US20060106456A9 - Devices, systems, and methods for reshaping a heart valve annulus - Google Patents

Devices, systems, and methods for reshaping a heart valve annulus Download PDF

Info

Publication number
US20060106456A9
US20060106456A9 US10/677,104 US67710403A US2006106456A9 US 20060106456 A9 US20060106456 A9 US 20060106456A9 US 67710403 A US67710403 A US 67710403A US 2006106456 A9 US2006106456 A9 US 2006106456A9
Authority
US
United States
Prior art keywords
implant
annulus
heart valve
valve annulus
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/677,104
Other languages
English (en)
Other versions
US20040127982A1 (en
Inventor
Timothy Machold
David Rahdert
John Macoviak
Robert Chang
Rick Soss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ample Medical Inc
Original Assignee
Ample Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2002/031376 external-priority patent/WO2003028558A2/en
Priority to US10/677,104 priority Critical patent/US20060106456A9/en
Application filed by Ample Medical Inc filed Critical Ample Medical Inc
Priority to US10/846,850 priority patent/US8784482B2/en
Publication of US20040127982A1 publication Critical patent/US20040127982A1/en
Priority to US10/894,433 priority patent/US8956407B2/en
Priority to US11/089,939 priority patent/US20050228422A1/en
Priority to US11/089,940 priority patent/US7691144B2/en
Priority to US11/089,949 priority patent/US20050222489A1/en
Priority to US11/389,819 priority patent/US20060252984A1/en
Publication of US20060106456A9 publication Critical patent/US20060106456A9/en
Priority to US11/903,472 priority patent/US20080091264A1/en
Priority to US11/980,838 priority patent/US20080140188A1/en
Priority to US12/460,647 priority patent/US20090287179A1/en
Priority to US12/462,956 priority patent/US9861475B2/en
Priority to US12/657,527 priority patent/US8187207B2/en
Priority to US12/658,909 priority patent/US20100161044A1/en
Priority to US12/924,219 priority patent/US8163013B2/en
Priority to US13/272,716 priority patent/US8979925B2/en
Priority to US13/454,767 priority patent/US8858622B2/en
Priority to US13/482,586 priority patent/US8690858B2/en
Priority to US14/248,012 priority patent/US20140222138A1/en
Priority to US14/624,131 priority patent/US20150157459A1/en
Priority to US14/659,157 priority patent/US9498331B2/en
Priority to US14/945,722 priority patent/US20160067043A1/en
Priority to US15/299,908 priority patent/US10219905B2/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/50—Supports for surgical instruments, e.g. articulated arms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2445—Annuloplasty rings in direct contact with the valve annulus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2454—Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2466—Delivery devices therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00243—Type of minimally invasive operation cardiac
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00243—Type of minimally invasive operation cardiac
    • A61B2017/00247—Making holes in the wall of the heart, e.g. laser Myocardial revascularization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22097—Valve removal in veins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320052—Guides for cutting instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345—Vascular system
    • A61B2018/00351—Heart
    • A61B2018/00392—Transmyocardial revascularisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A61F2220/0016—Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/902—Method of implanting
    • Y10S623/904—Heart

