004-07-27 Angiolink Corporation Advanced wound site management systems and methods
US7338506B2 (en) 2001-09-05 2008-03-04 Caro Nicholas C Scleral clip and procedures for using same
US6517555B1 (en) 2000-09-05 2003-02-11 Clear Sight, Inc. Method for treating presbyopia
DE60143324D1 (en) 2000-09-08 2010-12-02 Abbott Vascular Inc An apparatus for locating a punctured blood vessel
EP1318766A2 (en) 2000-09-21 2003-06-18 Atritech, Inc. Apparatus for implanting devices in atrial appendages
US6551319B2 (en) 2000-11-08 2003-04-22 The Cleveland Clinic Foundation Apparatus for implantation into bone
US6626918B1 (en) 2000-10-06 2003-09-30 Medical Technology Group Apparatus and methods for positioning a vascular sheath
US6776785B1 (en) 2000-10-12 2004-08-17 Cardica, Inc. Implantable superelastic anastomosis device
US6633234B2 (en) 2000-10-20 2003-10-14 Ethicon Endo-Surgery, Inc. Method for detecting blade breakage using rate and/or impedance information
US6663633B1 (en) 2000-10-25 2003-12-16 Pierson, Iii Raymond H. Helical orthopedic fixation and reduction device, insertion system, and associated methods
US6645225B1 (en) 2000-11-01 2003-11-11 Alvan W. Atkinson Method and apparatus for plugging a patent foramen ovale formed in the heart
US6508828B1 (en) 2000-11-03 2003-01-21 Radi Medical Systems Ab Sealing device and wound closure device
WO2002076281A3 (en) 2000-11-07 2003-06-19 Artemis Medical Inc Tissue separator assembly and method
US6966917B1 (en) 2000-11-09 2005-11-22 Innovation Interventional Technologies B.V. Deformable connector for mechanically connecting hollow structures
US6884235B2 (en) 2000-12-06 2005-04-26 Rex Medical, L.P. Introducer sheath with retainer and radiopaque insert
US7806904B2 (en) 2000-12-07 2010-10-05 Integrated Vascular Systems, Inc. Closure device
US7211101B2 (en) 2000-12-07 2007-05-01 Abbott Vascular Devices Methods for manufacturing a clip and clip
US8690910B2 (en) 2000-12-07 2014-04-08 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US6623510B2 (en) 2000-12-07 2003-09-23 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US6719777B2 (en) 2000-12-07 2004-04-13 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8083768B2 (en) 2000-12-14 2011-12-27 Ensure Medical, Inc. Vascular plug having composite construction
US6846319B2 (en) 2000-12-14 2005-01-25 Core Medical, Inc. Devices for sealing openings through tissue and apparatus and methods for delivering them
US6890343B2 (en) 2000-12-14 2005-05-10 Ensure Medical, Inc. Plug with detachable guidewire element and methods for use
US6969397B2 (en) 2000-12-14 2005-11-29 Ensure Medical, Inc. Guide wire element for positioning vascular closure devices and methods for use
US6623509B2 (en) 2000-12-14 2003-09-23 Core Medical, Inc. Apparatus and methods for sealing vascular punctures
CA2485282C (en) 2002-05-10 2011-05-24 Core Medical, Inc. Plug with collet and detachable guidewire element for positioning vascular closure devices and methods for use
US6896692B2 (en) 2000-12-14 2005-05-24 Ensure Medical, Inc. Plug with collet and apparatus and method for delivering such plugs
US6855161B2 (en) 2000-12-27 2005-02-15 Advanced Cardiovascular Systems, Inc. Radiopaque nitinol alloys for medical devices
US20040059376A1 (en) 2001-01-31 2004-03-25 Helmut Breuniger Device for the introduction and fashioning of skin clips
US6703047B2 (en) 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
US6569185B2 (en) 2001-02-15 2003-05-27 Scimed Life Systems Inc Continuous infusion technique for arterial sealing
US6743195B2 (en) 2001-03-14 2004-06-01 Cardiodex Balloon method and apparatus for vascular closure following arterial catheterization
USD457958S1 (en) 2001-04-06 2002-05-28 Sherwood Services Ag Vessel sealer and divider
US7025776B1 (en) 2001-04-24 2006-04-11 Advanced Catheter Engineering, Inc. Arteriotomy closure devices and techniques
US20020173803A1 (en) 2001-05-01 2002-11-21 Stephen Ainsworth Self-closing surgical clip for tissue
US6535764B2 (en) 2001-05-01 2003-03-18 Intrapace, Inc. Gastric treatment and diagnosis device and method
JP4267867B2 (en) 2001-05-03 2009-05-27 ラディ・メディカル・システムズ・アクチェボラーグ Guide instrument of the wound closure element
DE60104667T2 (en) 2001-05-09 2005-01-05 Radi Medical Systems Ab An apparatus for sealing an arterial perforation
US7083629B2 (en) 2001-05-30 2006-08-01 Satiety, Inc. Overtube apparatus for insertion into a body
US6537300B2 (en) 2001-05-30 2003-03-25 Scimed Life Systems, Inc. Implantable obstruction device for septal defects
