US20090043264A1 - Injection Device - Google Patents

Injection Device Download PDF

Info

Publication number
US20090043264A1
US20090043264A1 US11/911,871 US91187106A US2009043264A1 US 20090043264 A1 US20090043264 A1 US 20090043264A1 US 91187106 A US91187106 A US 91187106A US 2009043264 A1 US2009043264 A1 US 2009043264A1
Authority
US
United States
Prior art keywords
injection device
housing
dose setting
piston rod
thread
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/911,871
Other languages
English (en)
Inventor
Kristian Glejbol
Steven Linnebjerg
Claus Schmidt Moller
Michael Ejstrup Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of US20090043264A1 publication Critical patent/US20090043264A1/en
Assigned to NOVO NORDISK A/S reassignment NOVO NORDISK A/S ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GLEJBOL, KRISTIAN, MOLLER, CLAUS SCHMIDT, HANSEN, MICHAEL EJSTRUP, LINNEBJERG, STEVEN
Abandoned legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/3155Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/3152Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31535Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31541Means preventing setting of a dose beyond the amount remaining in the cartridge
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/31556Accuracy improving means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/31556Accuracy improving means
    • A61M5/31558Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/3156Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/31561Mechanically operated dose setting member using freely adjustable volume steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566Means improving security or handling thereof
    • A61M5/31573Accuracy improving means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566Means improving security or handling thereof
    • A61M5/31573Accuracy improving means
    • A61M5/31575Accuracy improving means using scaling up or down transmissions, e.g. gearbox
US11/911,871 2005-04-24 2006-04-21 Injection Device Abandoned US20090043264A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200500589 2005-04-24
DKPA200500589 2005-04-24
PCT/EP2006/061748 WO2006114396A1 (en) 2005-04-24 2006-04-21 Injection device

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/061748 A-371-Of-International WO2006114396A1 (en) 2005-04-24 2006-04-21 Injection device

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/571,721 Continuation US8197450B2 (en) 2005-04-24 2009-10-01 Injection device

Publications (1)

Publication Number Publication Date
US20090043264A1 true US20090043264A1 (en) 2009-02-12

Family

ID=36685844

Family Applications (3)

Application Number Title Priority Date Filing Date
US11/911,871 Abandoned US20090043264A1 (en) 2005-04-24 2006-04-21 Injection Device
US12/571,721 Expired - Fee Related US8197450B2 (en) 2005-04-24 2009-10-01 Injection device
US13/407,430 Expired - Fee Related US8641683B2 (en) 2005-04-24 2012-02-28 Injection device

Family Applications After (2)

Application Number Title Priority Date Filing Date
US12/571,721 Expired - Fee Related US8197450B2 (en) 2005-04-24 2009-10-01 Injection device
US13/407,430 Expired - Fee Related US8641683B2 (en) 2005-04-24 2012-02-28 Injection device

Country Status (5)

Country Link
US (3) US20090043264A1 (zh)
EP (1) EP1877121B1 (zh)
JP (1) JP4979686B2 (zh)
CN (1) CN101163514B (zh)
WO (1) WO2006114396A1 (zh)

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050209570A1 (en) * 2000-06-16 2005-09-22 Novo Nordisk A/S Injection device
US20090062748A1 (en) * 2006-03-10 2009-03-05 Novo Nordisk A/S Injection Device Having a Gearing Arrangement
US20090209920A1 (en) * 2006-05-18 2009-08-20 Novo Nordisk A/S Injection Device with Mode Locking Means
US20090254027A1 (en) * 2006-03-10 2009-10-08 Novo Nordisk A/S Injection Device and a Method of Changing a Cartridge in the Device
US20100016806A1 (en) * 2005-04-24 2010-01-21 Novo Nordisk A/S Injection Device
US20100022964A1 (en) * 2006-05-16 2010-01-28 Novo Nordisk A/S Gearing Mechanism for an Injection Device
US20100106099A1 (en) * 2006-12-21 2010-04-29 Novo Nordisk A/S Syringe Device
US20100114025A1 (en) * 2007-03-23 2010-05-06 Novo Nordisk A/S Injection device comprising a locking nut
US20100324498A1 (en) * 2006-12-15 2010-12-23 Novo Nordisk A/S Medical delivery system comprising a container and a dosing assembly with radially moving fastening means
US20120004640A1 (en) * 2008-12-09 2012-01-05 Melissa Rosen Open and closed valve medication delivery system for high pressure injections
KR20130120478A (ko) * 2010-10-06 2013-11-04 사노피-아벤티스 도이칠란트 게엠베하 약물 전달 디바이스를 위한 구동 메카니즘 및 약물 전달 디바이스
KR20130120477A (ko) * 2010-10-06 2013-11-04 사노피-아벤티스 도이칠란트 게엠베하 약물 전달 디바이스를 위한 구동 메카니즘 및 약물 전달 디바이스
KR20130120476A (ko) * 2010-10-06 2013-11-04 사노피-아벤티스 도이칠란트 게엠베하 약물 전달 디바이스를 위한 구동 메카니즘 및 약물 전달 디바이스
JP2014502890A (ja) * 2010-12-23 2014-02-06 ノボ ノルディスク ヘルス ケア アーゲー 薬剤送出装置のためのピストン棒駆動装置
US20160058952A1 (en) * 2013-04-10 2016-03-03 Sanofi Pen-type drug injection device and dose setting limiter mechanism therefor
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
USRE46363E1 (en) 2004-10-21 2017-04-11 Novo Nordisk A/S Dial-down mechanism for wind-up pen
US9670261B2 (en) 2012-12-21 2017-06-06 Sanofi Functionalized exendin-4 derivatives
US9694053B2 (en) 2013-12-13 2017-07-04 Sanofi Dual GLP-1/glucagon receptor agonists
US9750788B2 (en) 2013-12-13 2017-09-05 Sanofi Non-acylated exendin-4 peptide analogues
US9751926B2 (en) 2013-12-13 2017-09-05 Sanofi Dual GLP-1/GIP receptor agonists
US9758561B2 (en) 2014-04-07 2017-09-12 Sanofi Dual GLP-1/glucagon receptor agonists derived from exendin-4
US9771406B2 (en) 2014-04-07 2017-09-26 Sanofi Peptidic dual GLP-1/glucagon receptor agonists derived from exendin-4
US9775904B2 (en) 2014-04-07 2017-10-03 Sanofi Exendin-4 derivatives as peptidic dual GLP-1/glucagon receptor agonists
US9789165B2 (en) 2013-12-13 2017-10-17 Sanofi Exendin-4 peptide analogues as dual GLP-1/GIP receptor agonists
CN107314088A (zh) * 2017-07-11 2017-11-03 宜昌长机科技有限责任公司 一种可变传动比无侧隙定位齿条副装置及操作方法
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
US9982029B2 (en) 2015-07-10 2018-05-29 Sanofi Exendin-4 derivatives as selective peptidic dual GLP-1/glucagon receptor agonists
US20180361073A1 (en) * 2015-12-14 2018-12-20 Sanofi-Aventis Deutschland Gmbh Drive mechanism for an injection device
US10758592B2 (en) 2012-10-09 2020-09-01 Sanofi Exendin-4 derivatives as dual GLP1/glucagon agonists
US10806797B2 (en) 2015-06-05 2020-10-20 Sanofi Prodrugs comprising an GLP-1/glucagon dual agonist linker hyaluronic acid conjugate
US20220362477A1 (en) * 2021-05-11 2022-11-17 Stevanato Group S.P.A. Drug injection device

