US20030026776A1 - Water-soluble ginger root extract - Google Patents

Water-soluble ginger root extract Download PDF

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Publication number
US20030026776A1
US20030026776A1 US10/209,858 US20985802A US2003026776A1 US 20030026776 A1 US20030026776 A1 US 20030026776A1 US 20985802 A US20985802 A US 20985802A US 2003026776 A1 US2003026776 A1 US 2003026776A1
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United States
Prior art keywords
extract
ginger root
water
soluble
gingerols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/209,858
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English (en)
Inventor
Yusuke Shibuya
Shigeru Moriwaki
Naoko Tsuji
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Kao Corp
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Kao Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kao Corp filed Critical Kao Corp
Assigned to KAO CORPORATION reassignment KAO CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MORIWAKI, SHIGERU, SHIBUYA, YUSUKE, TSUJI, NAOKO
Publication of US20030026776A1 publication Critical patent/US20030026776A1/en
Priority to US11/246,218 priority Critical patent/US8282946B2/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A61Q7/02—Preparations for inhibiting or slowing hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant

Definitions

  • the present invention relates to a water-soluble ginger root extract substantially free of gingerols.
  • a ginger root is a root of Zingiber officinale Roscoe belonging to the Zingiberaceae plant family. It is a crude drug used for long years as a stomachic. The extract of this ginger root has also been used as a material for cosmetics because of its hair growth promoting and antipruritic actions.
  • the Japanese Cosmetic Ingredients Codex “ginger root extract” and “oil-soluble ginger root extract” are listed, while in “The Japanese Standards of Cosmetic Ingredients”, “ginger root tincture” is listed.
  • gingerols for example, 6-gingerol, 8-gingerol and 10-gingerol
  • a ginger root has been incorporated in a hair tonic or the like to improve the blood flow.
  • Natural Medicine, 40, 333-339(1986) that gingerols can satisfy the conditions as an indicator component of a ginger root.
  • the existing “ginger root extract” and “oil-soluble ginger root extract” need a confirmation test by thin-layer chromatography, while the “ginger root tincture” needs “pungency” as its properties.
  • Gingerols have a strong skin irritating property so that an upper limit on their content is determined.
  • “The Japanese Cosmetic Ingredients Codex” of Health and Welfare Ministry specifically limits the total amount of ginger root extract, oil soluble ginger root extract, ginger root tincture, capsicum tincture and cantharides tincture to 1% or less.
  • An object of the present invention is to provide a novel ginger root extract which is, different from the conventional one, substantially free of gingerols serving as a stimulant or pungent ingredient.
  • a water-soluble ginger root extract substantially free of gingerols is available by subjecting a water extract or a hydrous alcohol extract of a ginger root to isolation and purification such as adsorption treatment; and that to their surprise, it is useful as a hair growth inhibitor or a preparation for external use (which will hereinafter be called “external preparation”) owing to its action of suppressing the growth of body hairs.
  • a water-soluble ginger root extract which is a water or hydrous alcohol extract of a ginger root and is substantially free of gingerols; and a hair growth inhibitor and an external preparation each containing the extract.
  • the water-soluble ginger root extract of the invention causes less skin irritation because of being substantially free of gingerols, and has excellent body-hair growth inhibiting effects, so that it is useful as a hair grown inhibitor and an external preparation, each having a high degree of safety.
  • FIG. 1 illustrates the results of componential analysis by HPLC (A: water-soluble ginger root extract (Example 1), B: ginger root extract (Comparative Example).