US7338514B2 (en) 2001-06-01 2008-03-04 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and tools, and related methods of use
WO2002098302A1 (en) 2001-06-07 2002-12-12 Christy Cummins Surgical staple
US7033379B2 (en) 2001-06-08 2006-04-25 Incisive Surgical, Inc. Suture lock having non-through bore capture zone
EP1392181B1 (en) 2001-06-08 2014-10-15 Morris Innovative Research, Inc. Method and apparatus for sealing access
JP4159805B2 (en) 2001-06-15 2008-10-01 ラディ・メディカル・システムズ・アクチェボラーグ The pushing mechanism for the closure method
US20020198589A1 (en) 2001-06-22 2002-12-26 Leong Veronica Jade Tessellated stent and method of manufacture
US6626920B2 (en) 2001-07-05 2003-09-30 Converge Medical, Inc. Distal anastomosis system
US7288105B2 (en) 2001-08-01 2007-10-30 Ev3 Endovascular, Inc. Tissue opening occluder
US6743259B2 (en) 2001-08-03 2004-06-01 Core Medical, Inc. Lung assist apparatus and methods for use
US7208005B2 (en) 2001-08-06 2007-04-24 The Penn State Research Foundation Multifunctional tool and method for minimally invasive surgery
WO2003013364A1 (en) 2001-08-09 2003-02-20 Thomas Anthony Surgical stapling device
CA2456811A1 (en) 2001-08-09 2003-02-20 Christy Cummins Surgical stapling device and method
US6645205B2 (en) 2001-08-15 2003-11-11 Core Medical, Inc. Apparatus and methods for reducing lung volume
US6929634B2 (en) 2001-08-22 2005-08-16 Gore Enterprise Holdings, Inc. Apparatus and methods for treating stroke and controlling cerebral flow characteristics
US6634537B2 (en) 2001-08-23 2003-10-21 Tung-I Chen Detachable insulation wire-pressing element of a stapling device
US6989003B2 (en) 2001-08-31 2006-01-24 Conmed Corporation Obturator and cannula for a trocar adapted for ease of insertion and removal
US20090054912A1 (en) 2001-09-06 2009-02-26 Heanue Taylor A Systems and Methods for Treating Septal Defects
US6776784B2 (en) 2001-09-06 2004-08-17 Core Medical, Inc. Clip apparatus for closing septal defects and methods of use
US6596013B2 (en) 2001-09-20 2003-07-22 Scimed Life Systems, Inc. Method and apparatus for treating septal defects
US6685707B2 (en) 2001-09-25 2004-02-03 Walter Lorenz Surgical, Inc. Cranial clamp and method for fixating a bone plate
US6745079B2 (en) 2001-11-07 2004-06-01 Medtronic, Inc. Electrical tissue stimulation apparatus and method
JP2003190175A (en) 2001-11-15 2003-07-08 Cordis Neurovascular Inc Aneurysm neck cover for sealing aneurysm
US6620165B2 (en) 2001-11-26 2003-09-16 Bioplate, Inc. Bone alignment and fixation plate and installation method
US6746457B2 (en) 2001-12-07 2004-06-08 Abbott Laboratories Snared suture trimmer
US7338505B2 (en) * 2002-01-09 2008-03-04 Neoguide Systems, Inc. Apparatus and method for endoscopic colectomy
US20030139819A1 (en) 2002-01-18 2003-07-24 Beer Nicholas De Method and apparatus for closing septal defects
US7311702B2 (en) 2002-01-18 2007-12-25 Std Manufacturing, Inc. Ablation technology for catheter based delivery systems
US20040093027A1 (en) 2002-03-04 2004-05-13 Walter Fabisiak Barbed tissue connector for sealing vascular puncture wounds
US20030187457A1 (en) 2002-04-02 2003-10-02 Weber John A. Apparatus and method for removing an object from a body
WO2003088846A1 (en) 2002-04-22 2003-10-30 Tyco Healthcare Group, Lp Tack and tack applier
US7077850B2 (en) 2002-05-01 2006-07-18 Scimed Life Systems, Inc. Tissue fastening devices and related insertion tools and methods
DE60308501D1 (en) 2002-05-08 2006-11-02 Radi Medical Systems Soluble medical sealing device
WO2003096881A3 (en) 2002-05-14 2004-04-08 Univ Pittsburgh Device and method of use for functional isolation of animal or human tissues
CA2488688A1 (en) 2002-06-04 2003-12-11 Christy Cummins Blood vessel closure clip and delivery device
CA2488337A1 (en) 2002-06-05 2003-12-18 Nmt Medical, Inc. Patent foramen ovale (pfo) closure device with radial and circumferential support
US20030233095A1 (en) 2002-06-12 2003-12-18 Urbanski Mark G. Device and method for attaching soft tissue to bone
EP1646320B1 (en) 2002-07-03 2009-02-25 Abbott Vascular Inc Surgical stapling device
WO2004012602A3 (en) 2002-08-01 2004-03-18 Abbott Lab Vascular Entpr Ltd Autologous wound sealing apparatus
EP1528901A1 (en) 2002-08-15 2005-05-11 GMP Cardiac Care, Inc. Stent-graft with rails
WO2004023976A3 (en) 2002-09-13 2004-05-21 Damage Control Surgical Techno Method and apparatus for vascular and visceral clipping
US7731655B2 (en) 2002-09-20 2010-06-08 Id, Llc Tissue retractor and method for using the retractor
WO2004026147A3 (en) 2002-09-23 2004-08-12 Nmt Medical Inc Septal puncture device