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2314182T3 (es) 2002-02-11 2009-03-16 Antares Pharma, Inc. Inyector intradermico.
GB0304822D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
EP1850892B2 (en) 2005-01-24 2023-04-19 Antares Pharma, Inc. Prefilled needle assisted syringe jet injector
DE102005023824A1 (de) * 2005-05-24 2006-12-07 Tecpharma Licensing Ag Dosiervorrichtung für eine Injektionsvorrichtung
WO2007131013A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Two-stage reconstituting injector
US9144648B2 (en) 2006-05-03 2015-09-29 Antares Pharma, Inc. Injector with adjustable dosing
DE102006038101A1 (de) * 2006-08-14 2008-02-21 Tecpharma Licensing Ag Injektionsvorrichtung mit Klauensicherung
DE102007026083A1 (de) * 2007-05-25 2008-11-27 Haselmeier S.A.R.L. Injektionsgerät
WO2009039851A1 (en) * 2007-09-25 2009-04-02 Claus Schmidt Moeller Dose delivery device with gearing mechanism
WO2009114542A1 (en) 2008-03-10 2009-09-17 Antares Pharma, Inc. Injector safety device
EP2318075B1 (en) 2008-08-05 2019-05-22 Antares Pharma, Inc. Multiple dosage injector
US9545483B2 (en) * 2008-12-02 2017-01-17 Sanofi-Aventis Deutschland Gmbh Drive assembly suitable for use in a medication delivery device and medication delivery device
WO2010077277A1 (en) 2008-12-09 2010-07-08 Becton, Dickinson And Company Lever and gear force multiplier medication delivery system for high pressure injection system
MY156406A (en) * 2009-03-30 2016-02-26 Sanofi Aventis Deutschland Drug delivery device with an improved piston rod
US10034982B2 (en) * 2009-06-01 2018-07-31 Sanofi-Aventis Deutschland Gmbh Spindle for a drug delivery device
CN102470208A (zh) * 2009-07-15 2012-05-23 赛诺菲-安万特德国有限公司 推力轴承组件、驱动系和药物递送装置
US9402962B2 (en) * 2009-09-30 2016-08-02 Sanofi-Aventis Deutschland Gmbh Assembly for use in a drug delivery device
US9616178B2 (en) 2010-10-13 2017-04-11 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism and method of using the same
SG10201700601VA (en) 2011-03-16 2017-03-30 Becton Dickinson Co Multiple use disposable injection pen
US11577029B2 (en) 2012-03-15 2023-02-14 Becton, Dickinson And Company Multiple use disposable injection pen
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US10213556B2 (en) 2011-12-08 2019-02-26 Unl Holdings Llc Accurate dose control mechanisms and drug delivery syringes
PT2822618T (pt) 2012-03-06 2024-03-04 Antares Pharma Inc Seringa pré-cheia com característica de força de rutura
JP6457383B2 (ja) 2012-04-06 2019-01-23 アンタレス・ファーマ・インコーポレーテッド テストステロン組成物の針支援式ジェット注入投与
WO2013169804A1 (en) 2012-05-07 2013-11-14 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
ES2763633T3 (es) 2013-02-11 2020-05-29 Antares Pharma Inc Dispositivo de inyección por chorro asistido por aguja que tiene fuerza de disparo reducida
TWI653069B (zh) * 2013-03-11 2019-03-11 德商賽諾菲阿凡提斯德意志有限公司 活塞桿以及包含活塞桿的藥物輸送裝置
ES2742046T3 (es) 2013-03-11 2020-02-12 Antares Pharma Inc Inyector de dosis con sistema de piñón
CN105025965B (zh) * 2013-03-13 2019-07-05 赛诺菲-安万特德国有限公司 用于药物输送装置的包括反馈特征部的组件
WO2015032779A1 (en) * 2013-09-03 2015-03-12 Sanofi Piston rod for a drug delivery device and drug delivery device comprising a piston rod
US10569024B2 (en) * 2013-09-23 2020-02-25 Sanofi-Aventis Deutschland Gmbh Assembly for a drug delivery device and drug delivery device
EP3223887B1 (en) * 2014-11-24 2019-10-09 Sanofi Display and drug delivery device herewith
AU2015372441A1 (en) 2014-12-23 2017-08-10 Automed Pty Ltd Delivery apparatus, system and associated methods
BR112018074108A2 (pt) * 2016-05-24 2019-03-06 Unl Holdings Llc seringas de administração de medicamentos e mecanismos de controle de dose exata
CN107485760B (zh) * 2017-07-25 2023-06-30 广州瑞恺迪光电科技有限公司 一种注射装置
CN107875487B (zh) * 2017-10-27 2024-01-26 江苏德尔福医疗器械有限公司 高精度笔式注射器
US11957542B2 (en) 2020-04-30 2024-04-16 Automed Patent Holdco, Llc Sensing complete injection for animal injection device

Citations (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2392196A (en) * 1945-02-24 1946-01-01 Arthur E Smith Syringe
US3556099A (en) * 1968-05-27 1971-01-19 Johnson & Johnson Hypodermic syringe assembly
US3880162A (en) * 1973-04-25 1975-04-29 Lee G Simmons Pole-syringe for injecting from a remote distance
US4313439A (en) * 1980-03-24 1982-02-02 Biotek, Inc. Automated, spring-powered medicament infusion system
US4314556A (en) * 1980-04-21 1982-02-09 Ma Austin C Emergency syringe
US4368731A (en) * 1980-02-12 1983-01-18 Schramm Heinrich W Pistol-type syringe
USRE31315E (en) * 1979-07-02 1983-07-19 Imed Corporation Apparatus for converting a pump to a controller
US4430079A (en) * 1978-11-08 1984-02-07 Minnesota Mining And Manufacturing Company Fluid dispensing device
US4498904A (en) * 1981-02-12 1985-02-12 Turner Robert C Dose metering plunger devices for use with syringes
US4568335A (en) * 1981-08-28 1986-02-04 Markwell Medical Institute, Inc. Device for the controlled infusion of medications
US4585439A (en) * 1983-09-07 1986-04-29 Disetronic Ag. Portable infusion unit
US4676122A (en) * 1984-06-15 1987-06-30 Daltex Medical Sciences, Inc. Fail-safe mechanical drive for syringe
US4749109A (en) * 1983-11-15 1988-06-07 Kamen Dean L Volumetric pump with replaceable reservoir assembly
US4833379A (en) * 1988-01-13 1989-05-23 Sherwood Medical Company Motor control fail-safe circuit
US4919596A (en) * 1987-12-04 1990-04-24 Pacesetter Infusion, Ltd. Fluid delivery control and monitoring apparatus for a medication infusion system
US4936833A (en) * 1987-06-12 1990-06-26 Hypoguard (Uk) Limited Cartridge-holder assembly for medication dispensing unit
US4988337A (en) * 1988-08-10 1991-01-29 Terumo Kabushiki Kaisha Syringe pump apparatus
US4994033A (en) * 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5000744A (en) * 1989-10-23 1991-03-19 Gte Products Corporation Hypodermic syringe
US5078698A (en) * 1991-02-19 1992-01-07 Sterling Drug Inc. Axial eject hypodermic syringe holder
US5112317A (en) * 1988-01-22 1992-05-12 Nosta Ag Injection device
US5176646A (en) * 1991-02-19 1993-01-05 Takayuki Kuroda Motorized syringe pump
US5207752A (en) * 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
US5226895A (en) * 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
US5226342A (en) * 1989-02-07 1993-07-13 Agence Spatiale Europeenne Linear or circular rachet-type locking device with automatic unlocking and self-locking
US5279585A (en) * 1992-02-04 1994-01-18 Becton, Dickinson And Company Medication delivery pen having improved dose delivery features
US5281198A (en) * 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
US5284480A (en) * 1990-11-09 1994-02-08 Medtronic, Inc. Inflation/deflation syringe with threaded plunger
US5304152A (en) * 1990-03-29 1994-04-19 Bernard Sams Dispensing device
US5314412A (en) * 1991-04-17 1994-05-24 Novo Nordisk A S Manifold for a two barrel syringe
US5318540A (en) * 1990-04-02 1994-06-07 Pharmetrix Corporation Controlled release infusion device
US5320609A (en) * 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
US5331954A (en) * 1990-12-21 1994-07-26 Novo Nordisk A/S Device for nasal delivery of liquid medications
US5383865A (en) * 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
US5408387A (en) * 1991-11-30 1995-04-18 Meitaku System Co., Ltd. Edge light panel and its production
US5492534A (en) * 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
US5496286A (en) * 1994-08-17 1996-03-05 Sterling Winthrop Hypodermic syringe holder with disposable body
US5505704A (en) * 1993-04-02 1996-04-09 Eli Lilly And Company Manifold medication injection apparatus and method
US5505697A (en) * 1994-01-14 1996-04-09 Mckinnon, Jr.; Charles N. Electrically powered jet injector
US5591136A (en) * 1991-04-15 1997-01-07 Medico Development Investment Company Injection device
US5599314A (en) * 1992-09-19 1997-02-04 Hypoguard (Uk) Limited Syringe with incrementally actuated plunger
US5611783A (en) * 1991-11-29 1997-03-18 Novo Nordisk A/S Pen-shaped syringe
US5611784A (en) * 1993-06-30 1997-03-18 Hamilton Company Manual dispensing aid for a syringe
US5626566A (en) * 1991-10-18 1997-05-06 Novo Nordisk A/S Large dose pen
US5637095A (en) * 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
US5645052A (en) * 1991-04-26 1997-07-08 The Boc Group Plc Anaesthetic vaporizer with expandable/contractable reservoir for pumping liquid anaesthetic
US5709662A (en) * 1996-08-23 1998-01-20 Becton Dickinson France, S.A. Cartridge for an injection device
US5716990A (en) * 1987-03-09 1998-02-10 Cancer Research Campaign Technology Limited Drug delivery systems
US5725080A (en) * 1995-03-24 1998-03-10 Fichtel & Sachs Ag Clutch for motor vehicles having a clutch disc with spring elements connected in series
US5728559A (en) * 1993-07-09 1998-03-17 Novo Nordisk A/S Separation of proteins
US5743889A (en) * 1992-12-18 1998-04-28 Sams; Bernard Incrementing dosage mechanism for syringe
US5755692A (en) * 1994-09-28 1998-05-26 Manicom; Anthony William Method and apparatus for administering a drug to a patient
US5782633A (en) * 1996-04-10 1998-07-21 Muehlbauer; Ernst Applicator for a dental compound
US5882718A (en) * 1994-09-20 1999-03-16 Novo Nordisk A/S Method for treating an aqueous protein solution to kill microorganisms therein without causing coagulation and composition thereof
US5898028A (en) * 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
US5921966A (en) * 1997-08-11 1999-07-13 Becton Dickinson And Company Medication delivery pen having an improved clutch assembly
US6010485A (en) * 1996-09-20 2000-01-04 Novo Nordisk A/S Working cylinder
US6033377A (en) * 1997-02-04 2000-03-07 Novo Nordisk A/S Device for the administration of a liquid medicament suspension
US6033376A (en) * 1998-09-30 2000-03-07 Allergan Sales, Inc. Wound shaper sleeve
US6036675A (en) * 1999-02-03 2000-03-14 Specialized Health Products, Inc. Safety sterile cartride unit apparatus and methods
US6048336A (en) * 1997-03-03 2000-04-11 Medico Injection device
US6074372A (en) * 1997-06-09 2000-06-13 Novo Nordisk A/S Dose setting mechanism and an injection syringe having such a dose setting mechanism
US6193698B1 (en) * 1997-07-18 2001-02-27 Disetronic Licensing Ag System for locking a dosing button in a device for the adminstration of a product to be injected
US6221046B1 (en) * 1995-03-07 2001-04-24 Eli Lilly And Company Recyclable medication dispensing device
US6221053B1 (en) * 1998-02-20 2001-04-24 Becton, Dickinson And Company Multi-featured medication delivery pen
US6231540B1 (en) * 1997-07-14 2001-05-15 Novo Nordisk A/S Injection member
US6235004B1 (en) * 1998-01-30 2001-05-22 Novo Nordisk A/S Injection syringe
US6248095B1 (en) * 1998-02-23 2001-06-19 Becton, Dickinson And Company Low-cost medication delivery pen
US6248090B1 (en) * 1996-02-23 2001-06-19 Novo Nordisk A/S Syringe with electronic representation of parameters
US20020007154A1 (en) * 2000-05-04 2002-01-17 Steffen Hansen Injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device
US6340357B1 (en) * 1996-07-05 2002-01-22 Novo Nordisk A/S Dose setting device
US6379339B1 (en) * 1996-09-13 2002-04-30 Nova Nordisk A/S Syringe
US20020052578A1 (en) * 2000-06-16 2002-05-02 Moller Claus Schmidt Injection device
US6383167B2 (en) * 1996-04-02 2002-05-07 Disetronic Licensing Ag Injection device
US20020077852A1 (en) * 1992-10-15 2002-06-20 The General Hospital, Massachusetts Corporation Infusion pump with an electronically loadable drug library and a user interface for loading the library
US6514230B1 (en) * 1999-10-12 2003-02-04 Novo Nordisk A/S Air shot mechanism for electronic injection devices
US20030039679A1 (en) * 1998-02-13 2003-02-27 Duirs Graham Francois Drug delivery system
US6547763B2 (en) * 2000-05-18 2003-04-15 Novo Nordisk A/S Dose display for injection device
US6547764B2 (en) * 2000-05-31 2003-04-15 Novo Nordisk A/S Double pointed injection needle
US6562011B1 (en) * 1998-07-08 2003-05-13 Novo Nordisk A/S Medication delivery device
US6569126B1 (en) * 1997-07-14 2003-05-27 Novo Nordisk A/S Cylinder ampoule
US6716198B2 (en) * 2000-05-18 2004-04-06 Novo Nordisk A/S Injection device
US6752798B2 (en) * 2000-07-28 2004-06-22 Mdc Investment Holdings, Inc. Retractable needle medical device for injecting fluid from a pre-filled cartridge
US20050004529A1 (en) * 2003-04-10 2005-01-06 Veasey Robert Frederick Drive mechanisms suitable for use in drug delivery devices
US20050019400A1 (en) * 2003-01-27 2005-01-27 Deveney Thomas William Controlled-release drug delivery system
US6852404B2 (en) * 2002-03-29 2005-02-08 Tdk Corporation Magnetic recording medium
US20050033244A1 (en) * 2003-03-03 2005-02-10 Veasey Robert Frederick Drive mechanisms suitable for use in drug delivery devices
US20050055011A1 (en) * 2001-01-05 2005-03-10 Christian Enggaard Automatic injection device with reset feature
US6893415B2 (en) * 2000-09-22 2005-05-17 Novo Nordisk A/S Medication delivery device
US6899698B2 (en) * 2000-03-24 2005-05-31 Bernard Sams One-way clutch mechanisms and injector devices
US7008399B2 (en) * 2001-02-14 2006-03-07 Novo Nordisk A/S Electronically controlled device
US7175055B2 (en) * 2002-08-29 2007-02-13 Novo Nordisk, A/S Frontloaded injection device

