US20080289629A1 - Nasal Delivery Devices - Google Patents

Nasal Delivery Devices Download PDF

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Publication number
US20080289629A1
US20080289629A1 US11/663,099 US66309905A US2008289629A1 US 20080289629 A1 US20080289629 A1 US 20080289629A1 US 66309905 A US66309905 A US 66309905A US 2008289629 A1 US2008289629 A1 US 2008289629A1
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United States
Prior art keywords
container
delivery device
substance
chamber
nosepiece
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Abandoned
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US11/663,099
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English (en)
Inventor
Per Gisle Djupesland
Roderick Peter Hafner
Colin David Sheldrake
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Optinose AS
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Optinose AS
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Assigned to OPTINOSE AS reassignment OPTINOSE AS ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DJUPESLAND, PER GISLE, HAFNER, RODERICK PETER, SHELDRAKE, COLIN DAVID
Publication of US20080289629A1 publication Critical patent/US20080289629A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
    • A61M15/0008—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0098—Activated by exhalation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/105—Filters
    • A61M16/1055—Filters bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/105—Filters
    • A61M16/106—Filters in a path
    • A61M16/1065—Filters in a path in the expiratory path
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1075—Preparation of respiratory gases or vapours by influencing the temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • the present invention relates to nasal delivery devices and methods for delivering substances, in particular particulate substances, such as powdered substances, to the nasal cavities of subjects, and in particular multi-dose devices adapted for use with a plurality of containers, such as capsules, blisters and vials, which each contain a single dose of substance.
  • a large fraction of particles is deposited in the anterior region of the nasal cavity.
  • the nasal cavity becomes narrower during nasal inhalation, thus further reducing the deposition efficiency in the posterior regions of the nasal airway, in particular in narrow and congested noses.
  • nasal delivery systems which are suited to deliver substances, in particular particulate substances, such as powdered substances, to the nasal cavities of subjects, and in particular nasal powder delivery systems for both topical delivery and nose-to-brain (N2B) delivery.
  • Bi-directional nasal delivery is disclosed in the applicant's earlier WO-A-00/51672, the content of which is incorporated herein by reference.
  • the present invention provides a nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a pressure-sensitive valve which normally closes the fluid connection between the container chamber and the mouthpiece, and a temperature regulator upstream of the container chamber.
  • the present invention provides a nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and a moisture-reducing element for reducing condensation at or downstream of the container chamber.
  • the present invention provides a nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece.
  • the present invention provides a nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a body member; a carrier which is supported by the body member and carries a plurality of substance-containing containers; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject; a mouthpiece unit including a mouthpiece through which the subject in use exhales; and an actuating mechanism which is operative, in each operation, to open a plurality of the substance-containing containers, and including a valve unit for fluidly connecting the mouthpiece to a respective one of the opened substance-containing containers in successive exhalation cycles.
  • the present invention provides a method of delivering substance to a nasal cavity of a subject, the method comprising the steps of: disposing a substance-containing container which contains substance to be delivered to the nasal cavity of the subject in a container chamber, the container chamber including an inlet and an outlet; fitting a nosepiece in fluid communication with the outlet of the container chamber to a nasal cavity of the subject; the subject exhaling through a mouthpiece which is in fluid communication with the inlet of the container chamber, such as to deliver an air flow through the container chamber and entrain substance from the container and deliver the same through the nosepiece and into the nasal cavity of the subject; and drawing moisture from the exhaled air flow upstream of the container chamber, such as to reduce condensation at or downstream of the container chamber.
  • the present invention provides a method of delivering substance to a nasal cavity of a subject, the method comprising the steps of: disposing a substance-containing container which contains substance to be delivered to the nasal cavity of the subject in a container chamber, the container chamber including an inlet and an outlet; fitting a nosepiece in fluid communication with the outlet of the container chamber to a nasal cavity of the subject; and the subject exhaling through a mouthpiece which is in fluid communication with the inlet of the container chamber, such as to deliver an air flow through the container chamber and entrain substance from the container and deliver the same through the nosepiece and into the nasal cavity of the subject.
  • FIGS. 1( a ) to ( f ) illustrate a nasal delivery device in accordance with a first embodiment of the present invention
  • FIGS. 2( a ) to ( f ) illustrate a nasal delivery device in accordance with a second embodiment of the present invention
  • FIGS. 3( a ) to ( f ) illustrate a nasal delivery device in accordance with a third embodiment of the present invention.
