UA97812C2 - Прививочные макромолекулярные конъюгаты доксорубицина с противоопухолевой активностью и способ их получения - Google Patents
Прививочные макромолекулярные конъюгаты доксорубицина с противоопухолевой активностью и способ их полученияInfo
- Publication number
- UA97812C2 UA97812C2 UAA200903818A UAA200903818A UA97812C2 UA 97812 C2 UA97812 C2 UA 97812C2 UA A200903818 A UAA200903818 A UA A200903818A UA A200903818 A UAA200903818 A UA A200903818A UA 97812 C2 UA97812 C2 UA 97812C2
- Authority
- UA
- Ukraine
- Prior art keywords
- cancerostatic
- connected via
- polymeric drug
- via spacers
- hydroxypropyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
Полимерное лекарственное средство, в котором канцеростатик, связан при помощи спейсеров, содержащих гидролитически расщепляющие гидразоновые связи, связан с водорастворимым полимерным носителем, полученным на основе сополимера N-(2-гидроксипропил)метакриламида, при этом структура полимерного лекарственного средства состоит из главной цепи N-(2-гидроксипропил)метакриламида, которая несет канцеростатик, и другой цепи N-(2-гидроксипропил)метакриламида - привитой цепи, которая также может нести канцеростатик, при этом указанные привитые цепи связаны с главной цепью связью, которая стабильна в организме, и/или связью, расщепляющей в организме, в частности олигопептидным спейсером, выбранным из группы GlyLeuGly, GlyPheGly, GlyPheLeuGly и GlyLeuPheGly, и способ его получения.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CZ20060592A CZ298945B6 (cs) | 2006-09-18 | 2006-09-18 | Polymerní lécivo a zpusob jeho výroby |
PCT/CZ2007/000087 WO2008034391A1 (en) | 2006-09-18 | 2007-09-18 | Grafted macromolecular conjugates of doxorubicin with anticancer activity and method of their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
UA97812C2 true UA97812C2 (ru) | 2012-03-26 |
Family
ID=38982478
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200903818A UA97812C2 (ru) | 2006-09-18 | 2007-09-18 | Прививочные макромолекулярные конъюгаты доксорубицина с противоопухолевой активностью и способ их получения |
Country Status (6)
Country | Link |
---|---|
US (1) | US8603990B2 (ru) |
EP (1) | EP2063914B1 (ru) |
CZ (1) | CZ298945B6 (ru) |
EA (1) | EA017073B1 (ru) |
UA (1) | UA97812C2 (ru) |
WO (1) | WO2008034391A1 (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2739757C (en) | 2008-10-07 | 2016-07-05 | Rexahn Pharmaceuticals, Inc. | Hpma - docetaxel or gemcitabine conjugates and uses therefore |
CZ2008661A3 (cs) * | 2008-10-23 | 2009-12-30 | Zentiva, A. S | Polymerní prípravek se synergickým úcinkem pri lécbe nádorových onemocnení |
CZ303072B6 (cs) * | 2009-02-13 | 2012-03-21 | Zentiva, K.S. | Polymerní konjugáty paclitaxelu a docetaxelu s pH rízeným uvolnováním kancerostatika |
BR112012008772A2 (pt) | 2009-10-13 | 2017-06-20 | Rexahn Pharmaceuticals Inc | sistemas poliméricos para a liberação de agentes anti-câncer |
CZ302830B6 (cs) * | 2009-12-15 | 2011-11-30 | Ústav makromolekulární chemie AV CR, v.v.i. | Vysokomolekulární polymerní nosice léciv odvozené od dendrimeru a jejich konjugáty s lécivy pro lécbu zejména pevných nádoru |
