US20050159512A1 - Drive arrangement for a strip of cuvettes in an analytical device - Google Patents

Drive arrangement for a strip of cuvettes in an analytical device Download PDF

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Publication number
US20050159512A1
US20050159512A1 US10/503,238 US50323804A US2005159512A1 US 20050159512 A1 US20050159512 A1 US 20050159512A1 US 50323804 A US50323804 A US 50323804A US 2005159512 A1 US2005159512 A1 US 2005159512A1
Authority
US
United States
Prior art keywords
bowls
shoulders
strip
bowl
film
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/503,238
Other languages
English (en)
Inventor
Alain Rousseau
Khaled Abou-Saleh
Patrick Perin
Philippe Poutrel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stago Instruments SAS
Original Assignee
Stago Instruments SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stago Instruments SAS filed Critical Stago Instruments SAS
Publication of US20050159512A1 publication Critical patent/US20050159512A1/en
Assigned to STAGO INSTRUMENTS reassignment STAGO INSTRUMENTS ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ABOUSALEH, KHALED, PERIN, PATRICK, POUTREL, PHILIPPE, ROUSSEAU, ALAIN
Priority to US12/033,796 priority Critical patent/US7678332B2/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y10T436/114165—Automated chemical analysis with conveyance of sample along a test line in a container or rack with step of insertion or removal from test line
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y10T436/114998—Automated chemical analysis with conveyance of sample along a test line in a container or rack with treatment or replacement of aspirator element [e.g., cleaning, etc.]