US20040068273A1 (en) 2002-10-02 2004-04-08 Ibionics Corporation Automatic laparoscopic incision closing apparatus
US7087064B1 (en) 2002-10-15 2006-08-08 Advanced Cardiovascular Systems, Inc. Apparatuses and methods for heart valve repair
US7211089B2 (en) 2002-10-18 2007-05-01 Scimed Life Systems, Inc. Medical retrieval device
US7493154B2 (en) 2002-10-23 2009-02-17 Medtronic, Inc. Methods and apparatus for locating body vessels and occlusions in body vessels
US20040116943A1 (en) 2002-12-13 2004-06-17 Brandt C. Phillip Method and apparatus for endoscopically ligating an elongate tissue structure at multiple sites
US20040122349A1 (en) 2002-12-20 2004-06-24 Lafontaine Daniel M. Closure device with textured surface
US7160309B2 (en) 2002-12-31 2007-01-09 Laveille Kao Voss Systems for anchoring a medical device in a body lumen
GB0300786D0 (en) 2003-01-14 2003-02-12 Barker Stephen G E Laparoscopic port hernia device
US7008442B2 (en) 2003-01-20 2006-03-07 Medtronic Vascular, Inc. Vascular sealant delivery device and sheath introducer and method
US7115135B2 (en) 2003-01-22 2006-10-03 Cardia, Inc. Occlusion device having five or more arms
US8398656B2 (en) 2003-01-30 2013-03-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US7905900B2 (en) 2003-01-30 2011-03-15 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8202293B2 (en) 2003-01-30 2012-06-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US7857828B2 (en) 2003-01-30 2010-12-28 Integrated Vascular Systems, Inc. Clip applier and methods of use
JP4197965B2 (en) 2003-01-31 2008-12-17 オリンパス株式会社 High-frequency snare and medical equipment
JP4094445B2 (en) 2003-01-31 2008-06-04 オリンパス株式会社 Endoscopic mucosal resection tool
DE60309281D1 (en) 2003-02-10 2006-12-07 Heraeus Gmbh W C Improved metal alloy for medical devices and implants
US20070276488A1 (en) 2003-02-10 2007-11-29 Jurgen Wachter Medical implant or device
US7534242B2 (en) 2003-02-25 2009-05-19 Artemis Medical, Inc. Tissue separating catheter assembly and method
DE10310995B3 (en) 2003-03-06 2004-09-16 Aesculap Ag & Co. Kg Device for closing a branch canal and applicator
US20060259049A1 (en) 2003-03-17 2006-11-16 Sumitomo Bakelite Co., Ltd. Clip and clipping instrument for biological tissues
US7850654B2 (en) 2003-04-24 2010-12-14 St. Jude Medical Puerto Rico B.V. Device and method for positioning a closure device
US7112216B2 (en) 2003-05-28 2006-09-26 Boston Scientific Scimed, Inc. Stent with tapered flexibility
US6942641B2 (en) 2003-05-30 2005-09-13 J. Michael Seddon Catheter
EP1727474B1 (en) 2004-03-22 2009-10-14 Accessclosure, Inc. Apparatus for sealing a vascular puncture
US9289195B2 (en) 2003-06-04 2016-03-22 Access Closure, Inc. Auto-retraction apparatus and methods for sealing a vascular puncture
US7331979B2 (en) 2003-06-04 2008-02-19 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US20040249412A1 (en) 2003-06-04 2004-12-09 Snow Brent W. Apparatus and methods for puncture site closure
US7316706B2 (en) 2003-06-20 2008-01-08 Medtronic Vascular, Inc. Tensioning device, system, and method for treating mitral valve regurgitation
US7942897B2 (en) 2003-07-10 2011-05-17 Boston Scientific Scimed, Inc. System for closing an opening in a body cavity
ES2428967T3 (en) 2003-07-14 2013-11-12 W.L. Gore & Associates, Inc. tubular closure device patent foramen ovale (PFO) retention system
DE10335648A1 (en) 2003-07-30 2005-03-03 Eberhard-Karls-Universität Tübingen Sealing plug for an opening in a wall of a vessel or hollow organ
JP4266743B2 (en) 2003-08-08 2009-05-20 オリンパス株式会社 Endoscope hood and endoscopic mucosal resection tool
US8137364B2 (en) 2003-09-11 2012-03-20 Abbott Laboratories Articulating suturing device and method
WO2005027753A1 (en) 2003-09-19 2005-03-31 St. Jude Medical, Inc. Apparatus and methods for tissue gathering and securing
US20050075654A1 (en) 2003-10-06 2005-04-07 Brian Kelleher Methods and devices for soft tissue securement
US7931670B2 (en) 2003-10-15 2011-04-26 St. Jude Medical Puerto Rico Llc Tissue puncture closure device with automatic tamping
US7361183B2 (en) 2003-10-17 2008-04-22 Ensure Medical, Inc. Locator and delivery device and method of use
US8007514B2 (en) 2003-10-17 2011-08-30 St. Jude Medical Puerto Rico Llc Automatic suture locking device
US8852229B2 (en) 2003-10-17 2014-10-07 Cordis Corporation Locator and closure device and method of use
US7326230B2 (en) 2003-10-23 2008-02-05 Sundaram Ravikumar Vascular sealing device and method of use