  • FIGS. 4( a ) to ( f ) illustrate a nasal delivery device in accordance with a fourth embodiment of the present invention.
  • FIGS. 1( a ) to ( f ) illustrate a nasal delivery device in accordance with a first embodiment of the present invention.
  • the delivery device comprises a housing 15 , a capsule-receiving unit 16 for receiving a capsule C, a nosepiece unit 17 for fitting to a nasal cavity of a subject, a mouthpiece unit 19 through which the subject exhales, and a capsule-piercing mechanism 20 , which is operable to pierce a capsule C as contained by the capsule-receiving unit 16 and thereby prime the delivery device for operation, as will be described in more detail hereinbelow.
  • the housing 15 includes a first, nosepiece aperture 21 , in this embodiment at the upper end of the housing 15 , which receives the nosepiece unit 17 , and a second, lateral aperture 22 , in this embodiment in the lateral wall of the housing 15 , through which extends an actuator button 81 of the capsule-piercing mechanism 20 , as will be described in more detail hereinbelow.
  • the capsule-receiving unit 16 comprises a capsule-receiving member 23 , in this embodiment an elongate, upstanding chamber which is disposed opposite the nosepiece aperture 21 in the housing 15 , for receiving a capsule C, in this embodiment as contained within a capsule-containing member 49 of the nosepiece unit 17 , as will be described in more detail hereinbelow.
  • the capsule-receiving member 23 includes an inlet 24 and an outlet 25 for providing for an air flow therethrough, with the outlet 25 , as defined by an upper, downstream end of the capsule-receiving member 23 , being adapted to receive the capsule-containing member 49 of the nosepiece unit 17 , such that the capsule-containing member 49 is a sealing fit within the capsule-receiving member 23 .
  • the capsule-receiving unit 16 further comprises a pressure-sensitive valve 26 in fluid communication with the inlet 24 of the capsule-receiving member 23 , which is such as to prevent an air flow through the capsule-receiving member 23 until a predetermined pressure has been developed upstream thereof.
  • the pressure-sensitive valve 26 is located at the inlet 24 to the capsule-receiving member 23 .
  • the pressure-sensitive valve 26 comprises a flap member 27 which is hingeable about a pivot 28 and normally biased to a closed, sealing position by a resilient element 29 , here a spring, such that a predetermined pressure is required to overcome the biasing force of the resilient element 29 .
  • the nosepiece unit 17 comprises a main body member 45 which is configured to fit in the nosepiece aperture 21 of the housing 15 , a nosepiece 47 which extends outwardly of the main body member 45 for fitting to the nostril of the subject, and a capsule-containing member 49 which extends inwardly of the main body member 45 and contains a capsule C, the contents of which are to be delivered to the nasal cavity of the subject.
  • the capsule C is a conventional gelatine capsule which contains a particulate substance, such as a powdered substance, and typically a pharmaceutical substance.
  • the nosepiece 47 has a substantially frusto-conical outer section 53 for insertion into a nostril of the subject such as to provide a fluid-tight seal therewith, and includes an inner channel 55 , here of substantially cylindrical section, through which substance is delivered to the nasal cavity of the subject.
  • the nosepiece 47 in providing a fluid-tight seal with the nostril of the subject, provides for bi-directional delivery through the nasal airway of the subject, as disclosed in the applicant's earlier WO-A-00/51672.
  • the nosepiece 47 need not provide a sealing fit, thus encompassing delivery to the nasal cavity, but not necessarily bi-directional delivery.
  • the nosepiece 47 includes a trap element 57 , typically a perforated or mesh element, for preventing any foreign matter, such as a part of the capsule C, which is above a predetermined size from passing through the nosepiece 47 and into the nasal cavity of the subject.
  • a trap element 57 typically a perforated or mesh element, for preventing any foreign matter, such as a part of the capsule C, which is above a predetermined size from passing through the nosepiece 47 and into the nasal cavity of the subject.
  • the capsule-containing member 49 includes an elongate flow passage 63 , in this embodiment cylindrical in shape, in which the capsule C is oriented axially therealong such as to be rotatable therewithin when an air flow is delivered therethrough, and an inlet aperture 65 in fluid communication with one, the downstream, end of the flow passage 63 , which inlet aperture 65 provides a flow restriction to an air flow as delivered therethrough and acts as a seat for one, the lower, end of the capsule C prior to the delivery of an air flow through the flow passage 63 .