DK2683393T3 (en) | 2011-02-11 | 2018-07-23 | Univ Michigan Regents | TRIPEPTIME COMPOSITIONS AND THEIR USE IN TREATING DIABETES |
HUE033575T2 (hu) | 2011-05-26 | 2017-12-28 | Xuanzhu Pharma Co Ltd | Tirozin-kináz inhibitor kinazolin származék, elõállítási eljárása és alkalmazása |
CN103936945B (zh) * | 2013-01-23 | 2017-02-08 | 中国科学院化学研究所 | 一类高效抗肿瘤靶向药物载体及其制备方法 |
CN106995516B (zh) * | 2016-01-22 | 2019-08-02 | 北京化工大学 | 肿瘤特异性富集的纳米载药体系及其制备方法 |
CZ308419B6 (cs) * | 2016-04-11 | 2020-08-12 | Ústav makromolekulární chemie AV ČR, v. v. i. | Blokový kopolymer pro překonání lékové rezistence nádorů k chemoterapii, jeho polymerní konjugát s léčivem, farmaceutická kompozice je obsahující, způsob jejich přípravy a jejich použití |
CN105963706B (zh) * | 2016-04-15 | 2019-03-15 | 四川大学 | 一种支化hpma共聚物-dox偶联物及其制备方法和应用 |
CZ309585B6 (cs) * | 2019-12-17 | 2023-05-03 | Ústav makromolekulární chemie AV ČR, v. v. i. | Polymerní konjugát s hydrolytickým uvolňováním kancerostatika cytarabinu, způsob jeho přípravy a jeho použití |
CN112940248B (zh) * | 2021-02-04 | 2023-07-18 | 西安交通大学 | 一种pH响应型金属配位聚前药纳米粒子及其制备方法 |
CN113908289B (zh) * | 2021-10-09 | 2023-07-25 | 北京化工大学 | 一种具有精确调控药物比例的抗肿瘤多元载药体系及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE243501T1 (de) * | 1993-11-18 | 2003-07-15 | Sirtex Medical Ltd | Zubereitung mit gesteuerter freisetzung |
US6060518A (en) * | 1996-08-16 | 2000-05-09 | Supratek Pharma Inc. | Polymer compositions for chemotherapy and methods of treatment using the same |
GB9913359D0 (en) * | 1999-06-09 | 1999-08-11 | Cancer Res Campaign Tech | Polymer modified biological elements |
CZ293787B6 (cs) | 2001-12-20 | 2004-07-14 | Zentiva, A.S. | pH senzitivní polymerní konjugáty antracyklinového kancerostatika pro cílenou terapii |
CZ294996B6 (cs) * | 2003-07-16 | 2005-04-13 | Ústav Makromolekulární Chemie Av Čr | Reaktivní polymery a kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu, způsob jejich přípravy a jejich použití pro syntézu polymerních léčiv, pro modifikaci biologicky aktivních proteinů a přípravu systémů pro dopravu genů |
CZ2005558A3 (cs) * | 2005-09-05 | 2007-04-04 | Zentiva, A. S. | Zpusob prípravy polymerních konjugátu doxorubicinu s pH-rízeným uvolnováním léciva |
-
2006
- 2006-09-18 CZ CZ20060592A patent/CZ298945B6/cs not_active IP Right Cessation
-
2007
- 2007-09-18 EP EP07801128.5A patent/EP2063914B1/en not_active Not-in-force
- 2007-09-18 US US12/441,619 patent/US8603990B2/en active Active
- 2007-09-18 WO PCT/CZ2007/000087 patent/WO2008034391A1/en active Application Filing
- 2007-09-18 UA UAA200903818A patent/UA97812C2/ru unknown
- 2007-09-18 EA EA200900453A patent/EA017073B1/ru not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CZ2006592A3 (cs) | 2008-03-19 |
WO2008034391A1 (en) | 2008-03-27 |
US8603990B2 (en) | 2013-12-10 |
EP2063914A1 (en) | 2009-06-03 |
EA200900453A1 (ru) | 2009-10-30 |
EP2063914B1 (en) | 2018-12-26 |
CZ298945B6 (cs) | 2008-03-19 |
US20090306004A1 (en) | 2009-12-10 |
EA017073B1 (ru) | 2012-09-28 |
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