Definitions

  • the invention is directed to devices, systems, and methods for improving the function of a heart valve, e.g., in the treatment of mitral valve regurgitation.
  • the heart (see FIG. 1 ) is slightly larger than a clenched fist. It is a double (left and right side), self-adjusting muscular pump, the parts of which work in unison to propel blood to all parts of the body.
  • the right side of the heart receives poorly oxygenated (“venous”) blood from the body from the superior vena cava and inferior vena cava and pumps it through the pulmonary artery to the lungs for oxygenation.
  • the left side receives well-oxygenation (“arterial”) blood from the lungs through the pulmonary veins and pumps it into the aorta for distribution to the body.
  • the heart has four chambers, two on each side —the right and left atria, and the right and left ventricles.
  • the atria are the blood-receiving chambers, which pump blood into the ventricles.
  • the ventricles are the blood-discharging chambers.
  • the synchronous pumping actions of the left and right sides of the heart constitute the cardiac cycle.
  • the cycle begins with a period of ventricular relaxation, called ventricular diastole.
  • the cycle ends with a period of ventricular contraction, called ventricular systole.
  • the heart has four valves (see FIGS. 2 and 3 ) that ensure that blood does not flow in the wrong direction during the cardiac cycle; that is, to ensure that the blood does not back flow from the ventricles into the corresponding atria, or back flow from the arteries into the corresponding ventricles.
  • the valve between the left atrium and the left ventricle is the mitral valve.
  • the valve between the right atrium and the right ventricle is the tricuspid valve.
  • the pulmonary valve is at the opening of the pulmonary artery.
  • the aortic valve is at the opening of the aorta.
  • ventricular diastole i.e., ventricular filling
  • the aortic and pulmonary valves are closed to prevent back flow from the arteries into the ventricles.
  • the tricuspid and mitral valves open (as FIG. 2 shows), to allow flow from the atria into the corresponding ventricles.
  • the tricuspid and mitral valves close (see FIG. 3 )—to prevent back flow from the ventricles into the corresponding atria—and the aortic and pulmonary valves open—to permit discharge of blood into the arteries from the corresponding ventricles.
  • the opening and closing of heart valves occur primarily as a result of pressure differences.
  • the opening and closing of the mitral valve occurs as a result of the pressure differences between the left atrium and the left ventricle.
  • the mitral valve opens, allowing blood to enter the ventricle.
  • the ventricle contracts during ventricular systole, the intraventricular pressure rises above the pressure in the atrium and pushes the mitral valve shut.
  • the mitral and tricuspid valves are defined by fibrous rings of collagen, each called an annulus, which forms a part of the fibrous skeleton of the heart.
  • the annulus provides attachments for the two cusps or leaflets of the mitral valve (called the anterior and posterior cusps) and the three cusps or leaflets of the tricuspid valve.
  • the leaflets receive chordae tendineae from more than one papillary muscle. In a healthy heart, these muscles and their tendinous cords support the mitral and tricuspid valves, allowing the leaflets to resist the high pressure developed during contractions (pumping) of the left and right ventricles.
  • chordae tendineae become taut, preventing the leaflets from being forced into the left or right atria and everted. Prolapse is a term used to describe this condition. This is normally prevented by contraction of the papillary muscles within the ventricle, which are connected to the mitral valve leaflets by the chordae tendineae. Contraction of the papillary muscles is simultaneous with the contraction of the ventricle and serves to keep healthy valve leaflets tightly shut at peak contraction pressures exerted by the ventricle.
  • the leaflets coapt at the opposing medial and lateral sides of the annulus are called the leaflet commissures, and are designated in FIG. 4 and in other Figures as CP(denoting the posterior commissure) and CA (denoting the anterior commissure).
  • Valve malfunction can result from the chordae tendineae (the chords) becoming stretched, and in some cases tearing. When a chord tears, the result is a leaflet that flails. Also, a normally structured valve may not function properly because of an enlargement of or shape change in the valve annulus. This condition is referred to as a dilation of the annulus and generally results from heart muscle failure. In addition, the valve may be defective at birth or because of an acquired disease.
  • mitral valve dysfunction can occur when the leaflets do not coapt at peak contraction pressures.
  • FIG. 5 shows, the coaptation line of the two leaflets is not tight at ventricular systole. As a result, an undesired back flow of blood from the left ventricle into the left atrium can occur. This condition is called regurgitation.
  • the leaflets do not form a tight coaptation junction because the dimensions of the mitral valve annulus, measured from commissure to commissure—CP to CA—and/or septal to lateral—S to L—change. The changed dimensions no longer create the anatomic shape and tension in which the leaflets coapt at peak contraction pressures.
  • the unhealthy annulus is dilated and, in particular, the septal-to-lateral distance is increased.
  • the shape and tension defined by the annulus becomes less oval (see FIG. 4 ) and more round (see FIG. 6 ). This condition is called dilation.
  • the shape and tension conducive for coaptation at peak contraction pressures progressively deteriorate. Instead, at peak contraction pressures, the leaflets do not coapt completely, and a gap forms between the leaflets. During ventricular systole, regurgitation can occur through this gap.
  • the ratio between the commissure distance and septal-to-lateral distance bears a relationship to the effectiveness of leaflet coaptation. If the septal-to-lateral distance increases, the ratio changes, and when the ratio reaches a certain value, regurgitation or the likelihood of regurgitation is indicated.
  • Mitral valve regurgitation can be an acute or chronic condition. It is sometimes called mitral insufficiency.
  • diuretics and/or vasodilators can be used to help reduce the amount of blood flowing back into the left atrium.
  • An intra-aortic balloon counterpulsation device is used if the condition is not stabilized with medications.
  • surgery to repair or replace the mitral valve is often necessary.
  • annulus can be reshaped with annular or peri-annular rings or similar ring-like devices.
  • the repair devices are typically secured to the annulus and surrounding tissue with suture-based fixation.
  • the repair devices extend over the top and over much or all of the circumference of the annulus and leaflet surfaces.
  • a physician may decide to replace an unhealthy mitral valve rather than repair it.
  • Invasive, open heart surgical approaches are used to replace the natural valve with either a mechanical valve or biological tissue (bioprosthetic) taken from pigs, cows, or horses.
  • the invention provides devices, systems and methods that reshape a valve annulus.
  • the devices, systems, and methods include an implant that is sized and configured to rest near or within the leaflet commissures of a heart valve annulus. In use, the implant contacts and outwardly displaces tissue to reshape the heart valve annulus.
  • the implant in use, may restore to the heart valve annulus and leaflets a more effective anatomic shape and tension. The more normal anatomic shape and tension are conducive to coaptation of the leaflets, which, in turn, reduces retrograde flow or regurgitation.
  • the implant restores function to the valve, without surgically cinching, resecting, and/or fixing in position large portions of a dilated annulus, or without the surgical fixation of ring-like structures.
  • FIG. 1 is a perspective, anterior anatomic view of the interior of a healthy heart.
  • FIG. 2 is a superior anatomic view of the interior of a healthy heart, with the atria removed, showing the condition of the heart valves during ventricular diastole.
  • FIG. 3 is a superior anatomic view of the interior of a healthy heart, with the atria removed, showing the condition of the heart valves during ventricular systole.
  • FIG. 4 is a superior anatomic view of a healthy mitral valve during ventricular systole, showing the leaflets properly coapting.
  • FIG. 5 is a superior anatomic view of the interior of a heart, with the atria removed, showing the condition of the heart valves during ventricular systole, and further showing a dysfunctional mitral valve in which the leaflets are not properly coapting, causing regurgitation.
  • FIG. 6 is a superior anatomic view of a disfunctional mitral valve during ventricular systole, showing that the leaflets are not properly coapting, causing regurgitation.
  • FIG. 7A is a side perspective view of an elastic implant sized and configured to rest within or near the leaflet commissures of a dysfunctional heart valve annulus to reshape the annulus and improve leaflet coaptation.
  • FIGS. 7B to 7 E are side perspective views of illustrative alternative configurations of the elastic implant shown in FIG. 7A .
  • FIG. 8 is a side anterior anatomic view of a mitral valve annulus in which the elastic implant shown in FIG. 7A has been implanted.
  • FIG. 9 is a superior anatomic view of a mitral valve in which the elastic implant shown in FIG. 7A has been implanted, showing the implant stretching the commissures to restore leaflet coaptation.
  • FIG. 10 is a side perspective view of another embodiment of an elastic implant sized and configured to rest within or near the leaflet commissures of a dysfunctional heart valve annulus to reshape the annulus and restore leaflet coaptation, the implant defining a closed annular structure.
  • FIG. 11 is a perspective anatomic view, taken from an anterior and slightly superior viewpoint, of a mitral valve in which the elastic implant of the type shown in FIG. 10 has been implanted, showing the implant stretching the commissures to restore leaflet coaptation, and also showing the implant as hugging the annulus.
  • FIG. 12 is a perspective anatomic view, taken from an anterior and slightly superior viewpoint, of a mitral valve in which the elastic implant of the type shown in FIG. 10 has been implanted, showing the implant stretching the commissures to restore leaflet coaptation, and also showing the implant as rising above the annulus.
  • FIGS. 13A to 13 C are side perspective views of illustrative embodiments of an elastic implant sized and configured to rest within or near the leaflet commissures of a dysfunctional heart valve annulus to reshape the annulus and restore leaflet coaptation, the implant defining an open annular structure.
  • FIGS. 13D and 13E are side perspective views of illustrative embodiments of an elastic implant sized and configured to rest within or near the leaflet commissures of a dysfunctional heart valve annulus to reshape the annulus and restore leaflet coaptation, the implant defining an open annular structure that can be optionally closed.
  • FIG. 14 is a side perspective view of an elastic implant of the open annular type shown in FIGS. 13D and 13E , showing how the mechanical characteristics of the implant can be varied along its structure, surface area, and interface with the tissue.
  • FIG. 15A is a side perspective view of another embodiment of an elastic implant sized and configured to rest within or near the leaflet commissures of a dysfunctional heart valve annulus to reshape the annulus and restore leaflet coaptation, the implant defining a closed annular structure that can be symmetrically folded upon itself.
  • FIG. 15B is a side view of the implant shown in FIG. 15A when folded upon itself.
  • FIG. 15C is a perspective anatomic view, taken from an anterior and slightly superior viewpoint, of a mitral valve in which the elastic implant of the type shown in FIG. 15A has been implanted, showing the implant stretching the commissures to restore leaflet coaptation, and also showing the implant as hugging the annulus.
  • FIG. 15D is a side perspective view of another embodiment of an elastic implant sized and configured to rest within or near the leaflet commissures of a dysfunctional heart valve annulus to reshape the annulus and restore leaflet coaptation, the implant defining a closed annular structure that can be asymmetrically folded upon itself.
  • FIG. 15E is a perspective anatomic view, taken from an anterior and slightly superior viewpoint, of a mitral valve in which the elastic implant of the type shown in FIG. 15D has been implanted, showing the implant stretching the commissures to restore leaflet coaptation, and also showing the implant as hugging the annulus.
  • FIG. 16A is a side perspective view of an elastic implant of the type shown in FIG. 10 , showing an illustrative embodiment of tab structures that serve to anchor and stabilize the implant in an annulus.
  • FIG. 16B is a side anterior anatomic view of a mitral valve annulus in which the elastic implant shown in FIG. 16A has been implanted.
  • FIG. 17A is a side perspective view of an elastic implant of the type shown in FIG. 10 , showing an illustrative embodiment of multiple contact structures that serve to anchor and stabilize the implant in an annulus.
  • FIG. 17B is a side anterior anatomic view of a mitral valve annulus in which the elastic implant shown in FIG. 17A has been implanted.
  • FIGS. 18A and 18B are side perspective views of an elastic implant of the type shown in FIG. 10 , showing illustrative embodiments of frictional struts that serve to anchor and stabilize the implant in an annulus.
  • FIG. 19 is a side perspective view of an elastic implant of the type shown in FIG. 10 , showing an illustrative embodiment of tissue in-growth surfaces that serve to anchor and stabilize the implant in an annulus.
  • FIGS. 20A and 20B are, respectively, a side perspective view and an anatomic view (when implanted) of an elastic implant sized and configured to rest within or near the leaflet commissures of a dysfunctional heart valve annulus to reshape the annulus and restore leaflet coaptation and also showing the implant as rising significantly above the annulus.
  • FIGS. 20B and 20C are, respectively, a side perspective view and an anatomic view (when implanted) of an elastic implant sized and configured to rest within or near the leaflet commissures of a dysfunctional heart valve annulus to reshape the annulus and restore leaflet coaptation, and showing the presence of one rail that hugs the annulus and another rail that rises above the implant to serve as a mechanism that anchors and stabilizes the implant in the annulus.
  • FIG. 21 is a side elevation view of a tool for implanting an elastic implant in a valve annulus in a open heart surgical procedure to reshape the annulus and restore leaflet coaptation.
  • FIGS. 22A to 22 F diagrammatically show a method of using the tool shown in FIG. 21 to install an elastic implant in a valve annulus to reshape the annulus and restore leaflet coaptation.
  • FIGS. 23A to 23 C diagrammatically show a method of gaining intravascular access to the left atrium for the purpose of deploying a delivery catheter to place an implant in a valve annulus to reshape the annulus and restore leaflet coaptation.
  • FIG. 24 is a side elevation view of the distal end of the implant delivery catheter shown in FIG. 23C , showing an elastic implant of the type shown in FIG. 10 collapsed in a sleeve for deployment into the left atrium in the manner shown in FIGS. 23A to 23 C.
  • FIGS. 25A to 25 E are diagrammatic perspective views of a method for manipulating the distal end of the implant delivery catheter shown in FIG. 24 to deploy an elastic implant of the type shown in FIG. 10 into a valve annulus to reshape the annulus and restore leaflet coaptation.
  • FIG. 26 is a side view of the distal end of the implant delivery catheter of the type shown in FIG. 23C , showing an elastic implant of the type shown in FIG. 10 collapsed in a sleeve for deployment into the left atrium in the manner shown in FIGS. 23A to 23 C, also and showing the presence of a guide wire loop to aid in the deployment.
  • FIGS. 27A to 27 I are diagrammatic views of a method for deploying an elastic implant of the type shown in FIG. 10 into a valve annulus with the aid of a guide wire loop to reshape the annulus and restore leaflet coaptation.
  • FIGS. 28A and 28B are perspective view of elastic implants of the type shown in FIGS. 13B to 13 E, showing the tethering of such implants to one or more wire loops to aid in their deployment into a valve annulus to reshape the annulus and restore leaflet coaptation.
  • FIG. 29 is a side view of the distal end of the implant delivery catheter of the type shown in FIG. 23C , showing a symmetrical foldable elastic implant of the type shown in FIG. 15A folded and collapsed in a sleeve for deployment into the left atrium in the manner shown in FIGS. 23A to 23 C.
  • FIGS. 30A to 30 D are diagrammatic views of a method for manipulating the distal end of the implant delivery catheter shown in FIG. 29 to deploy a symmetrically folded and collapsed elastic implant of the type shown in FIG. 15A into a valve annulus to reshape the annulus and restore leaflet coaptation.
  • FIGS. 31A to 31 E are diagrammatic views of a method for manipulating the distal end of the implant delivery catheter shown in FIG. 29 to deploy an asymmetrically folded and collapsed elastic implant of the type shown in FIG. 15D into a valve annulus to reshape the annulus and restore leaflet coaptation.
  • FIG. 32 is a side view of the distal end of the implant delivery catheter of the type shown in FIG. 23C , showing a symmetrical foldable elastic implant of the type shown in FIG. 15A tethered to a guide wire loop to aid in its implantation into a valve annulus to reshape the annulus and restore leaflet coaptation.
  • FIGS. 33A to 33 D are diagrammatic views of a method for manipulating the distal end of the implant delivery catheter shown in FIG. 32 to deploy a symmetrically folded and collapsed elastic implant of the type shown in FIG. 15A into a valve annulus with the aid of a guide wire loop to reshape the annulus and restore leaflet coaptation.
  • FIG. 34 is a side elevation view of the distal end of the implant delivery catheter of the type shown in FIG. 23C , showing a symmetrical foldable elastic implant of the type shown in FIG. 15A tethered to two guide wire loops to aid in its implantation into a valve annulus to reshape the annulus and restore leaflet coaptation.
  • FIGS. 35 and 36 A to 36 D are diagrammatic views of a method for manipulating the distal end of the implant delivery catheter to deploy a symmetrically folded and collapsed elastic implant of the type shown in FIG. 15A into a valve annulus with the aid of a separate guide wires to reshape the annulus and restore leaflet coaptation.
  • FIGS. 37A to 37 C are diagrammatic views of the deployment a symmetrically folded and collapsed elastic implant of the type shown in FIG. 15A into a valve annulus with the aid of a wrapper or bag to reshape the annulus and restore leaflet coaptation.
  • FIG. 38 is a side perspective view of a plastically deformable implant sized and configured to be expanded in situ to rest within or near the leaflet commissures of a dysfunctional heart valve annulus to reshape the annulus and restore leaflet coaptation.
  • FIGS. 39A to 39 C are diagrammatic views of the deployment of a plastically deformable implant of the type shown in FIG. 38 into a valve annulus with the aid of a mechanical expansion device.
  • FIGS. 40A to 40 C are diagrammatic anatomic views of the deployment of a plastically deformable implant of the type shown in FIG. 38 into a valve annulus with the aid of a balloon expansion device.
  • FIG. 41 is a diagrammatic view of a non-compliant balloon deployed into a valve annulus for the purpose of assessing the size and mechanical properties of an implant for the annulus.
  • FIG. 42 is a side perspective view of a multi-functional elastic implant sized and configured to rest within or near the leaflet commissures of a dysfunctional heart valve annulus to reshape the annulus and restore leaflet coaptation as well serve as a neo-leaflet to either replace or supplement a damaged heart valve leaflet.
  • FIGS. 43 and 44 are side perspective views of a multi-functional elastic implants sized and configured to rest within or near the leaflet commissures of a dysfunctional heart valve annulus to reshape the annulus and restore leaflet coaptation as well serve as a leaflet retainer to prevent a native valve leaflet from being pushed into the atrium upon ventricular contraction.
  • FIGS. 45 to 47 are side perspective views of a multi-functional elastic implants sized and configured to rest within or near the leaflet commissures of a dysfunctional heart valve annulus to reshape the annulus and restore leaflet coaptation as well serve as a leaflet retainer to prevent a native valve leaflet from being pushed into the atrium upon ventricular contraction, the implants also including a framework that serves to help position and secure the implant in situ.
  • FIGS. 7A and 8 show an implant 10 sized and configured to rest within or near a heart valve annulus.
  • the implant is shown in a mitral valve, and, in this arrangement, extends along the major (i.e., longest) axis above and/or along the valve annulus.
  • the implant 10 is sized and shaped so that, in use, it applies a mechanical force along the major axis.
  • the mechanical force serves to outwardly displace tissue (i.e., to displace tissue away from the center of the annulus) to reshape the annulus.
  • the mechanical-force serves to lengthen the long axis of the annulus and, in doing so, can reactively shorten in the minor (i.e.
  • the implant may only need to reshape the annulus during a portion of the heart cycle, such as during ventricular systolic contraction.
  • the implant may be sized to produce small or negligible outward displacement of tissue during ventricular diastole when the tissue is relaxed, but restrict the inward movement of tissue during ventricular systolic contraction.
  • the mechanical force applied by the implant 10 restores to the heart valve annulus and leaflets a more normal anatomic shape and tension (see FIG. 9 ).
  • the more normal anatomic shape and tension are conducive to coaptation of the leaflets during ventricular systole, which, in turn, reduces regurgitation.
  • the implant 10 restores normal function to the valve, without surgically cinching, resecting, and/or fixing in position large portions of a dilated annulus or leaflets, or without the surgical fixation of ring-like structures.
  • the implant 10 lends itself to delivery to a targeted heart valve site by catheter-based, intravascular techniques, under image guidance.
  • Image guidance includes but is not limited to fluoroscopy, ultrasound, magnetic resonance, computed tomography, or combinations thereof.
  • the implant 10 can be delivered using conventional open heart surgical techniques or by thoracoscopic surgery techniques.
  • the implant 10 is made—e.g., by bending, shaping, joining, machining, molding, or extrusion—from a biocompatible metallic or polymer material, or a metallic or polymer material that is suitably coated, impregnated, or otherwise treated with a material to impart biocompatibility, or a combination of such materials.
  • the material is also desirably radio-opaque to facilitate fluoroscopic visualization.
  • the rail 14 spans the struts 12 .
  • the rail 14 (like the struts 12 ) can take various shapes and have various cross-sectional geometries.
  • the rail 14 (and/or the struts 12 ) can have, e.g., a generally curvilinear (i.e., round or oval) cross-section, or a generally rectilinear cross section (i.e., square or rectangular), or combinations thereof.
  • the implant is “elastic.”
  • the rail 14 is sized and configured to possess a normal, unloaded, shape or condition (shown in FIG. 7A ), in which the rail 14 is not in compression and the struts 12 are spaced apart farther than the anterior commissure to posterior commissure dimension of the targeted heart valve annulus.
  • the material of the implant is selected to possess a desired spring constant.
  • the spring constant imparts to the rail 14 the ability to be elastically compressed out of its normal, unloaded condition, in response to external compression forces applied at the struts.
  • the rail 14 is sized and configured to assume an elastically loaded, in compression condition, during which the struts 12 are spaced apart a sufficiently shorter distance to rest in engagement with tissue at or near the leaflet commissures (see FIG. 8 ).
  • the rail 14 When in its elastically loaded, compressed condition (see FIG. 9 ), the rail 14 exerts opposing forces to the tissues at or near the commissures through the struts 12 , tending to outwardly displace tissue and stretch the annulus along its major axis, which also typically stretches the leaflet commissures, shortens the minor axis, and/or reshapes surrounding anatomic structures.
  • the implant thereby reshapes the valve annulus toward a shape more conducive to leaflet coaptation.
  • An elastic implant can be made, e.g., from superelastic alloy, such that the implant can be elastically straightened and/or folded to fit within a catheter or sheath during deployment, and will regain its shape upon deployment (this characteristic will be described in greater detail later).
  • the elasticity of the implant 10 itself, along with the elasticity of the valve tissue, ensure that the implant 10 can be positioned in the valve under a state of net compression and thus remain anchored without the use of sutures, adhesives, or other fixation materials, i.e. which is called compressive anchoring.
  • the implant 10 may itself deform elastically, although not necessarily so, but the characteristic of the implant 10 being elastically deformable may help to maintain compressive anchoring. If the implant 10 does not deform elastically or does so only slightly, the implant 10 relies on tissue elasticity to keep the implant anchored.
  • the struts 12 may carry other structures or mechanisms 16 to further enhance the anchorage and stabilization of the implant in the heart valve annulus.
  • the mechanisms 16 may be located below the plane of the annulus, to engage infra-annular heart tissue adjoining the annulus in the ventricle, and/or be located at or above the plane of the annulus, to engage tissue on the annulus or in the atrium.
  • the spring constant of the implant may be selected to be greater than the spring constant of adjoining tissue.
  • the spring constant of the implant may be selected to approximate the spring constant of adjoining tissue, thereby providing compliance to allow the implant 10 to adapt to tissue morphology during use.
  • the spring constant of the implant 10 may vary along the length of the rail 14 , so that some portions of the rail 14 are stiffer or more compliant than other portions of the rail 14 .
  • the implant 10 may be formed from a plastically deformable material.
  • the implant 10 is manufactured in a normally collapsed condition.
  • the implant 10 is expanded in situ into an in use condition within the annulus, e.g., by an inflatable body (e.g., balloon) or by a suitable mechanical device (e.g., a scissorjack).
  • an inflatable body e.g., balloon
  • a suitable mechanical device e.g., a scissorjack
  • An elastic implant 10 having the characteristic just described can take various forms and configurations. The following describes various illustrative arrangements.
  • the implants 10 in FIGS. 7A to 7 C comprise a single rail 14 spanning the distance between the struts 12 .
  • an implant 10 can include more than a single rail 14 , imparting a normally closed, annular shape to the implant.
  • an implant 10 of this type can be conveyed to an implantation site, e.g., within a catheter or sheath, in a collapsed, straightened condition (with the rails 14 collapsed side-by-side) When deployed from the catheter or sheath, the implant 10 springs open to assume the normally closed, annular shape shown in FIGS. 7D and 10 .
  • the implant 10 includes two rails 14 spanning the struts 12 .
  • the shape and configuration of the rails 14 can be varied, depending upon the desired orientation of the rails 14 with respect to the annulus itself.
  • the two rails 14 are shaped and configured so that, when implanted, the rails 14 follow the circumferential path of the annulus and rest in generally the same plane as the annulus.
  • This implant can be characterized as “hugging” the annulus.
  • the two rails 14 are shaped and configured so that, when implanted, the rails 14 follow the circumferential path of the annulus, and also rise above the plane of the annulus.
  • This implant 10 can be characterized as “riding above” the annulus.
  • An implant 10 that “rides above” the annulus can extend close to the annulus (as FIG. 12 shows) or rise significantly above the annulus toward the dome of the atrium as FIGS. 20A and 20B show.
  • an implant 10 can include a rail 14 A that hugs the annulus and a rail 14 B that rides above the annulus and contacts a heart wall, serving as a mechanism 16 that orients and stabilizes the implant.
  • FIGS. 13A to 13 E show, the rails 14 of a given annular implant 10 can be interrupted to impart a normally open annular (“hemi”) shape to the implant 10 .
  • an implant 10 of this type also can be conveyed to an implantation site, e.g., within a catheter or sheath, in a collapsed, straightened condition, and then deployed to assume the open, annular shape shown in FIGS. 13A to 13 E.
  • the open annular shape is configured so that, when implanted, the implant 10 hugs the annulus.
  • the open annular shape is configured so that, when implanted, the implant rides above the annulus.
  • FIGS. 13C and 13D show another style of open annular implant, one that hugs the annulus ( FIG. 13C ) and the other that rides above the annulus ( FIG. 13D ).
  • the interrupted rail 14 includes interlocking hooks 18 that can be coupled, if desired, to close the annulus of the implant 10 (see FIG. 13E ).
  • the interlocked implant 10 is configured to ride above the annulus.
  • the struts 12 need not be placed at diametrically opposite sides of the rail or rails 14 .
  • the commissures of a given valve annulus may not be at geometrically opposite sides of the annulus. Accordingly, the position of the struts 12 may be selected to conform to an asymmetric morphology of the annulus.
  • the struts 12 may be used to simply locate the implant 10 in the valve, imparting little or no force on their own. In this arrangement, the annulus reshaping forces emanate from the rail or rails 14 above the commissures.
  • the implant possesses a spring constant that approximates the spring constant of tissue, making the implant more accommodating to the movement of the tissue.
  • a given rail or rails 14 can include undulations or the like to impart regions having different spring constants and/or mechanical properties along the length of the rail 14 .
  • the cross-sectional width and/or thickness and/or geometry of a given rail 14 need not be uniform, but can vary along the length of the rail 14 to impart regions of different spring constants and/or mechanical properties.
  • the region of the continuous rail 14 between the asymmetrically placed struts 12 may be thickened or thinned to impart different mechanical properties to achieve the desired shape changing objectives.
  • the implants 10 shown in FIGS. 15A to 15 E comprise more than a single rail 14 , imparting a normally closed, annular shape to the implant.
  • the rails 14 of the implants 10 shown in FIGS. 15A to 15 E include cusps 20 .
  • the cusps 20 permit the implants to be resiliently folded along their minor (transverse axis) axis—with the cusps 20 occupying the fold—without permanently deforming the implant (see FIG. 15B ).
  • an implant 10 of this type can be conveyed to an implantation site, e.g., within a catheter or sheath, in a folded as well as collapsed condition, and then deployed to assume the normally closed, annular shape shown in FIG. 15A , as FIG. 15C shows.
  • the shape and configuration of the rails 14 can be varied so that, when deployed, the implant hugs the annulus or rides above the annulus.
  • FIG. 15A the cusps 20 are symmetric, being formed on each rail 14 equidistant to the struts 12 .
  • the struts 12 are also shown symmetric as to height above the rail 14 .
  • FIG. 15D shows that the cusps 20 need not be symmetric in either respect. As will be described in greater detail later, this asymmetry permits a stepwise, staggered deployment of the implant, in which the parts of the implant are deployed one at a time in succession—e.g., one strut, then one cusp, then another strut, and then the other cusp—until the implant assumes the closed, annular shape shown in FIG. 15D , as FIG. 15E shows.
  • the struts 12 can include other structures or mechanisms 16 to further enhance the anchorage and stabilization of the implant in the heart valve annulus.
  • These structures or other mechanisms 16 can comprise, e.g., loops, pads, barbs, vertical legs, or circumferential legs, or other anchoring structures below, at, and/or above the valve plane.
  • the structures and mechanisms 16 desirably increase the surface area of contact between the struts 12 and tissue adjoining the annulus.
  • the structures and mechanism 16 desirably rely solely or partly on the valve and neighboring anatomic structures to anchor and fix the position of the implant in the annulus and resist its migration out of the annulus. Implant fixation can also assist in the achieving the desired coaptation of the leaflets and to resist upward movement or eversion of the leaflets during the cardiac cycle.
  • the rails 14 carry four struts 12 , two supra-annular (contacting tissue on the atrial side of the valve) and two infra-annular (contacting tissue on the ventricular size of the valve).
  • the struts 12 are separated by a thin spine that curves away from the struts 12 to avoid contact with the commissures themselves, so as not to interfere with the opening and closing of the valve.
  • the struts 12 may be cushioned to increase traction, decrease erosion, and improve their interaction with the valve annulus.
  • the struts 12 may be coated, covered, or impregnated with a tissue growth promoting material.
  • the rails 14 spanning the struts 12 functions to exert compressive forces on the annulus.
  • the struts 12 are secured by the compression forces created by the rail's interaction with the valve annulus. The struts 12 assure that the implant is positioned correctly in situ, because they will only seat when positioned at or near the commissures of the valve.
  • the struts 12 may be sized and shaped in various ways.
  • FIGS. 7B, 7C , and 7 D show various embodiments with alternative designs for the struts 12 .
  • the supra-annular struts 12 are somewhat larger than the infra-annular struts 12 to improve the anatomical fit of the device in situ.
  • the struts 12 can carry flat infra-annular tissue contacting pads 26 , located below the plane of the valve annulus.
  • the pads 26 rest on outwardly bowed extensions below the commissures, applying holding forces upon the heart walls.
  • the pads 26 can take the form of flat surfaces, as FIGS. 16A and 16B show.
  • Tissue penetrating barbs 28 may enhance the effect of the compression forces to fix the location of the implant.
  • the struts 12 can extend in an undulating fashion below the plane of the valve annulus, to create a series of infra-annular contact surfaces 30 between the implant and the heart walls below and adjoining the annulus.
  • the series of contact surfaces 30 increase the points of contact between the implant and tissue below the annulus. These multiple points of contact 30 are additive to the contact between the implant and tissue at or near the commissures themselves.
  • additional struts and/or barbs or similar anchoring surfaces are not shown associated with the contact surfaces, but they could be included, if desired.
  • the implant can include infra-annular frictional struts 32 located below the level of the annulus.
  • the infra-annular frictional struts 32 engage tissue of the heart walls below and adjoining the annulus.
  • the struts 32 resist migration of the implant out of the annulus.
  • the frictional struts 32 can be placed in a single level immediately below the commissures, or (as FIG. 18B shows) the struts 32 can be arranged in multiple levels below the commissures.
  • the struts 12 and/or the rails 14 can include tissue in-growth surfaces 34 .
  • the surfaces 14 provide an environment that encourages the in-growth of neighboring tissue on the implant. Once in-growth occurs, the implant 10 becomes resistant to migration or dislodgment from the annulus. Conventional in-growth materials such as polyester fabric can be used.
  • fixation mechanism or structure may, if desired, be combined with an adhesive or like material to further secure the implant.
  • the various implants as just described lend themselves to implantation in a heart valve annulus in various ways. They can be implanted, e.g., in an open heart surgical procedure. Alternatively, they can be implanted using catheter-based technology via a peripheral venous access site, such as in the femoral or jugular vein or femoral artery, or alternatively by thoracoscopically through the chest or by means of other surgical access through the right atrium.
  • FIG. 21 shows a tool 40 for deploying an elastic implant 10 of the type generally described in an annulus of a heart valve in an open surgical procedure.
  • FIGS. 22A to 22 F diagrammatically show the steps of an open surgical procedure for deploying the implant 10 in a mitral valve annulus using the tool 40 shown in FIG. 21 .
  • the tool 40 includes a scissors-action mechanism 42 comprising an operating end 46 and a handle end 48 .
  • the operating end 46 includes prongs 44 that can be moved apart and together by manipulation of the handle end 48 (see FIGS. 22A and 22B ).
  • the prongs 44 are sized and configured to mate with deployment apertures 50 formed on the struts 12 of the implant 10 (shown in FIG. 21 ).
  • the deployment apertures 50 are also shown in the implants in preceding FIGS. 10 to 19 , which can be likewise be deployed using the tool 40 .
  • the scissors-action mechanism 42 is manipulated to spread the prongs 44 apart (see FIGS. 22A and 22B ), so that they can be mated in the apertures 50 of the implant 10 .
  • the scissors-action mechanism 44 is manipulated to bring the prongs 44 together, thereby applying force to the struts 12 to place the implant 10 in a compressed condition (see FIG. 22C ).
  • the tool 40 and implant 10 are introduced through an open surgical approach into the left atrium.
  • the tool 40 places the implant 10 within the mitral valve annulus (see FIG. 22D ).
  • the annulus is shown to have a dimension of D 1 .
  • This dimension D 1 is not conducive to leaflet coaptation, and regurgitation is occurring. It is the purpose of the surgical procedure to repair this dysfunction by reshaping the annulus with the implant 10 .
  • the scissors-action mechanism 42 is manipulated to spread the prongs 44 apart until the struts 12 of the implant 10 rest within or near the commissures of the mitral valve (see FIG. 22E ). At this point in the procedure, the dimension D 1 of the annulus remains unchanged.
  • the tool 40 is withdrawn, freeing the prongs 12 from the apertures 50 (see FIG. 22F ).
  • the elastic unloading of the implant 10 displaces and spreads the valve tissue apart, achieving a new dimension D 2 for the annulus, which is larger than D 1 .
  • the new dimension D 2 is conducive to leaflet coaptation.
  • the implant 10 has reshaped the annulus to restore valve function.
  • FIGS. 23 to 25 show a representative embodiment of a percutaneous catheter-based linear deployment of an unfolded elastic implant 10 of the type shown in FIGS. 7 to 14 .
  • Percutaneous vascular access is achieved by conventional methods into the femoral or jugular vein.
  • a catheter 52 is steered through the vasculature into the right atrium.
  • a needle cannula 54 carried on the distal end of the catheter is deployed to pierce the septum between the right and left atrium.
  • a guide wire 56 is advanced trans-septally through the needle catheter 52 into the left atrium.
  • the first catheter 52 is withdrawn, and (as FIG. 23C shows) under image guidance, an implant delivery catheter 58 is advanced over the guide wire 56 into the left atrium into proximity with the mitral valve.
  • the implant delivery catheter 58 can be deployed trans-septally by means of surgical access through the right atrium.
  • the implant delivery catheter 58 carries a sheath 60 at its distal end (see FIG. 24 ).
  • the sheath 60 encloses an elastic implant 10 of a type shown in FIGS. 7 to 14 .
  • the implant 10 is constrained in a collapsed, straightened condition within the sheath, as FIG. 24 shows.
  • the sheath 60 can be sized and configured to be withdrawn (e.g., by sliding it proximally), to free the implant 10 . Free of the sheath 60 , the elastic implant 10 will expand.
  • a flexible push rod 62 in the catheter 58 can be used to expel the implant 10 from the sheath 60 , with the same result.
  • the strut 12 on the trailing end of the implant 10 is folded within the sheath 60 to reduce the collapsed profile and facilitate the expansion of the implant 10 once free from the sheath 60 .
  • FIG. 25A shows, under image guidance, the strut 12 on the leading end of the implant 10 is freed from the sheath 60 and seated retrograde in the posterior commissure of the valve annulus. Anchoring structures or mechanisms associated with the strut are also placed into desired contact with adjoining tissue below and/or above the plane of the annulus.
  • FIG. 25B shows, the delivery catheter 58 maintains force on the leading strut 12 within the posterior commissure, as the sheath 60 is withdrawn in line with the coaptation line in a posterior-to-anterior direction along the coaptation line. As shown in FIG.
  • the delivery catheter 58 may need to dip down retrograde below the plane of the leaflets to maintain sufficient force on the leading end of the implant while the trailing end is freed from the sheath 60 .
  • the delivery catheter 58 may be sized and configured to have the column strength sufficient to maintain force on the leading strut without passage below the leaflet plane.
  • the elastic implant 10 shapes and seats (as FIGS. 25 B/C and 25 D shows), until the trailing strut 12 unfolds and seats within the anterior commissure (see FIG. 25E ).
  • the implant can also be positioned or repositioned under image guidance within the left atrium using a catheter-deployed grasping instrument.
  • FIGS. 26 and 27 A to 27 I show another embodiment of an implant delivery catheter 58 that can be used to deploy a folded elastic implant 10 of the type shown in FIGS. 7 to 14 within the left atrium.
  • the implant delivery catheter 58 includes a sheath 60 that constrains the implant 10 in a collapsed, straightened condition for passage into the left atrium (see FIG. 26 ).
  • the sheath 60 is sized and configured to be withdrawn (e.g., by sliding it proximally), to free the implant for expansion within the left atrium, or a push rod 62 can be used to eject the implant from the sheath 60 .
  • a push rod 62 can be used to eject the implant from the sheath 60 .
  • one or both struts can be folded against the body of the implant within the sheath 60 .
  • a metallic, fiber, or polymer guide wire 64 is looped through the deployment apertures 50 on the struts 12 of the implant 10 prior to the insertion of the implant 12 into the sheath 60 .
  • the legs of the resulting guide wire loop 66 are passed out the proximal end of the sheath 60 for manipulation, as will now be described.
  • the implant delivery catheter 58 is introduced trans-septally into the left atrium in the manner previously described. With the distal end of the catheter 58 positioned above the valve annulus (see FIG. 27A ), and prior to withdrawal of the sheath 60 , both legs of the guide wire loop 66 are advanced distally in tandem through the sheath 60 to advance the loop 60 beyond the deployment apertures 50 and out the distal end of the sheath 60 .
  • the guide wire loop 66 desirably carries radio-opaque markers 68 to aid in fluoroscopic visualization.
  • the markers 68 identify a desired distance between them and the distal end of the sheath 60 , marking a space in which the implant 10 can freely expand without contacting tissue or anatomic structures within the atrium. Guided by the markers 68 , the loop 66 can be dropped into the annulus a desired distance beyond the distal end of the sheath 60 , as FIG. 27A shows.
  • the sheath 60 can be withdrawn to free the implant 10 for expansion (see FIG. 27B ). While tethered to the guide wire loop 66 , the implant 10 opens within the left atrium—first one strut, then the other—as the sheath 60 is withdrawn, as FIGS. 27C and 27D show.
  • both legs of the guide wire loop 66 can be advanced proximally in tandem through the sheath 60 (see FIG. 27E ).
  • the wire loop 66 applies force to the struts 12 and brings them together (see FIG. 27F ). This places the implant 10 in a compressed, elastically loaded condition. Proximal advancement of the legs of the wire loop 66 also draws the implant 10 in this condition snuggly against the distal end of the catheter 58 for greater control, as FIG. 27F shows.
  • the catheter 58 can be advanced under image guidance to place the implant 10 within the annulus. Manipulation of the catheter 58 will bring the struts of the implant into desired alignment. Subsequent distal advancement of the legs of the wire loop 66 (see FIG. 27H ) allows the struts of the implant 10 to be elastically unloaded and brought into contact with the surrounding tissue. Anchoring structures or mechanisms associated with the struts 12 can also be placed into desired contact with adjoining tissue below and/or above the plane of the annulus. The legs of the wire loop 66 can be manipulated to pull the struts 12 together and/or allow them to separate, until the desired orientation and tissue contact in and about the annulus are achieved.
  • one leg of the wire loop 66 can be pulled to release the implant from the guide wire 64 (see FIG. 27I ).
  • the implant 10 is allowed to fully unfold and seat within the annulus.
  • a guide loop 66 can be used to deploy open annular implants as well as closed annular implants. As shown in FIG. 28A , a single guide loop 66 can be threaded through an open annular implant 10 of the type shown in FIG. 13B . Or, as shown in FIG. 28B , two guide wire loops 66 A and 66 B can be threaded through an inter-locking implant of the type shown in FIGS. 13D and 13E . In this arrangement, the first guide wire loop 66 A can be manipulated to position the struts 12 of the implant within the annulus, as just described. The second guide wire loop 66 B can be separately manipulated to pull the rails 14 together for interlocking, once the struts rest in a desired manner in the commissures.
  • FIGS. 15A to 15 E show elastic implants 10 that can be folded about cusps 20 .
  • the folding allows the implant 10 to be conveyed into the left atrium within a sheath 60 of an implant delivery catheter 58 with a delivery profile that not only constitutes a side-to-side collapsed condition—which minimizes the delivery profile diameter—but also constitutes a lengthwise folded condition—which minimizes the delivery profile length.
  • FIGS. 30A to 30 D illustrate the deployment of a symmetrically folded elastic implant 10 of the type shown in FIGS. 15A and 15B .
  • the implant 10 is constrained in a symmetrically folded and collapsed condition within the sheath 60 , as FIG. 30A shows.
  • the struts 12 form the leading end of the implant.
  • a push rod 62 in the catheter 58 includes a gripping mechanism 70 that holds the folded implant 10 by the cusps 20 .
  • the push rod 62 is advanced to expel the implant 12 from the sheath 60 , both struts 12 first.
  • the folded implant 10 is aligned with coaptation line generally equidistant from the commissures, with the struts 12 oriented to face the commissures (the delivery catheter 58 has been previously introduced trans-septally into the left atrium, as already described).
  • Manipulating the push rod 62 advances the implant 10 , both struts first, from the sheath 60 .
  • Connecting the push rod 62 to the implant 10 allows the implant 10 to be translated and rotated and retracted during deployment. Freed from the sheath 60 (see FIG. 30B ), the implant 10 begins to unfold along the cusps 20 , and the struts 12 draw apart toward the commissures.
  • the implant 10 Prior to release of the cusps 20 from the gripping mechanism 70 , the implant 10 can be manipulated to assure that anchoring structures or mechanisms associated with the strut are placed into desired contact with adjoining tissue below and/or above the plane of the annulus. The gripping mechanism 70 can then be activated (see FIG. 30D ), releasing the implant 10 .
  • FIGS. 31A to 31 E illustrate the deployment of an asymmetrically folded elastic implant 10 of the type shown in FIGS. 15D and 15E .
  • the implant 10 is constrained in an asymmetrically folded and collapsed condition within the sheath 60 , as FIG. 31A shows.
  • the gripping mechanism 70 holds one, but not both of the cusps 20 . This is because the height of the cusps 20 above the rails 14 is also asymmetric.
  • the gripping mechanism 70 will couple to the taller cusp 20 .
  • the push rod 62 can be advanced to expel the implant 10 from the sheath 60 . Due to the asymmetry of the cusps 20 , one of the struts 12 is positioned for deployment before the other strut 12 . Also due to the asymmetry of the cusps 20 , the shorter cusp 20 is positioned for advancement out of the sheath 60 before the taller cusp 20 is released by the gripping mechanism 70 .
  • FIG. 31B shows, under image guidance, the folded and collapsed implant 10 is aligned with coaptation line near one of the commissures (the delivery catheter 58 has been previously introduced trans-septally into the left atrium, as already described).
  • Manipulating the push rod 62 advances the implant 10 from the sheath 60 .
  • the leading strut 12 is freed first (see FIG. 31B ) and placed against the adjacent commissure.
  • the implant 10 can be manipulated to assure that anchoring structures or mechanisms associated with the leading strut are placed into desired contact with adjoining tissue below and/or above the plane of the annulus. Further advancement of push rod 62 causes the implant 10 to unfold toward the opposite commissure.
  • FIG. 31C shows.
  • the implant 10 can be manipulated to assure that anchoring structures or mechanisms associated with the trailing strut 12 are placed into desired contact with adjoining tissue below and/or above the plane of the annulus. Further advancement of the push rod 62 frees the shorter cusp 12 from the sheath 60 , and the implant 10 springs open along this side (see FIG. 31D ). The gripping mechanism 70 can then be activated (see FIG. 31 ), releasing the taller cusp 12 . The implant 10 springs open in this direction. It can be seen that the. asymmetry of the implant 10 make possible a step-wise deployment of the implant 10 , one component at a time, in the annulus.
  • One or more guide loops 66 or tethers can likewise be employed to assist in the deployment of folded elastic implants of either symmetric or asymmetric types.
  • a metallic, fiber, or polymer guide wire 64 can be looped through the deployment apertures on the struts of a folded symmetric or asymmetric implant 10 prior to the folding and insertion of the implant 10 into the sheath 60 .
  • the legs of the resulting guide wire loop 66 are passed out the proximal end of the sheath 60 for manipulation.
  • both legs of the guide wire loop 66 are advanced distally in tandem through the sheath 60 to advance the loop 66 beyond the deployment apertures and out the distal end of the sheath 60 .
  • the loop 66 is placed within the annulus.
  • the push rod 62 is manipulated to free the folded implant 10 for expansion (see FIG. 33B ).
  • the implant 10 opens while tethered to the guide wire loop 66 .
  • the loop 66 increases in diameter as the struts 12 expand apart.
  • the perimeter of the loop 66 will orient itself along the greatest dimension of the annulus—which is the distance between the commissures.
  • the loop 66 thereby orients the implant 10 with the coaptation line during implant 10 expansion.
  • the legs of the loop 66 guide the struts 12 to the commissures (as FIG. 33C shows).
  • the implant 10 is deployed in the annulus.
  • the guide wire loop 66 maintains control of the strut spacing within the commissures during implant expansion.
  • the gripping mechanism 70 can release the implant 10 .
  • One leg of the wire loop 66 can be pulled to release the implant 10 from the guide wire (see FIG. 33D ).
  • the implant 10 is allowed to fully unfold and seat within the annulus.
  • a second guide wire loop 72 can also be passed through apertures on the cusps 20 .
  • This guide wire loop 72 can be manipulated independently of the first guide wire loop 66 , to control deployment of the expanding implant 10 in the septal-to-lateral dimension. Simultaneous, although independent, control of the expanding implant 10 can be achieved by manipulation of the first guide wire 66 .
  • separate metallic, fiber, or polymer guide wires 92 can be individually threaded (without looping) through small holes on the struts of a folded symmetric or asymmetric implant 10 prior to the folding and insertion of the implant 10 into the sheath 60 (see FIG. 35 ).
  • the separate guide wires 92 are passed out the proximal end of the sheath 60 for manipulation.
  • the implant delivery catheter 58 is introduced trans-septally into the left atrium in the manner previously described, and prior to activation of the push rod 62 —the separate guide wires 92 are advanced distally in tandem through the sheath 60 and out the distal end of the sheath 60 . The ends of the wires 92 are placed within the annulus.
  • the push rod 62 is manipulated to free the folded implant 10 for expansion (see FIG. 36B ).
  • the implant 10 opens while tethered to the separate guide wires 92 .
  • the guide wires 92 will orient themselves along the major axis of the annulus—which is the distance between the commissures, to orient the implant 10 with the coaptation line during implant 10 expansion.
  • the guide wires 92 separately guide the respective struts 12 to the commissures (as FIG. 36C shows).
  • the implant 10 is deployed in the annulus.
  • the guide wires 92 maintain control of the strut spacing within the commissures during implant expansion.
  • the gripping mechanism 70 can release the implant 10 .
  • the guide wires 92 can be pulled to release the implant 10 from the guide wires (see FIG. 36D ).
  • the implant 10 is allowed to fully unfold and seat within the annulus.
  • the foregoing embodiments demonstrate that the unfolding of an elastic implant 10 can be controlled during deployment in either the major axis dimension, or the minor axis (septal-to-lateral) dimension, or in both dimensions by means of guide wires.
  • Other forms of restraining mechanisms can be used to control the unfolding of the implant 10 .
  • the folded implant 10 can be restrained within a bag or wrapper 76 as the implant 10 is advanced from the delivery sheath 60 .
  • the bag or wrapper 76 restricts expansion of the implant 10 beyond a selected point (e.g., 80% of full deployment), allowing the physician to attend to the important task of seating the struts in the commissures before the implant 10 fully opens across the annulus.
  • a ripcord 78 coupled to the bag or wrapper 76 can be pulled, to release the bag or wrapper 76 from the implant 10 (see FIG. 37C ).
  • the implant 10 Freed from the bag or wrapper 76 , the implant 10 completes its expansion, to achieve final shaping and seating within the annulus.
  • One or more guide wires can be used in combination with the bag or wrapper 76 .
  • the bag or wrapper 76 can alternatively be sized and configured to tear away as a result of the implant 10 expanding beyond a given point, without the use of a ripcord 78 or similar induced tearing mechanism.
  • the implant 10 can be enclosed within a shrink-wrap structure having a score line.
  • the structure is sized and configured to restrain expansion of the implant 10 until the implant 10 is advanced outside of the delivery sheath beyond a given point, at which time the score line parts or the material strength of the structure is exceeded, to open and fully release the implant 10 .
  • the implant 10 may be formed from plastically deformable material (see FIG. 38 ).
  • the implant 10 includes struts and one or more rails, as previously described.
  • the implant 10 is deployed by an implant delivery catheter 58 into the left atrium in a normally collapsed condition.
  • an implant delivery catheter 58 can carry a mechanical expansion device 80 , such as a scissorjack or the like (see FIGS. 39A to 39 C), to expand the plastically deformable material of the implant 10 in situ within the annulus.
  • an implant delivery catheter 58 can carry an inflatable body 82 (e.g., balloon) (see FIGS. 40A to 40 C), to expand the implant 10 within the annulus.
  • the plastically deformable implant 10 stretches the annulus to achieve a desired major axis size. Once expanded, the plastically deformable implant 10 maintains the desired distance, thereby resisting contraction of the annulus.
  • the plastically deformable implant 10 may include other structures or mechanisms to further anchor and stabilize the implant 10 in the heart valve annulus.
  • a heart valve such as a mitral valve and the neighboring anatomic structures are generally understood by medical professionals using textbooks of human anatomy along with their knowledge of the site and its disease or injury. Ranges of shapes and dimensions for a given implant are defined by the site to be treated. Precise dimensions for a given patient can be determined by X-ray, MRI, or CT scanning of the site to be treated prior to implantation of an implant.
  • a physician may also ascertain the size and resistance for a given implant by the deployment of a non-compliant balloon gauge 84 in the targeted annulus, as shown in FIG. 41 .
  • the balloon gauge 84 can carry radio-opaque markers 86 so that dimensions of the annulus can be determined using imaging means and/or other forms of in situ visualization.
  • the compliance and tension forces of the annulus can also be physically measured, by sensing and quantifying the resistance the balloon gauge 84 encounters during expansion in the annulus. Based upon this data, and taking into account the physician's knowledge of the site and its disease or injury, a physician can select a desired size and mechanical properties for the implant.
  • implants 10 have described the context of reshaping a heart valve annulus.
  • a given implant 10 having technical features suited for this function can also incorporate other technical features well suited for other functions.
  • FIG. 42 shows an annulus remodeling implant 10 in which the rails 14 are sized and configured to define a pseudo-annulus.
  • a neoleaflet element 88 comprising a fabric-covered bridge structure is coupled to the rails.
  • the neoleaflet element is sized and configured to occupy the space of at least a portion of a native heart valve leaflet to provide a one-way valve function.
  • the one-way valve function assumes a valve opened condition within the pseudo-annulus.
  • ventricular systolic pressure the one-way valve function assumes a valve closed condition within the pseudo-annulus.
  • the neoleaflet element 88 serves to repair, replace, or supplement a damaged heart valve.
  • FIGS. 43 and 44 show an annulus remodeling implant 10 in which the rails 14 are sized and configured serve as a pseudo-annulus.
  • the implant 10 includes a retaining structure 90 near or within the pseudo-annulus that is sized and shaped to overlay at least a portion of one or more native valve leaflets.
  • the retaining structure 90 retains a native valve leaflet, keeping the valve leaflet from a retrograde flow condition, e.g., by being pushed into the atrium, i.e., eversion and/or prolapse.
  • FIGS. 45 to 47 shows an annulus remodeling implant 10 in which the rails further include a framework 38 (as previously described) to help position and secure the device in situ.
  • the framework 38 also includes a leaflet retaining structure 90 , as just described.