  • the capsule-containing member 49 further includes a plurality of, in this embodiment first and second piercing apertures 71 , 73 in a lateral wall thereof for enabling the capsule C to be pierced at locations spaced along the axial length thereof.
  • the first, lower aperture 71 is located such that the capsule C is pierced at a location above the height of the dose of substance as contained thereby when the lower end of the capsule C is seated in the inlet aperture 65 of the flow passage 63 . In this way, the dose of substance as contained by the capsule C is not released into the flow passage 63 until an air flow is delivered through the flow passage 63 .
  • the nosepiece unit 17 is provided as a replaceable unit which is replaced following each operation of the delivery device.
  • the nosepiece unit 17 can be packaged in air-tight packaging, for example, an aluminum foil package.
  • the capsule-containing member 49 could be replaceable, such as to be replaceable following each operation, with the nosepiece 47 being a sealing fit to the other, downstream end of the capsule-containing member 49 .
  • the capsule-containing member 49 can be packaged in air-tight packaging, for example, an aluminum foil package.
  • the nosepiece unit 17 could be a re-useable unit, with the capsule-containing member 49 being separable from the nosepiece 47 to allow for replacement of the capsule C following operation of the delivery device.
  • the capsule C can be packaged in air-tight packaging, for example, an aluminum foil package.
  • the mouthpiece unit 19 comprises a mouthpiece 77 , in this embodiment as gripped in the lips of the subject, through which the subject exhales to deliver an entraining air flow through the capsule-receiving unit 16 , and an air chamber 78 , in this embodiment an elongate tubular section, which fluidly connects the mouthpiece 77 and the pressure-sensitive valve 26 of the capsule-receiving unit 16 .
  • the air chamber 78 has a greater volume than the capsule-receiving member 23 of the capsule-receiving unit 16 , and preferably has a volume at least twice that of the capsule-receiving member 23 .
  • the air chamber 78 incorporates a temperature regulator 79 , here formed as a condenser for cooling the exhaled air flow, at least at the upstream end thereof.
  • a temperature regulator 79 here formed as a condenser for cooling the exhaled air flow, at least at the upstream end thereof.
  • the temperature regulator 79 comprises a labyrinthine structure.
  • the temperature regulator 79 could be provided by a filter element, which could also act as a microbiological filter.
  • the temperature regulator 79 could include means for drying the condensate as collected therein when the delivery device is not in use.
  • the air chamber 78 is removable, such as to allow for cleaning or replacement.
  • the capsule-piercing mechanism 20 comprises an actuator button 81 which extends through the lateral aperture 22 in the housing 15 such as to allow for operation by the subject, a plurality of, in this embodiment first and second piercing elements 83 , 85 which are supported by the actuator button 81 and extend forwardly thereof, such that, on depression of the actuator button 81 from a retracted position, as illustrated in FIG. 1( a ), to an extended position, as illustrated in FIG. 1( b ), the piercing elements 83 , 85 are driven through respective ones of the piercing apertures 71 , 73 in the lateral wall of the capsule-containing member 49 to pierce the capsule C.
  • the capsule-piercing mechanism 20 includes a resilient element 87 which acts to bias the actuator button 81 outwardly towards the retracted position, such that, following depression of the actuator button 81 to pierce the capsule C, the actuator button 81 is returned to the retracted position.
  • the resilient element 87 is formed as an integral part of the actuator button 81 , but in other embodiments could be provided by a separate element, such as a compression spring.
  • the subject depresses the actuator button 81 of the capsule-piercing mechanism 20 such as to pierce the capsule C as contained in the capsule-containing member 49 , as illustrated in FIG. 1( b ).
  • the capsule C is pierced by the piercing elements 83 , 85 at two locations spaced along the axial length thereof.
  • the first, lower piercing element 83 acts to pierce the capsule C at a location just above the height of the substance as contained by the capsule C, the capsule C only being part filled
  • the second, upper piercing element 85 acts to pierce the upper, distal end of the capsule C.
  • the actuator button 81 is then released, which causes the actuator button 81 to be returned to the retracted under the bias of the biasing element 87 , as illustrated in FIG. 1( c ). In this way, the delivery device is primed and ready for use.
  • the subject then inserts the nosepiece 53 into one of his nostrils, grips the mouthpiece 77 in his or her lips and begins to exhale through the mouthpiece 77 , as illustrated in FIG. 1( d ). Initially, this exhalation is resisted by the pressure-sensitive valve 26 , thereby preventing the delivery of an air flow through the capsule-containing member 49 and over the capsule C.
