UA99483C2 - Соединения-ингибиторы parp, композиции и их применение - Google Patents

Соединения-ингибиторы parp, композиции и их применение

Info

Publication number
UA99483C2
UA99483C2 UAA201005117A UAA201005117A UA99483C2 UA 99483 C2 UA99483 C2 UA 99483C2 UA A201005117 A UAA201005117 A UA A201005117A UA A201005117 A UAA201005117 A UA A201005117A UA 99483 C2 UA99483 C2 UA 99483C2
Authority
UA
Ukraine
Prior art keywords
relates
compounds
inhibitor compounds
parp inhibitor
disclosed
Prior art date
Application number
UAA201005117A
Other languages
English (en)
Ukrainian (uk)
Inventor
Вайженг Су
Грег ДЕЛАХАНТИ
Линг Вай
Джи Жанг
Original Assignee
Эйсай Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40526672&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA99483(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эйсай Инк. filed Critical Эйсай Инк.
Publication of UA99483C2 publication Critical patent/UA99483C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Представленное изобретение касается 8-(1,3-дигидроизоиндол-2-илметил)-2,9- дигидро-1,2,7,9-тетраазафенален-3-она формулы,который ингибирует поли(ADP-рибоза)полимеразу (PARP) и который применяют для химической сенсибилизации противораковых терапевтических средств, для повышения эффективности химиотерапевтических средств, таких как темозоломид, для радиоактивной сенсибилизации опухолевых клеток к ионизирующей радиации, для лечения разных видов рака с дефектами репарации ДНК.
UAA201005117A 2007-10-03 2008-10-02 Соединения-ингибиторы parp, композиции и их применение UA99483C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97711507P 2007-10-03 2007-10-03

Publications (1)

Publication Number Publication Date
UA99483C2 true UA99483C2 (ru) 2012-08-27

Family

ID=40526672

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201005117A UA99483C2 (ru) 2007-10-03 2008-10-02 Соединения-ингибиторы parp, композиции и их применение

Country Status (28)

Country Link
US (3) US8236802B2 (ru)
EP (2) EP2842956A1 (ru)
JP (1) JP5439380B2 (ru)
KR (1) KR101596526B1 (ru)
CN (1) CN102083314B (ru)
AU (1) AU2008308664B2 (ru)
BR (1) BRPI0820518B1 (ru)
CA (1) CA2700903C (ru)
CL (1) CL2010000320A1 (ru)
CY (1) CY1115747T1 (ru)
DK (1) DK2209375T3 (ru)
ES (1) ES2504690T3 (ru)
HK (1) HK1146792A1 (ru)
HR (1) HRP20140853T1 (ru)
IL (1) IL204776A (ru)
JO (1) JO3170B1 (ru)
MX (1) MX2010003564A (ru)
MY (1) MY155237A (ru)
NZ (1) NZ585012A (ru)
PL (1) PL2209375T3 (ru)
PT (1) PT2209375E (ru)
RU (1) RU2485122C2 (ru)
SG (1) SG185272A1 (ru)
SI (1) SI2209375T1 (ru)
TW (1) TWI426912B (ru)
UA (1) UA99483C2 (ru)
WO (1) WO2009046205A1 (ru)
ZA (1) ZA201002317B (ru)

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EP2800821B1 (en) 2012-01-05 2016-11-16 Centre National de la Recherche Scientifique (CNRS) Signature for the diagnosis of lung cancer aggressiveness
JP2016519684A (ja) 2013-04-08 2016-07-07 デニス エム ブラウン 準最適に投与された薬物療法の有効性を改善するための及び／又は副作用を低減するための方法および組成物
WO2015013579A1 (en) 2013-07-26 2015-01-29 Update Pharma Inc. Compositions to improve the therapeutic benefit of bisantrene
CN106659765B (zh) 2014-04-04 2021-08-13 德玛医药 二脱水半乳糖醇及其类似物或衍生物用于治疗非小细胞肺癌和卵巢癌的用途
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EP3265560B1 (en) 2015-03-02 2021-12-08 Sinai Health System Homologous recombination factors
CN104945406B (zh) * 2015-05-25 2017-10-10 苏州康润医药有限公司 氮杂非那烯‑3‑酮的衍生物、其制备方法及其作为parp抑制剂的应用
CA2993270C (en) 2015-07-23 2019-07-16 Institut Curie Use of a combination of dbait molecule and parp inhibitors to treat cancer
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WO2018165615A1 (en) * 2017-03-09 2018-09-13 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Parp-1 and methods of use thereof
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EP3765613A1 (en) 2018-03-13 2021-01-20 Onxeo A dbait molecule against acquired resistance in the treatment of cancer
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2021249996A1 (en) 2020-06-08 2021-12-16 Oncology Venture ApS Compositions comprising 2x-121 and methods for treating coronavirus infection
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Also Published As

Publication number Publication date
MX2010003564A (es) 2010-09-10
JP5439380B2 (ja) 2014-03-12
AU2008308664B2 (en) 2014-07-17
IL204776A (en) 2015-09-24
IL204776A0 (en) 2010-11-30
CN102083314A (zh) 2011-06-01
RU2010117397A (ru) 2011-11-10
CY1115747T1 (el) 2017-01-25
WO2009046205A1 (en) 2009-04-09
EP2209375A1 (en) 2010-07-28
JO3170B1 (ar) 2017-09-20
PL2209375T3 (pl) 2014-12-31
US8236802B2 (en) 2012-08-07
MY155237A (en) 2015-09-30
CA2700903C (en) 2017-05-30
RU2485122C2 (ru) 2013-06-20
CL2010000320A1 (es) 2011-03-11
EP2842956A1 (en) 2015-03-04
NZ585012A (en) 2012-06-29
CN102083314B (zh) 2014-04-30
BRPI0820518A2 (pt) 2020-01-14
BRPI0820518B1 (pt) 2021-09-28
US20090098084A1 (en) 2009-04-16
TWI426912B (zh) 2014-02-21
TW200932239A (en) 2009-08-01
HK1146792A1 (en) 2011-07-15
PT2209375E (pt) 2014-10-08
ZA201002317B (en) 2013-09-25
US20150141429A1 (en) 2015-05-21
SG185272A1 (en) 2012-11-29
EP2209375A4 (en) 2011-03-09
JP2010540655A (ja) 2010-12-24
SI2209375T1 (sl) 2014-12-31
KR20100100771A (ko) 2010-09-15
ES2504690T3 (es) 2014-10-08
KR101596526B1 (ko) 2016-02-22
CA2700903A1 (en) 2009-04-09
HRP20140853T1 (hr) 2014-10-24
DK2209375T3 (da) 2014-10-06
EP2209375B1 (en) 2014-08-27
US20130011365A1 (en) 2013-01-10
AU2008308664A1 (en) 2009-04-09
US8894989B2 (en) 2014-11-25

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