Definitions

  • the present invention concerns an improvement of an automatic analysis device able to be used, especially for determining the modification times of a medium in a physical state.
  • This device is particularly, but not exclusively, applicable to determination of the blood coagulation time in accordance with a process according to which the blood sample is placed at the bottom of a bowl containing a ferromagnetic ball driven in a periodic movement under the effect of an external magnetic field.
  • the modifications of the movements of the ferromagnetic ball (for example the amplitude and/or frequency variations), which are representative of changes of the physical state of the blood, are then detected with the aid of suitable means.
  • each bowl comprising a bent inward bottom constituting the rolling path of the ball, and a face opposite the bottom having an opening. Transversal edges of this opening extend two shoulders at a right angle with respect to the faces of the bowls.
  • the bowls are placed side by side and fixed on a flexible support strip which seals off their openings but said bowls can be removed.
  • the strip equipped with bowls can be wound onto a coil able to be engaged on an element provided in a storage and distribution compartment of the device. The bowls run off one by one into a detection station.
  • the object of the invention is thus to eliminate these drawbacks.
  • the invention concerns a device for moving a set of bowls forming a strip and joined together by a film in an automatic analysis device comprising at least one notched belt whose serrations gear with suitable adaptations of the bowls.
  • said bowls may have an opening at the level of which two opposing shoulders extend and projecting outside of the bowl on which said adaptations are embodied.
  • said shoulders may each have two oblique edges with respect to the longitudinal axis of the strip so that the unit formed by the strip and bowls has two serrated lateral edges.
  • the bowls/strip unit has a rack function.
  • the lateral borders of the film each have a serrated profile whose teeth are accentuated by the presence of the bowl shoulders.
  • This device exhibits no play during handling in either direction.
  • FIG. 1 is a diagrammatic representation of an automatic analysis device of medium size
  • FIG. 2 is a diagrammatic perspective view of a bowl mounted on the film
  • FIG. 3 is a diagrammatic top view of the film equipped with its bowls and the rack drive system.
  • FIG. 4 is a vertical diagrammatic section along A/A of FIG. 3 .
  • the automatic analysis device introduces a bowl feeding comprising a series of about a hundred bowls C forming a strip 2 .
  • the bowls C embodied by moulding a transparent plastic material each have a parallelpiped flat-shaped body whose bent inward bottom FI constitutes a rolling path for a ferromagnetic ball BE. Opposite this bottom FI, the bowl C has an opening at the level of which its two opposing edges BO 1 , BO 2 are extended at a right angle by two respective shoulders R 1 , R 2 each provided with a cylindrical protuberance PC extending from the side opposite the body. These two protuberances are intended to be engaged forcefully in two respective holes TR respectively provided on the two lateral borders of the film.
  • the shoulders R 1 , R 2 have for example the shape of a rectangular trapezium whose large base is integral with the bowl.
  • the lateral borders of a support film 3 then have in the gaps of the shoulders R 1 , R 2 of successive bowls trapezoid cuts whose oblique edges extend to the right of the oblique edges of the shoulders R 1 , R 2 .
  • the lateral borders of the film each have a serrated profile whose teeth are accentuated by the presence of the shoulders R 1 , R 2 of the bowls.
  • the film is flexible and is constituted by an absorbent material, such as paper.
  • the top of each bowl is pierced with an orifice 4 so as to allow the passage of a pipette.
  • the strip of bowls 2 is guided by a rail 5 .
  • This rail has a U-shaped cross section whose two vertical wings are extended at a right angle by two shoulders R 3 , R 4 , the shoulders R 1 , R 2 of the bowls resting on the shoulders R 3 , R 4 .
  • the strip successively passes through a pipette station 6 , a detection station 7 and a cutting station 8 at the outlet of which each bowl is recovered in a container 9 provided for this purpose.
  • a processor P comprising a central unit and peripheral units, such as a screen 10 /keyboard 11 unit.
  • the movement of the film is provided by a drive mechanism introducing an endless belt 12 guided at each extremity by rollers 13 , 14 , one of the latter being driven in rotation by a step motor M.
  • This belt comprises a serration whose notches are spaced by a distance equal to a multiple of the width of the bowls (for example 4-5 bowls). These notches have an involute to a circle profile which corresponds to a normal teeth-shaped rack so as to fully gear between the teeth of the serrated profile of the strip; these teeth thus accurately move the strip of bowls with automatic centering and compensation of any possible play (the notches being more or less engaged deeply between said teeth).
  • the pipette station 6 is controlled by an automated height-adjustable vertical pipette 15 so as to be able to assume a lower rinsing or pipette position and an upper position allowing it to move inside a horizontal plane.
  • This pipette 15 is fixed at one of its extremities of an arm 16 mounted rotating by its other extremity around a vertical spindle 17 .
  • the driving in rotation of the arm 16 is ensured by a motor controlled by the processor P.
  • the pipette 15 can be successively brought to the pipette area of the pipette station 6 , a rinsing area 18 diametrically opposite, and to two sampling areas 19 , 20 placed symmetrically with respect to the axis passing through the pipette area 6 and the rinsing area 18 .
  • sampling areas 19 , 20 are situated inside the path of the receptacles R 1 , R 2 borne by two respective carrousels CR 1 , CR 2 moving in rotation around two vertical spindles 21 , 22 and controlled by two motors controlled by the processor P.
  • carrousels CR 1 is used to contain the receptacles of the blood samples to be analysed, whereas the other carrousel CR 2 contains the receptacles R 2 allocated to the various reactive agents able to be used within the context of the analyses it is desired to carry out.
  • processor P is programmed so as to control pipette sequences appropriate to the nature of the analyses to be conducted and possible successively comprising:
  • the sole bar code reader 23 is mounted at the extremity of an arm 24 pivoting around a vertical spindle 25 so as to be able to occupy three positions, namely:
  • the measuring station 7 here comprises three successive measuring positions each comprising ( FIG. 4 ) a pair of coaxial electromagnets E 1 , E′ 1 -E 2 , E′ 2 -E 3 , E′ 3 situated on both sides of the film 3 at the right of the lateral faces of the bowls C.
  • the station 7 also comprises:
  • the electromagnets E 1 , E′ 1 -E 2 , E′ 2 -E 3 , E′ 3 are excited by a power circuit PR controlled by the processor P so as to generate a magnetic pulse field able to drive the ball BE along an alternative movement at the bottom of the bowl C.
  • the camera 27 is coupled to the processor C which analyses in real time the image by means of an appropriate software so as to measure the amplitude of the oscillations of the ball BE and determine the critical instant when this amplitude lowers below a specific threshold (for example 50% of the initial amplitude).
  • a specific threshold for example 50% of the initial amplitude
  • the processor P counts the time between the moment when the reactive agent has been injected into the bowl C and the critical instant so as to deduce from this a coagulation time.
  • the movements of the film are synchronised with the operating times of each of the stations of the device and in particular with the magnetic field pulses generated by the coils.
  • the pipette station could possibly be situated at the same location as the measuring station.
  • each infra red/camera source unit could have a field comprising several bowls each excited by a pair of separate electromagnets so as to follow the bowl over a forward distance of several steps with a processor programmed so as to simultaneously detect the movements of the balls of different bowls.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
US10/503,238 2002-02-01 2003-01-28 Drive arrangement for a strip of cuvettes in an analytical device Abandoned US20050159512A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/033,796 US7678332B2 (en) 2002-02-01 2008-02-19 Drive arrangements for a strip of cuvettes in analytical device