EP2213244A1 (en) 2003-10-24 2010-08-04 ev3 Endovascular, Inc. Patent foramen ovale closure system
CA2930497A1 (en) 2003-11-19 2005-06-02 Neovasc Medical Ltd. Vascular implant
CA2547999A1 (en) 2003-11-25 2005-06-09 Boston Scientific Limited Hemostatic pressure plug
US7731726B2 (en) 2003-12-03 2010-06-08 St. Jude Medical Puerto Rico Llc Suture based vascular closure apparatus and method incorporating a pre-tied knot
US7390328B2 (en) 2003-12-19 2008-06-24 Abbott Laboratories Device and method for suturing of internal puncture sites
US7717929B2 (en) 2003-12-19 2010-05-18 Radi Medical Systems Ab Technique for securing a suture
US20070060950A1 (en) 2003-12-24 2007-03-15 Farhad Khosravi Apparatus and methods for delivering sealing materials during a percutaneous procedure to facilitate hemostasis
US20050149117A1 (en) 2003-12-24 2005-07-07 Farhad Khosravi Apparatus and methods for delivering sealing materials during a percutaneous procedure to facilitate hemostasis
US20050245876A1 (en) 2003-12-24 2005-11-03 Accessclosure, Inc. Apparatus and methods for facilitating access through a puncture including sealing compound therein
US7618427B2 (en) 2003-12-29 2009-11-17 Ethicon Endo-Surgery, Inc. Device and method for intralumenal anastomosis
US20050154401A1 (en) 2004-01-08 2005-07-14 Scimed Life Systems, Inc. Suturing device for implantable device
WO2005070333A1 (en) 2004-01-13 2005-08-04 Orthobiologica, Inc. Drug delivery to a joint
EP1720595B1 (en) 2004-03-03 2011-05-11 C.R.Bard, Inc. Loop-tip catheter
US20050203550A1 (en) 2004-03-11 2005-09-15 Laufer Michael D. Surgical fastener
US9017374B2 (en) 2004-04-09 2015-04-28 Cardiva Medical, Inc. Device and method for sealing blood vessels
US7648493B2 (en) 2004-04-20 2010-01-19 St. Jude Medical Puerto Rico Llc Method and apparatus for locating vascular punctures
CA2563298A1 (en) 2004-05-07 2005-11-24 Nmt Medical, Inc. Catching mechanisms for tubular septal occluder
US20050256532A1 (en) 2004-05-12 2005-11-17 Asha Nayak Cardiovascular defect patch device and method
WO2005115521A1 (en) 2004-05-14 2005-12-08 Medtronic, Inc. Medical tubing connector assembly incorporating strain relief sleeve
JP4746348B2 (en) 2004-05-20 2011-08-10 オリンパス株式会社 Therapeutic treatment device
US8590760B2 (en) 2004-05-25 2013-11-26 Abbott Vascular Inc. Surgical stapler
US7678135B2 (en) 2004-06-09 2010-03-16 Usgi Medical, Inc. Compressible tissue anchor assemblies
EP1611850A1 (en) 2004-06-28 2006-01-04 Cardio Life Research S.A. Occlusion and tight punction device for an anatomical structure
US7556632B2 (en) 2004-07-09 2009-07-07 Reza Zadno Device and method for repairing tissue
US8348971B2 (en) 2004-08-27 2013-01-08 Accessclosure, Inc. Apparatus and methods for facilitating hemostasis within a vascular puncture
US20060089635A1 (en) 2004-10-22 2006-04-27 Scimed Life Systems, Inc. Methods and apparatus for focused bipolar tissue ablation using an insulated shaft
US7524318B2 (en) 2004-10-28 2009-04-28 Boston Scientific Scimed, Inc. Ablation probe with flared electrodes
US8262693B2 (en) 2004-11-05 2012-09-11 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US20060106420A1 (en) 2004-11-12 2006-05-18 Medtronic Vascular, Inc. Patch for treating a septal defect
US7582104B2 (en) 2004-12-08 2009-09-01 Cardia, Inc. Daisy design for occlusion device
US8105352B2 (en) 2004-12-16 2012-01-31 Radi Medical Systems Ab Medical sealing device
US20060142784A1 (en) 2004-12-28 2006-06-29 Stavros Kontos Device and method for suturing internal structures puncture wounds
EP1835856B1 (en) 2005-01-14 2013-07-31 Radi Medical Systems Ab Medical closure device
US7270672B1 (en) 2005-02-11 2007-09-18 Adam Joel Singer Rod for transferring and tightening knotted suture into patient's body
US7931671B2 (en) 2005-03-11 2011-04-26 Radi Medical Systems Ab Medical sealing device
US7344544B2 (en) 2005-03-28 2008-03-18 Cardica, Inc. Vascular closure system
US8002742B2 (en) 2005-04-22 2011-08-23 Accessclosure, Inc. Apparatus and methods for sealing a puncture in tissue
US7806856B2 (en) 2005-04-22 2010-10-05 Accessclosure, Inc. Apparatus and method for temporary hemostasis
ES2623217T3 (en) 2005-04-22 2017-07-10 Access Closure, Inc. Apparatus for sealing a perforation in the tissue
US7622628B2 (en) 2005-05-04 2009-11-24 Innovasa Corporation Hemostatic wire guided bandage and method of use
US8088144B2 (en) 2005-05-04 2012-01-03 Ensure Medical, Inc. Locator and closure device and method of use
USD566272S1 (en) 2005-05-19 2008-04-08 Integrated Vascular Systems, Inc. Vessel closure device
