US20110130445A1 - Substituted 3-phenylpropionic acids and the use thereof - Google Patents

Substituted 3-phenylpropionic acids and the use thereof Download PDF

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Publication number
US20110130445A1
US20110130445A1 US12/914,101 US91410110A US2011130445A1 US 20110130445 A1 US20110130445 A1 US 20110130445A1 US 91410110 A US91410110 A US 91410110A US 2011130445 A1 US2011130445 A1 US 2011130445A1
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United States
Prior art keywords
amino
methyl
trifluoro
mmol
chlorophenyl
Prior art date
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Abandoned
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US12/914,101
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English (en)
Inventor
Thomas Lampe
Michael Hahn
Johannes-Peter Stasch
Karl-Heinz Schlemmer
Frank Wunder
Sherif El Sheikh
Volkhart Min-Jian Li
Eva-Maria Becker
Friederike Stoll
Andreas Knorr
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Bayer Intellectual Property GmbH
Original Assignee
Bayer Schering Pharma AG
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Application filed by Bayer Schering Pharma AG filed Critical Bayer Schering Pharma AG
Publication of US20110130445A1 publication Critical patent/US20110130445A1/en
Assigned to BAYER SCHERING PHARMA AKTIENGESELLSCHAFT reassignment BAYER SCHERING PHARMA AKTIENGESELLSCHAFT ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SCHLEMMER, KARL-HEINZ, DR., HAHN, MICHAEL, DR., BECKER, EVA-MARIA, DR., LI, VOLKHART MIN-JIAN, DR., EL SHEIKH, SHERIF, DR., LAMPE, THOMAS, DR., STOLL, FRIEDERIKE, DR., WUNDER, FRANK, DR., KNORR, ANDREAS, DR., STASCH, JOHANNES-PETER, DR.
Assigned to BAYER INTELLECTUAL PROPERTY GMBH reassignment BAYER INTELLECTUAL PROPERTY GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BAYER PHARMA AKTIENGESELLSCHAFT
Priority to US14/045,630 priority Critical patent/US9018414B2/en
Abandoned legal-status Critical Current

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    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • C07C205/38—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. nitrodiphenyl ethers
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US12/914,101 2009-10-28 2010-10-28 Substituted 3-phenylpropionic acids and the use thereof Abandoned US20110130445A1 (en)

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US14/045,630 US9018414B2 (en) 2009-10-28 2013-10-03 Substituted 3-phenylpropionic acids and the use thereof

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DE102009046115.9 2009-10-28
DE102009046115A DE102009046115A1 (de) 2009-10-28 2009-10-28 Substituierte 3-Phenylpropansäuren und ihre Verwendung

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EP (1) EP2493845B1 (hr)
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KR (1) KR20120101411A (hr)
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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120028971A1 (en) * 2009-03-09 2012-02-02 Bayer Pharma Aktiengesellschaft Oxo-heterocyclically substituted alkyl carboxylic acids and use thereof
US20130079412A1 (en) * 2011-04-13 2013-03-28 Bayer Pharma Aktiengesellschaft Branched 3-phenylpropionic acid derivatives and their use
US8895583B2 (en) 2010-10-28 2014-11-25 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
US8987256B2 (en) 2008-04-14 2015-03-24 Bayer Intellectual Property Gmbh Oxo-heterocyclic substituted carboxylic acid derivatives and the use thereof
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