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR02/01236 2002-02-01
FR0201236A FR2835617B1 (fr) 2002-02-01 2002-02-01 Dispositif d'entrainement d'une bande de cuvettes dans un appareil d'analyse
PCT/FR2003/000256 WO2003065048A1 (fr) 2002-02-01 2003-01-28 Dispositif d'entrainement d'une bande de cuvettes dans un appareil d'analyse

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/033,796 Continuation US7678332B2 (en) 2002-02-01 2008-02-19 Drive arrangements for a strip of cuvettes in analytical device

Publications (1)

Publication Number Publication Date
US20050159512A1 true US20050159512A1 (en) 2005-07-21

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Family Applications (2)

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US10/503,238 Abandoned US20050159512A1 (en) 2002-02-01 2003-01-28 Drive arrangement for a strip of cuvettes in an analytical device
US12/033,796 Expired - Fee Related US7678332B2 (en) 2002-02-01 2008-02-19 Drive arrangements for a strip of cuvettes in analytical device

Family Applications After (1)

Application Number Title Priority Date Filing Date
US12/033,796 Expired - Fee Related US7678332B2 (en) 2002-02-01 2008-02-19 Drive arrangements for a strip of cuvettes in analytical device

Country Status (23)

Country Link
US (2) US20050159512A1 (es)
EP (1) EP1470426B1 (es)
JP (1) JP4411080B2 (es)
CN (1) CN100516881C (es)
AR (1) AR038474A1 (es)
AT (1) ATE339692T1 (es)
AU (1) AU2003219252B2 (es)
BR (1) BRPI0307378B1 (es)
CA (1) CA2474045C (es)
DE (1) DE60308314T2 (es)
DK (1) DK1470426T3 (es)
ES (1) ES2271553T3 (es)
FR (1) FR2835617B1 (es)
HK (1) HK1069437A1 (es)
MX (1) MXPA04007286A (es)
NO (1) NO20043374L (es)
PL (1) PL371351A1 (es)
PT (1) PT1470426E (es)
RU (1) RU2307340C2 (es)
TW (1) TWI280358B (es)
UA (1) UA84127C2 (es)
WO (1) WO2003065048A1 (es)
ZA (1) ZA200406795B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11426736B2 (en) * 2018-05-07 2022-08-30 Diagnostica Stago Gripping device for a container

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100916000B1 (ko) * 2002-02-01 2009-09-10 디아그노스티카 스타고 분석장치의 보울 구동장치
CA2542897A1 (en) 2003-10-30 2005-05-12 Bayer Healthcare Llc Optical cuvette with platform-and-well construction
WO2005043133A1 (en) 2003-10-30 2005-05-12 Bayer Healthcare Llc Formats for optical analysis and methods of manufacturing the same
JP2008089406A (ja) * 2006-10-02 2008-04-17 A & T Corp 分析装置、および反応容器
FR2927173B1 (fr) * 2008-02-05 2010-03-05 Stago Diagnostica Alimentation d'un appareil automatique d'analyse en cuvettes de reaction
CN101846612A (zh) * 2010-04-29 2010-09-29 北京众驰伟业科技发展有限公司 双工位全自动血流变测试仪
WO2013165911A1 (en) 2012-04-30 2013-11-07 Siemens Healthcare Diagnostics Inc. Articulated sample container rack apparatus, rack conveyor systems, and methods of conveying sample containers
CN104459112B (zh) * 2014-11-25 2016-03-30 成都威尔诺生物科技有限公司 便于夹持的搁置架
US10968423B2 (en) * 2018-02-26 2021-04-06 General Electric Company System and method for electric pulse based activation of biological samples
FR3100340B1 (fr) * 2019-09-04 2021-07-30 Arteion Dispositif d’entraînement pour un appareil d’analyse automatique pour diagnostic in vitro