US8926633B2 (en) 2005-06-24 2015-01-06 Abbott Laboratories Apparatus and method for delivering a closure element
US20060293698A1 (en) 2005-06-28 2006-12-28 Medtronic Vascular, Inc. Retainer device for mitral valve leaflets
USD611144S1 (en) 2006-06-28 2010-03-02 Abbott Laboratories Apparatus for delivering a closure element
US20080312686A1 (en) 2005-07-01 2008-12-18 Abbott Laboratories Antimicrobial closure element and closure element applier
US8007508B2 (en) 2005-07-01 2011-08-30 Cox John A System for tissue dissection and retraction
US8734362B2 (en) * 2005-07-26 2014-05-27 Edward M. Boyle, JR. Minimally invasive methods and apparatus
WO2007016349A3 (en) 2005-07-29 2007-06-07 Cvdevices Llc Devices and methods for percutaneous endo-ventricular reconstruction of the failing heart
US9456811B2 (en) 2005-08-24 2016-10-04 Abbott Vascular Inc. Vascular closure methods and apparatuses
US8758397B2 (en) 2005-08-24 2014-06-24 Abbott Vascular Inc. Vascular closure methods and apparatuses
WO2010031050A1 (en) 2008-09-15 2010-03-18 Abbott Vascular Inc. Redundant tissue closure methods and apparatuses
US20070203507A1 (en) 2005-08-26 2007-08-30 G-Surge Medical Solutions, Inc. Suturing apparatus and methods
US7846179B2 (en) 2005-09-01 2010-12-07 Ovalis, Inc. Suture-based systems and methods for treating septal defects
CA2621197A1 (en) 2005-09-01 2007-03-08 Cordis Corporation Patent foramen ovale closure method
US8758375B2 (en) 2005-09-28 2014-06-24 Olympus Medical Systems Corp Method for suturing perforation
CN101495047B (en) 2005-10-05 2011-12-28 洛马林达大学医学中心 The vessel wound closure apparatus and method
US20070083231A1 (en) 2005-10-07 2007-04-12 Benjamin Lee Vascular closure
US20070083230A1 (en) 2005-10-07 2007-04-12 Alex Javois Left atrial appendage occlusion device
US20070112365A1 (en) 2005-11-15 2007-05-17 Applied Medical Resources Corporation Partial occlusion surgical guide clip
US7815659B2 (en) 2005-11-15 2010-10-19 Ethicon Endo-Surgery, Inc. Suture anchor applicator
EP1971273B1 (en) 2006-01-09 2010-12-01 Cook Incorporated Patent foramen ovale closure device
US20070172430A1 (en) 2006-01-20 2007-07-26 Nastech Pharmaceutical Company Inc. Dry powder compositions for rna influenza therapeutics
US8162974B2 (en) 2006-02-02 2012-04-24 Boston Scientific Scimed, Inc. Occlusion apparatus, system, and method
US7625392B2 (en) 2006-02-03 2009-12-01 James Coleman Wound closure devices and methods
WO2007092323A1 (en) 2006-02-07 2007-08-16 Sutura, Inc. Reverse tapered guidewire and method of use
US7749249B2 (en) 2006-02-21 2010-07-06 Kardium Inc. Method and device for closing holes in tissue
US20070225758A1 (en) 2006-03-22 2007-09-27 Radi Medical Systems Ab Closure device
US20070225757A1 (en) 2006-03-22 2007-09-27 Radi Medical Systems Ab Closure device
US20070225755A1 (en) 2006-03-22 2007-09-27 Radi Medical Systems Ab Closure device
US20070225756A1 (en) 2006-03-22 2007-09-27 Radi Medical Systems Ab Closure device and insertion assembly
US8808310B2 (en) 2006-04-20 2014-08-19 Integrated Vascular Systems, Inc. Resettable clip applier and reset tools
CA2650287C (en) 2006-05-03 2015-11-17 Indiana University Research & Technology Corporation Methods and apparatuses for reshaping the esophagus and other body lumens
US20070265658A1 (en) 2006-05-12 2007-11-15 Aga Medical Corporation Anchoring and tethering system
US20070275036A1 (en) 2006-05-18 2007-11-29 Celldyne Biopharma, Llc Avian follistatin product
US8556930B2 (en) 2006-06-28 2013-10-15 Abbott Laboratories Vessel closure device
US20080033459A1 (en) 2006-08-03 2008-02-07 Surgsolutions, Llp Suturing apparatus for closing tissue defects
US7842048B2 (en) 2006-08-18 2010-11-30 Abbott Laboratories Articulating suture device and method
WO2008036384A3 (en) 2006-09-21 2008-07-24 Synecor Llc Stomach wall closure devices
US20080086075A1 (en) 2006-10-09 2008-04-10 Isik F Frank Vascular access devices and methods of use
JP4584230B2 (en) 2006-11-14 2010-11-17 オリンパスメディカルシステムズ株式会社 Clipping device
DE102006056283A1 (en) 2006-11-29 2008-06-05 Biomagnetik Park Gmbh Occlusion device for closing left heart auricle of patient, has cladding bag provided with fillable opening at its proximal end and partially made of thermoplastic polyurethane, where bag is partially filled with non-degradable plastic
US20080281350A1 (en) 2006-12-13 2008-11-13 Biomerix Corporation Aneurysm Occlusion Devices
US20080177288A1 (en) 2007-01-19 2008-07-24 Carlson Mark A Remote Suturing Device
US7533790B1 (en) 2007-03-08 2009-05-19 Cardica, Inc. Surgical stapler
