US20090010965A1 - Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin - Google Patents

Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin Download PDF

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Publication number
US20090010965A1
US20090010965A1 US12/154,982 US15498208A US2009010965A1 US 20090010965 A1 US20090010965 A1 US 20090010965A1 US 15498208 A US15498208 A US 15498208A US 2009010965 A1 US2009010965 A1 US 2009010965A1
Authority
US
United States
Prior art keywords
muscle relaxant
neurotoxic component
botulinum toxin
solution
reconstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/154,982
Other languages
English (en)
Inventor
Karl-Heinz Eisele
Harold V. Taylor
Matthias Marx
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merz Pharma GmbH and Co KGaA
Original Assignee
Merz Pharma GmbH and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07010912A external-priority patent/EP1997509A1/en
Priority claimed from EP07020025A external-priority patent/EP2048156A1/en
Application filed by Merz Pharma GmbH and Co KGaA filed Critical Merz Pharma GmbH and Co KGaA
Priority to US12/154,982 priority Critical patent/US20090010965A1/en
Priority to TW097120348A priority patent/TW200902050A/zh
Priority to TW097120349A priority patent/TW200914039A/zh
Publication of US20090010965A1 publication Critical patent/US20090010965A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
US12/154,982 2007-06-01 2008-05-29 Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin Abandoned US20090010965A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/154,982 US20090010965A1 (en) 2007-06-01 2008-05-29 Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin
TW097120348A TW200902050A (en) 2007-06-01 2008-05-30 Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin
TW097120349A TW200914039A (en) 2007-06-01 2008-05-30 Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin in solid form

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US93262407P 2007-06-01 2007-06-01
EP07010912.9 2007-06-01
EP07010912A EP1997509A1 (en) 2007-06-01 2007-06-01 Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin
US99885807P 2007-10-12 2007-10-12
EP07020025A EP2048156A1 (en) 2007-10-12 2007-10-12 Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin
EP07020025.8 2007-10-12
US12/154,982 US20090010965A1 (en) 2007-06-01 2008-05-29 Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin

Publications (1)

Publication Number Publication Date
US20090010965A1 true US20090010965A1 (en) 2009-01-08

Family

ID=40074591

Family Applications (2)

Application Number Title Priority Date Filing Date
US12/154,983 Abandoned US20090028906A1 (en) 2007-06-01 2008-05-29 Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin in a solid form
US12/154,982 Abandoned US20090010965A1 (en) 2007-06-01 2008-05-29 Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US12/154,983 Abandoned US20090028906A1 (en) 2007-06-01 2008-05-29 Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin in a solid form

Country Status (15)

Country Link
US (2) US20090028906A1 (zh)
EP (2) EP2170375A1 (zh)
JP (2) JP2010529000A (zh)
KR (2) KR20100020971A (zh)
CN (2) CN101720331A (zh)
AR (2) AR066783A1 (zh)
AU (2) AU2008256419A1 (zh)
BR (2) BRPI0812322A2 (zh)
CA (2) CA2686637A1 (zh)
IL (2) IL202130A0 (zh)
MX (2) MX2009012570A (zh)
RU (1) RU2009149604A (zh)
TW (2) TW200914039A (zh)
WO (2) WO2008145358A1 (zh)
ZA (2) ZA200907874B (zh)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100330123A1 (en) * 2009-06-25 2010-12-30 Revance Therapeutics, Inc. Albumin-free botulinum toxin formulations
KR101135486B1 (ko) * 2011-05-25 2012-04-13 함종욱 보툴리눔 에이형 독소의 액상제품
US20170029795A1 (en) * 2009-10-21 2017-02-02 Revance Therapeutics, Inc. Methods and Systems for Purifying Non-Complexed Botulinum Neurotoxin
EP3253364A1 (en) * 2015-02-03 2017-12-13 Merz Pharma GmbH & Co. KGaA Botulinum toxin prefilled container
US20180052426A1 (en) * 2015-03-17 2018-02-22 Omega S.A. Wristwatch comprising a dial with luminous indices
US10549042B2 (en) 2014-12-23 2020-02-04 Merz Pharma Gmbh & Co. Kgaa Botulinum toxin prefilled glass syringe
US11033625B2 (en) * 2005-10-06 2021-06-15 Allergan, Inc. Method for stabilizing a toxin
US11306121B2 (en) 2018-12-26 2022-04-19 Caregen Co., Ltd. Composition for muscle relaxation
US11471708B2 (en) 2008-12-31 2022-10-18 Revance Therapeutics, Inc. Injectable botulinum toxin formulations