Landscapes

  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Prostheses (AREA)
  • Surgical Instruments (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Materials For Medical Uses (AREA)
  • External Artificial Organs (AREA)
US10/677,104 2000-09-20 2003-10-01 Devices, systems, and methods for reshaping a heart valve annulus Abandoned US20060106456A9 (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
US10/677,104 US20060106456A9 (en) 2002-10-01 2003-10-01 Devices, systems, and methods for reshaping a heart valve annulus
US10/846,850 US8784482B2 (en) 2000-09-20 2004-05-14 Method of reshaping a heart valve annulus using an intravascular device
US10/894,433 US8956407B2 (en) 2000-09-20 2004-07-19 Methods for reshaping a heart valve annulus using a tensioning implant
US11/089,949 US20050222489A1 (en) 2003-10-01 2005-03-25 Devices, systems, and methods for reshaping a heart valve annulus, including the use of a bridge implant
US11/089,940 US7691144B2 (en) 2003-10-01 2005-03-25 Devices, systems, and methods for reshaping a heart valve annulus
US11/089,939 US20050228422A1 (en) 2002-11-26 2005-03-25 Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US11/389,819 US20060252984A1 (en) 2000-09-20 2006-03-27 Devices, systems, and methods for reshaping a heart valve annulus
US11/903,472 US20080091264A1 (en) 2002-11-26 2007-09-21 Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US11/980,838 US20080140188A1 (en) 2001-10-01 2007-10-31 Devices, systems, and methods for reshaping a heart valve annulus
US12/460,647 US20090287179A1 (en) 2003-10-01 2009-07-22 Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US12/462,956 US9861475B2 (en) 2000-09-20 2009-08-12 Devices, systems, and methods for reshaping a heart valve annulus
US12/657,527 US8187207B2 (en) 2003-10-01 2010-01-22 Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US12/658,909 US20100161044A1 (en) 2003-10-01 2010-02-17 Devices, systems, and methods for reshaping a heart valve annulus
US12/924,219 US8163013B2 (en) 2001-10-01 2010-09-23 Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US13/272,716 US8979925B2 (en) 2000-09-20 2011-10-13 Devices, systems, and methods for reshaping a heart valve annulus
US13/454,767 US8858622B2 (en) 2000-09-20 2012-04-24 Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US13/482,586 US8690858B2 (en) 2000-09-20 2012-05-29 Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US14/248,012 US20140222138A1 (en) 2000-09-20 2014-04-08 Devices, Systems, and Methods for Reshaping a Heart Valve Annulus, Including the Use of Magnetic Tools
US14/624,131 US20150157459A1 (en) 2000-09-20 2015-02-17 Devices and Systems for Reshaping a Heart Valve Annulus, Using a Tensioning Implant
US14/659,157 US9498331B2 (en) 2000-09-20 2015-03-16 Devices, systems, and methods for reshaping a heart valve annulus
US14/945,722 US20160067043A1 (en) 2000-09-20 2015-11-19 Devices, systems, and methods for reshaping a heart valve annulus including the use of magnetic tools
US15/299,908 US10219905B2 (en) 2003-10-01 2016-10-21 Devices, systems, and methods for reshaping a heart valve annulus

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
PCT/US2002/031376 WO2003028558A2 (en) 2001-10-01 2002-10-01 Methods and devices for heart valve treatments
US42944402P 2002-11-26 2002-11-26
US42970902P 2002-11-26 2002-11-26
US42946202P 2002-11-26 2002-11-26
PCT/US2003/030831 WO2004030569A2 (en) 2002-10-01 2003-10-01 Devices, systems, and methods for reshaping a heart valve annulus
US10/677,104 US20060106456A9 (en) 2002-10-01 2003-10-01 Devices, systems, and methods for reshaping a heart valve annulus

Related Parent Applications (7)

Application Number Title Priority Date Filing Date
US09/666,617 Continuation-In-Part US6893459B1 (en) 2000-09-20 2000-09-20 Heart valve annulus device and method of using same
US09/666,617 Continuation US6893459B1 (en) 2000-09-20 2000-09-20 Heart valve annulus device and method of using same
PCT/US2002/031376 Continuation-In-Part WO2003028558A2 (en) 2000-09-20 2002-10-01 Methods and devices for heart valve treatments
PCT/US2002/031376 Continuation WO2003028558A2 (en) 2000-09-20 2002-10-01 Methods and devices for heart valve treatments
US09666617 Continuation 2002-10-01
US10/846,850 Continuation-In-Part US8784482B2 (en) 2000-09-20 2004-05-14 Method of reshaping a heart valve annulus using an intravascular device
US10/894,433 Continuation-In-Part US8956407B2 (en) 2000-09-20 2004-07-19 Methods for reshaping a heart valve annulus using a tensioning implant

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10/846,850 Continuation-In-Part US8784482B2 (en) 2000-09-20 2004-05-14 Method of reshaping a heart valve annulus using an intravascular device
US10/894,433 Continuation-In-Part US8956407B2 (en) 2000-09-20 2004-07-19 Methods for reshaping a heart valve annulus using a tensioning implant
US12/462,956 Continuation US9861475B2 (en) 2000-09-20 2009-08-12 Devices, systems, and methods for reshaping a heart valve annulus

Publications (2)

Publication Number Publication Date
US20040127982A1 US20040127982A1 (en) 2004-07-01
US20060106456A9 true US20060106456A9 (en) 2006-05-18

Family

ID=44585015

Family Applications (2)

Application Number Title Priority Date Filing Date
US10/677,104 Abandoned US20060106456A9 (en) 2000-09-20 2003-10-01 Devices, systems, and methods for reshaping a heart valve annulus
US12/462,956 Active 2027-01-31 US9861475B2 (en) 2000-09-20 2009-08-12 Devices, systems, and methods for reshaping a heart valve annulus

Family Applications After (1)

Application Number Title Priority Date Filing Date
US12/462,956 Active 2027-01-31 US9861475B2 (en) 2000-09-20 2009-08-12 Devices, systems, and methods for reshaping a heart valve annulus

Country Status (9)

Country Link
US (2) US20060106456A9 (enExample)
EP (1) EP1562522B1 (enExample)
JP (1) JP2006501033A (enExample)
CN (1) CN100553590C (enExample)
AT (1) ATE418938T1 (enExample)
AU (2) AU2003277116A1 (enExample)
CA (1) CA2498030A1 (enExample)
DE (1) DE60325634D1 (enExample)
WO (1) WO2004030569A2 (enExample)

Cited By (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050171601A1 (en) * 2000-10-05 2005-08-04 Cosgrove Delos M. Minimally-invasive annuloplasty repair segment delivery system
US20060247672A1 (en) * 2005-04-27 2006-11-02 Vidlund Robert M Devices and methods for pericardial access
US7244242B2 (en) 2002-12-30 2007-07-17 Boston Scientific Scimed, Inc. Valve treatment catheter and methods
US20070208417A1 (en) * 2006-03-01 2007-09-06 Cook Incorporated Methods of reducing retrograde flow
US7267686B2 (en) 1999-10-21 2007-09-11 Boston Scientific Scimed, Inc Implantable prosthetic valve
US20080126131A1 (en) * 2006-07-17 2008-05-29 Walgreen Co. Predictive Modeling And Risk Stratification Of A Medication Therapy Regimen
US20080167713A1 (en) * 2007-01-08 2008-07-10 Bolling Steven F Reconfiguring Heart Features
US7416557B2 (en) 2002-10-24 2008-08-26 Boston Scientific Scimed, Inc. Venous valve apparatus and method
US7566343B2 (en) 2004-09-02 2009-07-28 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US7569071B2 (en) 2005-09-21 2009-08-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US20090264995A1 (en) * 2008-04-16 2009-10-22 Subramanian Valavanur A Transvalvular intraannular band for valve repair
US7666224B2 (en) 2002-11-12 2010-02-23 Edwards Lifesciences Llc Devices and methods for heart valve treatment
US7670368B2 (en) 2005-02-07 2010-03-02 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7678145B2 (en) 2002-01-09 2010-03-16 Edwards Lifesciences Llc Devices and methods for heart valve treatment
US7682385B2 (en) 2002-04-03 2010-03-23 Boston Scientific Corporation Artificial valve
US20100121437A1 (en) * 2008-04-16 2010-05-13 Cardiovascular Technologies, Llc Transvalvular intraannular band and chordae cutting for ischemic and dilated cardiomyopathy
US20100121435A1 (en) * 2008-04-16 2010-05-13 Cardiovascular Technologies, Llc Percutaneous transvalvular intrannular band for mitral valve repair
US20100121433A1 (en) * 2007-01-08 2010-05-13 Millipede Llc, A Corporation Of Michigan Reconfiguring heart features
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US20100131057A1 (en) * 2008-04-16 2010-05-27 Cardiovascular Technologies, Llc Transvalvular intraannular band for aortic valve repair
US7776053B2 (en) 2000-10-26 2010-08-17 Boston Scientific Scimed, Inc. Implantable valve system
US7780722B2 (en) 2005-02-07 2010-08-24 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7799038B2 (en) 2006-01-20 2010-09-21 Boston Scientific Scimed, Inc. Translumenal apparatus, system, and method
US20100249920A1 (en) * 2007-01-08 2010-09-30 Millipede Llc Reconfiguring heart features
US7854761B2 (en) 2003-12-19 2010-12-21 Boston Scientific Scimed, Inc. Methods for venous valve replacement with a catheter
US7854755B2 (en) 2005-02-01 2010-12-21 Boston Scientific Scimed, Inc. Vascular catheter, system, and method
US7867274B2 (en) 2005-02-23 2011-01-11 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US7883539B2 (en) 1997-01-02 2011-02-08 Edwards Lifesciences Llc Heart wall tension reduction apparatus and method
US7892276B2 (en) 2007-12-21 2011-02-22 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
US7967853B2 (en) 2007-02-05 2011-06-28 Boston Scientific Scimed, Inc. Percutaneous valve, system and method
US8012198B2 (en) 2005-06-10 2011-09-06 Boston Scientific Scimed, Inc. Venous valve, system, and method
US8128681B2 (en) 2003-12-19 2012-03-06 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US8133270B2 (en) 2007-01-08 2012-03-13 California Institute Of Technology In-situ formation of a valve
US8163010B1 (en) 2008-06-03 2012-04-24 Cardica, Inc. Staple-based heart valve treatment
EP2478868A1 (en) 2011-01-25 2012-07-25 The Provost, Fellows, Foundation Scholars, and the other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Implant device
US20120191182A1 (en) * 2006-06-01 2012-07-26 Edwards Lifesciences Corporation Prosthetic insert for treating a mitral valve
US8496671B1 (en) 2010-06-16 2013-07-30 Cardica, Inc. Mitral valve treatment
US8828079B2 (en) 2007-07-26 2014-09-09 Boston Scientific Scimed, Inc. Circulatory valve, system and method
US9034032B2 (en) 2011-10-19 2015-05-19 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9125740B2 (en) 2011-06-21 2015-09-08 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US9180005B1 (en) 2014-07-17 2015-11-10 Millipede, Inc. Adjustable endolumenal mitral valve ring
US9198757B2 (en) 2000-10-06 2015-12-01 Edwards Lifesciences, Llc Methods and devices for improving mitral valve function
US9421098B2 (en) 2010-12-23 2016-08-23 Twelve, Inc. System for mitral valve repair and replacement
US9579198B2 (en) 2012-03-01 2017-02-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
US9744037B2 (en) 2013-03-15 2017-08-29 California Institute Of Technology Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves
US9763780B2 (en) 2011-10-19 2017-09-19 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9795480B2 (en) 2010-08-24 2017-10-24 Millipede, Inc. Reconfiguring tissue features of a heart annulus
US9848983B2 (en) 2015-02-13 2017-12-26 Millipede, Inc. Valve replacement using rotational anchors
US9861475B2 (en) * 2000-09-20 2018-01-09 Mvrx Inc. Devices, systems, and methods for reshaping a heart valve annulus
US9901443B2 (en) 2011-10-19 2018-02-27 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10111747B2 (en) 2013-05-20 2018-10-30 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
US10238490B2 (en) 2015-08-21 2019-03-26 Twelve, Inc. Implant heart valve devices, mitral valve repair devices and associated systems and methods
US10265172B2 (en) 2016-04-29 2019-04-23 Medtronic Vascular, Inc. Prosthetic heart valve devices with tethered anchors and associated systems and methods
US10278819B2 (en) 2015-06-01 2019-05-07 Edwards Lifesciences Corporation Cardiac valve repair devices configured for percutaneous delivery
US10335275B2 (en) 2015-09-29 2019-07-02 Millipede, Inc. Methods for delivery of heart valve devices using intravascular ultrasound imaging
US10433961B2 (en) 2017-04-18 2019-10-08 Twelve, Inc. Delivery systems with tethers for prosthetic heart valve devices and associated methods
US10456259B2 (en) 2008-04-16 2019-10-29 Heart Repair Technologies, Inc. Transvalvular intraannular band for mitral valve repair
US10543088B2 (en) 2012-09-14 2020-01-28 Boston Scientific Scimed, Inc. Mitral valve inversion prostheses
US10548731B2 (en) 2017-02-10 2020-02-04 Boston Scientific Scimed, Inc. Implantable device and delivery system for reshaping a heart valve annulus
US10555813B2 (en) 2015-11-17 2020-02-11 Boston Scientific Scimed, Inc. Implantable device and delivery system for reshaping a heart valve annulus
US10575950B2 (en) 2017-04-18 2020-03-03 Twelve, Inc. Hydraulic systems for delivering prosthetic heart valve devices and associated methods
US10646338B2 (en) 2017-06-02 2020-05-12 Twelve, Inc. Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods
US20200146854A1 (en) * 2016-05-16 2020-05-14 Elixir Medical Corporation Methods and devices for heart valve repair
US10702378B2 (en) 2017-04-18 2020-07-07 Twelve, Inc. Prosthetic heart valve device and associated systems and methods
US10702380B2 (en) 2011-10-19 2020-07-07 Twelve, Inc. Devices, systems and methods for heart valve replacement
US10709591B2 (en) 2017-06-06 2020-07-14 Twelve, Inc. Crimping device and method for loading stents and prosthetic heart valves
US10729541B2 (en) 2017-07-06 2020-08-04 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10786352B2 (en) 2017-07-06 2020-09-29 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10792151B2 (en) 2017-05-11 2020-10-06 Twelve, Inc. Delivery systems for delivering prosthetic heart valve devices and associated methods
US10849755B2 (en) 2012-09-14 2020-12-01 Boston Scientific Scimed, Inc. Mitral valve inversion prostheses
US10912546B2 (en) 2005-04-22 2021-02-09 Laurent Schaller Catheter-based tissue remodeling devices and methods
US10940167B2 (en) 2012-02-10 2021-03-09 Cvdevices, Llc Methods and uses of biological tissues for various stent and other medical applications
US11013599B2 (en) 2008-04-16 2021-05-25 Heart Repair Technologies, Inc. Percutaneous transvalvular intraannular band for mitral valve repair
US11033391B2 (en) 2016-12-22 2021-06-15 Heart Repair Technologies, Inc. Percutaneous delivery systems for anchoring an implant in a cardiac valve annulus
US11083579B2 (en) 2008-04-16 2021-08-10 Heart Repair Technologies, Inc. Transvalvular intraanular band and chordae cutting for ischemic and dilated cardiomyopathy
US11202704B2 (en) 2011-10-19 2021-12-21 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US11406495B2 (en) 2013-02-11 2022-08-09 Cook Medical Technologies Llc Expandable support frame and medical device
US12364604B2 (en) 2019-02-11 2025-07-22 Heart Repair Technologies, Inc. Percutaneous delivery systems for anchoring an implant in a cardiac valve annulus
US12502178B2 (en) 2022-08-16 2025-12-23 Boston Scientific Scimed, Inc. Medical device for occluding a left atrial appendage