  • ginger root means a root of Zingiber officinale Roscoe belonging to the Zingiberaceae plant family.
  • substantially free of gingerols means that the extract does not substantially contain gingerols such as 1-gingerol, 6-gingerol, 8-gingerol and 10-gingerol and in particular, the amount of 6-gingerol is not greater than 0.5 ppm, preferably not greater than a detection limit in HPLC analysis under the below-described conditions.
  • Solvent Solvent A: acetonitrile-water (30/70, v/v), Solvent B: acetonitrile
  • the water-soluble ginger root extract according to the invention can be prepared, for example, by (a) extracting a ginger root with water or a hydrous alcohol and (b) subjecting the water-soluble extract solution to treatment with an adsorbent or liquid-liquid fractionation in a low-polarity solvent.
  • This step is for extracting a ginger root with water or a hydrous alcohol.
  • a ginger root cut into pieces or pulverized into powder is usable as the raw material to be extracted.
  • a ginger root from which gingerols have been removed in advance for example, a residue after removal of gingerols by extraction with a low-polarity solvent such as hexane, acetone or ethyl acetate or supercritical carbon dioxide is also usable.
  • water or a hydrous alcohol is usable.
  • the alcohol include ethanol, methanol, 1,3-butylene glycol and glycerin, of which ethanol and 1,3-butylene glycol are particularly preferred.
  • the hydrous alcohol preferably has an alcohol concentration not greater than 70% (v/v) . When the hydrous alcohol has an alcohol concentration exceeding 70%, a large amount of gingerols is mixed therein, which presumably disturbs smooth removal of gingerols.
  • the extract can be obtained by adding 5 to 30 parts by weight of water or the hydrous alcohol to 1 part by weight of the ginger root and then extracting the latter one with the former one while stirring at 5 to 60° C. for 0.5 hour to 3 days.
  • This step is for subjecting the extract solution obtained in the step (a) to treatment with an adsorbent or liquid-liquid fractionation in a low-polarity solvent, thereby obtaining the water-soluble ginger root extract of the invention.
  • the treatment with an adsorbent is, for example, a treatment to remove gingerols by adsorbing them to activated charcoal (powdered activated charcoal, granular activated charcoal, or the like) or to an aromatic adsorbent such as “Diaion HP20” (trade name; product of Mitsubishi Chemical Corp.) or “Amberlite XAD-2” or “Amberlite XAD-4” (trade name; product of Rohm & Haas Company).
  • the treatment with an adsorbent can be carried out by subjecting the extract solution to the treatment with about 0.1 to 15 wt. %, preferably about 0.4 to 5 wt. % of activated charcoal for 1 to 6 hours in a batch system and then removing the resulting adsorbent by filtration or centrifugal separation; or by filling a column with an adsorbent, causing the extract solution to pass through the column, thereby adsorbing gingerols to the adsorbent.
  • Examples of the low-polarity solvent to be used for the liquid-liquid fractionation include hexane, ethyl acetate and petroleum ether.
  • This liquid-liquid fractionation can be achieved by adding the low-polarity solvent to the extract solution obtained in the step (a), bringing them in contact each other by agitation or stirring, separating the mixture into two layers by standing the mixture alone or centrifugal separation, and then removing the upper layer (organic layer) containing low-polarity ingredients such as 6-gingerol. If the mixture cannot be separated easily, it may be subjected to liquid-liquid fractionation after the extract solution is concentrated under reduced pressure to remove alcohols therefrom.
  • the treatment with an adsorbent or liquid-liquid fractionation in the step (b) may be followed by an ordinarily employed treatment such as filtration through a membrane filter as needed.
  • FIG. 1-A The componential analysis of the water-soluble ginger root extract by HPLC is shown in FIG. 1-A. It has revealed that different from the conventional ginger root extract (FIG. 1-B), it does not substantially contain pungent ingredients such as 6-gingerol.