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR061669A1 (es) 2006-06-29 2008-09-10 Merz Pharma Gmbh & Co Kgaa Aplicacion de alta frecuencia de terapia con toxina botulinica
US10792344B2 (en) 2006-06-29 2020-10-06 Merz Pharma Gmbh & Co. Kgaa High frequency application of botulinum toxin therapy
US20100184685A1 (en) * 2009-01-19 2010-07-22 Zavala Jr Gerardo Systems and methods for treating post- operative, acute, and chronic pain using an intra-muscular catheter administrated combination of a local anesthetic and a neurotoxin protein
CN102325792B (zh) * 2009-02-19 2018-01-09 莫茨制药有限及两合公司 用于生产高纯度神经毒素的手段和方法
EP2248518B1 (en) * 2009-04-17 2013-01-16 Merz Pharma GmbH & Co. KGaA Formulation for stabilizing proteins, peptides or mixtures thereof.
BRPI1015311B1 (pt) * 2009-04-27 2024-01-09 Merz Pharma Gmbh & Co. Kgaa Método para determinar a quantidade de polipeptídeo de neurotoxina processada em uma solução, dispositivo para determinação da quantidade de polipeptídeo de neurotoxina processada contida em uma solução e kit adaptado
MX355771B (es) * 2011-03-31 2018-04-30 Medy Tox Inc Preparacion liofilizada de toxinas de botulismo.
KR101357999B1 (ko) * 2012-03-20 2014-02-03 함종욱 보툴리눔 에이형 독소의 액상제품
WO2018038301A1 (en) * 2016-08-26 2018-03-01 Hugel Inc. Stabilized liquid formulation of botulinum toxin and preparation method thereof
WO2020138674A1 (ko) 2018-12-26 2020-07-02 (주)케어젠 근육 이완용 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756468A (en) * 1994-10-13 1998-05-26 Wisconsin Alumni Research Foundation Pharmaceutical compositions of botulinum toxin or botulinum neurotoxin and methods of preparation
WO2000074703A2 (de) * 1999-06-07 2000-12-14 Merz + Co. Gmbh & Co. Therapeutikum mit einem botulinum-neurotoxin
US20030118598A1 (en) * 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
US20030224020A1 (en) * 2002-05-31 2003-12-04 Zabudkin Alexander F. Pharmaceutical preparation of botulinum neurotoxin, methods of synthesis and methods of clinical use
US20070026019A1 (en) * 2005-08-01 2007-02-01 Allergan, Inc. Botulinum toxin compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW574036B (en) * 1998-09-11 2004-02-01 Elan Pharm Inc Stable liquid compositions of botulinum toxin
KR100852822B1 (ko) * 2004-07-26 2008-08-18 메르츠 파마 게엠베하 운트 코. 카가아 보툴리눔 신경독소를 포함하는 치료 조성물
DE102004043009A1 (de) * 2004-09-06 2006-03-23 Toxogen Gmbh Transportprotein zum Einbringen chemischer Verbindungen in Nervenzellen
DE102005019302A1 (de) 2005-04-26 2006-11-16 Toxogen Gmbh Carrier zum Targeting von Nervenzellen
DE602006006671D1 (de) * 2005-06-17 2009-06-18 Merz Pharma Gmbh & Co Kgaa Vorrichtung und verfahren zur fermentativen herstellung biologisch wirksamer verbindungen
AR061669A1 (es) * 2006-06-29 2008-09-10 Merz Pharma Gmbh & Co Kgaa Aplicacion de alta frecuencia de terapia con toxina botulinica

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756468A (en) * 1994-10-13 1998-05-26 Wisconsin Alumni Research Foundation Pharmaceutical compositions of botulinum toxin or botulinum neurotoxin and methods of preparation
WO2000074703A2 (de) * 1999-06-07 2000-12-14 Merz + Co. Gmbh & Co. Therapeutikum mit einem botulinum-neurotoxin
US20030118598A1 (en) * 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
US20030224020A1 (en) * 2002-05-31 2003-12-04 Zabudkin Alexander F. Pharmaceutical preparation of botulinum neurotoxin, methods of synthesis and methods of clinical use
US20070026019A1 (en) * 2005-08-01 2007-02-01 Allergan, Inc. Botulinum toxin compositions