Families Citing this family (386)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406420B1 (en) 1997-01-02 2002-06-18 Myocor, Inc. Methods and devices for improving cardiac function in hearts
US6050936A (en) 1997-01-02 2000-04-18 Myocor, Inc. Heart wall tension reduction apparatus
JP4162270B2 (ja) * 1997-06-27 2008-10-08 ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク 循環弁修復のための装置
FR2768324B1 (fr) 1997-09-12 1999-12-10 Jacques Seguin Instrument chirurgical permettant, par voie percutanee, de fixer l'une a l'autre deux zones de tissu mou, normalement mutuellement distantes
US6332893B1 (en) * 1997-12-17 2001-12-25 Myocor, Inc. Valve to myocardium tension members device and method
US6260552B1 (en) 1998-07-29 2001-07-17 Myocor, Inc. Transventricular implant tools and devices
US8216256B2 (en) 1999-04-09 2012-07-10 Evalve, Inc. Detachment mechanism for implantable fixation devices
US7226467B2 (en) 1999-04-09 2007-06-05 Evalve, Inc. Fixation device delivery catheter, systems and methods of use
DE60045429D1 (de) 1999-04-09 2011-02-03 Evalve Inc Vorrichtung zur Herzklappenoperation
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US10327743B2 (en) * 1999-04-09 2019-06-25 Evalve, Inc. Device and methods for endoscopic annuloplasty
US7811296B2 (en) 1999-04-09 2010-10-12 Evalve, Inc. Fixation devices for variation in engagement of tissue
EP1113497A3 (en) * 1999-12-29 2006-01-25 Texas Instruments Incorporated Semiconductor package with conductor impedance selected during assembly
US20050222489A1 (en) 2003-10-01 2005-10-06 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of a bridge implant
US8784482B2 (en) * 2000-09-20 2014-07-22 Mvrx, Inc. Method of reshaping a heart valve annulus using an intravascular device
WO2004030570A2 (en) * 2002-10-01 2004-04-15 Ample Medical, Inc. Devices for retaining native heart valve leaflet
US20080091264A1 (en) 2002-11-26 2008-04-17 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US6974476B2 (en) 2003-05-05 2005-12-13 Rex Medical, L.P. Percutaneous aortic valve
US6800090B2 (en) 2001-05-14 2004-10-05 Cardiac Dimensions, Inc. Mitral valve therapy device, system and method
US6949122B2 (en) 2001-11-01 2005-09-27 Cardiac Dimensions, Inc. Focused compression mitral valve device and method
US7635387B2 (en) 2001-11-01 2009-12-22 Cardiac Dimensions, Inc. Adjustable height focal tissue deflector
US6824562B2 (en) 2002-05-08 2004-11-30 Cardiac Dimensions, Inc. Body lumen device anchor, device and assembly
US7311729B2 (en) * 2002-01-30 2007-12-25 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US6575971B2 (en) 2001-11-15 2003-06-10 Quantum Cor, Inc. Cardiac valve leaflet stapler device and methods thereof
US7179282B2 (en) * 2001-12-05 2007-02-20 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US6793673B2 (en) * 2002-12-26 2004-09-21 Cardiac Dimensions, Inc. System and method to effect mitral valve annulus of a heart
US6976995B2 (en) 2002-01-30 2005-12-20 Cardiac Dimensions, Inc. Fixed length anchor and pull mitral valve device and method
US20050209690A1 (en) * 2002-01-30 2005-09-22 Mathis Mark L Body lumen shaping device with cardiac leads
US7004958B2 (en) * 2002-03-06 2006-02-28 Cardiac Dimensions, Inc. Transvenous staples, assembly and method for mitral valve repair
US7007698B2 (en) 2002-04-03 2006-03-07 Boston Scientific Corporation Body lumen closure
CA2744868C (en) 2002-05-08 2015-12-29 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
WO2003105667A2 (en) * 2002-06-12 2003-12-24 Mitral Interventions, Inc. Method and apparatus for tissue connection
US7247134B2 (en) 2002-11-12 2007-07-24 Myocor, Inc. Devices and methods for heart valve treatment
US7837729B2 (en) 2002-12-05 2010-11-23 Cardiac Dimensions, Inc. Percutaneous mitral valve annuloplasty delivery system
US7316708B2 (en) 2002-12-05 2008-01-08 Cardiac Dimensions, Inc. Medical device delivery system
US7314485B2 (en) 2003-02-03 2008-01-01 Cardiac Dimensions, Inc. Mitral valve device using conditioned shape memory alloy
US20040158321A1 (en) * 2003-02-12 2004-08-12 Cardiac Dimensions, Inc. Method of implanting a mitral valve therapy device
US20040220654A1 (en) 2003-05-02 2004-11-04 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US10631871B2 (en) 2003-05-19 2020-04-28 Evalve, Inc. Fixation devices, systems and methods for engaging tissue
US7887582B2 (en) 2003-06-05 2011-02-15 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US7351259B2 (en) * 2003-06-05 2008-04-01 Cardiac Dimensions, Inc. Device, system and method to affect the mitral valve annulus of a heart
US8052751B2 (en) * 2003-07-02 2011-11-08 Flexcor, Inc. Annuloplasty rings for repairing cardiac valves
WO2005009285A2 (en) * 2003-07-21 2005-02-03 The Trustees Of The University Of Pennsylvania Percutaneous heart valve
US7794496B2 (en) 2003-12-19 2010-09-14 Cardiac Dimensions, Inc. Tissue shaping device with integral connector and crimp
US9526616B2 (en) 2003-12-19 2016-12-27 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US20050137449A1 (en) * 2003-12-19 2005-06-23 Cardiac Dimensions, Inc. Tissue shaping device with self-expanding anchors
US7837728B2 (en) * 2003-12-19 2010-11-23 Cardiac Dimensions, Inc. Reduced length tissue shaping device
US8287584B2 (en) * 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
EP3628239B1 (en) 2004-05-14 2022-04-27 Evalve, Inc. Locking mechanisms for fixation devices for engaging tissue
CN101056596B (zh) 2004-09-14 2011-08-03 爱德华兹生命科学股份公司 用于治疗心脏瓣膜反流的装置和方法
US8052592B2 (en) 2005-09-27 2011-11-08 Evalve, Inc. Methods and devices for tissue grasping and assessment
CA2748617C (en) 2004-09-27 2014-09-23 Evalve, Inc. Methods and devices for tissue grasping and assessment
CA3005526C (en) 2004-10-02 2019-10-22 Edwards Lifesciences Cardiaq, Llc Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support
WO2006041877A2 (en) * 2004-10-05 2006-04-20 Ample Medical, Inc. Atrioventricular valve annulus repair systems and methods including retro-chordal anchors
SE0403046D0 (sv) * 2004-12-15 2004-12-15 Medtentia Ab A device and method for improving the function of a heart valve
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
EP1855619A4 (en) * 2005-01-20 2013-10-02 Cardiac Dimensions Inc FABRIC FORMING DEVICE
US20060173490A1 (en) 2005-02-01 2006-08-03 Boston Scientific Scimed, Inc. Filter system and method
US7878966B2 (en) 2005-02-04 2011-02-01 Boston Scientific Scimed, Inc. Ventricular assist and support device
US8470028B2 (en) 2005-02-07 2013-06-25 Evalve, Inc. Methods, systems and devices for cardiac valve repair
EP1855623B1 (en) 2005-02-07 2019-04-17 Evalve, Inc. Devices for cardiac valve repair
US8608797B2 (en) 2005-03-17 2013-12-17 Valtech Cardio Ltd. Mitral valve treatment techniques
AU2006241065B2 (en) * 2005-04-25 2012-09-20 Evalve, Inc. Device and methods for endoscopic annuloplasty
US9549739B2 (en) 2005-05-20 2017-01-24 Neotract, Inc. Devices, systems and methods for treating benign prostatic hyperplasia and other conditions
US10925587B2 (en) 2005-05-20 2021-02-23 Neotract, Inc. Anchor delivery system
US8333776B2 (en) 2005-05-20 2012-12-18 Neotract, Inc. Anchor delivery system
US9504461B2 (en) 2005-05-20 2016-11-29 Neotract, Inc. Anchor delivery system
US7896891B2 (en) 2005-05-20 2011-03-01 Neotract, Inc. Apparatus and method for manipulating or retracting tissue and anatomical structure
US7758594B2 (en) 2005-05-20 2010-07-20 Neotract, Inc. Devices, systems and methods for treating benign prostatic hyperplasia and other conditions
US8945152B2 (en) 2005-05-20 2015-02-03 Neotract, Inc. Multi-actuating trigger anchor delivery system
US8834492B2 (en) 2005-05-20 2014-09-16 Neotract, Inc. Continuous indentation lateral lobe apparatus and method
US8425535B2 (en) 2005-05-20 2013-04-23 Neotract, Inc. Multi-actuating trigger anchor delivery system
US8529584B2 (en) 2005-05-20 2013-09-10 Neotract, Inc. Median lobe band implant apparatus and method
US7645286B2 (en) 2005-05-20 2010-01-12 Neotract, Inc. Devices, systems and methods for retracting, lifting, compressing, supporting or repositioning tissues or anatomical structures
US8394113B2 (en) 2005-05-20 2013-03-12 Neotract, Inc. Coiled anchor device
US9364212B2 (en) 2005-05-20 2016-06-14 Neotract, Inc. Suture anchoring devices and methods for use
US8668705B2 (en) 2005-05-20 2014-03-11 Neotract, Inc. Latching anchor device
US8603106B2 (en) 2005-05-20 2013-12-10 Neotract, Inc. Integrated handle assembly for anchor delivery system
US10195014B2 (en) 2005-05-20 2019-02-05 Neotract, Inc. Devices, systems and methods for treating benign prostatic hyperplasia and other conditions
US9149266B2 (en) 2005-05-20 2015-10-06 Neotract, Inc. Deforming anchor device
US8628542B2 (en) 2005-05-20 2014-01-14 Neotract, Inc. Median lobe destruction apparatus and method
US7616122B2 (en) 2005-06-20 2009-11-10 Biovigil, Llc Hand cleanliness
US8502681B2 (en) 2005-06-20 2013-08-06 Biovigil, Llc Hand cleanliness
US7286057B2 (en) 2005-06-20 2007-10-23 Biovigil Llc Hand cleanliness
US8951285B2 (en) 2005-07-05 2015-02-10 Mitralign, Inc. Tissue anchor, anchoring system and methods of using the same
ES2566635T3 (es) 2005-09-07 2016-04-14 Medtentia International Ltd Oy Dispositivo y método para mejorar la función de una válvula del corazón
US7530253B2 (en) * 2005-09-09 2009-05-12 Edwards Lifesciences Corporation Prosthetic valve crimping device
CA2629534C (en) 2005-11-10 2015-02-24 Arshad Quadri Balloon-expandable, self-expanding, vascular prosthesis connecting stent
US7503932B2 (en) 2006-04-11 2009-03-17 Cardiac Dimensions, Inc. Mitral valve annuloplasty device with vena cava anchor
US20110276127A1 (en) * 2006-05-24 2011-11-10 Forster David C Multiple inflation of an expandable member as a precursor to an implant procedure
US8585594B2 (en) * 2006-05-24 2013-11-19 Phoenix Biomedical, Inc. Methods of assessing inner surfaces of body lumens or organs
US11285005B2 (en) 2006-07-17 2022-03-29 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US20090306768A1 (en) 2006-07-28 2009-12-10 Cardiaq Valve Technologies, Inc. Percutaneous valve prosthesis and system and method for implanting same
US7854849B2 (en) * 2006-10-10 2010-12-21 Multiphase Systems Integration Compact multiphase inline bulk water separation method and system for hydrocarbon production
SE530568C2 (sv) * 2006-11-13 2008-07-08 Medtentia Ab Anordning och metod för förbättring av funktionen hos en hjärtklaff
US9883943B2 (en) 2006-12-05 2018-02-06 Valtech Cardio, Ltd. Implantation of repair devices in the heart
JP2010511469A (ja) * 2006-12-05 2010-04-15 バルテック カーディオ，リミティド セグメント化リング配置
US11259924B2 (en) 2006-12-05 2022-03-01 Valtech Cardio Ltd. Implantation of repair devices in the heart
US20080208328A1 (en) 2007-02-23 2008-08-28 Endovalve, Inc. Systems and Methods For Placement of Valve Prosthesis System
US8070802B2 (en) 2007-02-23 2011-12-06 The Trustees Of The University Of Pennsylvania Mitral valve system
US11660190B2 (en) 2007-03-13 2023-05-30 Edwards Lifesciences Corporation Tissue anchors, systems and methods, and devices
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US8529620B2 (en) * 2007-05-01 2013-09-10 Ottavio Alfieri Inwardly-bowed tricuspid annuloplasty ring
US20090222081A1 (en) * 2008-01-24 2009-09-03 Coherex Medical, Inc. Methods and apparatus for reducing valve prolapse
BR112012021347A2 (pt) 2008-02-26 2019-09-24 Jenavalve Tecnology Inc stent para posicionamento e ancoragem de uma prótese valvular em um local de implantação no coração de um paciente
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
US8382829B1 (en) 2008-03-10 2013-02-26 Mitralign, Inc. Method to reduce mitral regurgitation by cinching the commissure of the mitral valve
US20090276040A1 (en) 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve
US7976578B2 (en) * 2008-06-04 2011-07-12 James Marvel Buffer for a human joint and method of arthroscopically inserting
US9192472B2 (en) 2008-06-16 2015-11-24 Valtec Cardio, Ltd. Annuloplasty devices and methods of delivery therefor
US8323335B2 (en) * 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
WO2010014825A1 (en) 2008-07-30 2010-02-04 Neotract, Inc. Slotted anchor device
US8006594B2 (en) * 2008-08-11 2011-08-30 Cardiac Dimensions, Inc. Catheter cutting tool
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
EP2358308B1 (en) * 2008-09-15 2019-11-27 Medtronic, Inc. Tools for remodeling tissue
US8403983B2 (en) 2008-09-29 2013-03-26 Cardiaq Valve Technologies, Inc. Heart valve
US7951111B2 (en) * 2008-10-10 2011-05-31 Intervalve, Inc. Valvuloplasty catheter and methods
US8715342B2 (en) 2009-05-07 2014-05-06 Valtech Cardio, Ltd. Annuloplasty ring with intra-ring anchoring
US8940044B2 (en) 2011-06-23 2015-01-27 Valtech Cardio, Ltd. Closure element for use with an annuloplasty structure
WO2010073246A2 (en) 2008-12-22 2010-07-01 Valtech Cardio, Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
US8147542B2 (en) 2008-12-22 2012-04-03 Valtech Cardio, Ltd. Adjustable repair chords and spool mechanism therefor
US10517719B2 (en) 2008-12-22 2019-12-31 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US9011530B2 (en) 2008-12-22 2015-04-21 Valtech Cardio, Ltd. Partially-adjustable annuloplasty structure
US8241351B2 (en) 2008-12-22 2012-08-14 Valtech Cardio, Ltd. Adjustable partial annuloplasty ring and mechanism therefor
US8545553B2 (en) 2009-05-04 2013-10-01 Valtech Cardio, Ltd. Over-wire rotation tool
US20100174363A1 (en) * 2009-01-07 2010-07-08 Endovalve, Inc. One Piece Prosthetic Valve Support Structure and Related Assemblies
US20100179565A1 (en) * 2009-01-13 2010-07-15 Medtronic Vascular, Inc. Rail for Delivering an Endovascular Stapler
US8353956B2 (en) 2009-02-17 2013-01-15 Valtech Cardio, Ltd. Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
WO2010106438A2 (en) * 2009-03-17 2010-09-23 Biomedxl Heart valve prosthesis with collapsible valve and method of delivery thereof
CN101919750A (zh) 2009-03-30 2010-12-22 卡迪万蒂奇医药公司 无缝合肺动脉瓣膜或二尖瓣膜的移植方法
CA2961053C (en) 2009-04-15 2019-04-30 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
EP4035623A1 (en) 2009-04-29 2022-08-03 Edwards Lifesciences Corporation Apparatus and method for replacing a diseased cardiac valve
US9968452B2 (en) 2009-05-04 2018-05-15 Valtech Cardio, Ltd. Annuloplasty ring delivery cathethers
US12485010B2 (en) 2009-05-07 2025-12-02 Edwards Lifesciences Innovation (Israel) Ltd. Multiple anchor delivery tool
EP2633821B1 (en) 2009-09-15 2016-04-06 Evalve, Inc. Device for cardiac valve repair
JP5774594B2 (ja) * 2009-10-14 2015-09-09 ハート・リペアー・テクノロジーズ・インコーポレーテッド 僧帽弁修復のための経皮的弁口環内バンド
US9011520B2 (en) 2009-10-29 2015-04-21 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US9180007B2 (en) 2009-10-29 2015-11-10 Valtech Cardio, Ltd. Apparatus and method for guide-wire based advancement of an adjustable implant
US10098737B2 (en) 2009-10-29 2018-10-16 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
EP2506777B1 (en) 2009-12-02 2020-11-25 Valtech Cardio, Ltd. Combination of spool assembly coupled to a helical anchor and delivery tool for implantation thereof
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
KR101231140B1 (ko) * 2011-08-12 2013-02-07 부산대학교 산학협력단 승모판막 서클라지 시술용 장치
US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
US9307980B2 (en) 2010-01-22 2016-04-12 4Tech Inc. Tricuspid valve repair using tension
US8475525B2 (en) 2010-01-22 2013-07-02 4Tech Inc. Tricuspid valve repair using tension
US10058323B2 (en) 2010-01-22 2018-08-28 4 Tech Inc. Tricuspid valve repair using tension
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
AU2011257298B2 (en) 2010-05-25 2014-07-31 Jenavalve Technology Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
EP3061422B1 (en) 2010-06-21 2021-11-03 Edwards Lifesciences CardiAQ LLC Replacement heart valve
EP4241701B1 (en) 2010-07-09 2024-09-18 Highlife SAS Transcatheter atrio-ventricular valve prosthesis
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
EP4548880A3 (en) 2010-07-23 2025-07-09 Edwards Lifesciences Corporation A system for delivering a prosthetic valve
EP3459500B1 (en) 2010-09-23 2020-09-16 Edwards Lifesciences CardiAQ LLC Replacement heart valves and delivery devices
US9198756B2 (en) 2010-11-18 2015-12-01 Pavilion Medical Innovations, Llc Tissue restraining devices and methods of use
WO2012068541A2 (en) 2010-11-18 2012-05-24 Pavilion Medical Innovations Tissue restraining devices and methods of use
WO2012094406A1 (en) * 2011-01-04 2012-07-12 The Cleveland Clinic Foundation Apparatus and method for treating a regurgitant heart valve
CN103987341B (zh) * 2011-01-04 2017-02-22 克利夫兰临床基金会 治疗心脏瓣膜返流的装置和方法
WO2012103173A2 (en) * 2011-01-25 2012-08-02 Emory University Devices and methods for surgical and percutaneous repair of heart valve lesions
US9161749B2 (en) 2011-04-14 2015-10-20 Neotract, Inc. Method and apparatus for treating sexual dysfunction
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US12502276B2 (en) 2011-05-16 2025-12-23 Edwards Lifesciences Corporation Inversion delivery device and method for a prosthesis
US9918840B2 (en) 2011-06-23 2018-03-20 Valtech Cardio, Ltd. Closed band for percutaneous annuloplasty
EP2723274B1 (en) 2011-06-23 2017-12-27 Valtech Cardio, Ltd. Closure element for use with annuloplasty structure
US10792152B2 (en) 2011-06-23 2020-10-06 Valtech Cardio, Ltd. Closed band for percutaneous annuloplasty
US8945177B2 (en) 2011-09-13 2015-02-03 Abbott Cardiovascular Systems Inc. Gripper pusher mechanism for tissue apposition systems
US8858623B2 (en) 2011-11-04 2014-10-14 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
US9724192B2 (en) 2011-11-08 2017-08-08 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
US10143553B2 (en) 2011-12-12 2018-12-04 Cardiac Implants, Llc Heart valve repair device
US9078747B2 (en) 2011-12-21 2015-07-14 Edwards Lifesciences Corporation Anchoring device for replacing or repairing a heart valve
EP2620125B1 (en) 2012-01-24 2017-10-11 Medtentia International Ltd Oy An arrangement, a loop-shaped support, a prosthetic heart valve and a method of repairing or replacing a native heart valve
EP3326585B1 (en) * 2012-01-31 2019-06-19 Mitral Valve Technologies Sàrl Mitral valve docking devices and systems
EP2822473B1 (en) * 2012-03-06 2018-08-22 Highlife SAS Treatment catheter member with encircling function
ES2535295T3 (es) 2012-03-23 2015-05-08 Sorin Group Italia S.R.L. Prótesis de válvula plegable
US10292801B2 (en) 2012-03-29 2019-05-21 Neotract, Inc. System for delivering anchors for treating incontinence
US9427315B2 (en) 2012-04-19 2016-08-30 Caisson Interventional, LLC Valve replacement systems and methods
US9011515B2 (en) 2012-04-19 2015-04-21 Caisson Interventional, LLC Heart valve assembly systems and methods
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
DE102012010798A1 (de) * 2012-06-01 2013-12-05 Universität Duisburg-Essen Implantierbare Vorrichtung zur Verbesserung oder Behebung einer Herzklappeninsuffizienz
US10130353B2 (en) 2012-06-29 2018-11-20 Neotract, Inc. Flexible system for delivering an anchor
EP2695586B1 (en) 2012-08-10 2019-05-08 Sorin Group Italia S.r.l. A valve prosthesis and kit
EP2900150B1 (en) 2012-09-29 2018-04-18 Mitralign, Inc. Plication lock delivery system
EP3517052A1 (en) 2012-10-23 2019-07-31 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
US10376266B2 (en) 2012-10-23 2019-08-13 Valtech Cardio, Ltd. Percutaneous tissue anchor techniques
EP2730252A1 (en) * 2012-11-07 2014-05-14 Medtentia International Ltd Oy Medical device for a cardiac valve implant, and a metod of manufacturing the medical device
EP2922592B1 (en) 2012-11-21 2022-09-21 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic heart valves
US9730793B2 (en) 2012-12-06 2017-08-15 Valtech Cardio, Ltd. Techniques for guide-wire based advancement of a tool
EP2943132B1 (en) 2013-01-09 2018-03-28 4Tech Inc. Soft tissue anchors
ITRM20130016A1 (it) * 2013-01-10 2014-07-11 Jacob Zeitani Dispositivo per plastica della valvola mitrale.
EP2948103B1 (en) 2013-01-24 2022-12-07 Cardiovalve Ltd Ventricularly-anchored prosthetic valves
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US9724084B2 (en) 2013-02-26 2017-08-08 Mitralign, Inc. Devices and methods for percutaneous tricuspid valve repair
US11065118B2 (en) * 2013-03-04 2021-07-20 The Medical Research, Infrastructure And Health Services Fund Of The Tel-Aviv Medical Center Cardiac valve commissure brace
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
EP2967810B1 (en) 2013-03-14 2020-04-22 Suzhou Jiecheng Medical Technology Co., Ltd. Embolic protection devices
US20140277427A1 (en) 2013-03-14 2014-09-18 Cardiaq Valve Technologies, Inc. Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
JP6329570B2 (ja) 2013-03-14 2018-05-23 ４テック インコーポレイテッド テザーインターフェースを有するステント
US11259923B2 (en) 2013-03-14 2022-03-01 Jc Medical, Inc. Methods and devices for delivery of a prosthetic valve
US10449333B2 (en) 2013-03-14 2019-10-22 Valtech Cardio, Ltd. Guidewire feeder
US11406497B2 (en) 2013-03-14 2022-08-09 Jc Medical, Inc. Heart valve prosthesis
US9724195B2 (en) 2013-03-15 2017-08-08 Mitralign, Inc. Translation catheters and systems
MX377522B (es) * 2013-03-15 2025-03-10 Fabian Hermann Urban Fueglister Implante de deformacion de la lengua.
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US10524904B2 (en) * 2013-07-11 2020-01-07 Medtronic, Inc. Valve positioning device
US9895219B2 (en) 2013-07-31 2018-02-20 Medtronic Vascular Galway Mitral valve prosthesis for transcatheter valve implantation
EP2835112B1 (en) 2013-08-08 2021-01-27 Sorin Group Italia S.r.l. Heart valve prosthesis
CN105491978A (zh) 2013-08-30 2016-04-13 耶拿阀门科技股份有限公司 用于假体瓣膜的径向可折叠框架及其制造方法
US10070857B2 (en) 2013-08-31 2018-09-11 Mitralign, Inc. Devices and methods for locating and implanting tissue anchors at mitral valve commissure
WO2015048738A1 (en) * 2013-09-30 2015-04-02 The Cleveland Clinic Foundation Apparatus and method for treating a regurgitant heart valve
WO2015059699A2 (en) 2013-10-23 2015-04-30 Valtech Cardio, Ltd. Anchor magazine
US9421094B2 (en) 2013-10-23 2016-08-23 Caisson Interventional, LLC Methods and systems for heart valve therapy
US10022114B2 (en) 2013-10-30 2018-07-17 4Tech Inc. Percutaneous tether locking
US10052095B2 (en) 2013-10-30 2018-08-21 4Tech Inc. Multiple anchoring-point tension system
US9622863B2 (en) 2013-11-22 2017-04-18 Edwards Lifesciences Corporation Aortic insufficiency repair device and method
US9610162B2 (en) 2013-12-26 2017-04-04 Valtech Cardio, Ltd. Implantation of flexible implant
EP3107497B1 (en) 2014-02-21 2020-07-22 Edwards Lifesciences CardiAQ LLC Delivery device for controlled deployment of a replacement valve
US9572666B2 (en) 2014-03-17 2017-02-21 Evalve, Inc. Mitral valve fixation device removal devices and methods
US10390943B2 (en) 2014-03-17 2019-08-27 Evalve, Inc. Double orifice device for transcatheter mitral valve replacement
US9763778B2 (en) * 2014-03-18 2017-09-19 St. Jude Medical, Cardiology Division, Inc. Aortic insufficiency valve percutaneous valve anchoring
US10245141B2 (en) 2014-05-14 2019-04-02 Sorin Group Italia S.R.L. Implant device and implantation kit
CN106456328A (zh) 2014-05-19 2017-02-22 爱德华兹生命科学卡迪尔克有限责任公司 带有环形活瓣的二尖瓣膜替代品
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US9974647B2 (en) 2014-06-12 2018-05-22 Caisson Interventional, LLC Two stage anchor and mitral valve assembly
US9801720B2 (en) 2014-06-19 2017-10-31 4Tech Inc. Cardiac tissue cinching
JP2017520375A (ja) * 2014-07-03 2017-07-27 メドテンティア インターナショナル アェルテーデー オーイューＭｅｄｔｅｎｔｉａ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｔｄ Ｏｙ 弁輪形成システム
WO2016016899A1 (en) 2014-07-30 2016-02-04 Mitraltech Ltd. Articulatable prosthetic valve
EP3197397B1 (en) 2014-09-28 2021-01-13 Cardiokinetix, Inc. Apparatuses for treating cardiac dysfunction
US10195030B2 (en) 2014-10-14 2019-02-05 Valtech Cardio, Ltd. Leaflet-restraining techniques
FR3027212A1 (fr) * 2014-10-16 2016-04-22 Seguin Jacques Implant intervalvulaire pour valve mitrale
US9750605B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US9750607B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
EP3223751B1 (en) 2014-11-26 2024-06-19 Edwards Lifesciences Corporation Transcatheter prosthetic heart valve and delivery system
CN106999178B (zh) 2014-12-02 2019-12-24 4科技有限公司 偏心组织锚定器
EP3226810A4 (en) 2014-12-04 2018-08-15 Edwards Lifesciences Corporation Percutaneous clip for repairing a heart valve
US10188392B2 (en) 2014-12-19 2019-01-29 Abbott Cardiovascular Systems, Inc. Grasping for tissue repair
WO2016125160A1 (en) 2015-02-05 2016-08-11 Mitraltech Ltd. Prosthetic valve with axially-sliding frames
US20160256269A1 (en) 2015-03-05 2016-09-08 Mitralign, Inc. Devices for treating paravalvular leakage and methods use thereof
US10751064B2 (en) 2015-03-20 2020-08-25 Edwards Lifescience Corporation Systems and methods for delivering an implantable device
JP6829692B2 (ja) 2015-03-20 2021-02-10 イェーナヴァルヴ テクノロジー インコーポレイテッド 心臓弁プロテーゼ送出システム及び導入体シースにより心臓弁プロテーゼを送出するための方法
US10524912B2 (en) 2015-04-02 2020-01-07 Abbott Cardiovascular Systems, Inc. Tissue fixation devices and methods
US10376363B2 (en) 2015-04-30 2019-08-13 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
EP4450000A3 (en) 2015-04-30 2024-12-25 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty technologies
EP4403138A3 (en) 2015-05-01 2024-10-09 JenaValve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
US10517726B2 (en) 2015-05-14 2019-12-31 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US10376673B2 (en) 2015-06-19 2019-08-13 Evalve, Inc. Catheter guiding system and methods
US10226335B2 (en) 2015-06-22 2019-03-12 Edwards Lifesciences Cardiaq Llc Actively controllable heart valve implant and method of controlling same
US10092400B2 (en) 2015-06-23 2018-10-09 Edwards Lifesciences Cardiaq Llc Systems and methods for anchoring and sealing a prosthetic heart valve
US10238494B2 (en) 2015-06-29 2019-03-26 Evalve, Inc. Self-aligning radiopaque ring
US10667815B2 (en) 2015-07-21 2020-06-02 Evalve, Inc. Tissue grasping devices and related methods
US10413408B2 (en) 2015-08-06 2019-09-17 Evalve, Inc. Delivery catheter systems, methods, and devices
US10117744B2 (en) 2015-08-26 2018-11-06 Edwards Lifesciences Cardiaq Llc Replacement heart valves and methods of delivery
US10575951B2 (en) 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
US10350066B2 (en) 2015-08-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
US10765517B2 (en) 2015-10-01 2020-09-08 Neochord, Inc. Ringless web for repair of heart valves
US10238495B2 (en) 2015-10-09 2019-03-26 Evalve, Inc. Delivery catheter handle and methods of use
EP3386440A4 (en) 2015-12-10 2019-11-13 MVRx, Inc. DEVICES, SYSTEMS AND METHOD FOR FORMING A HEADLOCK RING
US10631984B2 (en) 2015-12-15 2020-04-28 Neovasc Tiara Inc. Transseptal delivery system
US10265166B2 (en) 2015-12-30 2019-04-23 Caisson Interventional, LLC Systems and methods for heart valve therapy
US10751182B2 (en) 2015-12-30 2020-08-25 Edwards Lifesciences Corporation System and method for reshaping right heart
WO2017117370A2 (en) 2015-12-30 2017-07-06 Mitralign, Inc. System and method for reducing tricuspid regurgitation
CA3007670C (en) 2016-01-29 2024-09-17 Neovasc Tiara Inc. PROSTHETIC VALVE PREVENTING OBSTRUCTION THAT WOULD PREVENT FLOW
US10531866B2 (en) 2016-02-16 2020-01-14 Cardiovalve Ltd. Techniques for providing a replacement valve and transseptal communication
US10357365B2 (en) * 2016-03-07 2019-07-23 Serca Biomedical, LLC Annuloplasty repair devices, systems and methods
US10799677B2 (en) 2016-03-21 2020-10-13 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US10799676B2 (en) 2016-03-21 2020-10-13 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US10835714B2 (en) 2016-03-21 2020-11-17 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US11219746B2 (en) 2016-03-21 2022-01-11 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US10799675B2 (en) 2016-03-21 2020-10-13 Edwards Lifesciences Corporation Cam controlled multi-direction steerable handles
CN105726072B (zh) * 2016-04-14 2018-02-27 江苏大学 一种经心尖植入的二尖瓣气囊闭合板阻塞体及植入方法
EP4183371A1 (en) 2016-05-13 2023-05-24 JenaValve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
WO2017198789A1 (en) 2016-05-20 2017-11-23 Vivasure Medical Limited Vascular closure device
US10702274B2 (en) 2016-05-26 2020-07-07 Edwards Lifesciences Corporation Method and system for closing left atrial appendage
US20170354500A1 (en) * 2016-06-08 2017-12-14 Cook Medical Technologies Llc Mitral prolapse valve restrictor
US10736632B2 (en) 2016-07-06 2020-08-11 Evalve, Inc. Methods and devices for valve clip excision
US10973638B2 (en) 2016-07-07 2021-04-13 Edwards Lifesciences Corporation Device and method for treating vascular insufficiency
GB201611910D0 (en) 2016-07-08 2016-08-24 Valtech Cardio Ltd Adjustable annuloplasty device with alternating peaks and troughs
US10828150B2 (en) * 2016-07-08 2020-11-10 Edwards Lifesciences Corporation Docking station for heart valve prosthesis
US10350062B2 (en) 2016-07-21 2019-07-16 Edwards Lifesciences Corporation Replacement heart valve prosthesis
US20190231525A1 (en) 2016-08-01 2019-08-01 Mitraltech Ltd. Minimally-invasive delivery systems
ES3018641T3 (es) 2016-08-10 2025-05-16 Cardiovalve Ltd Válvula protésica con marcos concéntricos
EP3515364A4 (en) * 2016-09-26 2020-04-22 Innercore Medical Ltd. MITRAL VALVE REPAIR DEVICE AND METHOD
US11071564B2 (en) 2016-10-05 2021-07-27 Evalve, Inc. Cardiac valve cutting device
CN106618798B (zh) * 2016-10-24 2019-10-11 宁波健世生物科技有限公司 一种通过室间隔固定的心脏瓣膜假体及其输送和释放方法
EP3531974A1 (en) * 2016-10-28 2019-09-04 Coramaze Technologies GmbH Heart implant
US10653862B2 (en) 2016-11-07 2020-05-19 Edwards Lifesciences Corporation Apparatus for the introduction and manipulation of multiple telescoping catheters
US10363138B2 (en) 2016-11-09 2019-07-30 Evalve, Inc. Devices for adjusting the curvature of cardiac valve structures
US10398553B2 (en) 2016-11-11 2019-09-03 Evalve, Inc. Opposing disk device for grasping cardiac valve tissue
US10426616B2 (en) 2016-11-17 2019-10-01 Evalve, Inc. Cardiac implant delivery system
AU2017361296B2 (en) 2016-11-21 2022-09-29 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
US10779837B2 (en) 2016-12-08 2020-09-22 Evalve, Inc. Adjustable arm device for grasping tissues
US10314586B2 (en) 2016-12-13 2019-06-11 Evalve, Inc. Rotatable device and method for fixing tricuspid valve tissue
US10905554B2 (en) 2017-01-05 2021-02-02 Edwards Lifesciences Corporation Heart valve coaptation device
US11197754B2 (en) 2017-01-27 2021-12-14 Jenavalve Technology, Inc. Heart valve mimicry
US10675017B2 (en) 2017-02-07 2020-06-09 Edwards Lifesciences Corporation Transcatheter heart valve leaflet plication
US10390953B2 (en) 2017-03-08 2019-08-27 Cardiac Dimensions Pty. Ltd. Methods and devices for reducing paravalvular leakage
ES2890936T3 (es) * 2017-03-27 2022-01-25 Truleaf Medical Ltd Elementos de acoplamiento
US11224511B2 (en) 2017-04-18 2022-01-18 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11045627B2 (en) 2017-04-18 2021-06-29 Edwards Lifesciences Corporation Catheter system with linear actuation control mechanism
KR20250102117A (ko) 2017-04-18 2025-07-04 에드워즈 라이프사이언시스 코포레이션 심장 판막 밀봉 장치 및 그를 위한 전달 장치
US10799312B2 (en) 2017-04-28 2020-10-13 Edwards Lifesciences Corporation Medical device stabilizing apparatus and method of use
US10959846B2 (en) 2017-05-10 2021-03-30 Edwards Lifesciences Corporation Mitral valve spacer device
US11065119B2 (en) 2017-05-12 2021-07-20 Evalve, Inc. Long arm valve repair clip
US10842619B2 (en) 2017-05-12 2020-11-24 Edwards Lifesciences Corporation Prosthetic heart valve docking assembly
US10517598B2 (en) * 2017-06-07 2019-12-31 Evalve, Inc. Tissue tensioning device for cardiac valve repair
US11123186B2 (en) 2017-07-06 2021-09-21 Edwards Lifesciences Corporation Steerable delivery system and components
US11069220B2 (en) 2017-07-10 2021-07-20 Biovigil Hygiene Technologies, Llc Hand cleanliness monitoring
US11793633B2 (en) 2017-08-03 2023-10-24 Cardiovalve Ltd. Prosthetic heart valve
US12064347B2 (en) 2017-08-03 2024-08-20 Cardiovalve Ltd. Prosthetic heart valve
WO2019036810A1 (en) 2017-08-25 2019-02-28 Neovasc Tiara Inc. TRANSCATHETER MITRAL VALVULE PROSTHESIS WITH SEQUENTIAL DEPLOYMENT
US11051940B2 (en) 2017-09-07 2021-07-06 Edwards Lifesciences Corporation Prosthetic spacer device for heart valve
US11065117B2 (en) 2017-09-08 2021-07-20 Edwards Lifesciences Corporation Axisymmetric adjustable device for treating mitral regurgitation
US11040174B2 (en) 2017-09-19 2021-06-22 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US12458493B2 (en) 2017-09-19 2025-11-04 Cardiovalve Ltd. Prosthetic heart valve and delivery systems and methods
US10835221B2 (en) 2017-11-02 2020-11-17 Valtech Cardio, Ltd. Implant-cinching devices and systems
US11135062B2 (en) 2017-11-20 2021-10-05 Valtech Cardio Ltd. Cinching of dilated heart muscle
ES2953556T3 (es) 2017-12-23 2023-11-14 Teleflex Life Sciences Ltd Aparato de acoplamiento de tejido expandible
CN117796968A (zh) 2018-01-07 2024-04-02 苏州杰成医疗科技有限公司 瓣膜假体
CN210582753U (zh) 2018-01-07 2020-05-22 苏州杰成医疗科技有限公司 用于输送瓣膜假体的输送系统
US10159570B1 (en) 2018-01-09 2018-12-25 Edwards Lifesciences Corporation Native valve repair devices and procedures
IL275010B2 (en) 2018-01-09 2024-11-01 Edwards Lifesciences Corp Native valve repair devices and procedures
US10245144B1 (en) 2018-01-09 2019-04-02 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10238493B1 (en) 2018-01-09 2019-03-26 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10136993B1 (en) 2018-01-09 2018-11-27 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10111751B1 (en) 2018-01-09 2018-10-30 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10076415B1 (en) 2018-01-09 2018-09-18 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10231837B1 (en) 2018-01-09 2019-03-19 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10973639B2 (en) 2018-01-09 2021-04-13 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10123873B1 (en) 2018-01-09 2018-11-13 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10507109B2 (en) 2018-01-09 2019-12-17 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10105222B1 (en) 2018-01-09 2018-10-23 Edwards Lifesciences Corporation Native valve repair devices and procedures
EP3743015A1 (en) 2018-01-24 2020-12-02 Valtech Cardio, Ltd. Contraction of an annuloplasty structure
WO2019147846A2 (en) 2018-01-25 2019-08-01 Edwards Lifesciences Corporation Delivery system for aided replacement valve recapture and repositioning post- deployment
EP3743014B1 (en) 2018-01-26 2023-07-19 Edwards Lifesciences Innovation (Israel) Ltd. Techniques for facilitating heart valve tethering and chord replacement
US11051934B2 (en) 2018-02-28 2021-07-06 Edwards Lifesciences Corporation Prosthetic mitral valve with improved anchors and seal
US11026791B2 (en) 2018-03-20 2021-06-08 Medtronic Vascular, Inc. Flexible canopy valve repair systems and methods of use
US11285003B2 (en) 2018-03-20 2022-03-29 Medtronic Vascular, Inc. Prolapse prevention device and methods of use thereof
US11389297B2 (en) 2018-04-12 2022-07-19 Edwards Lifesciences Corporation Mitral valve spacer device
US11207181B2 (en) 2018-04-18 2021-12-28 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
CN112423709A (zh) * 2018-05-18 2021-02-26 万能医药公司 心脏瓣膜修复的方法和装置
WO2019224577A1 (en) 2018-05-23 2019-11-28 Sorin Group Italia S.R.L. A cardiac valve prosthesis
EP3796872B1 (en) 2018-05-23 2022-07-20 Corcym S.r.l. A device for the in-situ delivery of heart valve prostheses
MX2020013973A (es) 2018-07-12 2021-06-15 Valtech Cardio Ltd Sistemas de anuloplastia y herramientas de bloqueo para ello.
US10945844B2 (en) 2018-10-10 2021-03-16 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US12102531B2 (en) 2018-10-22 2024-10-01 Evalve, Inc. Tissue cutting systems, devices and methods
US12440301B2 (en) 2018-11-07 2025-10-14 Teleflex Life Sciences Llc System for delivery of a fiducial marker
AU2019374743B2 (en) 2018-11-08 2022-03-03 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
EP3880124B1 (en) * 2018-11-14 2025-01-01 Half Moon Medical, Inc. Leaflet extension for cardiac valve leaflet
WO2020106705A1 (en) 2018-11-20 2020-05-28 Edwards Lifesciences Corporation Deployment tools and methods for delivering a device to a native heart valve
EP3883499A1 (en) 2018-11-21 2021-09-29 Edwards Lifesciences Corporation Heart valve sealing devices, delivery devices therefor, and retrieval devices
KR20250081946A (ko) 2018-11-29 2025-06-05 에드워즈 라이프사이언시스 코포레이션 카테터 삽입 방법 및 장치
CN113677298A (zh) 2019-02-06 2021-11-19 Inqb8医疗科技有限责任公司 心内左心房以及双支持系统
BR122021018588A2 (pt) 2019-02-14 2021-10-13 Edwards Lifesciences Corporation "fecho para um dispositivo de tratamento de válvula cardíaca"
EP3930629A1 (en) 2019-02-25 2022-01-05 Edwards Lifesciences Corporation Heart valve sealing devices
EP3934591A4 (en) 2019-03-08 2022-11-23 Neovasc Tiara Inc. RETRIEVABLE PROSTHETIC RELEASE SYSTEM
EP3946163B1 (en) 2019-04-01 2025-08-20 Neovasc Tiara Inc. Controllably deployable prosthetic valve
AU2020271896B2 (en) 2019-04-10 2022-10-13 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
WO2020210794A1 (en) 2019-04-12 2020-10-15 W. L. Gore & Associates, Inc. Valve with multi-part frame and associated resilient bridging features
WO2020219459A1 (en) 2019-04-23 2020-10-29 Edwards Lifesciences Corporation Motorized implant delivery system
CN114025813B (zh) 2019-05-20 2024-05-14 内奥瓦斯克迪亚拉公司 具有止血机构的引入器
BR112021023706A2 (pt) 2019-05-29 2022-03-22 Valtech Cardio Ltd Sistemas e métodos de manuseio de ancoragem de tecido
AU2020295566B2 (en) 2019-06-20 2023-07-20 Neovasc Tiara Inc. Low profile prosthetic mitral valve
CN114449979B (zh) 2019-07-15 2025-08-19 埃瓦尔维公司 独立的近端元件致动方法
CA3146859A1 (en) 2019-07-16 2021-01-21 Heartchord Medical, Inc. Tissue remodeling systems and methods
US12364606B2 (en) 2019-07-23 2025-07-22 Edwards Lifesciences Innovation (Israel) Ltd. Fluoroscopic visualization of heart valve anatomy
CA3143177A1 (en) 2019-08-28 2021-03-04 Valtech Cardio, Ltd. Low-profile steerable catheter
JP2022546160A (ja) 2019-08-30 2022-11-04 エドワーズ ライフサイエンシーズ イノベーション （イスラエル） リミテッド アンカーチャネル先端
KR20220066398A (ko) 2019-09-25 2022-05-24 카디악 임플란츠 엘엘씨 심장 판막 고리 감소 시스템
AU2020375903B2 (en) 2019-10-29 2025-10-30 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty and tissue anchor technologies
US12414811B2 (en) 2020-05-06 2025-09-16 Evalve, Inc. Devices and methods for leaflet cutting
US12048448B2 (en) 2020-05-06 2024-07-30 Evalve, Inc. Leaflet grasping and cutting device
US12171486B2 (en) 2020-05-06 2024-12-24 Evalve, Inc. Devices and methods for clip separation
US12178444B2 (en) 2020-05-06 2024-12-31 Evalve, Inc. Clip removal systems and methods
US12171485B2 (en) 2020-05-06 2024-12-24 Evalve, Inc. Systems and methods for leaflet cutting using a hook catheter
CA3183115A1 (en) 2020-05-20 2021-11-25 Cardiac Implants Llc Reducing the diameter of a cardiac valve annulus with independent control over each of the anchors that are launched into the annulus
CA3182316A1 (en) 2020-06-19 2021-12-23 Edwards Lifesciences Innovation (Israel) Ltd. Self-stopping tissue anchors
IL299776A (en) * 2020-07-21 2023-03-01 The Usa As Represented By The Sec Dep Of Health And Human Services Systems and methods for mitral valve replacement
EP3989844B1 (en) 2020-08-03 2023-09-06 Teleflex Life Sciences Limited Handle and cartridge system for medical interventions
EP4247302A1 (en) 2020-11-20 2023-09-27 Half Moon Medical, Inc. Tricuspid valve repair devices and associated systems and methods
US12357459B2 (en) 2020-12-03 2025-07-15 Cardiovalve Ltd. Transluminal delivery system
WO2022132571A1 (en) 2020-12-14 2022-06-23 Cardiac Dimensions Pty. Ltd. Modular pre-loaded medical implants and delivery systems
WO2022132569A1 (en) 2020-12-18 2022-06-23 Edwards Lifesciences Corporation Storage jar assembly for aprosthetic heart valve
US11712237B1 (en) * 2022-07-20 2023-08-01 Samothrace Medical Innovations, Inc. Anatomical tissue anchor and related methods
WO2024102411A1 (en) 2022-11-09 2024-05-16 Jenavalve Technology, Inc. Catheter system for sequential deployment of an expandable implant
USD1071198S1 (en) 2023-06-28 2025-04-15 Edwards Lifesciences Corporation Cradle

Citations (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US191528A (en) * 1877-06-05 Improvement in check-row attachments to seed-planters
US4056854A (en) * 1976-09-28 1977-11-08 The United States Of America As Represented By The Department Of Health, Education And Welfare Aortic heart valve catheter
US4275469A (en) * 1979-12-13 1981-06-30 Shelhigh Inc. Prosthetic heart valve
US4994069A (en) * 1988-11-02 1991-02-19 Target Therapeutics Vaso-occlusion coil and method
US5360444A (en) * 1991-03-19 1994-11-01 Kenji Kusuhara Occluder supporter and a method of attachment thereof
US5370685A (en) * 1991-07-16 1994-12-06 Stanford Surgical Technologies, Inc. Endovascular aortic valve replacement
US5545241A (en) * 1995-01-17 1996-08-13 Donaldson Company, Inc. Air cleaner
US5716397A (en) * 1996-12-06 1998-02-10 Medtronic, Inc. Annuloplasty device with removable stiffening element
US5776189A (en) * 1997-03-05 1998-07-07 Khalid; Naqeeb Cardiac valvular support prosthesis
US5792155A (en) * 1991-07-16 1998-08-11 Van Cleef; Jean-Francois Process for partially or totally flattening a vein
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US5961440A (en) * 1997-01-02 1999-10-05 Myocor, Inc. Heart wall tension reduction apparatus and method
US6050936A (en) * 1997-01-02 2000-04-18 Myocor, Inc. Heart wall tension reduction apparatus
US6077214A (en) * 1998-07-29 2000-06-20 Myocor, Inc. Stress reduction apparatus and method
US6102932A (en) * 1998-12-15 2000-08-15 Micrus Corporation Intravascular device push wire delivery system
US6149695A (en) * 1998-03-09 2000-11-21 Adia; Moosa Mahomed Abrasive body
US6183411B1 (en) * 1998-09-21 2001-02-06 Myocor, Inc. External stress reduction device and method
US6210432B1 (en) * 1999-06-29 2001-04-03 Jan Otto Solem Device and method for treatment of mitral insufficiency
US6260552B1 (en) * 1998-07-29 2001-07-17 Myocor, Inc. Transventricular implant tools and devices
US20010010017A1 (en) * 1996-12-31 2001-07-26 Brice Letac Alve prosthesis for implantation in body channels
US6287339B1 (en) * 1999-05-27 2001-09-11 Sulzer Carbomedics Inc. Sutureless heart valve prosthesis
US20010021872A1 (en) * 1999-12-31 2001-09-13 Bailey Steven R. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US6299637B1 (en) * 1999-08-20 2001-10-09 Samuel M. Shaolian Transluminally implantable venous valve
US6312464B1 (en) * 1999-04-28 2001-11-06 NAVIA JOSé L. Method of implanting a stentless cardiac valve prosthesis
US6312465B1 (en) * 1999-07-23 2001-11-06 Sulzer Carbomedics Inc. Heart valve prosthesis with a resiliently deformable retaining member
US20010051824A1 (en) * 2000-04-07 2001-12-13 Hopkins Richard A. Cardiac valve replacement
US6332893B1 (en) * 1997-12-17 2001-12-25 Myocor, Inc. Valve to myocardium tension members device and method
US6338470B1 (en) * 2000-12-05 2002-01-15 Kevin L. Steely Powered lift for raising a two-wheeled vehicle
US6338740B1 (en) * 1999-01-26 2002-01-15 Edwards Lifesciences Corporation Flexible heart valve leaflets
US20020032481A1 (en) * 2000-09-12 2002-03-14 Shlomo Gabbay Heart valve prosthesis and sutureless implantation of a heart valve prosthesis
US20020065554A1 (en) * 2000-10-25 2002-05-30 Streeter Richard B. Mitral shield
US6419695B1 (en) * 2000-05-22 2002-07-16 Shlomo Gabbay Cardiac prosthesis for helping improve operation of a heart valve
US6419696B1 (en) * 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
US20020094573A1 (en) * 1999-10-19 2002-07-18 Eugene Bell Cardiovascular components for transplantation and methods of making thereof
US6440164B1 (en) * 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
US20020123802A1 (en) * 2000-02-02 2002-09-05 Snyders Robert V. Artificial heart valve, implantation instrument and method therefor
US20020129820A1 (en) * 2001-03-15 2002-09-19 Medtronic, Inc Annuloplasty band and method
US6454799B1 (en) * 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US20020138138A1 (en) * 2001-03-23 2002-09-26 Jibin Yang Rolled minimally-invasive heart valves and methods of use
US6503272B2 (en) * 2001-03-21 2003-01-07 Cordis Corporation Stent-based venous valves
US6537198B1 (en) * 2000-03-21 2003-03-25 Myocor, Inc. Splint assembly for improving cardiac function in hearts, and method for implanting the splint assembly
US6629534B1 (en) * 1999-04-09 2003-10-07 Evalve, Inc. Methods and apparatus for cardiac valve repair
US20030191528A1 (en) * 2000-06-02 2003-10-09 Quijano Rodolfo C. Expandable medical implant and percutaneous delivery
US20030233022A1 (en) * 2002-06-12 2003-12-18 Vidlund Robert M. Devices and methods for heart valve treatment
US6676699B2 (en) * 2002-04-26 2004-01-13 Medtronic Ave, Inc Stent graft with integrated valve device and method
US6702826B2 (en) * 2000-06-23 2004-03-09 Viacor, Inc. Automated annular plication for mitral valve repair
US6764510B2 (en) * 2002-01-09 2004-07-20 Myocor, Inc. Devices and methods for heart valve treatment
US20040148019A1 (en) * 2002-11-12 2004-07-29 Vidlund Robert M. Devices and methods for heart valve treatment
US20040162610A1 (en) * 2001-12-26 2004-08-19 Tradinco Ab Mitral and tricuspid vlave repair
US6893459B1 (en) * 2000-09-20 2005-05-17 Ample Medical, Inc. Heart valve annulus device and method of using same
US6913608B2 (en) * 2000-10-23 2005-07-05 Viacor, Inc. Automated annular plication for mitral valve repair
US6945978B1 (en) * 2002-11-15 2005-09-20 Advanced Cardiovascular Systems, Inc. Heart valve catheter
US7004176B2 (en) * 2003-10-17 2006-02-28 Edwards Lifesciences Ag Heart valve leaflet locator
US20060241745A1 (en) * 2005-04-21 2006-10-26 Solem Jan O Blood flow controlling apparatus
US7166126B2 (en) * 2000-02-02 2007-01-23 Paul A. Spence Heart valve repair apparatus and methods

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491986A (en) * 1976-05-12 1985-01-08 Shlomo Gabbay Heart valve
US5830224A (en) 1996-03-15 1998-11-03 Beth Israel Deaconess Medical Center Catheter apparatus and methodology for generating a fistula on-demand between closely associated blood vessels at a pre-chosen anatomic site in-vivo
US6045497A (en) 1997-01-02 2000-04-04 Myocor, Inc. Heart wall tension reduction apparatus and method
US7452371B2 (en) * 1999-06-02 2008-11-18 Cook Incorporated Implantable vascular device
US6626899B2 (en) * 1999-06-25 2003-09-30 Nidus Medical, Llc Apparatus and methods for treating tissue
US6402781B1 (en) 2000-01-31 2002-06-11 Mitralife Percutaneous mitral annuloplasty and cardiac reinforcement
WO2004030570A2 (en) * 2002-10-01 2004-04-15 Ample Medical, Inc. Devices for retaining native heart valve leaflet
WO2004030568A2 (en) * 2002-10-01 2004-04-15 Ample Medical, Inc. Device and method for repairing a native heart valve leaflet
US6602288B1 (en) * 2000-10-05 2003-08-05 Edwards Lifesciences Corporation Minimally-invasive annuloplasty repair segment delivery template, system and method of use
US6723038B1 (en) 2000-10-06 2004-04-20 Myocor, Inc. Methods and devices for improving mitral valve function
US6616684B1 (en) 2000-10-06 2003-09-09 Myocor, Inc. Endovascular splinting devices and methods
EP1367962A4 (en) 2001-02-05 2008-10-01 Viacor Inc METHOD AND APPARATUS FOR AMINING THE FUNCTION OF THE MITRAL VALVE
CN101108144A (zh) * 2001-10-01 2008-01-23 安普尔医药公司 心脏瓣膜治疗的方法和装置
ATE418938T1 (de) * 2002-10-01 2009-01-15 Ample Medical Inc Vorrichtungen und systeme zur umformung eines herzklappen-annulus
US8052751B2 (en) * 2003-07-02 2011-11-08 Flexcor, Inc. Annuloplasty rings for repairing cardiac valves
EP1855623B1 (en) * 2005-02-07 2019-04-17 Evalve, Inc. Devices for cardiac valve repair
EP1991168B1 (en) * 2006-02-16 2016-01-27 Transcatheter Technologies GmbH Minimally invasive heart valve replacement

Patent Citations (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US191528A (en) * 1877-06-05 Improvement in check-row attachments to seed-planters
US4056854A (en) * 1976-09-28 1977-11-08 The United States Of America As Represented By The Department Of Health, Education And Welfare Aortic heart valve catheter
US4275469A (en) * 1979-12-13 1981-06-30 Shelhigh Inc. Prosthetic heart valve
US4994069A (en) * 1988-11-02 1991-02-19 Target Therapeutics Vaso-occlusion coil and method
US5360444A (en) * 1991-03-19 1994-11-01 Kenji Kusuhara Occluder supporter and a method of attachment thereof
US5370685A (en) * 1991-07-16 1994-12-06 Stanford Surgical Technologies, Inc. Endovascular aortic valve replacement
US6338735B1 (en) * 1991-07-16 2002-01-15 John H. Stevens Methods for removing embolic material in blood flowing through a patient's ascending aorta
US5792155A (en) * 1991-07-16 1998-08-11 Van Cleef; Jean-Francois Process for partially or totally flattening a vein
US5545241B1 (en) * 1995-01-17 1999-09-28 Donaldson Co Inc Air cleaner
US5545241A (en) * 1995-01-17 1996-08-13 Donaldson Company, Inc. Air cleaner
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US5716397A (en) * 1996-12-06 1998-02-10 Medtronic, Inc. Annuloplasty device with removable stiffening element
US20010010017A1 (en) * 1996-12-31 2001-07-26 Brice Letac Alve prosthesis for implantation in body channels
US20030014104A1 (en) * 1996-12-31 2003-01-16 Alain Cribier Value prosthesis for implantation in body channels
US5961440A (en) * 1997-01-02 1999-10-05 Myocor, Inc. Heart wall tension reduction apparatus and method
US6050936A (en) * 1997-01-02 2000-04-18 Myocor, Inc. Heart wall tension reduction apparatus
US6165119A (en) * 1997-01-02 2000-12-26 Myocor, Inc. Heart wall tension reduction apparatus and method
US5776189A (en) * 1997-03-05 1998-07-07 Khalid; Naqeeb Cardiac valvular support prosthesis
US6332893B1 (en) * 1997-12-17 2001-12-25 Myocor, Inc. Valve to myocardium tension members device and method
US6149695A (en) * 1998-03-09 2000-11-21 Adia; Moosa Mahomed Abrasive body
US6077214A (en) * 1998-07-29 2000-06-20 Myocor, Inc. Stress reduction apparatus and method
US6260552B1 (en) * 1998-07-29 2001-07-17 Myocor, Inc. Transventricular implant tools and devices
US6183411B1 (en) * 1998-09-21 2001-02-06 Myocor, Inc. External stress reduction device and method
US6102932A (en) * 1998-12-15 2000-08-15 Micrus Corporation Intravascular device push wire delivery system
US6338740B1 (en) * 1999-01-26 2002-01-15 Edwards Lifesciences Corporation Flexible heart valve leaflets
US6629534B1 (en) * 1999-04-09 2003-10-07 Evalve, Inc. Methods and apparatus for cardiac valve repair
US6312464B1 (en) * 1999-04-28 2001-11-06 NAVIA JOSé L. Method of implanting a stentless cardiac valve prosthesis
US6287339B1 (en) * 1999-05-27 2001-09-11 Sulzer Carbomedics Inc. Sutureless heart valve prosthesis
US6210432B1 (en) * 1999-06-29 2001-04-03 Jan Otto Solem Device and method for treatment of mitral insufficiency
US6312465B1 (en) * 1999-07-23 2001-11-06 Sulzer Carbomedics Inc. Heart valve prosthesis with a resiliently deformable retaining member
US6299637B1 (en) * 1999-08-20 2001-10-09 Samuel M. Shaolian Transluminally implantable venous valve
US20020094573A1 (en) * 1999-10-19 2002-07-18 Eugene Bell Cardiovascular components for transplantation and methods of making thereof
US6440164B1 (en) * 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
US6685739B2 (en) * 1999-10-21 2004-02-03 Scimed Life Systems, Inc. Implantable prosthetic valve
US6458153B1 (en) * 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US20010021872A1 (en) * 1999-12-31 2001-09-13 Bailey Steven R. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US20020123802A1 (en) * 2000-02-02 2002-09-05 Snyders Robert V. Artificial heart valve, implantation instrument and method therefor
US7166126B2 (en) * 2000-02-02 2007-01-23 Paul A. Spence Heart valve repair apparatus and methods
US6537198B1 (en) * 2000-03-21 2003-03-25 Myocor, Inc. Splint assembly for improving cardiac function in hearts, and method for implanting the splint assembly
US6454799B1 (en) * 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US20010051824A1 (en) * 2000-04-07 2001-12-13 Hopkins Richard A. Cardiac valve replacement
US6419695B1 (en) * 2000-05-22 2002-07-16 Shlomo Gabbay Cardiac prosthesis for helping improve operation of a heart valve
US20030191528A1 (en) * 2000-06-02 2003-10-09 Quijano Rodolfo C. Expandable medical implant and percutaneous delivery
US6702826B2 (en) * 2000-06-23 2004-03-09 Viacor, Inc. Automated annular plication for mitral valve repair
US6419696B1 (en) * 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
US20020032481A1 (en) * 2000-09-12 2002-03-14 Shlomo Gabbay Heart valve prosthesis and sutureless implantation of a heart valve prosthesis
US20030040792A1 (en) * 2000-09-12 2003-02-27 Shlomo Gabbay Heart valve prosthesis and sutureless implantation of a heart valve prosthesis
US6893459B1 (en) * 2000-09-20 2005-05-17 Ample Medical, Inc. Heart valve annulus device and method of using same
US6913608B2 (en) * 2000-10-23 2005-07-05 Viacor, Inc. Automated annular plication for mitral valve repair
US20020065554A1 (en) * 2000-10-25 2002-05-30 Streeter Richard B. Mitral shield
US7070618B2 (en) * 2000-10-25 2006-07-04 Viacor, Inc. Mitral shield
US6338470B1 (en) * 2000-12-05 2002-01-15 Kevin L. Steely Powered lift for raising a two-wheeled vehicle
US20020129820A1 (en) * 2001-03-15 2002-09-19 Medtronic, Inc Annuloplasty band and method
US6503272B2 (en) * 2001-03-21 2003-01-07 Cordis Corporation Stent-based venous valves
US20020138138A1 (en) * 2001-03-23 2002-09-26 Jibin Yang Rolled minimally-invasive heart valves and methods of use
US20040162610A1 (en) * 2001-12-26 2004-08-19 Tradinco Ab Mitral and tricuspid vlave repair
US6764510B2 (en) * 2002-01-09 2004-07-20 Myocor, Inc. Devices and methods for heart valve treatment
US7077862B2 (en) * 2002-01-09 2006-07-18 Myocor, Inc. Devices and methods for heart valve treatment
US6676699B2 (en) * 2002-04-26 2004-01-13 Medtronic Ave, Inc Stent graft with integrated valve device and method
US20030233022A1 (en) * 2002-06-12 2003-12-18 Vidlund Robert M. Devices and methods for heart valve treatment
US20040148019A1 (en) * 2002-11-12 2004-07-29 Vidlund Robert M. Devices and methods for heart valve treatment
US6945978B1 (en) * 2002-11-15 2005-09-20 Advanced Cardiovascular Systems, Inc. Heart valve catheter
US7004176B2 (en) * 2003-10-17 2006-02-28 Edwards Lifesciences Ag Heart valve leaflet locator
US20060241745A1 (en) * 2005-04-21 2006-10-26 Solem Jan O Blood flow controlling apparatus

Cited By (194)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8460173B2 (en) 1997-01-02 2013-06-11 Edwards Lifesciences, Llc Heart wall tension reduction apparatus and method
US7883539B2 (en) 1997-01-02 2011-02-08 Edwards Lifesciences Llc Heart wall tension reduction apparatus and method
US8267852B2 (en) 1997-01-02 2012-09-18 Edwards Lifesciences, Llc Heart wall tension reduction apparatus and method
US7267686B2 (en) 1999-10-21 2007-09-11 Boston Scientific Scimed, Inc Implantable prosthetic valve
US9861475B2 (en) * 2000-09-20 2018-01-09 Mvrx Inc. Devices, systems, and methods for reshaping a heart valve annulus
US7931684B2 (en) * 2000-10-05 2011-04-26 Edwards Lifesciences Corporation Minimally-invasive annuloplasty repair segment delivery system
US20050171601A1 (en) * 2000-10-05 2005-08-04 Cosgrove Delos M. Minimally-invasive annuloplasty repair segment delivery system
US9198757B2 (en) 2000-10-06 2015-12-01 Edwards Lifesciences, Llc Methods and devices for improving mitral valve function
US7776053B2 (en) 2000-10-26 2010-08-17 Boston Scientific Scimed, Inc. Implantable valve system
US8070805B2 (en) 2002-01-09 2011-12-06 Edwards Lifesciences Llc Devices and methods for heart valve treatment
US7678145B2 (en) 2002-01-09 2010-03-16 Edwards Lifesciences Llc Devices and methods for heart valve treatment
US8506624B2 (en) 2002-01-09 2013-08-13 Edwards Lifesciences, Llc Devices and methods for heart valve treatment
US7682385B2 (en) 2002-04-03 2010-03-23 Boston Scientific Corporation Artificial valve
US7416557B2 (en) 2002-10-24 2008-08-26 Boston Scientific Scimed, Inc. Venous valve apparatus and method
US7666224B2 (en) 2002-11-12 2010-02-23 Edwards Lifesciences Llc Devices and methods for heart valve treatment
US7780627B2 (en) 2002-12-30 2010-08-24 Boston Scientific Scimed, Inc. Valve treatment catheter and methods
US7244242B2 (en) 2002-12-30 2007-07-17 Boston Scientific Scimed, Inc. Valve treatment catheter and methods
US9301843B2 (en) 2003-12-19 2016-04-05 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US8128681B2 (en) 2003-12-19 2012-03-06 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US10869764B2 (en) 2003-12-19 2020-12-22 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US8721717B2 (en) 2003-12-19 2014-05-13 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7854761B2 (en) 2003-12-19 2010-12-21 Boston Scientific Scimed, Inc. Methods for venous valve replacement with a catheter
US9918834B2 (en) 2004-09-02 2018-03-20 Boston Scientific Scimed, Inc. Cardiac valve, system and method
US8932349B2 (en) 2004-09-02 2015-01-13 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US7566343B2 (en) 2004-09-02 2009-07-28 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US8002824B2 (en) 2004-09-02 2011-08-23 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US7854755B2 (en) 2005-02-01 2010-12-21 Boston Scientific Scimed, Inc. Vascular catheter, system, and method
US7780722B2 (en) 2005-02-07 2010-08-24 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7670368B2 (en) 2005-02-07 2010-03-02 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US9370419B2 (en) 2005-02-23 2016-06-21 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US9808341B2 (en) 2005-02-23 2017-11-07 Boston Scientific Scimed Inc. Valve apparatus, system and method
US7867274B2 (en) 2005-02-23 2011-01-11 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US8512399B2 (en) 2005-04-15 2013-08-20 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US9861473B2 (en) 2005-04-15 2018-01-09 Boston Scientific Scimed Inc. Valve apparatus, system and method
US10912546B2 (en) 2005-04-22 2021-02-09 Laurent Schaller Catheter-based tissue remodeling devices and methods
US10966696B2 (en) 2005-04-22 2021-04-06 Laurent Schaller Catheter-based tissue remodeling devices and methods
US20060247672A1 (en) * 2005-04-27 2006-11-02 Vidlund Robert M Devices and methods for pericardial access
US8012198B2 (en) 2005-06-10 2011-09-06 Boston Scientific Scimed, Inc. Venous valve, system, and method
US9028542B2 (en) 2005-06-10 2015-05-12 Boston Scientific Scimed, Inc. Venous valve, system, and method
US11337812B2 (en) 2005-06-10 2022-05-24 Boston Scientific Scimed, Inc. Venous valve, system and method
US7951189B2 (en) 2005-09-21 2011-05-31 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US10548734B2 (en) 2005-09-21 2020-02-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US7569071B2 (en) 2005-09-21 2009-08-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US8672997B2 (en) 2005-09-21 2014-03-18 Boston Scientific Scimed, Inc. Valve with sinus
US9474609B2 (en) 2005-09-21 2016-10-25 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US8460365B2 (en) 2005-09-21 2013-06-11 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US7799038B2 (en) 2006-01-20 2010-09-21 Boston Scientific Scimed, Inc. Translumenal apparatus, system, and method
US8323332B2 (en) 2006-03-01 2012-12-04 Cook Medical Technologies Llc Methods of reducing retrograde flow
US20070208417A1 (en) * 2006-03-01 2007-09-06 Cook Incorporated Methods of reducing retrograde flow
US20100131053A1 (en) * 2006-03-01 2010-05-27 Cook Incorporated Methods of reducing retrograde flow
US9101468B2 (en) 2006-03-01 2015-08-11 Cook Medical Technologies Llc Methods of reducing retrograde flow
US7648527B2 (en) 2006-03-01 2010-01-19 Cook Incorporated Methods of reducing retrograde flow
US20120191182A1 (en) * 2006-06-01 2012-07-26 Edwards Lifesciences Corporation Prosthetic insert for treating a mitral valve
US8968395B2 (en) * 2006-06-01 2015-03-03 Edwards Lifesciences Corporation Prosthetic insert for treating a mitral valve
US20080126131A1 (en) * 2006-07-17 2008-05-29 Walgreen Co. Predictive Modeling And Risk Stratification Of A Medication Therapy Regimen
US20100249920A1 (en) * 2007-01-08 2010-09-30 Millipede Llc Reconfiguring heart features
US20090182419A1 (en) * 2007-01-08 2009-07-16 Millipede Llc Reconfiguring heart features
US20080167713A1 (en) * 2007-01-08 2008-07-10 Bolling Steven F Reconfiguring Heart Features
US9192471B2 (en) * 2007-01-08 2015-11-24 Millipede, Inc. Device for translumenal reshaping of a mitral valve annulus
US8348999B2 (en) 2007-01-08 2013-01-08 California Institute Of Technology In-situ formation of a valve
US8133270B2 (en) 2007-01-08 2012-03-13 California Institute Of Technology In-situ formation of a valve
US20100121433A1 (en) * 2007-01-08 2010-05-13 Millipede Llc, A Corporation Of Michigan Reconfiguring heart features
US10226344B2 (en) 2007-02-05 2019-03-12 Boston Scientific Scimed, Inc. Percutaneous valve, system and method
US7967853B2 (en) 2007-02-05 2011-06-28 Boston Scientific Scimed, Inc. Percutaneous valve, system and method
US11504239B2 (en) 2007-02-05 2022-11-22 Boston Scientific Scimed, Inc. Percutaneous valve, system and method
US9421083B2 (en) 2007-02-05 2016-08-23 Boston Scientific Scimed Inc. Percutaneous valve, system and method
US8470023B2 (en) 2007-02-05 2013-06-25 Boston Scientific Scimed, Inc. Percutaneous valve, system, and method
US8828079B2 (en) 2007-07-26 2014-09-09 Boston Scientific Scimed, Inc. Circulatory valve, system and method
US7892276B2 (en) 2007-12-21 2011-02-22 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
US8137394B2 (en) 2007-12-21 2012-03-20 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
US8414641B2 (en) 2007-12-21 2013-04-09 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
US8956406B2 (en) 2008-04-16 2015-02-17 Heart Repair Technologies, Inc. Transvalvular intraanular band and chordae cutting for ischemic and dilated cardiomyopathy
US11083579B2 (en) 2008-04-16 2021-08-10 Heart Repair Technologies, Inc. Transvalvular intraanular band and chordae cutting for ischemic and dilated cardiomyopathy
US10219903B2 (en) 2008-04-16 2019-03-05 Heart Repair Technologies, Inc. Transvalvular intraanular band and chordae cutting for ischemic and dilated cardiomyopathy
US10238488B2 (en) 2008-04-16 2019-03-26 Heart Repair Technologies, Inc. Percutaneous transvalvular intraannular band for mitral valve repair
US8262725B2 (en) 2008-04-16 2012-09-11 Cardiovascular Technologies, Llc Transvalvular intraannular band for valve repair
US10456259B2 (en) 2008-04-16 2019-10-29 Heart Repair Technologies, Inc. Transvalvular intraannular band for mitral valve repair
US20090264995A1 (en) * 2008-04-16 2009-10-22 Subramanian Valavanur A Transvalvular intraannular band for valve repair
US20100131057A1 (en) * 2008-04-16 2010-05-27 Cardiovascular Technologies, Llc Transvalvular intraannular band for aortic valve repair
US20100076550A1 (en) * 2008-04-16 2010-03-25 Cardiovascular Technologies, Llc Transvalvular intraannular band for valve repair
US12201526B2 (en) 2008-04-16 2025-01-21 Heart Repair Technologies, Inc. Percutaneous transvalvular intraannular band for mitral valve repair
US9468526B2 (en) 2008-04-16 2016-10-18 Heart Repair Technologies, Inc. Percutaneous transvalvular intraannular band for mitral valve repair
US8961597B2 (en) 2008-04-16 2015-02-24 Heart Repair Technologies, Inc. Percutaneous transvalvular intraannular band for mitral valve repair
US20100121437A1 (en) * 2008-04-16 2010-05-13 Cardiovascular Technologies, Llc Transvalvular intraannular band and chordae cutting for ischemic and dilated cardiomyopathy
US8480732B2 (en) 2008-04-16 2013-07-09 Heart Repair Technologies, Inc. Transvalvular intraannular band for valve repair
US20100121435A1 (en) * 2008-04-16 2010-05-13 Cardiovascular Technologies, Llc Percutaneous transvalvular intrannular band for mitral valve repair
US11013599B2 (en) 2008-04-16 2021-05-25 Heart Repair Technologies, Inc. Percutaneous transvalvular intraannular band for mitral valve repair
US9585753B2 (en) 2008-04-16 2017-03-07 Heart Repair Technologies, Inc. Transvalvular intraannular band for valve repair
US9615925B2 (en) 2008-04-16 2017-04-11 Heart Repair Technologies, Inc. Transvalvular intraanular band for ischemic and dilated cardiomyopathy
US9168137B2 (en) 2008-04-16 2015-10-27 Heart Repair Technologies, Inc. Transvalvular intraannular band for aortic valve repair
US8163010B1 (en) 2008-06-03 2012-04-24 Cardica, Inc. Staple-based heart valve treatment
US8496671B1 (en) 2010-06-16 2013-07-30 Cardica, Inc. Mitral valve treatment
US8888794B2 (en) 2010-06-16 2014-11-18 Cardica, Inc. Mitral valve treatment
US9795480B2 (en) 2010-08-24 2017-10-24 Millipede, Inc. Reconfiguring tissue features of a heart annulus
US9421098B2 (en) 2010-12-23 2016-08-23 Twelve, Inc. System for mitral valve repair and replacement
US12178702B2 (en) 2010-12-23 2024-12-31 Twelve, Inc. System for mitral valve repair and replacement
US11571303B2 (en) 2010-12-23 2023-02-07 Twelve, Inc. System for mitral valve repair and replacement
US10517725B2 (en) 2010-12-23 2019-12-31 Twelve, Inc. System for mitral valve repair and replacement
US9770331B2 (en) 2010-12-23 2017-09-26 Twelve, Inc. System for mitral valve repair and replacement
EP2478868A1 (en) 2011-01-25 2012-07-25 The Provost, Fellows, Foundation Scholars, and the other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Implant device
WO2012101190A1 (en) 2011-01-25 2012-08-02 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Implant device
US9572662B2 (en) 2011-06-21 2017-02-21 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10751173B2 (en) 2011-06-21 2020-08-25 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US9585751B2 (en) 2011-06-21 2017-03-07 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10028827B2 (en) 2011-06-21 2018-07-24 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10034750B2 (en) 2011-06-21 2018-07-31 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US11523900B2 (en) 2011-06-21 2022-12-13 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US11712334B2 (en) 2011-06-21 2023-08-01 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US9125740B2 (en) 2011-06-21 2015-09-08 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US9579196B2 (en) 2011-06-21 2017-02-28 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
US10335278B2 (en) 2011-10-19 2019-07-02 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US11826249B2 (en) 2011-10-19 2023-11-28 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9295552B2 (en) 2011-10-19 2016-03-29 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US11497603B2 (en) 2011-10-19 2022-11-15 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US11617648B2 (en) 2011-10-19 2023-04-04 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US11628063B2 (en) 2011-10-19 2023-04-18 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US11202704B2 (en) 2011-10-19 2021-12-21 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10299917B2 (en) 2011-10-19 2019-05-28 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10299927B2 (en) 2011-10-19 2019-05-28 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US11197758B2 (en) 2011-10-19 2021-12-14 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9039757B2 (en) 2011-10-19 2015-05-26 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9034032B2 (en) 2011-10-19 2015-05-19 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10052204B2 (en) 2011-10-19 2018-08-21 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10016271B2 (en) 2011-10-19 2018-07-10 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US12370042B2 (en) 2011-10-19 2025-07-29 Twelve, Inc. Devices, systems and methods for heart valve replacement
US10945835B2 (en) 2011-10-19 2021-03-16 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10702380B2 (en) 2011-10-19 2020-07-07 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9763780B2 (en) 2011-10-19 2017-09-19 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9901443B2 (en) 2011-10-19 2018-02-27 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9034033B2 (en) 2011-10-19 2015-05-19 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10940167B2 (en) 2012-02-10 2021-03-09 Cvdevices, Llc Methods and uses of biological tissues for various stent and other medical applications
US11129714B2 (en) 2012-03-01 2021-09-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US9579198B2 (en) 2012-03-01 2017-02-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US12161552B2 (en) 2012-03-01 2024-12-10 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US10258468B2 (en) 2012-03-01 2019-04-16 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US10849755B2 (en) 2012-09-14 2020-12-01 Boston Scientific Scimed, Inc. Mitral valve inversion prostheses
US12419750B2 (en) 2012-09-14 2025-09-23 Boston Scientific Scimed, Inc. Cardiac prosthesis
US12318295B2 (en) 2012-09-14 2025-06-03 Boston Scientific Scimed, Inc. Cardiac prosthesis
US10543088B2 (en) 2012-09-14 2020-01-28 Boston Scientific Scimed, Inc. Mitral valve inversion prostheses
US11406495B2 (en) 2013-02-11 2022-08-09 Cook Medical Technologies Llc Expandable support frame and medical device
US9744037B2 (en) 2013-03-15 2017-08-29 California Institute Of Technology Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves
US11234821B2 (en) 2013-05-20 2022-02-01 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
US10111747B2 (en) 2013-05-20 2018-10-30 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
US9615926B2 (en) 2014-07-17 2017-04-11 Millipede, Inc. Adjustable endolumenal implant for reshaping the mitral valve annulus
US9913706B2 (en) 2014-07-17 2018-03-13 Millipede, Inc. Adjustable endolumenal implant for reshaping the mitral valve annulus
US10136985B2 (en) 2014-07-17 2018-11-27 Millipede, Inc. Method of reconfiguring a mitral valve annulus
US9622862B2 (en) 2014-07-17 2017-04-18 Millipede, Inc. Prosthetic mitral valve with adjustable support
US9180005B1 (en) 2014-07-17 2015-11-10 Millipede, Inc. Adjustable endolumenal mitral valve ring
US10695160B2 (en) 2014-07-17 2020-06-30 Boston Scientific Scimed, Inc. Adjustable endolumenal implant for reshaping the mitral valve annulus
US12023235B2 (en) 2014-07-17 2024-07-02 Boston Scientific Scimed, Inc. Adjustable endolumenal implant for reshaping the mitral valve annulus
US11918462B2 (en) 2015-02-13 2024-03-05 Boston Scientific Scimed, Inc. Valve replacement using moveable restraints and angled struts
US10258466B2 (en) 2015-02-13 2019-04-16 Millipede, Inc. Valve replacement using moveable restrains and angled struts
US9848983B2 (en) 2015-02-13 2017-12-26 Millipede, Inc. Valve replacement using rotational anchors
US10278819B2 (en) 2015-06-01 2019-05-07 Edwards Lifesciences Corporation Cardiac valve repair devices configured for percutaneous delivery
US11166817B2 (en) 2015-06-01 2021-11-09 Edwards Lifesciences Corporation Cardiac valve repair devices configured for percutaneous delivery
US12245940B2 (en) 2015-06-01 2025-03-11 Edwards Lifesciences Corporation Cardiac valve repair devices configured for percutaneous delivery
US10820996B2 (en) 2015-08-21 2020-11-03 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
US10238490B2 (en) 2015-08-21 2019-03-26 Twelve, Inc. Implant heart valve devices, mitral valve repair devices and associated systems and methods
US11576782B2 (en) 2015-08-21 2023-02-14 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
US10335275B2 (en) 2015-09-29 2019-07-02 Millipede, Inc. Methods for delivery of heart valve devices using intravascular ultrasound imaging
US10555813B2 (en) 2015-11-17 2020-02-11 Boston Scientific Scimed, Inc. Implantable device and delivery system for reshaping a heart valve annulus
US10265172B2 (en) 2016-04-29 2019-04-23 Medtronic Vascular, Inc. Prosthetic heart valve devices with tethered anchors and associated systems and methods
US12109113B2 (en) 2016-04-29 2024-10-08 Medtronic Vascular, Inc. Prosthetic heart valve devices with tethered anchors and associated systems and methods
US11033390B2 (en) 2016-04-29 2021-06-15 Medtronic Vascular, Inc. Prosthetic heart valve devices with tethered anchors and associated systems and methods
US20200146854A1 (en) * 2016-05-16 2020-05-14 Elixir Medical Corporation Methods and devices for heart valve repair
US11191656B2 (en) 2016-05-16 2021-12-07 Elixir Medical Corporation Methods and devices for heart valve repair
US10973662B2 (en) 2016-05-16 2021-04-13 Elixir Medical Corporation Methods and devices for heart valve repair
US11033391B2 (en) 2016-12-22 2021-06-15 Heart Repair Technologies, Inc. Percutaneous delivery systems for anchoring an implant in a cardiac valve annulus
US11986391B2 (en) 2016-12-22 2024-05-21 Heart Repair Technologies, Inc. Percutaneous delivery systems for anchoring an implant in a cardiac valve annulus
US10548731B2 (en) 2017-02-10 2020-02-04 Boston Scientific Scimed, Inc. Implantable device and delivery system for reshaping a heart valve annulus
US12201523B2 (en) 2017-04-18 2025-01-21 Twelve, Inc. Hydraulic systems for delivering prosthetic heart valve devices and associated methods
US10433961B2 (en) 2017-04-18 2019-10-08 Twelve, Inc. Delivery systems with tethers for prosthetic heart valve devices and associated methods
US11389295B2 (en) 2017-04-18 2022-07-19 Twelve, Inc. Delivery systems with tethers for prosthetic heart valve devices and associated methods
US11654021B2 (en) 2017-04-18 2023-05-23 Twelve, Inc. Prosthetic heart valve device and associated systems and methods
US11737873B2 (en) 2017-04-18 2023-08-29 Twelve, Inc. Hydraulic systems for delivering prosthetic heart valve devices and associated methods
US10575950B2 (en) 2017-04-18 2020-03-03 Twelve, Inc. Hydraulic systems for delivering prosthetic heart valve devices and associated methods
US10702378B2 (en) 2017-04-18 2020-07-07 Twelve, Inc. Prosthetic heart valve device and associated systems and methods
US10792151B2 (en) 2017-05-11 2020-10-06 Twelve, Inc. Delivery systems for delivering prosthetic heart valve devices and associated methods
US11786370B2 (en) 2017-05-11 2023-10-17 Twelve, Inc. Delivery systems for delivering prosthetic heart valve devices and associated methods
US10646338B2 (en) 2017-06-02 2020-05-12 Twelve, Inc. Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods
US12329639B2 (en) 2017-06-02 2025-06-17 Twelve, Inc. Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods
US11559398B2 (en) 2017-06-02 2023-01-24 Twelve, Inc. Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods
US12274632B2 (en) 2017-06-06 2025-04-15 Twelve, Inc. Crimping device for loading stents and prosthetic heart valves
US10709591B2 (en) 2017-06-06 2020-07-14 Twelve, Inc. Crimping device and method for loading stents and prosthetic heart valves
US11464659B2 (en) 2017-06-06 2022-10-11 Twelve, Inc. Crimping device for loading stents and prosthetic heart valves
US12016772B2 (en) 2017-07-06 2024-06-25 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10786352B2 (en) 2017-07-06 2020-09-29 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US11877926B2 (en) 2017-07-06 2024-01-23 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10729541B2 (en) 2017-07-06 2020-08-04 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US12364604B2 (en) 2019-02-11 2025-07-22 Heart Repair Technologies, Inc. Percutaneous delivery systems for anchoring an implant in a cardiac valve annulus
US12502178B2 (en) 2022-08-16 2025-12-23 Boston Scientific Scimed, Inc. Medical device for occluding a left atrial appendage

Also Published As

Publication number Publication date
AU2009208049A1 (en) 2009-08-27
US20090306622A1 (en) 2009-12-10
US9861475B2 (en) 2018-01-09
DE60325634D1 (de) 2009-02-12
AU2003277116A1 (en) 2004-04-23
ATE418938T1 (de) 2009-01-15
WO2004030569A2 (en) 2004-04-15
CN1703176A (zh) 2005-11-30
HK1082175A1 (en) 2006-06-02
JP2006501033A (ja) 2006-01-12
CN100553590C (zh) 2009-10-28
EP1562522A4 (en) 2007-02-28
EP1562522B1 (en) 2008-12-31
CA2498030A1 (en) 2004-04-15
US20040127982A1 (en) 2004-07-01
EP1562522A2 (en) 2005-08-17
WO2004030569A3 (en) 2004-12-29

Similar Documents

Publication Publication Date Title
US9861475B2 (en) Devices, systems, and methods for reshaping a heart valve annulus
JP7469395B2 (ja) 埋込可能な心臓弁デバイス、僧帽弁修復デバイス、ならびに関連するシステム及び方法
JP7780845B2 (ja) 心臓弁尖用の尖延長器具
EP1748745B1 (en) Devices, systems, and methods for reshaping a heart valve annulus
US7527646B2 (en) Devices, systems, and methods for retaining a native heart valve leaflet
US20200352707A1 (en) Implantable heart valve devices, mitral valve repair devices and associated systems and methods
US9504570B2 (en) Device and method for reshaping tricuspid valve annulus
US7381220B2 (en) Devices, systems, and methods for supplementing, repairing, or replacing a native heart valve leaflet
CA2910751C (en) Heart valve assistive prosthesis
HK1082175B (en) Devices and systems for reshaping a heart valve annulus
CN116669660A (zh) 用于横穿解剖血管壁的方法

Legal Events

Date Code Title Description
AS Assignment

Owner name: AMPLE MEDICAL, INC., CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:RAHDERT, DAVID A.;MACOVIAK, JOHN A.;MACHOLD, TIMOTHY R.;AND OTHERS;REEL/FRAME:014759/0215

Effective date: 20031106

AS Assignment

Owner name: VENTURE LENDING & LEASING IV, INC., CALIFORNIA

Free format text: SECURITY INTEREST;ASSIGNOR:AMPLE MEDICAL, INC.;REEL/FRAME:016127/0400

Effective date: 20041217

AS Assignment

Owner name: VENTURE LENDING & LEASING IV, INC. AND VENTURE LEN

Free format text: SECURITY INTEREST;ASSIGNOR:AMPLE MEDICAL, INC.;REEL/FRAME:020814/0208

Effective date: 20080328

Owner name: VENTURE LENDING & LEASING IV, INC. AND VENTURE LENDING & LEASING V, INC., CALIFORNIA

Free format text: SECURITY INTEREST;ASSIGNOR:AMPLE MEDICAL, INC.;REEL/FRAME:020814/0208

Effective date: 20080328

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION

AS Assignment

Owner name: VENTURE LENDING & LEASING V, INC.,CALIFORNIA

Free format text: PATENT TRANSFER STATEMENT (UNDER UNIFORM COMMERCIAL CODE SECTION 9-619);ASSIGNOR:AMPLE MEDICAL, INC.;REEL/FRAME:023699/0672

Effective date: 20091130

Owner name: VENTURE LENDING & LEASING IV, INC.,CALIFORNIA

Free format text: PATENT TRANSFER STATEMENT (UNDER UNIFORM COMMERCIAL CODE SECTION 9-619);ASSIGNOR:AMPLE MEDICAL, INC.;REEL/FRAME:023699/0672

Effective date: 20091130

Owner name: VENTURE LENDING & LEASING V, INC., CALIFORNIA

Free format text: PATENT TRANSFER STATEMENT (UNDER UNIFORM COMMERCIAL CODE SECTION 9-619);ASSIGNOR:AMPLE MEDICAL, INC.;REEL/FRAME:023699/0672

Effective date: 20091130

Owner name: VENTURE LENDING & LEASING IV, INC., CALIFORNIA

Free format text: PATENT TRANSFER STATEMENT (UNDER UNIFORM COMMERCIAL CODE SECTION 9-619);ASSIGNOR:AMPLE MEDICAL, INC.;REEL/FRAME:023699/0672

Effective date: 20091130

AS Assignment

Owner name: MVRX, INC., CALIFORNIA

Free format text: BILL OF SALE;ASSIGNORS:VENTURE LENDING & LEASING IV, INC.;VENTURE LENDING & LEASING V, INC.;REEL/FRAME:023882/0030

Effective date: 20091130

Owner name: MVRX, INC.,CALIFORNIA

Free format text: BILL OF SALE;ASSIGNORS:VENTURE LENDING & LEASING IV, INC.;VENTURE LENDING & LEASING V, INC.;REEL/FRAME:023882/0030

Effective date: 20091130

AS Assignment

Owner name: VENTURE LENDING & LEASING IV, INC., CALIFORNIA

Free format text: CORRECTIVE ASSIGNMENT TO CORRECT THE SIGNATURES ON THE ORIGINALLY DOCUMENT PREVIOUSLY RECORDED AT REEL: 020814 FRAME: 0208. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT/SECURITY AGREEMENT;ASSIGNOR:AMPLE MEDICAL, INC.;REEL/FRAME:037974/0732

Effective date: 20080328

Owner name: VENTURE LENDING & LEASING IV, INC., CALIFORNIA

Free format text: CORRECTIVE ASSIGNMENT TO CORRECT THE OMISSION OF PAGE 3 IN THE ORIGINAL FILED DOCUMENT PREVIOUSLY RECORDED AT REEL: 016127 FRAME: 0400. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT;ASSIGNOR:AMPLE MEDICAL, INC.;REEL/FRAME:037974/0803

Effective date: 20041217

Owner name: VENTURE LENDING & LEASING V, INC., CALIFORNIA

Free format text: CORRECTIVE ASSIGNMENT TO CORRECT THE SIGNATURES ON THE ORIGINALLY DOCUMENT PREVIOUSLY RECORDED AT REEL: 020814 FRAME: 0208. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT/SECURITY AGREEMENT;ASSIGNOR:AMPLE MEDICAL, INC.;REEL/FRAME:037974/0732

Effective date: 20080328