  • the water-soluble ginger root extract has a hair growth suppressing action. It can therefore be used as a drug or cosmetic, more specifically, a hair growth inhibitor or an external preparation without any further treatment or after diluting, concentrating or lyophilizing the extract and then grinding it into powder or paste.
  • the administration route of the hair growth inhibitor of the invention can be selected from transdermal administration, local intradermal administration and systemic administration, depending on the purpose of the administration or subject or site to be administered.
  • the hair growth suppressor or external preparation according to the invention which is to be administered transdermally, preferably contains the water-soluble ginger root extract in an amount of 0.00001 to 10 wt. %, especially 0.0001 to 5 wt. % in terms of a solid content.
  • the hair growth suppressor or external preparation according to the invention is usable as pharmaceuticals, cosmetics or quasi-drugs. Use of it as hair-removing, depilatory, or shaving cosmetics or pharmaceuticals is especially preferred.
  • cosmetics or pharmaceuticals include hair removers in the form of paste, cream or aerosol, epilatories in the form of wax, gel and sheet, post-treatment lotions used after hair removal or depilation, anti-perspiration and deodorant cosmetics such as deodorant lotion, deodorant powder, deodorant spray and deodorant stick, cosmetics for use before shaving such as pre-shave lotion, shaving cosmetics such as shaving cream and cosmetics for use after shaving such as aftershave lotion.
  • the hair growth inhibitor or external preparation according to the invention may contain, in addition to the water-soluble ginger root extract, various ingredients ordinarily employed for pharmaceuticals, cosmetics or quasi-drugs, for example, purified water, ethanol, oily substance, humectant, thickener, antiseptic, emulsifier, medicinally effective ingredient, powder, ultraviolet absorber, colorant, perfume and emulsion stabilizer.
  • various ingredients ordinarily employed for pharmaceuticals, cosmetics or quasi-drugs for example, purified water, ethanol, oily substance, humectant, thickener, antiseptic, emulsifier, medicinally effective ingredient, powder, ultraviolet absorber, colorant, perfume and emulsion stabilizer.
  • Examples of the medicinally effective ingredient include keratolytic agents and ingredients having a hair growth suppressing or depilating action such as thioglycolic acid and salts thereof.
  • examples of the keratolytic agents include lactic acid, BIOPRASE (trade mark, product of Nagase ChemteX Corp.), salicylic acid, glycolic acid, citric acid and malic acid, while examples of the salts of thioglycolic acid include sodium thioglycolate, potassium thioglycolate, ammonium thioglycolate and alkanolamine salts such as monoethanolamine thioglycolate, diethanolamine thioglycolate and triethanolamine thioglycolate.
  • the kelatolytic agent, or thioglycolic acid or salt thereof is added preferably in an amount of 0.01 to 10 wt. %, especially 0.05 to 5%.
  • Test 1 Assay of 6-gingerol in samples
  • Solvent Solvent A: acetonitrile-water (30/70, v/v),
  • Test 2 Hair growth suppressing effects
  • Example 1 Each of the extract solutions obtained in Example 1 and Comparative Example was dissolved in 80% ethanol to give the final concentration of 1%, whereby a hair growth inhibitor was prepared.
  • the picture of the shaved site was taken at a fixed magnification and the day-dependent change of the area ratio of the regrowth hair (regrowth hair area/shaved area) was measured by an image analyzer.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
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  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
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  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
US10/209,858 2001-08-03 2002-08-02 Water-soluble ginger root extract Abandoned US20030026776A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/246,218 US8282946B2 (en) 2001-08-03 2005-10-11 Water-soluble ginger root extract

Applications Claiming Priority (2)

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JP2001236854A JP4759182B2 (ja) 2001-08-03 2001-08-03 水溶性ショウキョウエキス
JP2001-236854 2001-08-03

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US (2) US20030026776A1 (fr)
EP (1) EP1281402B1 (fr)
JP (1) JP4759182B2 (fr)
CN (1) CN1254270C (fr)
CA (1) CA2396809C (fr)
DE (1) DE60206450T2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060051437A1 (en) * 2004-08-28 2006-03-09 Boehringer Ingelheim International Gmbh Process for preparing a ginger fraction and the use thereof for inhibiting human CYP enzymes
US20070203240A1 (en) * 2006-02-27 2007-08-30 The Procter & Gamble Company Personal care compositions and methods for regulating mammalian hair growth
EP4140317A4 (fr) * 2020-05-28 2023-10-04 Hanamoa Co., Ltd. Composition d'eau de gingembre contenant un extrait de gingembre et son procédé de fabrication

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US7727516B2 (en) * 2006-02-28 2010-06-01 The Procter & Gamble Company Reduction of hair growth
JP5103296B2 (ja) * 2008-06-23 2012-12-19 花王株式会社 ジンジャーオレオレジン精製物の製造方法
EP2459187B1 (fr) 2009-07-29 2021-01-06 Olsen, Elise Compositions et procédés destinés à inhiber la croissance des poils
US8685472B2 (en) 2010-03-01 2014-04-01 Access Business Group International Llc Skin whitening composition containing chia seed extract
US8409636B2 (en) 2010-09-29 2013-04-02 Access Business Group International Llc Chia seed extract and related method of manufacture
EP2772245B1 (fr) 2013-02-27 2018-08-22 Symrise AG Extrait de gingembre pour le protection de cellules souches
EP3097905B1 (fr) 2015-05-28 2020-11-04 Symrise AG Compositions cosmetiques
KR102657242B1 (ko) 2016-05-30 2024-04-12 시므라이즈 아게 스크라레올라이드 (sclareolide) 를 포함하는 화장품 조성물
BR112018074580B1 (pt) 2016-05-30 2021-10-13 Symrise Ag Método não terapêutico para tratamento da hiperpigmentação induzida por luz visível e uso cosmético de um extrato de raiz de gengibre com co2
KR102667506B1 (ko) 2016-06-30 2024-05-20 시므라이즈 아게 레조르시놀 유도체를 포함하는 약제 및 화장품 조성물
RU2712049C2 (ru) * 2017-10-13 2020-01-24 Кривоносова Нина Ивановна Комплексная биологически активная добавка для подавления роста волос и способ ее использования

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US4720489A (en) * 1984-10-15 1988-01-19 Douglas Shander Hair growth modification with ornithine decarboxylase inhibitors
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US5096911A (en) * 1990-06-25 1992-03-17 Ahluwalia Gurpreet S Alteration of rate and character of hair growth
US5132293A (en) * 1990-08-14 1992-07-21 Douglas Shander Enzymic alteration of hair growth
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US5674477A (en) * 1995-02-28 1997-10-07 Ahluwalia; Gurpreet S. Reduction of hair growth
US6093748A (en) * 1995-02-28 2000-07-25 Ahluwalia; Gurpreet S. Inhibition of hair growth
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US5968488A (en) * 1996-10-21 1999-10-19 Henkel Kommanditgesellschaft Auf Aktien Deodorizing preparations containing cationic biopolymers, aluminum hydrochlorate and esterase inhibitors
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060051437A1 (en) * 2004-08-28 2006-03-09 Boehringer Ingelheim International Gmbh Process for preparing a ginger fraction and the use thereof for inhibiting human CYP enzymes
US20070203240A1 (en) * 2006-02-27 2007-08-30 The Procter & Gamble Company Personal care compositions and methods for regulating mammalian hair growth
EP4140317A4 (fr) * 2020-05-28 2023-10-04 Hanamoa Co., Ltd. Composition d'eau de gingembre contenant un extrait de gingembre et son procédé de fabrication

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CN1404856A (zh) 2003-03-26
EP1281402A1 (fr) 2003-02-05
CN1254270C (zh) 2006-05-03
CA2396809A1 (fr) 2003-02-03
EP1281402B1 (fr) 2005-10-05
US8282946B2 (en) 2012-10-09
DE60206450T2 (de) 2006-08-03
JP2003048845A (ja) 2003-02-21
DE60206450D1 (de) 2005-11-10
JP4759182B2 (ja) 2011-08-31
US20060099280A1 (en) 2006-05-11
CA2396809C (fr) 2011-09-27

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