  • the pressure-sensitive valve 26 When the subject exhales with sufficient force to develop a pressure upstream of the pressure-sensitive valve 26 which is greater than a predetermined pressure, the pressure-sensitive valve 26 is opened, causing a sudden flow of air, as a burst of air, through the capsule-containing member 49 , as illustrated in FIG. 1( e ).
  • This burst of air acts to lift the capsule C from the seat as defined by the inlet aperture 65 of the capsule-containing member 49 and initiate the rotation of the capsule C, which rotation acts to release the substance from within the capsule C. With continued exhalation, the capsule C continues to rotate.
  • the pressure-sensitive valve 26 is returned to the closed, sealing position and the, now empty, capsule C is returned to a rest position.
  • This operation of the delivery device can be repeated with a new capsule C.
  • the entire nosepiece unit 17 is replaced, but in other embodiments either the capsule-containing member 49 or just the capsule C could be replaced.
  • FIGS. 2( a ) to ( f ) illustrate a nasal delivery device in accordance with a second embodiment of the present invention.
  • the delivery device of this embodiment is very similar to the delivery device of the above-described first embodiment, and thus, in order to avoid unnecessary duplication of description, only the differences will be described in detail.
  • the delivery device of this embodiment differs from that of the above-described embodiment in that the nosepiece 53 includes first and second channels 55 a , 55 b , in this embodiment concentric annular channels, which are centred about the longitudinal axis of the capsule-containing member 49 , where the first, inner channel 55 a is fluidly connected to the downstream end of the capsule-containing member 49 such that the substance as contained by the capsule C is delivered therethrough and the second, outer channel 55 b is fluidly connected by a ducting channel 91 to the mouthpiece 77 , in this embodiment upstream of the air chamber 78 .
  • a focussed powder aerosol is delivered from the outlet end of the inner channel 55 a , and entrained by the co-axial air flow as delivered from the mouthpiece 77 .
  • This arrangement is particularly advantageous in targeting specific regions of the nasal airway, in particular posterior regions, such as the olfactory region. As this entraining air flow does not pass over the capsule C, the humidity of the entraining air flow is not significant.
  • FIGS. 3( a ) to ( f ) illustrate a nasal delivery device in accordance with a third embodiment of the present invention.
  • the delivery device comprises a housing 101 which includes a central support spindle 105 , a carrier 109 which carries a plurality of substance-containing capsules C, the contents of which are to be delivered to a nasal cavity of the subject, and is movably disposed to the housing 101 , in this embodiment rotatably mounted to the housing 101 about the support spindle 105 , a nosepiece unit 119 for fitting to a nasal cavity of a subject, a mouthpiece unit 121 through which the subject exhales, and a capsule-piercing mechanism 123 , which is operable, in this embodiment simultaneously, to pierce a pair of capsules C and thereby prime the delivery device for operation, as will be described in more detail hereinbelow.
  • the capsules C are conventional gelatine capsules which contain a particulate substance, such as a powdered substance, and typically a pharmaceutical substance.
  • the carrier 109 comprises a body member 131 , in this embodiment an annular element, and a plurality of capsule-containing members 133 , each containing a capsule C, which are disposed symmetrically in adjacent pairs about the support spindle 105 , such that, as the carrier 109 is indexed successively to new positions, new pairs of capsule-containing members 133 are indexed to the capsule-piercing mechanism 123 .
  • the capsule-containing members 133 each comprise a tubular element 137 which defines an elongate flow passage 139 , in this embodiment cylindrical in shape, in which the capsule C is oriented axially therealong such as to be rotatable therewithin when an air flow is delivered therethrough, and first and second sealing members 141 , 142 which seal the opposite, lower and upper ends of the tubular element 137 .
  • the capsule-containing members 133 each include a plurality of, in this embodiment first and second piercing apertures 143 , 144 in a lateral wall thereof for enabling the capsule C to be pierced at locations spaced along the axial length thereof.
  • the first, lower aperture 143 is located such that the capsule C is pierced at a location above the height of the dose of substance as contained thereby. In this way, the dose of substance as contained by the capsule C is not released into the flow passage 139 until an air flow is delivered through the flow passage 139 .
  • the nosepiece unit 119 comprises a body member 145 which is movably, in this embodiment pivotally, coupled to the housing 101 such as to be movable between a first, inoperative position, as illustrated in FIG. 3( a ), in which the nosepiece unit 119 is stowed away and a second, operative position, as illustrated in FIG. 3( c ), and a nosepiece 147 which extends outwardly of the body member 145 for fitting to a nostril of the subject.