US8080034B2 (en) 2007-03-29 2011-12-20 St. Jude Medical, Inc. Vascular hemostasis device and deployment apparatus
US8623035B1 (en) * 2007-05-09 2014-01-07 University Of South Florida Methods for resection of a luminal structure
US7967842B2 (en) 2007-06-01 2011-06-28 Ethicon Endo-Surgery, Inc. Integrated securement and closure apparatus
US20080300628A1 (en) 2007-06-01 2008-12-04 Abbott Laboratories Medical Devices
US8226681B2 (en) 2007-06-25 2012-07-24 Abbott Laboratories Methods, devices, and apparatus for managing access through tissue
US7875054B2 (en) 2007-10-01 2011-01-25 Boston Scientific Scimed, Inc. Connective tissue closure device and method
US8142490B2 (en) 2007-10-24 2012-03-27 Cordis Corporation Stent segments axially connected by thin film
EP2214740B1 (en) 2007-10-31 2014-07-30 Cordis Corporation Method of making a vascular closure device
US8893947B2 (en) 2007-12-17 2014-11-25 Abbott Laboratories Clip applier and methods of use
US7841502B2 (en) 2007-12-18 2010-11-30 Abbott Laboratories Modular clip applier
US20090187215A1 (en) 2007-12-19 2009-07-23 Abbott Laboratories Methods and apparatus to reduce a dimension of an implantable device in a smaller state
US8103327B2 (en) 2007-12-28 2012-01-24 Rhythmia Medical, Inc. Cardiac mapping catheter
US20090216267A1 (en) 2008-02-26 2009-08-27 Boston Scientific Scimed, Inc. Closure device with rapidly dissolving anchor
US20090227938A1 (en) 2008-03-05 2009-09-10 Insitu Therapeutics, Inc. Wound Closure Devices, Methods of Use, and Kits
US9282965B2 (en) 2008-05-16 2016-03-15 Abbott Laboratories Apparatus and methods for engaging tissue
US9943302B2 (en) 2008-08-12 2018-04-17 Covidien Lp Medical device for wound closure and method of use
EP2330985A4 (en) 2008-09-04 2015-11-18 Curaseal Inc Inflatable devices for enteric fistula treatment
DE102008053809A1 (en) 2008-10-29 2010-05-12 Medi-Globe Gmbh A surgical Fadenpositioniersystem for sealing an opening within a tissue wall
US8398676B2 (en) 2008-10-30 2013-03-19 Abbott Vascular Inc. Closure device
US8858594B2 (en) 2008-12-22 2014-10-14 Abbott Laboratories Curved closure device
US8323312B2 (en) 2008-12-22 2012-12-04 Abbott Laboratories Closure device
US9486191B2 (en) 2009-01-09 2016-11-08 Abbott Vascular, Inc. Closure devices
US9089311B2 (en) 2009-01-09 2015-07-28 Abbott Vascular Inc. Vessel closure devices and methods
US20100179567A1 (en) 2009-01-09 2010-07-15 Abbott Vascular Inc. Closure devices, systems, and methods
US9173644B2 (en) 2009-01-09 2015-11-03 Abbott Vascular Inc. Closure devices, systems, and methods
US9414820B2 (en) 2009-01-09 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US20100179589A1 (en) 2009-01-09 2010-07-15 Abbott Vascular Inc. Rapidly eroding anchor
US20110218568A1 (en) 2009-01-09 2011-09-08 Voss Laveille K Vessel closure devices, systems, and methods
US20100185234A1 (en) 2009-01-16 2010-07-22 Abbott Vascular Inc. Closure devices, systems, and methods
US8905937B2 (en) 2009-02-26 2014-12-09 Integrated Vascular Systems, Inc. Methods and apparatus for locating a surface of a body lumen
US20110054492A1 (en) 2009-08-26 2011-03-03 Abbott Laboratories Medical device for repairing a fistula
US8480687B2 (en) 2009-10-30 2013-07-09 Cook Medical Technologies Llc Apparatus and methods for achieving serosa-to-serosa closure of a bodily opening
US8303624B2 (en) 2010-03-15 2012-11-06 Abbott Cardiovascular Systems, Inc. Bioabsorbable plug
US8758399B2 (en) 2010-08-02 2014-06-24 Abbott Cardiovascular Systems, Inc. Expandable bioabsorbable plug apparatus and method
US8603116B2 (en) 2010-08-04 2013-12-10 Abbott Cardiovascular Systems, Inc. Closure device with long tines
US8821534B2 (en) 2010-12-06 2014-09-02 Integrated Vascular Systems, Inc. Clip applier having improved hemostasis and methods of use
US8617184B2 (en) 2011-02-15 2013-12-31 Abbott Cardiovascular Systems, Inc. Vessel closure system
US8821529B2 (en) 2011-03-25 2014-09-02 Aga Medical Corporation Device and method for occluding a septal defect
US8556932B2 (en) 2011-05-19 2013-10-15 Abbott Cardiovascular Systems, Inc. Collapsible plug for tissue closure
US9414822B2 (en) 2011-05-19 2016-08-16 Abbott Cardiovascular Systems, Inc. Tissue eversion apparatus and tissue closure device and methods for use thereof
US9332976B2 (en) 2011-11-30 2016-05-10 Abbott Cardiovascular Systems, Inc. Tissue closure device

Patent Citations (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1242139A (en) * 1915-08-20 1917-10-09 Robert L Callahan Means for fastening sacks.
US1480935A (en) * 1922-04-03 1924-01-15 Dora P Gleason Barrette
US3357070A (en) * 1966-03-11 1967-12-12 Harriet L Soloan Accessories for hairdos and articles of apparel
US3348595A (en) * 1967-03-15 1967-10-24 Walter Landor Bag closure structure
US3682180A (en) * 1970-06-08 1972-08-08 Coilform Co Inc Drain clip for surgical drain
US4189808A (en) * 1978-09-20 1980-02-26 Brown Theodore G Retainer and closure for a garbage can liner bag
US4267995A (en) * 1979-10-09 1981-05-19 Mcmillan Ronald R Wire holder
US4697312A (en) * 1985-06-27 1987-10-06 Haagexport, B.V. Device for carrying and closing bags
US5404621A (en) * 1994-03-10 1995-04-11 Heinke; Richard M. Closure for plastic bags
US5735736A (en) * 1994-06-06 1998-04-07 Volk Enterprises, Inc. Retainer for poultry hocks
US6984238B2 (en) * 1995-02-24 2006-01-10 Gifford Iii Hanson S Devices and methods for performing avascular anastomosis
US5669935A (en) * 1995-07-28 1997-09-23 Ethicon, Inc. One-way suture retaining device for braided sutures
US6095155A (en) * 1997-05-16 2000-08-01 Criscuolo; Joseph Michael Paul Retaining apparatus
US5845657A (en) * 1997-05-29 1998-12-08 Carberry; Geoff Hair styling device
US6613060B2 (en) * 1997-06-02 2003-09-02 Scimed Life Systems, Inc. Textured ligating band
US6161263A (en) * 1997-06-25 2000-12-19 Anderson; Paul Sock pair retention apparatus
US6120513A (en) * 1998-01-09 2000-09-19 Bailey; Robert W. Laparoscopic surgery instrumentation and method of its use
US6904647B2 (en) * 1999-02-10 2005-06-14 James H. Byers, Jr. Clamping devices
US6676685B2 (en) * 1999-02-22 2004-01-13 Tyco Healthcare Group Lp Arterial hole closure apparatus
US6849078B2 (en) * 1999-11-18 2005-02-01 Ovesco Endoscopy, Gmbh Apparatus and method for compressing body tissue
US6942674B2 (en) * 2000-01-05 2005-09-13 Integrated Vascular Systems, Inc. Apparatus and methods for delivering a closure device
US20010053909A1 (en) * 2000-05-26 2001-12-20 Olympus Optical Co., Ltd. Endoscope hood for mucous membrane resection
US6578585B1 (en) * 2001-02-21 2003-06-17 Barbara Stachowski Barrette
US6736822B2 (en) * 2002-02-20 2004-05-18 Mcclellan Scott B. Device and method for internal ligation of tubular structures
US6695867B2 (en) * 2002-02-21 2004-02-24 Integrated Vascular Systems, Inc. Plunger apparatus and methods for delivering a closure device
US6749621B2 (en) * 2002-02-21 2004-06-15 Integrated Vascular Systems, Inc. Sheath apparatus and methods for delivering a closure device
US8226666B2 (en) * 2003-03-14 2012-07-24 Edwards Lifesciences Corporation Mitral valve repair system and method for use
US7799042B2 (en) * 2004-05-13 2010-09-21 The Cleveland Clinic Foundation Skin lesion exciser and skin-closure device therefor
US7645285B2 (en) * 2004-05-26 2010-01-12 Idx Medical, Ltd Apparatus and methods for occluding a hollow anatomical structure
US20060058844A1 (en) * 2004-09-13 2006-03-16 St. Jude Medical Puerto Rico B.V. Vascular sealing device with locking system
US20080004636A1 (en) * 2005-07-01 2008-01-03 Abbott Laboratories Clip applier and methods of use
US20100130965A1 (en) * 2005-08-24 2010-05-27 Abbott Vascular Inc. Redundant Tissue Closure Methods and Apparatuses
US20070049968A1 (en) * 2005-08-24 2007-03-01 Sibbitt Wilmer L Jr Vascular opening edge eversion methods and apparatuses
US20070060951A1 (en) * 2005-09-15 2007-03-15 Shannon Francis L Atrial tissue fixation device
US20070123936A1 (en) * 2005-11-15 2007-05-31 Aoi Medical, Inc. Arterial Closure Button
US20090306681A1 (en) * 2006-01-30 2009-12-10 Del Nido Pedro J Tissue tack
US20070213747A1 (en) * 2006-03-09 2007-09-13 Leonid Monassevitch Surgical compression clips
US20080065152A1 (en) * 2006-09-08 2008-03-13 Abbott Laboratories Apparatus and method for delivering a closure element
US20080287988A1 (en) * 2007-05-17 2008-11-20 Smith Paul J Tissue aperture securing and sealing apparatuses and related methods of use
US20090105728A1 (en) * 2007-10-23 2009-04-23 Minos Medical Devices and methods for securing tissue
US20090157101A1 (en) * 2007-12-17 2009-06-18 Abbott Laboratories Tissue closure system and methods of use
US20110066163A1 (en) * 2009-09-14 2011-03-17 National Cancer Center Hemostatic Clip and Hemostatic Clip Operation Apparatus Using the Same

Cited By (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8758400B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Closure system and methods of use
US9579091B2 (en) 2000-01-05 2017-02-28 Integrated Vascular Systems, Inc. Closure system and methods of use
US8956388B2 (en) 2000-01-05 2015-02-17 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant
US9050087B2 (en) 2000-01-05 2015-06-09 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
US8758396B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US9060769B2 (en) 2000-09-08 2015-06-23 Abbott Vascular Inc. Surgical stapler
US8784447B2 (en) 2000-09-08 2014-07-22 Abbott Vascular Inc. Surgical stapler
US9402625B2 (en) 2000-09-08 2016-08-02 Abbott Vascular Inc. Surgical stapler
US9089674B2 (en) 2000-10-06 2015-07-28 Integrated Vascular Systems, Inc. Apparatus and methods for positioning a vascular sheath
US8690910B2 (en) 2000-12-07 2014-04-08 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8597325B2 (en) 2000-12-07 2013-12-03 Integrated Vascular Systems, Inc. Apparatus and methods for providing tactile feedback while delivering a closure device