Family Cites Families (245)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US854399A (en) 1906-04-18 1907-05-21 Walter G Bridge Syringe.
US854390A (en) 1906-08-16 1907-05-21 Twitchell Co S Apparatus for carbonating liquids.
GB664044A (en) 1948-03-02 1951-01-02 Becton Dickinson Co Injection device
US2956563A (en) 1958-10-02 1960-10-18 Cartrix Corp Hypodermic syringe devices
US3110310A (en) 1961-07-20 1963-11-12 Ideal Instr & Mfg Co Inc Metering hypodermic syringe
US3115135A (en) 1962-03-12 1963-12-24 Stanley J Sarnoff Aspirating piston and plunger coupling
US3144178A (en) 1962-03-12 1964-08-11 Stanley J Sarnoff Cartridge holder
US3729003A (en) 1971-02-11 1973-04-24 Ampoules Inc Variable dosage ampoule applicator
CH563690A5 (zh) * 1973-03-09 1975-06-30 Radioelectrique Comp Ind
US4026288A (en) 1975-10-21 1977-05-31 Insulin Injector Inc. Syringe injecting device
US4634431A (en) * 1976-11-12 1987-01-06 Whitney Douglass G Syringe injector
DE2812729A1 (de) 1978-03-23 1979-09-27 Michael Becker Injektionsvorrichtung zur intramuskulaeren einspritzung, vornehmlich von insulin
US4298000A (en) 1978-11-08 1981-11-03 Minnesota Mining And Manufacturing Company Fluid dispensing device
DE2906830C2 (de) 1979-02-22 1981-07-16 B. Braun Melsungen Ag, 3508 Melsungen Gerät für Dauerinfusionen
US4277227A (en) 1979-07-02 1981-07-07 Imed Corporation Apparatus for converting a pump to a controller
US4275727A (en) 1980-01-07 1981-06-30 Keeri Szanto Michael Device for monitoring and controlling self-administered intravenous drug dosage
DE3048135A1 (de) 1980-12-19 1982-07-15 Imed Corp., 92131 San Diego, Calif. Regelvorrichtung
IT1168101B (it) 1981-01-15 1987-05-20 Domenico Colombo Siringa a pressione manuale perfezionata, per uso odontoiatrico
US4393723A (en) 1981-04-16 1983-07-19 Glen Brand Fluid flow meter
AR228395A1 (es) 1981-05-07 1983-02-28 Merck & Co Inc Jeringa para regular la cantidad suministrada de una sustancia plastica
DE3204178C2 (de) 1982-02-06 1986-03-20 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg Pipettiervorrichtung
US4515584A (en) 1982-07-06 1985-05-07 Fujisawa Pharmaceutical Co., Ltd. Artificial pancreas
DE3236374A1 (de) 1982-10-01 1984-04-05 Brown, Boveri & Cie Ag, 6800 Mannheim Sicherheitspapier
US4465478A (en) 1982-10-14 1984-08-14 Collagen Corporation Syringe force amplification device
US4493704A (en) * 1982-11-29 1985-01-15 Oximetrix, Inc. Portable fluid infusion apparatus
ES277095Y (es) 1984-01-25 1985-02-16 Fernandez-Tresguerres Hernandez Jesus A. Suministrador-dosificador de productos inyectables
EP0213139A1 (de) 1984-09-07 1987-03-11 Wagner, Wolfgang, Dr.med. Injektionsvorrichtung mit sensor
CA1254091A (en) 1984-09-28 1989-05-16 Vladimir Feingold Implantable medication infusion system
US4812724A (en) * 1984-11-13 1989-03-14 Liebel-Flarsheim Corporation Injector control
FR2583291A1 (fr) 1985-06-14 1986-12-19 Hazon Bernard Dispositif d'avancement pas a pas du piston de seringues par double vis coaxiale avec controle du debit d'injection. application aux injections medicamenteuses intra-dermiques repetitives
AU6541986A (en) 1985-11-08 1987-06-02 Disetronic A.G. Injection instrument
DE3609555A1 (de) 1986-03-21 1987-09-24 Josef Porner Blutentnahmespritze
DE3638984C3 (de) 1986-11-14 1993-11-18 Haselmeier Wilhelm Fa Injektionsgerät
NL8701091A (nl) 1987-05-08 1988-12-01 Spruyt Hillen Bv Injectiepen.
US4838860A (en) 1987-06-26 1989-06-13 Pump Controller Corporation Infusion pump
GB8720477D0 (en) * 1987-08-29 1987-10-07 Bick P A Resynchronisation of body clock
FR2622457A1 (fr) 1987-11-03 1989-05-05 Piccinali Eric Injecteur mesotherapique a microprocesseur
US4898578A (en) * 1988-01-26 1990-02-06 Baxter International Inc. Drug infusion system with calculator
DK166948B1 (da) 1988-02-10 1993-08-09 Dcp Af 1988 As Doseringsenhed til dosering af et antal afmaalte maengder af en vaeske, saasom insulin, fra en glastubule
US4973318A (en) 1988-02-10 1990-11-27 D.C.P. Af 1988 A/S Disposable syringe
GB8809115D0 (en) 1988-04-18 1988-05-18 Turner R C Syringes
DE3833821A1 (de) 1988-10-05 1990-04-12 Braun Melsungen Ag Injektionsvorrichtung
US5244465A (en) 1988-10-19 1993-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Reusable injection device for distributing a preselected dose
GB2229497B (en) 1989-03-10 1992-06-03 Graseby Medical Ltd Infusion pump
DE3923079A1 (de) 1989-07-13 1991-01-24 Fresenius Ag Verfahren und vorrichtung zum messen der fuellstandshoehe von elektrisch leitenden fluessigkeiten
US5002537A (en) * 1989-10-23 1991-03-26 Gte Products Corporation Hypodermic syringe
US5122317A (en) 1990-01-12 1992-06-16 The Regents Of The University Of Michigan Method of superplastically deforming zirconia materials
DK17890A (da) 1990-01-22 1991-07-23 Novo Nordisk As Fremgangsmaade og apparat til opblanding og injicering af et laegemiddel
US5064098A (en) 1990-02-23 1991-11-12 Physical Systems, Inc. Dual component dispenser gun
US5226896A (en) * 1990-04-04 1993-07-13 Eli Lilly And Company Dose indicating injection pen
US5104388A (en) * 1990-05-08 1992-04-14 Fbk International Corporation Membrane splittable tubing
US5257987A (en) 1990-05-21 1993-11-02 Pharmetrix Corporation Controlled release osmotic infusion system
US5113869A (en) 1990-08-21 1992-05-19 Telectronics Pacing Systems, Inc. Implantable ambulatory electrocardiogram monitor
GB9026191D0 (en) 1990-12-01 1991-01-16 Harris Pharma Ltd Breath actuated dispensing device
US5135485A (en) 1991-02-25 1992-08-04 Louis Cohen Capacitance-type fluid level sensor for i.v. and catheter bags
ES2074771T3 (es) 1991-07-24 1995-09-16 Medico Dev Investment Co Inyector.
US5163904A (en) 1991-11-12 1992-11-17 Merit Medical Systems, Inc. Syringe apparatus with attached pressure gauge
DK194291D0 (da) 1991-11-29 1991-11-29 Novo Nordisk As Sproejte til automatisk injektion.
US5221268A (en) 1991-12-06 1993-06-22 Block Medical, Inc. Multiple dose control apparatus
US5246417A (en) 1991-12-11 1993-09-21 Alza Corporation Indicator for iontophoresis system
CH682806A5 (de) 1992-02-21 1993-11-30 Medimpex Ets Injektionsgerät.
EP0632734B1 (en) 1992-03-25 1998-06-10 Tebro S.A. Powder jet dispenser for medicament inhalation therapies
US5271527A (en) 1992-04-02 1993-12-21 Habley Medical Technology Corporation Reusable pharmaceutical dispenser with full stroke indicator
FR2697434A1 (fr) 1992-11-02 1994-05-06 Godillon Jean Francois Dispositif pour actionner le poussoir d'une seringue en vue d'y créer une dépression, système et procédé en faisant application pour la mise en place temporaire d'un cathéter et/ou d'un fil guide.
US5378233A (en) * 1992-11-18 1995-01-03 Habley Medical Technology Corporation Selected dose pharmaceutical dispenser
JP2530150Y2 (ja) 1993-01-06 1997-03-26 城田電気炉材株式会社 歯科用の麻酔剤等の注射装置
US5383856A (en) * 1993-03-19 1995-01-24 Bersin; Robert M. Helical spiral balloon catheter
US5584815A (en) 1993-04-02 1996-12-17 Eli Lilly And Company Multi-cartridge medication injection device
US5292976A (en) * 1993-04-27 1994-03-08 Mobil Oil Corporation Process for the selective conversion of naphtha to aromatics and olefins
SE9301494D0 (sv) 1993-04-30 1993-04-30 Kabi Pharmacia Ab A device for dosing liquid preparation
GB9309151D0 (en) 1993-05-04 1993-06-16 Zeneca Ltd Syringes and syringe pumps
US5957889A (en) 1993-09-27 1999-09-28 Novo Nordisk A/S Displacement system for controlled infusion of a liquid
CA2129284C (en) 1993-11-24 1999-03-09 Kenneth J. Niehoff Controlling plunger drives for fluid injection in animals
US5998989A (en) 1993-12-22 1999-12-07 Itt Automotive Europe Gmbh Device including magnet-biased magnetoresistive sensor and rotatable, magnetized encoder for detecting rotary movements
AUPM348594A0 (en) * 1994-01-21 1994-02-17 University Of Melbourne, The Improvements in syringe pumps
US5478316A (en) 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
US5562623A (en) 1994-02-14 1996-10-08 Univec Single-use syringe assembly including spring clip lock and plunger
US5536249A (en) * 1994-03-09 1996-07-16 Visionary Medical Products, Inc. Pen-type injector with a microprocessor and blood characteristic monitor
DE4414744C1 (de) 1994-04-27 1995-11-02 Eppendorf Geraetebau Netheler Repetierpipette
DK1228777T3 (da) 1994-05-30 2004-03-01 B D Medico S A R L Injektionsudstyr
DE4419235C2 (de) 1994-06-01 1999-03-11 Thomas Braeger Injektionsspritze mit einem Aufnahmebehälter
CA2197671A1 (en) 1994-06-15 1995-12-21 Hubert Menendez Locking device for syringe or like instrument
US5725508A (en) * 1994-06-22 1998-03-10 Becton Dickinson And Company Quick connect medication delivery pen