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168775A (en) * 1977-07-12 1979-09-25 Actus, Inc. Idler sprockets for sample changer tracks
US4200000A (en) * 1978-10-04 1980-04-29 Societe Suisse Pour L'industrie Horlogere Management Services S.A. Gear train
US4731225A (en) * 1986-01-31 1988-03-15 Kabushiki Kaisha Nittec Automatic analysis apparatus
US5849247A (en) * 1994-11-07 1998-12-15 Merck S.A. Automatic apparatus for immunological assay
US6328164B1 (en) * 1996-11-14 2001-12-11 Kone Instruments Oy Multicell cuvette package, method of loading multicell cuvettes into a measurement instrument and a dispensing device for loading cuvettes
US6767511B1 (en) * 1998-06-10 2004-07-27 Junior Instruments Automatic analysis apparatus used for timing blood coagulation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4867308A (en) * 1987-05-14 1989-09-19 Crawford Richard J Storage tape for electronic components
JPH01158356A (ja) * 1987-12-16 1989-06-21 Olympus Optical Co Ltd 分析装置用サンプラ
FR2754599B1 (fr) * 1996-10-15 1998-12-04 Merck Clevenot Laboratoires Appareil automatique de dosage immunologique

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168775A (en) * 1977-07-12 1979-09-25 Actus, Inc. Idler sprockets for sample changer tracks
US4200000A (en) * 1978-10-04 1980-04-29 Societe Suisse Pour L'industrie Horlogere Management Services S.A. Gear train
US4731225A (en) * 1986-01-31 1988-03-15 Kabushiki Kaisha Nittec Automatic analysis apparatus
US5849247A (en) * 1994-11-07 1998-12-15 Merck S.A. Automatic apparatus for immunological assay
US6328164B1 (en) * 1996-11-14 2001-12-11 Kone Instruments Oy Multicell cuvette package, method of loading multicell cuvettes into a measurement instrument and a dispensing device for loading cuvettes
US6767511B1 (en) * 1998-06-10 2004-07-27 Junior Instruments Automatic analysis apparatus used for timing blood coagulation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11426736B2 (en) * 2018-05-07 2022-08-30 Diagnostica Stago Gripping device for a container

Also Published As

Publication number Publication date
CA2474045C (fr) 2009-06-30
JP4411080B2 (ja) 2010-02-10
EP1470426A1 (fr) 2004-10-27
PT1470426E (pt) 2006-12-29
BRPI0307378B1 (pt) 2016-11-29
HK1069437A1 (en) 2005-05-20
WO2003065048A1 (fr) 2003-08-07
DE60308314D1 (de) 2006-10-26
CA2474045A1 (fr) 2003-08-07
AU2003219252B2 (en) 2008-03-06
FR2835617A1 (fr) 2003-08-08
BR0307378A (pt) 2004-12-07
ES2271553T3 (es) 2007-04-16
JP2005516219A (ja) 2005-06-02
US20090120769A1 (en) 2009-05-14
CN100516881C (zh) 2009-07-22
NO20043374L (no) 2004-08-13
TW200302915A (en) 2003-08-16
UA84127C2 (ru) 2008-09-25
AR038474A1 (es) 2005-01-19
RU2004126428A (ru) 2005-03-20
MXPA04007286A (es) 2005-05-16
RU2307340C2 (ru) 2007-09-27
FR2835617B1 (fr) 2004-04-30
DE60308314T2 (de) 2007-04-12
TWI280358B (en) 2007-05-01
DK1470426T3 (da) 2007-01-15
ATE339692T1 (de) 2006-10-15
US7678332B2 (en) 2010-03-16
CN1625691A (zh) 2005-06-08
ZA200406795B (en) 2007-12-27
EP1470426B1 (fr) 2006-09-13
PL371351A1 (en) 2005-06-13

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AS Assignment

Owner name: STAGO INSTRUMENTS, FRANCE

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ROUSSEAU, ALAIN;ABOUSALEH, KHALED;PERIN, PATRICK;AND OTHERS;REEL/FRAME:018421/0310

Effective date: 20040628

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION