MX355771B - Preparacion liofilizada de toxinas de botulismo. - Google Patents

Preparacion liofilizada de toxinas de botulismo.

Info

Publication number
MX355771B
MX355771B MX2016004606A MX2016004606A MX355771B MX 355771 B MX355771 B MX 355771B MX 2016004606 A MX2016004606 A MX 2016004606A MX 2016004606 A MX2016004606 A MX 2016004606A MX 355771 B MX355771 B MX 355771B
Authority
MX
Mexico
Prior art keywords
botulinum toxin
lyophilized preparation
present
transportation
animal
Prior art date
Application number
MX2016004606A
Other languages
English (en)
Inventor
Ho Jung Hyun
Hyeok Yang Gi
Hoon Rhee Chang
Woo Kim Hack
Bum Kim Sung
Hwan Baek Seung
Original Assignee
Medy Tox Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47282510&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX355771(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medy Tox Inc filed Critical Medy Tox Inc
Publication of MX355771B publication Critical patent/MX355771B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a una preparación liofilizada de toxina botulínica que no contiene agentes estabilizadores de proteína derivados de animales. La preparación liofilizada de toxina botulínica divulgada en la presente invención logra mantener una actividad de la toxina botulínica alcanzando notoriamente una estabilidad superior a largo plazo aún bajo condiciones de alta temperatura, las cuales suelen ocurrir durante el almacenamiento, transporte o uso de la toxina botulínica. En donde el preparado está libre de albúmina, y en donde la estabilidad de la toxina botulínica se mantiene durante al menos 30 días a 40°C y 70% de humedad relativa.
MX2016004606A 2011-03-31 2012-03-30 Preparacion liofilizada de toxinas de botulismo. MX355771B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20110029577 2011-03-31
PCT/KR2012/002418 WO2012134240A2 (ko) 2011-03-31 2012-03-30 보툴리눔 독소의 동결건조제제
KR1020120033374A KR101395064B1 (ko) 2011-03-31 2012-03-30 보톨리눔 독소의 동결건조제제

Publications (1)

Publication Number Publication Date
MX355771B true MX355771B (es) 2018-04-30

Family

ID=47282510

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016004606A MX355771B (es) 2011-03-31 2012-03-30 Preparacion liofilizada de toxinas de botulismo.
MX2013011119A MX338436B (es) 2011-03-31 2012-03-30 Preparacion liofilizada de toxinas de botulismo.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2013011119A MX338436B (es) 2011-03-31 2012-03-30 Preparacion liofilizada de toxinas de botulismo.

Country Status (22)

Country Link
US (3) US8920795B2 (es)
EP (3) EP3241547B1 (es)
JP (3) JP5826914B2 (es)
KR (1) KR101395064B1 (es)
CN (2) CN109925284A (es)
AU (2) AU2012233845B2 (es)
BR (1) BR112013025256B1 (es)
CA (1) CA2831908C (es)
CO (1) CO6821888A2 (es)
DK (2) DK3241547T3 (es)
ES (2) ES2636680T5 (es)
HU (1) HUE050037T2 (es)
IL (1) IL228607B (es)
MX (2) MX355771B (es)
PH (1) PH12013502022B1 (es)
PL (2) PL3241547T3 (es)
PT (1) PT3241547T (es)
RU (2) RU2640922C1 (es)
SG (3) SG194039A1 (es)
SI (1) SI3241547T1 (es)
WO (1) WO2012134240A2 (es)
ZA (1) ZA201308115B (es)

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JP7646555B2 (ja) 2019-02-21 2025-03-17 メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン 振戦治療のためのボツリヌス神経毒素の新規用途
CN110637814B (zh) * 2019-10-22 2021-11-19 青海省畜牧兽医科学院 一种d型肉毒毒素的微囊化制备方法
EP4052753A4 (en) * 2019-10-31 2023-11-15 Hugel Inc. Microstructure formulation technique for botulinum toxin
US20230256064A1 (en) * 2020-07-23 2023-08-17 Medytox Inc. Cancer therapeutic agent
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KR102940220B1 (ko) * 2021-02-08 2026-03-17 주식회사 대웅 장기 저장이 가능한 보툴리눔 독소 동결건조 제형 조성물
KR20230001260A (ko) 2021-06-28 2023-01-04 (주)메디톡스 재조합 보툴리눔 독소 타입 a 경쇄, 재조합 보툴리눔 독소 및 이의 조성물, 용도 및 방법
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Also Published As

Publication number Publication date
EP2692350A4 (en) 2014-12-10
EP2692350B2 (en) 2023-06-28
MX2013011119A (es) 2014-02-27
JP2016199599A (ja) 2016-12-01
PH12013502022B1 (en) 2018-12-12
CA2831908C (en) 2018-11-13
PL3241547T3 (pl) 2021-02-08
HUE050037T2 (hu) 2020-11-30
KR20120112248A (ko) 2012-10-11
US8920795B2 (en) 2014-12-30
AU2016201040B2 (en) 2017-05-25
JP6173547B2 (ja) 2017-08-02
SI3241547T1 (sl) 2020-10-30
PL2692350T3 (pl) 2017-10-31
AU2012233845B2 (en) 2015-11-19
IL228607A0 (en) 2013-12-31
RU2640922C1 (ru) 2018-01-12
JP5826914B2 (ja) 2015-12-02
RU2574011C2 (ru) 2016-01-27
CO6821888A2 (es) 2013-12-31
JP6005239B2 (ja) 2016-10-12
WO2012134240A2 (ko) 2012-10-04
DK2692350T4 (da) 2023-09-04
SG10202013124XA (en) 2021-02-25
DK2692350T3 (en) 2017-08-21
US20160089442A1 (en) 2016-03-31
PH12013502022A1 (en) 2013-12-16
EP3241547A1 (en) 2017-11-08
BR112013025256B1 (pt) 2022-01-18
IL228607B (en) 2018-10-31
KR101395064B1 (ko) 2014-05-19
US20140086900A1 (en) 2014-03-27
EP3756656A1 (en) 2020-12-30
CN103596580A (zh) 2014-02-19
CN109925284A (zh) 2019-06-25
DK3241547T3 (da) 2020-08-17
EP3241547B1 (en) 2020-05-20
ES2636680T3 (es) 2017-10-06
PL2692350T5 (pl) 2023-10-09
SG194039A1 (en) 2013-11-29
AU2012233845A1 (en) 2013-10-31
RU2013148119A (ru) 2015-05-27
AU2016201040A1 (en) 2016-03-10
EP2692350A2 (en) 2014-02-05
ES2810098T3 (es) 2021-03-08
US20150064166A1 (en) 2015-03-05
HK1246174A1 (en) 2018-09-07
CA2831908A1 (en) 2012-10-04
JP2016020382A (ja) 2016-02-04
US9198958B2 (en) 2015-12-01
BR112013025256A2 (pt) 2017-02-07
SG10201605324PA (en) 2016-08-30
ES2636680T5 (es) 2023-10-31
MX338436B (es) 2016-04-18
EP3756656B1 (en) 2024-09-11
WO2012134240A3 (ko) 2013-01-03
ZA201308115B (en) 2014-07-30
EP2692350B1 (en) 2017-05-03
PT3241547T (pt) 2020-08-26
JP2014509644A (ja) 2014-04-21

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