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11033625B2 (en) * 2005-10-06 2021-06-15 Allergan, Inc. Method for stabilizing a toxin
US11524075B2 (en) 2005-10-06 2022-12-13 Allergan, Inc. Animal protein-free pharmaceutical compositions
US11446382B2 (en) 2005-10-06 2022-09-20 Allergan, Inc. Animal protein-free pharmaceutical compositions
US11285216B2 (en) 2005-10-06 2022-03-29 Allergan, Inc. Animal protein-free pharmaceutical compositions
US11147878B2 (en) 2005-10-06 2021-10-19 Allergan, Inc. Animal protein-free pharmaceutical compositions
US11471708B2 (en) 2008-12-31 2022-10-18 Revance Therapeutics, Inc. Injectable botulinum toxin formulations
US11351232B2 (en) 2009-06-25 2022-06-07 Revance Therapeutics, Inc. Albumin-free botulinum toxin formulations
US20100330123A1 (en) * 2009-06-25 2010-12-30 Revance Therapeutics, Inc. Albumin-free botulinum toxin formulations
US10111939B2 (en) 2009-06-25 2018-10-30 Revance Therapeutics, Inc. Albumin-free botulinum toxin formulations
US11911449B2 (en) 2009-06-25 2024-02-27 Revance Therapeutics, Inc. Albumin-free botulinum toxin formulations
US9340587B2 (en) 2009-06-25 2016-05-17 Revance Therapeutics, Inc. Albumin-free botulinum toxin formulations
US20170029795A1 (en) * 2009-10-21 2017-02-02 Revance Therapeutics, Inc. Methods and Systems for Purifying Non-Complexed Botulinum Neurotoxin
KR101135486B1 (ko) * 2011-05-25 2012-04-13 함종욱 보툴리눔 에이형 독소의 액상제품
US10549042B2 (en) 2014-12-23 2020-02-04 Merz Pharma Gmbh & Co. Kgaa Botulinum toxin prefilled glass syringe
US11167090B2 (en) 2014-12-23 2021-11-09 Merz Pharma Gmbh & Co. Kgaa Botulinum toxin prefilled container
EP3253364A1 (en) * 2015-02-03 2017-12-13 Merz Pharma GmbH & Co. KGaA Botulinum toxin prefilled container
US10406290B2 (en) 2015-02-03 2019-09-10 Merz Pharma Gmbh & Co. Kgaa Botulinum toxin prefilled plastic syringe
US11219717B2 (en) 2015-02-03 2022-01-11 Merz Pharma Gmbh & Co. Kgaa Botulinum toxin prefilled plastic syringe
US20180052426A1 (en) * 2015-03-17 2018-02-22 Omega S.A. Wristwatch comprising a dial with luminous indices
US11306121B2 (en) 2018-12-26 2022-04-19 Caregen Co., Ltd. Composition for muscle relaxation

Also Published As

Publication number Publication date
AR066782A1 (es) 2009-09-09
AU2008256418A1 (en) 2008-12-04
CA2686637A1 (en) 2008-12-04
ZA200907875B (en) 2010-11-24
KR20100020971A (ko) 2010-02-23
ZA200907874B (en) 2011-03-30
JP2010529000A (ja) 2010-08-26
BRPI0812322A2 (pt) 2014-11-25
TW200914039A (en) 2009-04-01
MX2009012570A (es) 2010-03-15
WO2008145358A1 (en) 2008-12-04
JP2010528999A (ja) 2010-08-26
BRPI0812245A2 (pt) 2014-10-21
IL202130A0 (en) 2010-06-16
IL202129A0 (en) 2010-06-16
CN101720331A (zh) 2010-06-02
RU2009149604A (ru) 2011-07-20
MX2009012990A (es) 2010-04-01
EP2170375A1 (en) 2010-04-07
WO2008145359A1 (en) 2008-12-04
US20090028906A1 (en) 2009-01-29
TW200902050A (en) 2009-01-16
CA2686642A1 (en) 2008-12-04
CN101687018A (zh) 2010-03-31
AU2008256419A1 (en) 2008-12-04
AR066783A1 (es) 2009-09-09
KR20100020972A (ko) 2010-02-23
EP2164861A1 (en) 2010-03-24

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