  • the body member 145 includes a flow channel 149 which fluidly connects the flow passages 139 of an adjacent pair of the capsule-containing members 133 to the nosepiece 147 when the nosepiece unit 119 is in the operative position.
  • the body member 145 includes first and second cutters 151 which are adapted to cut the upper sealing members 142 of the adjacent pair of capsule-containing members 133 when the nosepiece unit 119 is in the operative position.
  • the body member 145 includes a catch member 155 , here having a diamond-shaped cross section which presents forwardly-directed, tapering surfaces when the nosepiece unit 119 is pivoted in either sense from or to the operative position, which acts to operate in part the capsule-piercing mechanism 123 and also latch the nosepiece unit 119 in the operative position, as will be described in more detail hereinbelow.
  • a catch member 155 here having a diamond-shaped cross section which presents forwardly-directed, tapering surfaces when the nosepiece unit 119 is pivoted in either sense from or to the operative position, which acts to operate in part the capsule-piercing mechanism 123 and also latch the nosepiece unit 119 in the operative position, as will be described in more detail hereinbelow.
  • the nosepiece 147 has a substantially frusto-conical outer section 157 for insertion into a nostril of the subject such as to provide a fluid-tight seal therewith, and includes an inner channel 159 through which substance is delivered to the nasal cavity of the subject.
  • the nosepiece 147 in providing a fluid-tight seal with the nostril of the subject, provides for bi-directional delivery through the nasal airway of the subject, as disclosed in the applicant's earlier WO-A-00/51672.
  • the nosepiece 147 need not provide a sealing fit, thus encompassing delivery to the nasal cavity, but not necessarily bi-directional delivery.
  • the mouthpiece unit 121 comprises a body member 165 which is movably, in this embodiment pivotally, coupled to the housing 101 such as to be movable between a first, inoperative position, as illustrated in FIG. 3( a ), in which the mouthpiece unit 121 is stowed away and a second, operative position, as illustrated in FIG. 3( c ), a mouthpiece 167 which extends outwardly of the body member 165 , in this embodiment as gripped in the lips of the subject, through which the subject exhales to deliver an entraining air flow, and a valve unit 169 which is operative fluidly to connect the mouthpiece 167 to a respective one of the adjacent pair of opened capsule-containing members 133 in successive exhalation cycles.
  • valve unit 169 comprises a pressure sensor which is operative to detect the pressure as developed in the mouthpiece 167 and an electro-mechanical valve, which includes two flow channels and is switchable such as fluidly to connect the mouthpiece 167 first to one of the pair of capsule-containing members 133 and, following the first exhalation cycle, which is represented by a return to ambient pressure, then to the other of the pair of capsule-containing members 133 .
  • the body member 165 includes first and second cutters 171 which are adapted to cut the lower sealing members 141 of the adjacent pair of capsule-containing members 133 when the mouthpiece unit 121 is in the operative position.
  • the body member 165 includes a catch member 175 , here having a diamond-shaped cross section which presents forwardly-directed, tapering surfaces when the mouthpiece unit 121 is pivoted in either sense from or to the operative position, which acts to operate in part the capsule-piercing mechanism 123 and also latch the mouthpiece unit 121 in the operative position, as will be described in more detail hereinbelow.
  • a catch member 175 here having a diamond-shaped cross section which presents forwardly-directed, tapering surfaces when the mouthpiece unit 121 is pivoted in either sense from or to the operative position, which acts to operate in part the capsule-piercing mechanism 123 and also latch the mouthpiece unit 121 in the operative position, as will be described in more detail hereinbelow.
  • the capsule-piercing mechanism 123 comprises first and second piercing units 181 , which are disposed in opposed, back-to-back relation and are actuated by movement of the nosepiece unit 119 and the mouthpiece unit 121 from the inoperative, stowed positions to the operative positions.
  • Each of the piercing units 181 includes an actuator button 182 and a plurality of, in this embodiment first and second piercing elements 183 , 185 which are supported by the actuator button 182 and extend forwardly thereof, such that, on depression of the actuator button 182 from a retracted position, as illustrated in FIG. 3( a ), to an extended position, as illustrated in FIG. 3( b ), the piercing elements 183 , 185 are driven through respective ones of the piercing apertures 143 , 144 in the lateral wall of the respective capsule-containing member 133 to pierce the capsule C.
  • the capsule-piercing units 181 each include a resilient element 187 which acts to bias the respective actuator button 182 inwardly towards the retracted position, such that, following depression of the actuator button 182 to pierce the capsule C, the actuator button 182 is returned to the retracted position.
  • the actuator buttons 182 each include first and second recesses 189 , 191 in a rear surface thereof, here V-shaped in cross section, which are configured such as to engage respective ones of the catches 155 , 175 on the body members 145 , 165 of the nosepiece and mouthpiece units 119 , 121 , such as to latch the same in the operative positions.
  • the subject indexes the carrier 109 such as to present the next pair of capsule-containing members 133 at the capsule-piercing mechanism 123 , as illustrated in FIG. 3( a ).
  • the subject then moves the nosepiece unit 119 and the mouthpiece unit 121 to the respective operative positions, in this embodiment by pivoting the same relative to the housing 101 , as illustrated in FIGS. 3( b ) and ( c ).
  • the catch member 155 on the body member 145 of the nosepiece unit 119 and the catch member 175 on the body member 165 of the mouthpiece unit 121 engage between the respective ends of the opposing actuator buttons 182 of the piercing units 181 , such as to bias the actuator buttons 182 outwardly and pierce the capsules C as contained in the capsule-containing members 133 , as illustrated in FIG. 3( b ).
  • the capsules C are pierced by the piercing elements 183 , 185 at two locations spaced along the axial length thereof, with the piercing elements 183 , 185 extending through the piercing apertures 143 , 144 in the lateral walls of the tubular elements 137 of the capsule-containing members 133 .
  • the first, lower piercing elements 183 act to pierce the capsules C at locations just above the height of the substance as contained by the capsules C, the capsules C only being part filled, and the second, upper piercing elements 185 act to pierce the upper, distal ends of the capsules C.
  • the catch member 155 on the body member 145 of the nosepiece unit 119 and the catch member 175 on the body member 165 of the mouthpiece unit 121 engage in the respective recesses 189 , 191 in the rear surfaces of the opposing actuator buttons 182 of the piercing units 181 , as illustrated in FIG. 3( c ), with the actuator buttons 182 being returned to the retracted positions under the bias of the biasing elements 187 , whereby the nosepiece unit 119 and the mouthpiece unit 121 are latched in the operative positions.
  • the cutters 151 on the body member 145 of the nosepiece unit 119 act to rupture the upper sealing members 142 of the capsule-containing members 133 and the cutters 171 on the body member 165 of the mouthpiece unit 121 act to rupture the lower sealing members 141 of the capsule-containing members 133 .
  • the subject then inserts the nosepiece 147 into one of his or her nostrils, grips the mouthpiece 167 in his or her lips and exhales through the mouthpiece 167 , as illustrated in FIG. 3( d ).
  • valve unit 169 is configured such as to direct the exhaled air flow through one of the pair of capsule-containing members 133 , which air flow acts to lift the capsule C and cause rotation of the capsule C, and which rotation acts to release the substance from within the capsule C. With continued exhalation, the capsule C continues to rotate.
  • the valve unit 169 is re-configured such that the mouthpiece 167 is fluidly connected to the other of the pair of capsule-containing members 133 , whereby the air flow as developed by a subsequent exhalation breath is directed through the other of the pair of capsule-containing members 133 .
  • the nosepiece 147 is inserted in the other of the nostrils of the subject, and the subject grips the mouthpiece 167 in his or her lips and exhales through the mouthpiece 167 , as illustrated in FIG. 3( e ).
  • valve unit 169 is configured such as to direct the exhaled air flow through the other of the pair of capsule-containing members 133 , which air flow acts to lift the capsule C and cause rotation of the capsule C, and which rotation acts to release the substance from within the capsule C. With continued exhalation, the capsule C continues to rotate.
  • the nosepiece 147 is not moved to the other nostril of the subject.
  • the nosepiece unit 119 and the mouthpiece unit 121 are returned to the respective stowed, inoperative positions, in this embodiment by pivoting the same relative to the housing 101 , as illustrated in FIG. 3( f ).
  • the catch member 155 on the body member 145 of the nosepiece unit 119 and the catch member 175 on the body member 165 of the mouthpiece unit 121 are released from engagement with the recesses 189 , 191 in the rear surfaces of the opposing actuator buttons 182 of the piercing units 181 .
  • This operation of the delivery device can then subsequently be repeated for the next pair of capsules C.