US5827232A (en) 1994-06-22 1998-10-27 Becton Dickinson And Company Quick connect medication delivery pen
US5720733A (en) * 1994-07-22 1998-02-24 Raya Systems, Inc. Apparatus for determining and recording injection doses in syringes using electrical capacitance measurements
US6110148A (en) 1994-07-22 2000-08-29 Health Hero Network, Inc. Capacitance-based dose measurements in syringes
US5440976A (en) 1994-08-23 1995-08-15 Fred Giuliano Adjustable dispensing stirrer for soluble sweeteners
US5823998A (en) 1994-08-24 1998-10-20 Eli Lilly Japan Kabushiki Kaisha Injection apparatus
US5549575A (en) 1994-09-13 1996-08-27 Becton Dickinson And Company Cartridge retainer assembly for medication delivery pen
US5582598A (en) 1994-09-19 1996-12-10 Becton Dickinson And Company Medication delivery pen with variable increment dose scale
DE19503230A1 (de) 1995-02-02 1996-08-08 Dietmar Dr Med Enk Spritze mit einer in den Kolben integrierten Dämpfungs- und Druckmeßeinrichtung und Verfahren zur vergleichmäßigten und druckkontrollierten Injektion mittels dieser Spritze
GB9503969D0 (en) * 1995-02-28 1995-04-19 Sams Bernard Incrementing mechanism
GB2309644B (en) 1995-05-22 2000-05-31 Wolfgang Wagner A method and device for diagnosis and injection
US5700904A (en) 1995-06-07 1997-12-23 Eli Lilly And Company Preparation of an acylated protein powder
DE29513214U1 (de) 1995-08-21 1997-01-02 Adamaszek Franz Heinz Dosier- und automatisches Injektionssystem
AU1860697A (en) 1995-09-08 1997-07-28 Visionary Medical Products Corporation Pen-type injector drive mechanism
US5688251A (en) 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
US5674204A (en) 1995-09-19 1997-10-07 Becton Dickinson And Company Medication delivery pen cap actuated dose delivery clutch
US6159161A (en) 1995-10-20 2000-12-12 Hodosh; Milton Microprocessor-controlled fluid dispensing apparatus
KR100469207B1 (ko) 1995-10-20 2005-03-16 화이자 헬스 에이비 전자식주입조정장치
US5807334A (en) 1995-10-20 1998-09-15 Hodosh; Milton Fluid dispensing apparatus
FR2740345A1 (fr) 1995-10-26 1997-04-30 Neftel Frederic Dispositif d'automedication
US5741211A (en) * 1995-10-26 1998-04-21 Medtronic, Inc. System and method for continuous monitoring of diabetes-related blood constituents
US5899879A (en) 1995-12-19 1999-05-04 Genesis Medical Technologies, Inc. Spring-actuated needleless injector
US5628309A (en) 1996-01-25 1997-05-13 Raya Systems, Inc. Meter for electrically measuring and recording injection syringe doses
US5814022A (en) 1996-02-06 1998-09-29 Plasmaseal Llc Method and apparatus for applying tissue sealant
FR2745637B1 (fr) * 1996-03-04 1998-05-22 Motorola Semiconducteurs Dispositif capteur chimique a semiconducteur et procede de formation d'un thermocouple pour ce dispositif
UA35653C2 (uk) 1996-03-12 2001-04-16 Ново Нордіск А/С Пристрій для ін'єкцій
US20010016571A1 (en) 1996-03-13 2001-08-23 Fujisawa Pharmaceutical Co., Ltd. N-[ (R) -1-{3- (4- piperidyl) propionyl } -3-piperidylcarbonyl] -2 (S) -acetylamino-beta -alanine as fibrinogen receptor antagonist
US6086567A (en) 1996-04-02 2000-07-11 Disetronic Licensing Ag Injection device
JP2001527435A (ja) 1996-04-24 2001-12-25 ノボ ノルディスク アクティーゼルスカブ 注射針
PL330757A1 (en) 1996-07-05 1999-05-24 Novo Nordisk As Elastic piston rod
CA2258491A1 (en) 1996-07-05 1998-01-15 Novo Nordisk A/S Automatic needle insertion mechanism
DE19632402C1 (de) 1996-08-02 1998-04-09 Schering Ag Verfahren zur Herstellung einer vorgefüllten, sterilen Spritze
US5843036A (en) 1996-08-23 1998-12-01 Becton Dickinson And Company Non-dosing cartridge for an injection device
US5947934A (en) 1996-09-13 1999-09-07 Novo Nordisk A/S Dose display for an injection syringe
US6110149A (en) 1996-09-13 2000-08-29 Novo Nordisk A/S Syringe
US5830194A (en) 1996-09-20 1998-11-03 Azam Anwar Power syringe
US6146361A (en) 1996-09-26 2000-11-14 Becton Dickinson And Company Medication delivery pen having a 31 gauge needle
US5954689A (en) 1996-12-20 1999-09-21 Novo Nordisk A/S Jet injector
GB2321419B (en) 1997-01-27 2001-02-07 Medic Aid Ltd Atomizer
US20010020155A1 (en) 1997-03-25 2001-09-06 Soren Mikkelsen Injection system
RU2111019C1 (ru) 1997-05-22 1998-05-20 Сергей Александрович Хворостов Универсальный инъектор
DE19723647C1 (de) * 1997-06-05 1998-12-24 Disetronic Licensing Ag Rücksetzbare Anzeigeeinrichtung einer Vorrichtung zur dosierten Abgabe eines Medikamentfluids
US6003736A (en) 1997-06-09 1999-12-21 Novo Nordisk A/S Device for controlled dispensing of a dose of a liquid contained in a cartridge
US6796970B1 (en) 1997-06-17 2004-09-28 Novo Nordisk A/S Dose setting device
US5961496A (en) 1997-06-17 1999-10-05 Novo Nordisk A/S Syringe with tiltable nut for quick piston disengagement
AU7331598A (en) 1997-07-11 1999-02-08 Novo Nordisk A/S An apparatus for the registration of the setting of a medical device
US6171276B1 (en) * 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
FR2767479B1 (fr) 1997-08-22 1999-10-22 Aguettant Lab Dispositif d'injection de medicament
US6312413B1 (en) 1997-10-30 2001-11-06 Novo Nordisk A/S Cylinder ampoule
US5954700A (en) 1998-01-13 1999-09-21 Minimed Inc. Medication cartridge for an electronic pen-type injector, or the like, and method of making the same
US5961495A (en) 1998-02-20 1999-10-05 Becton, Dickinson And Company Medication delivery pen having a priming mechanism
JP3436683B2 (ja) 1998-03-17 2003-08-11 株式会社日立ユニシアオートモティブ 回動角検出装置
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
JP3017167B2 (ja) 1998-05-20 2000-03-06 インターナショナル・ビジネス・マシーンズ・コーポレイション デ一タ記憶媒体からのリ一ド信号の2値化方法および装置
CA2332314A1 (en) 1998-06-11 1999-12-16 Cerus Corporation Use of alkylating compounds for inhibiting proliferation of arterial smooth muscle cells
GB9812472D0 (en) 1998-06-11 1998-08-05 Owen Mumford Ltd A dose setting device for medical injectors
JP2002518108A (ja) 1998-06-15 2002-06-25 メドラッド インコーポレイテッド シリンジ情報のコード化
US6743202B2 (en) 1998-06-15 2004-06-01 Medrad, Inc. Encoding of syringe information
US5933671A (en) 1998-07-07 1999-08-03 Eastman Kodak Company Camera with touch sensitive switch
US6558320B1 (en) * 2000-01-20 2003-05-06 Medtronic Minimed, Inc. Handheld personal data assistant (PDA) with a medical device and method of using the same
US5993423A (en) 1998-08-18 1999-11-30 Choi; Soo Bong Portable automatic syringe device and injection needle unit thereof
DE19838760A1 (de) 1998-08-26 2000-04-20 Bauer Jlona Injektionsgerät zur Applikation von flüssigen Substanzen
US6605067B1 (en) 1998-11-20 2003-08-12 Novo Nordisk A/S Injection needle
DE19900792C1 (de) 1999-01-12 2000-06-15 Disetronic Licensing Ag Vorrichtung zur Verabreichung eines injizierbaren Produkts
DE29900482U1 (de) 1999-01-14 2000-08-31 Medico Dev Investment Co Injektionsgerät
JP2000237308A (ja) 1999-02-22 2000-09-05 Ckd Corp 輸液ポンプ
US6258062B1 (en) 1999-02-25 2001-07-10 Joseph M. Thielen Enclosed container power supply for a needleless injector
DE19909602A1 (de) 1999-03-05 2000-09-07 Roche Diagnostics Gmbh Gerät zur Entnahme von Blut für Diagnosezwecke
US6245046B1 (en) 1999-05-03 2001-06-12 University Of New Mexico Reciprocating syringes
SE9901736D0 (sv) 1999-05-12 1999-05-12 Pharmacia & Upjohn Ab Injectino device and method for ITS operation
US6277099B1 (en) 1999-08-06 2001-08-21 Becton, Dickinson And Company Medication delivery pen
TW453884B (en) 1999-09-16 2001-09-11 Novo Nordisk As Dose setting limiter
US6585698B1 (en) 1999-11-01 2003-07-01 Becton, Dickinson & Company Electronic medical delivery pen having a multifunction actuator
US6673033B1 (en) * 1999-11-24 2004-01-06 Medrad, Inc. Injectors, injector systems and injector control
CA2390477C (en) 2000-02-16 2010-05-18 B D Medico S.A.R.L. Method for reconstituting an injection liquid and an injection appliance for carrying out such a method
US6485465B2 (en) * 2000-03-29 2002-11-26 Medtronic Minimed, Inc. Methods, apparatuses, and uses for infusion pump fluid pressure and force detection
US6558382B2 (en) 2000-04-27 2003-05-06 Medtronic, Inc. Suction stabilized epicardial ablation devices
US6613019B2 (en) 2000-07-14 2003-09-02 Novo Nordisk A/S Liquid medication delivery device and a method of delivering an intended dose
US6994261B2 (en) * 2000-08-10 2006-02-07 Novo Nirdisk A/S Support for a cartridge for transferring an electronically readable item of information from the cartridge to an electronic circuit
CA2418941A1 (en) 2000-08-10 2003-02-10 Synthes (U.S.A.) Device for the introduction of medical items
JP4975208B2 (ja) * 2000-10-03 2012-07-11 株式会社根本杏林堂 自動注入装置