US9320522B2 (en) 2000-12-07 2016-04-26 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8728119B2 (en) 2001-06-07 2014-05-20 Abbott Vascular Inc. Surgical staple
US9498196B2 (en) 2002-02-21 2016-11-22 Integrated Vascular Systems, Inc. Sheath apparatus and methods for delivering a closure device
US8579932B2 (en) 2002-02-21 2013-11-12 Integrated Vascular Systems, Inc. Sheath apparatus and methods for delivering a closure device
US9295469B2 (en) 2002-06-04 2016-03-29 Abbott Vascular Inc. Blood vessel closure clip and delivery device
US8585836B2 (en) 2002-12-31 2013-11-19 Integrated Vascular Systems, Inc. Methods for manufacturing a clip and clip
US9398914B2 (en) 2003-01-30 2016-07-26 Integrated Vascular Systems, Inc. Methods of use of a clip applier
US8926656B2 (en) 2003-01-30 2015-01-06 Integated Vascular Systems, Inc. Clip applier and methods of use
US9271707B2 (en) 2003-01-30 2016-03-01 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8590760B2 (en) 2004-05-25 2013-11-26 Abbott Vascular Inc. Surgical stapler
US8926633B2 (en) 2005-06-24 2015-01-06 Abbott Laboratories Apparatus and method for delivering a closure element
US9050068B2 (en) 2005-07-01 2015-06-09 Abbott Laboratories Clip applier and methods of use
US8932324B2 (en) 2005-08-24 2015-01-13 Abbott Vascular Inc. Redundant tissue closure methods and apparatuses
US9456811B2 (en) 2005-08-24 2016-10-04 Abbott Vascular Inc. Vascular closure methods and apparatuses
US8920442B2 (en) 2005-08-24 2014-12-30 Abbott Vascular Inc. Vascular opening edge eversion methods and apparatuses
US8808310B2 (en) 2006-04-20 2014-08-19 Integrated Vascular Systems, Inc. Resettable clip applier and reset tools
US8556930B2 (en) 2006-06-28 2013-10-15 Abbott Laboratories Vessel closure device
US9962144B2 (en) 2006-06-28 2018-05-08 Abbott Laboratories Vessel closure device
US8758398B2 (en) 2006-09-08 2014-06-24 Integrated Vascular Systems, Inc. Apparatus and method for delivering a closure element
US8893947B2 (en) 2007-12-17 2014-11-25 Abbott Laboratories Clip applier and methods of use
US8672953B2 (en) 2007-12-17 2014-03-18 Abbott Laboratories Tissue closure system and methods of use
US8820602B2 (en) 2007-12-18 2014-09-02 Abbott Laboratories Modular clip applier
US9282965B2 (en) 2008-05-16 2016-03-15 Abbott Laboratories Apparatus and methods for engaging tissue
US8657852B2 (en) 2008-10-30 2014-02-25 Abbott Vascular Inc. Closure device
US9241696B2 (en) 2008-10-30 2016-01-26 Abbott Vascular Inc. Closure device
US8858594B2 (en) 2008-12-22 2014-10-14 Abbott Laboratories Curved closure device
US9486191B2 (en) 2009-01-09 2016-11-08 Abbott Vascular, Inc. Closure devices
US9089311B2 (en) 2009-01-09 2015-07-28 Abbott Vascular Inc. Vessel closure devices and methods
US9173644B2 (en) 2009-01-09 2015-11-03 Abbott Vascular Inc. Closure devices, systems, and methods
US9414820B2 (en) 2009-01-09 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US8905937B2 (en) 2009-02-26 2014-12-09 Integrated Vascular Systems, Inc. Methods and apparatus for locating a surface of a body lumen
US8758399B2 (en) 2010-08-02 2014-06-24 Abbott Cardiovascular Systems, Inc. Expandable bioabsorbable plug apparatus and method
US8821534B2 (en) 2010-12-06 2014-09-02 Integrated Vascular Systems, Inc. Clip applier having improved hemostasis and methods of use
US8617184B2 (en) 2011-02-15 2013-12-31 Abbott Cardiovascular Systems, Inc. Vessel closure system
US9955960B2 (en) 2011-02-26 2018-05-01 Abbott Cardiovascular Systems, Inc. Hinged tissue support device
US20120296374A1 (en) * 2011-05-19 2012-11-22 Abbott Cardiovascular Systems, Inc. Tissue eversion apparatus and tissue closure device and methods for use thereof
US9414822B2 (en) * 2011-05-19 2016-08-16 Abbott Cardiovascular Systems, Inc. Tissue eversion apparatus and tissue closure device and methods for use thereof
US8556932B2 (en) 2011-05-19 2013-10-15 Abbott Cardiovascular Systems, Inc. Collapsible plug for tissue closure
US9332976B2 (en) 2011-11-30 2016-05-10 Abbott Cardiovascular Systems, Inc. Tissue closure device
US20150057682A1 (en) * 2012-02-01 2015-02-26 St. Jude Medical, Inc. Clip delivery system for heart valve repair and method of use
US20150250461A1 (en) * 2012-09-26 2015-09-10 Eric Berreklouw Constrictor for closing or narrowing a passage through tissue of a hollow organ
US20170112484A1 (en) * 2013-01-17 2017-04-27 Abbott Cardiovascular Systems, Inc. Access device for accessing tissue
US20140200409A1 (en) * 2013-01-17 2014-07-17 Abbott Cardiovascular Systems, Inc. Access device for accessing tissue
US9486132B2 (en) * 2013-01-17 2016-11-08 Abbott Cardiovascular Systems, Inc. Access device for accessing tissue
US20140257341A1 (en) * 2013-03-06 2014-09-11 St. Jude Medical, Cardiology Division, Inc. Pmvr clip configurations for mitral leaflet
US9788842B2 (en) * 2013-03-06 2017-10-17 St. Jude Medical, Cardiology Division, Inc. PMVR clip configurations for mitral leaflet
US20150012006A1 (en) * 2013-07-02 2015-01-08 Cardica, Inc. Anastomosis stapling/clipping devices, systems and methods
US20150038800A1 (en) * 2013-08-02 2015-02-05 Covidien Lp Devices, systems, and methods for wound closure
US9681868B2 (en) * 2013-08-02 2017-06-20 Covidien Lp Devices, systems, and methods for wound closure
WO2016069779A1 (en) * 2014-10-28 2016-05-06 Trocare, LLC Fascia closure device and method
WO2017053872A1 (en) * 2015-09-25 2017-03-30 Steven Craig Anderson Apparatus and method for adhesion

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