  • FIGS. 4( a ) to ( f ) illustrate a nasal delivery device in accordance with a fourth embodiment of the present invention.
  • the delivery device comprises a housing 201 which includes a central support spindle 205 , a carrier 209 which carries a plurality of substance-containing blisters B, the contents of which are to be delivered to a nasal cavity of the subject, and is movably disposed to the housing 201 , in this embodiment rotatably mounted to the housing 201 about the support spindle 205 , an interface assembly 211 which provides the interface to the subject, and a latch mechanism 223 which acts to latch the interface assembly 211 in the operative position, as will be described in more detail hereinbelow.
  • the blisters B are conventional blisters which contain a particulate substance, such as a powdered substance, and typically a pharmaceutical substance.
  • the carrier 209 comprises a body member 231 , in this embodiment an annular element, and a plurality of blisters B which are disposed symmetrically in adjacent pairs about the support spindle 205 , such that, as the carrier 209 is indexed successively to new positions, new pairs of blisters B are indexed to the operative position of the interface assembly 211 .
  • the interface assembly 211 comprises a body member 235 which is movably, in this embodiment pivotally, coupled to the housing 201 such as to be movable between a first, inoperative position, as illustrated in FIG. 4( a ), in which the interface assembly 211 is stowed away and a second, operative position, as illustrated in FIG.
  • a nosepiece unit 219 which includes a nosepiece 247 which extends outwardly of the body member 235 for fitting to a nostril of the subject, a mouthpiece unit 221 which includes a mouthpiece 249 which extends outwardly of the body member 235 , in this embodiment as gripped in the lips of the subject, through which the subject exhales to deliver an entraining air flow, and a valve unit 251 which is operative fluidly to connect the mouthpiece 249 to a respective one of the adjacent pair of opened blisters B in successive exhalation cycles.
  • the body member 235 includes a flow channel 259 which fluidly connects the adjacent pair of blisters B to the nosepiece 249 when the interface assembly 211 is in the operative position.
  • the body member 235 includes first and second cutters 261 which are adapted to cut the sealing members of the adjacent pair of blisters B when the interface assembly 211 is in the operative position.
  • the body member 235 includes a catch member 265 , here having a diamond-shaped cross section which presents forwardly-directed, tapering surfaces when the interface assembly 211 is pivoted in either sense from or to the operative position, which acts to latch the interface assembly 211 in the operative position, as will be described in more detail hereinbelow.
  • a catch member 265 here having a diamond-shaped cross section which presents forwardly-directed, tapering surfaces when the interface assembly 211 is pivoted in either sense from or to the operative position, which acts to latch the interface assembly 211 in the operative position, as will be described in more detail hereinbelow.
  • the nosepiece 247 has a substantially frusto-conical outer section 267 for insertion into a nostril of the subject such as to provide a fluid-tight seal therewith, and includes an inner channel 269 through which substance is delivered to the nasal cavity of the subject.
  • the nosepiece 247 in providing a fluid-tight seal with the nostril of the subject, provides for bi-directional delivery through the nasal airway of the subject, as disclosed in the applicant's earlier WO-A-00/51672.
  • the nosepiece 247 need not provide a sealing fit, thus encompassing delivery to the nasal cavity, but not necessarily bi-directional delivery.
  • valve unit 251 comprises a pressure sensor which is operative to detect the pressure as developed in the mouthpiece 249 and an electro-mechanical valve, which includes two flow channels and is switchable such as fluidly to connect the mouthpiece 249 first to one of the pair of blisters B and, following the first exhalation cycle, which is represented by a return to ambient pressure, then to the other of the pair of blisters B.
  • the latch mechanism 223 comprises first and second latch elements 281 , which are disposed in opposed, back-to-back relation, and each comprise a latch body 282 and a resilient element 287 which acts to bias the latch body 282 forwardly to a latching position.
  • the latch bodies 282 each include a recess 289 in a rear surface thereof, here V-shaped in cross section, which acts to engage the catch 265 on the body member 235 of the interface assembly 211 when the interface assembly 211 is in the operative position.
  • the subject indexes the carrier 209 such as to present the next pair of blisters B at the operative position of the interface assembly 211 , as illustrated in FIG. 4( a ).
  • the subject then moves the interface assembly 211 to the operative position, in this embodiment by pivoting the same relative to the housing 201 , as illustrated in FIGS. 4( b ) and ( c ).
  • the catch member 265 on the body member 235 of the interface assembly 211 engages between the respective ends of the latch bodies 282 of the latch units 281 , such as to bias the latch bodies 282 outwardly, as illustrated in FIG. 4( b ).
  • the catch member 265 on the body member 235 of the interface assembly 211 engages in the respective recesses 289 in the rear surfaces of the opposing latch bodies 282 of the latch units 281 , as illustrated in FIG. 4( c ), with the latch bodies 282 being returned to the retracted positions under the bias of the biasing elements 287 , whereby the interface assembly 211 is latched in the operative position.
  • the cutters 261 on the body member 235 of the interface assembly 211 act to rupture the sealing members of the adjacent pair of blisters B.
  • the subject then inserts the nosepiece 247 into one of his or her nostrils, grips the mouthpiece 249 in his or her lips and exhales through the mouthpiece 249 , as illustrated in FIG. 4( d ).
  • valve unit 251 is configured such as to direct the exhaled air flow through one of the pair of blisters B, which air flow acts to entrain the substance from the blister B.
  • the blister B is emptied, and, as detected by the absence of any pressure in the mouthpiece 249 , the valve unit 251 is re-configured such that the mouthpiece 249 is fluidly connected to the other of the pair of blisters B, whereby the air flow as developed by a subsequent exhalation breath is directed through the other of the pair of blisters B.
  • the nosepiece 247 is inserted in the other of the nostrils of the subject, and the subject grips the mouthpiece 249 in his or her lips and exhales through the mouthpiece 249 , as illustrated in FIG. 4( e ).
  • valve unit 251 is configured such as to direct the exhaled air flow through the other of the pair of blisters B, which acts to entrain the substance from the blister B.
  • the nosepiece 247 is not moved to the other nostril of the subject.
  • the interface assembly 211 is returned to the stowed, inoperative position, in this embodiment by pivoting the same relative to the housing 201 , as illustrated in FIG. 4( f ).
  • the catch member 265 on the body member 235 of the interface assembly 211 is released from engagement with the recesses 289 in the rear surfaces of the opposing latch bodies 282 of the latch units 281 .
  • This operation of the delivery device can then subsequently be repeated for the next pair of blisters B.
  • the delivery device could be modified to include a rotatable cartridge which includes a plurality of capsule-containing members 49 , which are each successively indexed into the capsule-receiving chamber 23 of the capsule-receiving unit 16 .

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • External Artificial Organs (AREA)
  • Massaging Devices (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Medicinal Preparation (AREA)
US11/663,099 2004-09-15 2005-09-15 Nasal Delivery Devices Abandoned US20080289629A1 (en)

Applications Claiming Priority (3)

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GB0420513.4 2004-09-15
GB0420513A GB0420513D0 (en) 2004-09-15 2004-09-15 Powder delivery devices
PCT/GB2005/003549 WO2006030210A2 (en) 2004-09-15 2005-09-15 Nasal delivery devices

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US13/471,146 Continuation US8590530B2 (en) 2004-09-15 2012-05-14 Nasal delivery devices

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US11/663,099 Abandoned US20080289629A1 (en) 2004-09-15 2005-09-15 Nasal Delivery Devices
US13/471,146 Active US8590530B2 (en) 2004-09-15 2012-05-14 Nasal delivery devices
US14/058,647 Active US9108015B2 (en) 2004-09-15 2013-10-21 Nasal delivery devices
US14/798,221 Active 2027-12-19 US10398859B2 (en) 2004-09-15 2015-07-13 Nasal delivery devices
US16/525,716 Pending US20200023146A1 (en) 2004-09-15 2019-07-30 Nasal delivery devices

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US13/471,146 Active US8590530B2 (en) 2004-09-15 2012-05-14 Nasal delivery devices
US14/058,647 Active US9108015B2 (en) 2004-09-15 2013-10-21 Nasal delivery devices
US14/798,221 Active 2027-12-19 US10398859B2 (en) 2004-09-15 2015-07-13 Nasal delivery devices
US16/525,716 Pending US20200023146A1 (en) 2004-09-15 2019-07-30 Nasal delivery devices

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US (5) US20080289629A1 (de)
EP (3) EP2462973B1 (de)
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CN (2) CN102000374B (de)
AU (1) AU2005283922A1 (de)
BR (1) BRPI0515289B8 (de)
CA (3) CA2580217C (de)
DK (2) DK2462972T3 (de)
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GB (4) GB0420513D0 (de)
IL (1) IL181940A0 (de)
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