US6537251B2 (en) * 2000-10-05 2003-03-25 Novo Nordisk A/S Medication delivery device with bended piston rod
US7500959B2 (en) 2000-10-05 2009-03-10 Novo Nordisk A/S Medication delivery system with improved dose accuracy
EP1404214A2 (en) 2000-11-24 2004-04-07 CKM Diagnostics, Inc. Nerve stimulator output control needle with depth determination capability and method of use
GB0107607D0 (en) 2001-03-27 2001-05-16 Dca Design Int Ltd Improvements in and relating to an injection device
US6854620B2 (en) * 2001-04-13 2005-02-15 Nipro Diabetes, Systems, Inc. Drive system for an infusion pump
EP2258425B1 (en) 2001-05-16 2013-01-30 Eli Lilly and Company Medication injector apparatus
GB0113881D0 (en) 2001-06-07 2001-08-01 Innovate Biomed Ltd Foil cutting system
US6752781B2 (en) 2001-06-08 2004-06-22 Sergio Landau Durable hypodermic jet injector apparatus and method
US7080936B1 (en) 2001-06-13 2006-07-25 Simpson Frank B Wrap spring clutch syringe ram and frit mixer
DE10133216B4 (de) 2001-07-09 2005-01-27 Tecpharma Licensing Ag Positionsdetektion
DE10163326A1 (de) 2001-07-30 2003-02-27 Disetronic Licensing Ag Verabreichungsgerät mit Dosiervorrichtung
DK200100240U3 (da) 2001-09-18 2001-11-23 Niels Tessing Hvidløgsknuser
EP1462134A4 (en) 2001-12-13 2010-03-31 Panasonic Corp INSTRUMENT OF ADMINISTRATION FOR MEDICAL USE
GB0130138D0 (en) 2001-12-18 2002-02-06 Dca Design Int Ltd Improvements in an relating to a medicament injection apparatus
DE10201875C1 (de) 2002-01-18 2003-05-22 Austriamicrosystems Ag Sensorsystem und Verfahren zum Betrieb des Sensorsystems
US7169107B2 (en) 2002-01-25 2007-01-30 Karen Jersey-Willuhn Conductivity reconstruction based on inverse finite element measurements in a tissue monitoring system
AU2003209475A1 (en) 2002-03-07 2003-09-16 Vectura Limited Fast melt multiparticulate formulations for oral delivery
EP1487520A1 (en) * 2002-03-18 2004-12-22 Eli Lilly And Company Medication dispensing apparatus with gear set for mechanical advantage
US20040010204A1 (en) * 2002-03-28 2004-01-15 Pearl Technology Holdings, Llc Electronic/fiberoptic tissue differentiation instrumentation
JP4064138B2 (ja) 2002-03-28 2008-03-19 スーガン株式会社 医療用チューブ開閉装置
DE10226643A1 (de) * 2002-06-14 2004-01-15 Disetronic Licensing Ag Kolbenstopfen für Injektionsvorrichtung, Produktbehälter und Injektionsvorrichtung
DE10229122B4 (de) * 2002-06-28 2006-09-07 Tecpharma Licensing Ag Verabreichungsgerät mit rücksetzbarer Betätigungssperre
US7328064B2 (en) 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
US6945961B2 (en) 2002-07-10 2005-09-20 Novo Nordisk A/S Injection device
WO2004007002A1 (en) 2002-07-10 2004-01-22 Novo Nordisk A/S An injection device
JP2005532129A (ja) 2002-07-10 2005-10-27 ノボ・ノルデイスク・エー/エス 投与量設定リミッタを備える注入器
EP1391794A1 (en) 2002-07-23 2004-02-25 Novo Nordisk A/S Device with time indicating means
US6929619B2 (en) * 2002-08-02 2005-08-16 Liebel-Flarshiem Company Injector
DE10240166A1 (de) 2002-08-30 2004-03-18 Disetronic Licensing Ag Vorrichtung zur kontrollierten Ausschüttung einer injizierbaren Flüssigkeit
DE10240165A1 (de) 2002-08-30 2004-03-18 Disetronic Licensing Ag Vorrichtung zum dosierten Ausstoßen eines flüssigen Wirkstoffes und Infusionspumpe
US20040051368A1 (en) * 2002-09-17 2004-03-18 Jimmy Caputo Systems and methods for programming pumps
EP1542744B1 (en) 2002-09-24 2009-06-24 SHL Group AB Injecting device
AU2003266644B2 (en) 2002-09-26 2008-04-03 Men-Dar Wu Therapeutic causing contraction of mucosal tissue, method of treating diseases relating to mucosal tissues, injector and therapeutic set
JP4224764B2 (ja) 2002-10-07 2009-02-18 豊田合成株式会社 オープニングトリムウエザストリップ
EP1554000A2 (en) 2002-10-15 2005-07-20 Eli Lilly And Company Medication dispensing apparatus with squeezable actuator
US8016798B2 (en) 2003-02-24 2011-09-13 Integrated Sensing Systems, Inc. Fluid delivery system and sensing unit therefor
GB0304824D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304823D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
RU2004132832A (ru) 2003-03-06 2005-08-27 Лайфскен, Инк. (Us) Система и способ для прокалывания дермальной ткани
GB0306642D0 (en) 2003-03-22 2003-04-30 Dca Design Int Ltd Improvements in and relating to an injector for a medical product
EP1608305B1 (en) 2003-03-24 2008-07-30 Novo Nordisk A/S Transparent electronic marking of a medicament container
MXPA05011377A (es) 2003-04-23 2006-01-30 Vasogen Ireland Ltd Sistemas distribuidores.
US7641668B2 (en) 2003-05-16 2010-01-05 Scimed Life Systems, Inc. Fluid delivery system and related methods of use
FR2857654B1 (fr) 2003-07-16 2007-04-27 Prodonta Dispositif d'ejection d'un produit liquide ou pateux
WO2005018721A1 (en) 2003-08-12 2005-03-03 Eli Lilly And Company Medication dispensing apparatus with triple screw threads for mechanical advantage
JP4507059B2 (ja) 2003-08-28 2010-07-21 大阪瓦斯株式会社 コージェネレーションシステム
US7708732B2 (en) 2003-10-16 2010-05-04 Nps Pharmaceuticals, Inc. Methods of administering therapeutic injections
DE20317377U1 (de) 2003-11-03 2005-03-17 B D Medico S A R L Injektionsgerät
EP1541185A1 (en) 2003-12-08 2005-06-15 Novo Nordisk A/S Automatic syringe with priming mechanism
CN103143079B (zh) 2004-03-03 2016-09-28 株式会社根本杏林堂 药液注入系统
GB0406088D0 (en) 2004-03-18 2004-04-21 Smiths Group Plc Infusion apparatus and methods
PL1732629T3 (pl) 2004-03-30 2019-10-31 Lilly Co Eli Urządzenie do dozowania leków z napędzaną sprężyną blokadą załączaną na skutek podania ostatniej dawki
PT1732628E (pt) 2004-03-30 2011-12-07 Lilly Co Eli Aparelho de administração de medicamentos com um conjunto de engrenagens que tem uma abertura de acomodação de um componente de accionamento
US7448385B2 (en) 2004-06-07 2008-11-11 Purepharm Inc. Nasal adaptation of an oral inhaler device
WO2006006643A1 (ja) 2004-07-14 2006-01-19 Nemoto Kyorindo Co., Ltd. 薬液注入システム
DE102004046003A1 (de) 2004-09-17 2006-03-30 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Pharmazeutisches Packmittel und Verfahren zu dessen Herstellung
EP1645301A1 (en) 2004-10-11 2006-04-12 Novo Nordisk A/S Injection device
CN101039713B (zh) 2004-10-14 2011-10-12 诺和诺德公司 具有剂量机构的注射装置
ATE452671T1 (de) 2004-10-21 2010-01-15 Novo Nordisk As Injektionsvorrichtung mit einem prozessor zur sammlung von ausstossinformationen
ATE445429T1 (de) 2004-10-21 2009-10-15 Novo Nordisk As Injektionsvorrichtung mit internem dosisanzeiger
CN101084028B (zh) 2004-10-21 2010-06-09 诺和诺德公司 具有扭转弹簧和可旋转显示器的注射设备
ITVR20040168A1 (it) 2004-10-25 2005-01-25 C M Tecnologie S R L Selettore, particolarmente ma non esclusivamente per distributori automatici di bevande
DE102004063644A1 (de) 2004-12-31 2006-07-20 Tecpharma Licensing Ag Vorrichtung zur dosierten Verabreichung eines fluiden Produkts mit Drehfederantrieb
ES2633917T3 (es) 2005-01-21 2017-09-26 Novo Nordisk A/S Dispositivo de inyección automático con un mecanismo de liberación superior
JP2006250582A (ja) 2005-03-08 2006-09-21 Hitachi Plant Technologies Ltd 荷重センサ付きrfidタグ
US20080221530A1 (en) 2005-04-24 2008-09-11 Novo Nordisk A/S Injection Device With A GearBox
US20090043264A1 (en) * 2005-04-24 2009-02-12 Novo Nordisk A/S Injection Device
WO2006116997A1 (en) 2005-04-29 2006-11-09 Novo Nordisk A/S Handheld injection device with integrated force sensor
DK200500116U3 (da) 2005-05-23 2005-06-24 Novo Nordisk As Motordrevet injektionsapparat
WO2006128794A2 (en) 2005-05-31 2006-12-07 Novo Nordisk A/S Injection device with visual end-of-content indication
US20060276753A1 (en) 2005-06-01 2006-12-07 Victor Kronestedt Device for delivering medicament
US7327261B2 (en) * 2005-07-27 2008-02-05 Zih Corp. Visual identification tag deactivation
DE102005060929A1 (de) 2005-09-14 2007-03-15 Tecpharma Licensing Ag Injektionsvorrichtung mit Zweiwege-Rutschkupplung
EP1948112A4 (en) 2005-10-11 2011-04-13 Podaima Blake SMART MEDICAL COMPLIANCE PROCESS AND SYSTEM
EP1996260B1 (en) * 2006-03-10 2015-09-23 Novo Nordisk A/S An injection device having a gearing arrangement
EP1999441B1 (en) 2006-03-20 2013-06-19 Novo Nordisk A/S Determination of cartridge content by capacitive means
CN101405044B (zh) 2006-03-20 2013-10-16 诺沃-诺迪斯克有限公司 注射针位置的测定
ATE458517T1 (de) 2006-05-16 2010-03-15 Novo Nordisk As Getriebemechanismus für ein injektionsgerät
JP5253387B2 (ja) 2006-05-18 2013-07-31 ノボ・ノルデイスク・エー/エス モード固定手段を備えている注入装置
CN102895718B (zh) 2006-09-29 2015-01-14 诺沃—诺迪斯克有限公司 具有电子检测工具的注射装置
JP5588678B2 (ja) 2006-10-26 2014-09-10 マリンクロッド エルエルシー 熱機械的駆動部を有する医療用流体注射器
US20080306443A1 (en) 2007-06-06 2008-12-11 Mallinckrodt Inc. Medical Fluid Injector Having Wireless Pressure Monitoring Feature

Patent Citations (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2392196A (en) * 1945-02-24 1946-01-01 Arthur E Smith Syringe
US3556099A (en) * 1968-05-27 1971-01-19 Johnson & Johnson Hypodermic syringe assembly
US3880162A (en) * 1973-04-25 1975-04-29 Lee G Simmons Pole-syringe for injecting from a remote distance
US4430079A (en) * 1978-11-08 1984-02-07 Minnesota Mining And Manufacturing Company Fluid dispensing device
USRE31315E (en) * 1979-07-02 1983-07-19 Imed Corporation Apparatus for converting a pump to a controller
US4368731A (en) * 1980-02-12 1983-01-18 Schramm Heinrich W Pistol-type syringe
US4313439A (en) * 1980-03-24 1982-02-02 Biotek, Inc. Automated, spring-powered medicament infusion system
US4314556A (en) * 1980-04-21 1982-02-09 Ma Austin C Emergency syringe
US4498904A (en) * 1981-02-12 1985-02-12 Turner Robert C Dose metering plunger devices for use with syringes
US4568335A (en) * 1981-08-28 1986-02-04 Markwell Medical Institute, Inc. Device for the controlled infusion of medications
US4585439A (en) * 1983-09-07 1986-04-29 Disetronic Ag. Portable infusion unit
US4749109A (en) * 1983-11-15 1988-06-07 Kamen Dean L Volumetric pump with replaceable reservoir assembly
US4676122A (en) * 1984-06-15 1987-06-30 Daltex Medical Sciences, Inc. Fail-safe mechanical drive for syringe
US5716990A (en) * 1987-03-09 1998-02-10 Cancer Research Campaign Technology Limited Drug delivery systems
US4936833A (en) * 1987-06-12 1990-06-26 Hypoguard (Uk) Limited Cartridge-holder assembly for medication dispensing unit
US4919596A (en) * 1987-12-04 1990-04-24 Pacesetter Infusion, Ltd. Fluid delivery control and monitoring apparatus for a medication infusion system
US4833379A (en) * 1988-01-13 1989-05-23 Sherwood Medical Company Motor control fail-safe circuit
US5112317A (en) * 1988-01-22 1992-05-12 Nosta Ag Injection device
US4988337A (en) * 1988-08-10 1991-01-29 Terumo Kabushiki Kaisha Syringe pump apparatus
US5226342A (en) * 1989-02-07 1993-07-13 Agence Spatiale Europeenne Linear or circular rachet-type locking device with automatic unlocking and self-locking
US4994033A (en) * 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5308340A (en) * 1989-06-05 1994-05-03 Eli Lilly And Company Multiple dose injection pen
US5226895A (en) * 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
US5000744A (en) * 1989-10-23 1991-03-19 Gte Products Corporation Hypodermic syringe
US5304152A (en) * 1990-03-29 1994-04-19 Bernard Sams Dispensing device
US5207752A (en) * 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
US5318540A (en) * 1990-04-02 1994-06-07 Pharmetrix Corporation Controlled release infusion device
US5492534A (en) * 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
US5284480A (en) * 1990-11-09 1994-02-08 Medtronic, Inc. Inflation/deflation syringe with threaded plunger
US5331954A (en) * 1990-12-21 1994-07-26 Novo Nordisk A/S Device for nasal delivery of liquid medications
US5078698A (en) * 1991-02-19 1992-01-07 Sterling Drug Inc. Axial eject hypodermic syringe holder
US5176646A (en) * 1991-02-19 1993-01-05 Takayuki Kuroda Motorized syringe pump
US5591136A (en) * 1991-04-15 1997-01-07 Medico Development Investment Company Injection device
US5314412A (en) * 1991-04-17 1994-05-24 Novo Nordisk A S Manifold for a two barrel syringe
US5645052A (en) * 1991-04-26 1997-07-08 The Boc Group Plc Anaesthetic vaporizer with expandable/contractable reservoir for pumping liquid anaesthetic
US5626566A (en) * 1991-10-18 1997-05-06 Novo Nordisk A/S Large dose pen
US5611783A (en) * 1991-11-29 1997-03-18 Novo Nordisk A/S Pen-shaped syringe
US5408387A (en) * 1991-11-30 1995-04-18 Meitaku System Co., Ltd. Edge light panel and its production
US5279586A (en) * 1992-02-04 1994-01-18 Becton, Dickinson And Company Reusable medication delivery pen
US5279585A (en) * 1992-02-04 1994-01-18 Becton, Dickinson And Company Medication delivery pen having improved dose delivery features
US5281198A (en) * 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
US5599314A (en) * 1992-09-19 1997-02-04 Hypoguard (Uk) Limited Syringe with incrementally actuated plunger
US20020077852A1 (en) * 1992-10-15 2002-06-20 The General Hospital, Massachusetts Corporation Infusion pump with an electronically loadable drug library and a user interface for loading the library
US5320609A (en) * 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
US5743889A (en) * 1992-12-18 1998-04-28 Sams; Bernard Incrementing dosage mechanism for syringe
US5383865A (en) * 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
US5505704A (en) * 1993-04-02 1996-04-09 Eli Lilly And Company Manifold medication injection apparatus and method
US5611784A (en) * 1993-06-30 1997-03-18 Hamilton Company Manual dispensing aid for a syringe
US5728559A (en) * 1993-07-09 1998-03-17 Novo Nordisk A/S Separation of proteins
US5505697A (en) * 1994-01-14 1996-04-09 Mckinnon, Jr.; Charles N. Electrically powered jet injector
US5496286A (en) * 1994-08-17 1996-03-05 Sterling Winthrop Hypodermic syringe holder with disposable body
US5882718A (en) * 1994-09-20 1999-03-16 Novo Nordisk A/S Method for treating an aqueous protein solution to kill microorganisms therein without causing coagulation and composition thereof
US5755692A (en) * 1994-09-28 1998-05-26 Manicom; Anthony William Method and apparatus for administering a drug to a patient
US5637095A (en) * 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
US6221046B1 (en) * 1995-03-07 2001-04-24 Eli Lilly And Company Recyclable medication dispensing device
US5725080A (en) * 1995-03-24 1998-03-10 Fichtel & Sachs Ag Clutch for motor vehicles having a clutch disc with spring elements connected in series
US6248090B1 (en) * 1996-02-23 2001-06-19 Novo Nordisk A/S Syringe with electronic representation of parameters
US6383167B2 (en) * 1996-04-02 2002-05-07 Disetronic Licensing Ag Injection device
US5782633A (en) * 1996-04-10 1998-07-21 Muehlbauer; Ernst Applicator for a dental compound
US6340357B1 (en) * 1996-07-05 2002-01-22 Novo Nordisk A/S Dose setting device
US5709662A (en) * 1996-08-23 1998-01-20 Becton Dickinson France, S.A. Cartridge for an injection device
US6379339B1 (en) * 1996-09-13 2002-04-30 Nova Nordisk A/S Syringe
US6010485A (en) * 1996-09-20 2000-01-04 Novo Nordisk A/S Working cylinder
US6033377A (en) * 1997-02-04 2000-03-07 Novo Nordisk A/S Device for the administration of a liquid medicament suspension
US6048336A (en) * 1997-03-03 2000-04-11 Medico Injection device
US5898028A (en) * 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
US6074372A (en) * 1997-06-09 2000-06-13 Novo Nordisk A/S Dose setting mechanism and an injection syringe having such a dose setting mechanism
US6569126B1 (en) * 1997-07-14 2003-05-27 Novo Nordisk A/S Cylinder ampoule
US6231540B1 (en) * 1997-07-14 2001-05-15 Novo Nordisk A/S Injection member
US6193698B1 (en) * 1997-07-18 2001-02-27 Disetronic Licensing Ag System for locking a dosing button in a device for the adminstration of a product to be injected
US5921966A (en) * 1997-08-11 1999-07-13 Becton Dickinson And Company Medication delivery pen having an improved clutch assembly
US6235004B1 (en) * 1998-01-30 2001-05-22 Novo Nordisk A/S Injection syringe
US20030039679A1 (en) * 1998-02-13 2003-02-27 Duirs Graham Francois Drug delivery system
US6221053B1 (en) * 1998-02-20 2001-04-24 Becton, Dickinson And Company Multi-featured medication delivery pen
US6248095B1 (en) * 1998-02-23 2001-06-19 Becton, Dickinson And Company Low-cost medication delivery pen
US6562011B1 (en) * 1998-07-08 2003-05-13 Novo Nordisk A/S Medication delivery device
US6033376A (en) * 1998-09-30 2000-03-07 Allergan Sales, Inc. Wound shaper sleeve
US6036675A (en) * 1999-02-03 2000-03-14 Specialized Health Products, Inc. Safety sterile cartride unit apparatus and methods
US6726661B2 (en) * 1999-10-12 2004-04-27 Novo Nordisk A/S Air shot mechanism for electronic injection devices
US6514230B1 (en) * 1999-10-12 2003-02-04 Novo Nordisk A/S Air shot mechanism for electronic injection devices
US6899698B2 (en) * 2000-03-24 2005-05-31 Bernard Sams One-way clutch mechanisms and injector devices
US6692472B2 (en) * 2000-05-04 2004-02-17 Novo Nordisk A/S Injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device
US20020007154A1 (en) * 2000-05-04 2002-01-17 Steffen Hansen Injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device
US6547763B2 (en) * 2000-05-18 2003-04-15 Novo Nordisk A/S Dose display for injection device
US6716198B2 (en) * 2000-05-18 2004-04-06 Novo Nordisk A/S Injection device
US6547764B2 (en) * 2000-05-31 2003-04-15 Novo Nordisk A/S Double pointed injection needle
US20040059299A1 (en) * 2000-06-16 2004-03-25 Moller Claus Schmidt Injection device
US20020052578A1 (en) * 2000-06-16 2002-05-02 Moller Claus Schmidt Injection device
US6752798B2 (en) * 2000-07-28 2004-06-22 Mdc Investment Holdings, Inc. Retractable needle medical device for injecting fluid from a pre-filled cartridge
US6893415B2 (en) * 2000-09-22 2005-05-17 Novo Nordisk A/S Medication delivery device
US20050055011A1 (en) * 2001-01-05 2005-03-10 Christian Enggaard Automatic injection device with reset feature
US6899699B2 (en) * 2001-01-05 2005-05-31 Novo Nordisk A/S Automatic injection device with reset feature
US7008399B2 (en) * 2001-02-14 2006-03-07 Novo Nordisk A/S Electronically controlled device
US6852404B2 (en) * 2002-03-29 2005-02-08 Tdk Corporation Magnetic recording medium
US7175055B2 (en) * 2002-08-29 2007-02-13 Novo Nordisk, A/S Frontloaded injection device
US20050019400A1 (en) * 2003-01-27 2005-01-27 Deveney Thomas William Controlled-release drug delivery system
US20050033244A1 (en) * 2003-03-03 2005-02-10 Veasey Robert Frederick Drive mechanisms suitable for use in drug delivery devices
US20070093761A1 (en) * 2003-03-03 2007-04-26 Dca Design International Ltd. Drive mechanisms suitable for use in drug delivery devices
US20050004529A1 (en) * 2003-04-10 2005-01-06 Veasey Robert Frederick Drive mechanisms suitable for use in drug delivery devices

Cited By (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8333739B2 (en) 2000-06-16 2012-12-18 Novo Nordisk A/S Injection device
US8202256B2 (en) 2000-06-16 2012-06-19 Novo Nordisk A/S Injection device
US20080065026A1 (en) * 2000-06-16 2008-03-13 Novo Nordisk A/S Injection Device
US20080281275A1 (en) * 2000-06-16 2008-11-13 Novo Nordisk A/S Injection Device
US8267899B2 (en) 2000-06-16 2012-09-18 Novo Nordisk A/S Injection device
US10245383B2 (en) 2000-06-16 2019-04-02 Novo Nordisk A/S Injection device
US20070244445A1 (en) * 2000-06-16 2007-10-18 Novo Nordisk A/S Injection Device
US8206361B2 (en) 2000-06-16 2012-06-26 Novo Nordisk A/S Injection device
US20050209570A1 (en) * 2000-06-16 2005-09-22 Novo Nordisk A/S Injection device
US9022991B2 (en) 2000-06-16 2015-05-05 Novo Nordisk A/S Injection device
USRE46363E1 (en) 2004-10-21 2017-04-11 Novo Nordisk A/S Dial-down mechanism for wind-up pen
US8641683B2 (en) 2005-04-24 2014-02-04 Novo Nordisk A/S Injection device
US20100016806A1 (en) * 2005-04-24 2010-01-21 Novo Nordisk A/S Injection Device
US8197450B2 (en) 2005-04-24 2012-06-12 Novo Nordisk A/S Injection device
US20090062748A1 (en) * 2006-03-10 2009-03-05 Novo Nordisk A/S Injection Device Having a Gearing Arrangement
US8361036B2 (en) 2006-03-10 2013-01-29 Novo Nordisk A/S Injection device having a gearing arrangement
US20090254027A1 (en) * 2006-03-10 2009-10-08 Novo Nordisk A/S Injection Device and a Method of Changing a Cartridge in the Device
US8298194B2 (en) 2006-03-10 2012-10-30 Novo Nordisk A/S Injection device and a method of changing a cartridge in the device
US8900204B2 (en) 2006-05-16 2014-12-02 Novo Nordisk A/S Gearing mechanism for an injection device
US8226618B2 (en) 2006-05-16 2012-07-24 Novo Nordisk A/S Gearing mechanism for an injection device
US20100022964A1 (en) * 2006-05-16 2010-01-28 Novo Nordisk A/S Gearing Mechanism for an Injection Device
US20090209920A1 (en) * 2006-05-18 2009-08-20 Novo Nordisk A/S Injection Device with Mode Locking Means
US9192727B2 (en) 2006-05-18 2015-11-24 Novo Nordisk A/S Injection device with mode locking means
US8617125B2 (en) 2006-12-15 2013-12-31 Novo Nordisk A/S Medical delivery system comprising a container and a dosing assembly with radially moving fastening means
US20100324498A1 (en) * 2006-12-15 2010-12-23 Novo Nordisk A/S Medical delivery system comprising a container and a dosing assembly with radially moving fastening means
US20100106099A1 (en) * 2006-12-21 2010-04-29 Novo Nordisk A/S Syringe Device
US8740857B2 (en) * 2006-12-21 2014-06-03 Novo Nordisk A/S Syringe device
US20100114025A1 (en) * 2007-03-23 2010-05-06 Novo Nordisk A/S Injection device comprising a locking nut
US8353878B2 (en) 2007-03-23 2013-01-15 Novo Nordisk A/S Injection device comprising a locking nut
US20120004640A1 (en) * 2008-12-09 2012-01-05 Melissa Rosen Open and closed valve medication delivery system for high pressure injections
US9220851B2 (en) * 2008-12-09 2015-12-29 Becton, Dickinson And Company Open and closed valve medication delivery system for high pressure injections
US20130310761A1 (en) * 2010-10-06 2013-11-21 Sanofi-Aventis Deutschland Gmbh Drive Mechanism for a Drug Delivery Device and Drug Delivery Device
KR20130120477A (ko) * 2010-10-06 2013-11-04 사노피-아벤티스 도이칠란트 게엠베하 약물 전달 디바이스를 위한 구동 메카니즘 및 약물 전달 디바이스
AU2011311615B2 (en) * 2010-10-06 2015-07-30 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device and drug delivery device
KR101880027B1 (ko) * 2010-10-06 2018-07-20 사노피-아벤티스 도이칠란트 게엠베하 약물 전달 디바이스를 위한 구동 메커니즘 및 약물 전달 디바이스
KR101880028B1 (ko) * 2010-10-06 2018-07-20 사노피-아벤티스 도이칠란트 게엠베하 약물 전달 디바이스를 위한 구동 메커니즘 및 약물 전달 디바이스
KR101897949B1 (ko) 2010-10-06 2018-09-12 사노피-아벤티스 도이칠란트 게엠베하 약물 전달 디바이스를 위한 구동 메커니즘 및 약물 전달 디바이스
US9440029B2 (en) * 2010-10-06 2016-09-13 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device and drug delivery device
KR20130120478A (ko) * 2010-10-06 2013-11-04 사노피-아벤티스 도이칠란트 게엠베하 약물 전달 디바이스를 위한 구동 메카니즘 및 약물 전달 디바이스
US20170000948A1 (en) * 2010-10-06 2017-01-05 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device and drug delivery device
KR20130120476A (ko) * 2010-10-06 2013-11-04 사노피-아벤티스 도이칠란트 게엠베하 약물 전달 디바이스를 위한 구동 메카니즘 및 약물 전달 디바이스
US10456528B2 (en) * 2010-10-06 2019-10-29 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device and drug delivery device
US20140058320A1 (en) * 2010-12-23 2014-02-27 Novo Nordisk Healthcare Ag Piston Rod Drive System for a Drug Delivery Device
JP2014502890A (ja) * 2010-12-23 2014-02-06 ノボ ノルディスク ヘルス ケア アーゲー 薬剤送出装置のためのピストン棒駆動装置
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
US10758592B2 (en) 2012-10-09 2020-09-01 Sanofi Exendin-4 derivatives as dual GLP1/glucagon agonists
US9670261B2 (en) 2012-12-21 2017-06-06 Sanofi Functionalized exendin-4 derivatives
US9745360B2 (en) 2012-12-21 2017-08-29 Sanofi Dual GLP1/GIP or trigonal GLP1/GIP/glucagon agonists
US10253079B2 (en) 2012-12-21 2019-04-09 Sanofi Functionalized Exendin-4 derivatives
US20160058952A1 (en) * 2013-04-10 2016-03-03 Sanofi Pen-type drug injection device and dose setting limiter mechanism therefor
US9694053B2 (en) 2013-12-13 2017-07-04 Sanofi Dual GLP-1/glucagon receptor agonists
US9751926B2 (en) 2013-12-13 2017-09-05 Sanofi Dual GLP-1/GIP receptor agonists
US9789165B2 (en) 2013-12-13 2017-10-17 Sanofi Exendin-4 peptide analogues as dual GLP-1/GIP receptor agonists
US9750788B2 (en) 2013-12-13 2017-09-05 Sanofi Non-acylated exendin-4 peptide analogues
US9775904B2 (en) 2014-04-07 2017-10-03 Sanofi Exendin-4 derivatives as peptidic dual GLP-1/glucagon receptor agonists
US9758561B2 (en) 2014-04-07 2017-09-12 Sanofi Dual GLP-1/glucagon receptor agonists derived from exendin-4
US9771406B2 (en) 2014-04-07 2017-09-26 Sanofi Peptidic dual GLP-1/glucagon receptor agonists derived from exendin-4
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
US10806797B2 (en) 2015-06-05 2020-10-20 Sanofi Prodrugs comprising an GLP-1/glucagon dual agonist linker hyaluronic acid conjugate
US9982029B2 (en) 2015-07-10 2018-05-29 Sanofi Exendin-4 derivatives as selective peptidic dual GLP-1/glucagon receptor agonists
US20180361073A1 (en) * 2015-12-14 2018-12-20 Sanofi-Aventis Deutschland Gmbh Drive mechanism for an injection device
US10881806B2 (en) * 2015-12-14 2021-01-05 Sanofi-Aventis Deutschland Gmbh Drive mechanism for an injection device
CN107314088A (zh) * 2017-07-11 2017-11-03 宜昌长机科技有限责任公司 一种可变传动比无侧隙定位齿条副装置及操作方法
US20220362477A1 (en) * 2021-05-11 2022-11-17 Stevanato Group S.P.A. Drug injection device
US11696987B2 (en) * 2021-05-11 2023-07-11 Stevanato Group S.P.A. Drug injection device

Also Published As

Publication number Publication date
WO2006114396A1 (en) 2006-11-02
US20100016806A1 (en) 2010-01-21
CN101163514A (zh) 2008-04-16
CN101163514B (zh) 2012-01-25
US8641683B2 (en) 2014-02-04
US20120157932A1 (en) 2012-06-21
EP1877121A1 (en) 2008-01-16
US8197450B2 (en) 2012-06-12
JP4979686B2 (ja) 2012-07-18
EP1877121B1 (en) 2015-09-23
JP2008538719A (ja) 2008-11-06

Similar Documents

Publication Publication Date Title
US8197450B2 (en) Injection device
US20080221530A1 (en) Injection Device With A GearBox
US8206361B2 (en) Injection device
DK1610847T3 (en) DOSAGE ADJUSTMENT AND DRIVE MECHANISM SUITABLE FOR USE IN PHARMACEUTICAL DISPENSER DEVICES
DK2083890T3 (en) DOSAGE AND DRIVE MECHANISM FOR PHARMACEUTICAL ADMINISTRATION DEVICE
AU2007321446B2 (en) Dosing and drive mechanism for drug delivery device
AU2001273890A1 (en) An injection device with a gearbox
AU2004222587B2 (en) Dose dial and drive mechanism suitable for use in drug delivery devices
IL153335A (en) Injector with gearbox

Legal Events

Date Code Title Description
AS Assignment

Owner name: NOVO NORDISK A/S, DENMARK

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GLEJBOL, KRISTIAN;LINNEBJERG, STEVEN;MOLLER, CLAUS SCHMIDT;AND OTHERS;REEL/FRAME:023433/0547;SIGNING DATES FROM 20080428 TO 20080515

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION