US20040087548A1 - Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function - Google Patents

Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function Download PDF

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Publication number
US20040087548A1
US20040087548A1 US10/075,870 US7587002A US2004087548A1 US 20040087548 A1 US20040087548 A1 US 20040087548A1 US 7587002 A US7587002 A US 7587002A US 2004087548 A1 US2004087548 A1 US 2004087548A1
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US
United States
Prior art keywords
isoindole
dione
tetrahydro
substituted
methano
Prior art date
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Abandoned
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US10/075,870
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English (en)
Inventor
Mark Salvati
Ricardo Attar
Marco Gottardis
James Balog
Dacia Pickering
Rogelio Martinez
Chongping Sun
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to US10/075,870 priority Critical patent/US20040087548A1/en
Assigned to BRISTOL-MYERS SQUIBB COMPANY reassignment BRISTOL-MYERS SQUIBB COMPANY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GOTTARDIS, MARCO M., ATTAR, RICARDO M., BALOG, JAMES AARON, MARTINEZ, ROGELIO L., PICKERING, DACIA A., SALVATI, MARK E., SUN, CHONGQING
Publication of US20040087548A1 publication Critical patent/US20040087548A1/en
Priority to US11/311,731 priority patent/US7655688B2/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
US10/075,870 2001-02-27 2002-02-14 Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function Abandoned US20040087548A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/075,870 US20040087548A1 (en) 2001-02-27 2002-02-14 Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US11/311,731 US7655688B2 (en) 2001-02-27 2005-12-19 Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27167201P 2001-02-27 2001-02-27
US10/075,870 US20040087548A1 (en) 2001-02-27 2002-02-14 Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

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US11/311,731 Continuation US7655688B2 (en) 2001-02-27 2005-12-19 Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

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US11/311,731 Active 2025-01-28 US7655688B2 (en) 2001-02-27 2005-12-19 Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

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US (2) US20040087548A1 (US07655688-20100202-C00359.png)
EP (1) EP1379249A4 (US07655688-20100202-C00359.png)
JP (1) JP2004523558A (US07655688-20100202-C00359.png)
CA (1) CA2439265A1 (US07655688-20100202-C00359.png)
HU (1) HUP0304055A2 (US07655688-20100202-C00359.png)
WO (1) WO2002067939A1 (US07655688-20100202-C00359.png)

Cited By (40)

* Cited by examiner, † Cited by third party
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US20040077606A1 (en) * 2000-06-28 2004-04-22 Salvati Mark E. Fused cyclic modulators of nuclear hormone receptor function
US20050187273A1 (en) * 2001-12-19 2005-08-25 Salvati Mark E. Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function
US20050192253A1 (en) * 2000-09-19 2005-09-01 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US20060079686A1 (en) * 2004-08-06 2006-04-13 Ellen Baxter Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE)
US20060079687A1 (en) * 2004-08-06 2006-04-13 Ellen Baxter Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE)
US20060178383A1 (en) * 2004-08-06 2006-08-10 Bischoff Francois P Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE)
US20060264459A1 (en) * 2000-06-28 2006-11-23 Salvati Mark E Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US20070112044A1 (en) * 2003-10-10 2007-05-17 Kyowa Hakko Kogyo Co., Ltd. Thiadiazoline derivative
US20070155804A1 (en) * 2003-04-18 2007-07-05 Kyowa Hakko Kogyo Co., Ltd. Of Tokyo, Japan Fuji Photo Film Co., Ltd. Kanagawa, Japan Mitotic kinesin inhibitor
US20070232630A1 (en) * 2006-02-06 2007-10-04 Baxter Ellen W MACROCYCLE DERIVATIVES USEFUL AS INHIBITORS OF beta-SECRETASE (BACE)
US20070232642A1 (en) * 2006-02-06 2007-10-04 Baxter Ellen W 2-amino-3,4-dihydro-quinoline derivatives useful as inhibitors of beta-secretase (bace)
US20070276017A1 (en) * 2003-06-10 2007-11-29 Chikara Murakata Thiadiazoline Derivative
US20080194653A1 (en) * 2005-03-22 2008-08-14 Kyowa Hakko Kogyo Co., Ltd. Therapeutic Agent For Solid Tumor
US20080194624A1 (en) * 2006-02-06 2008-08-14 Ellen Baxter 2-amino-quinoline derivatives useful as inhibitors of beta-secretase (bace)
US20080207706A1 (en) * 2001-12-11 2008-08-28 Kyowa Hakko Kogyo Co., Ltd Thiadiazoline derivative
US20080262049A1 (en) * 2005-03-22 2008-10-23 Kyowa Hakko Kogyo Co., Ltd. Therapeutic Agent for Hematopoietic Tumor
US20090227581A1 (en) * 2008-01-29 2009-09-10 Ellen Baxter 2-amino-quinoline derivatives useful as inhibitors of beta-secretase (bace)
US20090227627A1 (en) * 2008-01-28 2009-09-10 Ellen Baxter 6-substituted-thio-2-amino-quinoline derivatives useful as inhibitors of beta-secretase (bace)
US20100029625A1 (en) * 2005-06-24 2010-02-04 Kyowa Hakko Kirin Co., Ltd. Therapeutic Agent for Restenosis
US8633178B2 (en) 2011-11-23 2014-01-21 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US8933059B2 (en) 2012-06-18 2015-01-13 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US9289382B2 (en) 2012-06-18 2016-03-22 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CN106349160A (zh) * 2016-08-05 2017-01-25 浙江工业大学 一种8‑氨基喹啉衍生物及其制备与应用
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
CN107954992A (zh) * 2017-12-15 2018-04-24 田元强 吡咯二酮衍生物及其在小菜蛾和桃蚜防治中的应用
US10052386B2 (en) 2012-06-18 2018-08-21 Therapeuticsmd, Inc. Progesterone formulations
US10206932B2 (en) 2014-05-22 2019-02-19 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10258630B2 (en) 2014-10-22 2019-04-16 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10471148B2 (en) 2012-06-18 2019-11-12 Therapeuticsmd, Inc. Progesterone formulations having a desirable PK profile
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
CN113620969A (zh) * 2020-05-07 2021-11-09 贵州医科大学 带桥环的环己烷二羧酸衍生物及其药物组合物和应用
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CN115340483A (zh) * 2022-08-31 2022-11-15 南京吉星生物技术开发有限公司 一种萘基吡咯啉二酮化合物及其制备方法与它的用途
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

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AU2002950217A0 (en) 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
US7737168B2 (en) 2003-06-20 2010-06-15 Siga Technologies, Inc. Compounds, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US8530509B2 (en) 2003-06-20 2013-09-10 Siga Technologies, Inc. Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
WO2004112718A2 (en) * 2003-06-20 2004-12-29 Siga Technologies, Inc. Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
KR20070112775A (ko) * 2005-01-10 2007-11-27 아카디아 파마슈티칼스 인코포레이티드 선택적인 안드로겐 수용체 조절자로서의 아미노페닐 유도체
US7468439B2 (en) * 2006-09-06 2008-12-23 Bristol-Myers Squibb Company Alkylene bridged sultam compounds useful as modulators of nuclear hormone receptor function
CA2866037C (en) 2007-04-23 2017-05-16 Siga Technologies, Inc. Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US8466171B2 (en) * 2007-11-01 2013-06-18 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as modulators of nuclear hormone receptor function
DE102008022221A1 (de) * 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
CA2726164A1 (en) 2008-05-27 2009-12-23 The Board Of Regents Of The University Of Texas System Wnt protein signalling inhibitors
JPWO2011007819A1 (ja) 2009-07-17 2012-12-27 塩野義製薬株式会社 ラクタムまたはベンゼンスルホンアミド化合物を含有する医薬
CA3030671A1 (en) 2010-03-23 2011-09-29 Shanthakumar R. Tyavanagimatt Polymorphic forms of st-246 and methods of preparation
EP2735567B1 (en) * 2011-07-21 2016-10-26 Xuanzhu Pharma Co., Ltd. Heterocyclic substituted pyrimidine compound
CN103193696B (zh) * 2013-04-18 2015-11-11 北京大学 降冰片烯基酰亚胺体系甲壳型聚合物单体及其聚合物
GB201507937D0 (en) * 2015-05-08 2015-06-24 Univ Hertfordshire Higher Education Corp Compounds for treatment of pancreatic cancer
EP3383846B1 (en) * 2015-11-30 2022-06-22 Otago Innovation Limited Carbon monoxide releasing norbornenone compounds
US10596168B2 (en) 2016-04-27 2020-03-24 Forschungsverbund Berlin E.V. Antagonists of the thyroid-stimulating hormone receptor (TSHR)
CN110183456A (zh) * 2019-07-11 2019-08-30 河南师范大学 一种2-芳基吲唑琥珀酰亚胺螺环化合物的合成方法
WO2023192782A2 (en) * 2022-03-27 2023-10-05 Board Of Regents, The University Of Texas System Small molecule inhibitors of lanosterol synthase

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US7655688B2 (en) 2010-02-02
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