UA94717C2 - Модифицированный вирус гриппа, предназначенный для мониторинга и повышения эффективности вакцины - Google Patents

Модифицированный вирус гриппа, предназначенный для мониторинга и повышения эффективности вакцины

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Publication number
UA94717C2
UA94717C2 UAA200802674A UAA200802674A UA94717C2 UA 94717 C2 UA94717 C2 UA 94717C2 UA A200802674 A UAA200802674 A UA A200802674A UA A200802674 A UAA200802674 A UA A200802674A UA 94717 C2 UA94717 C2 UA 94717C2
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Ukraine
Prior art keywords
influenza virus
molecule
monitoring
modified influenza
vaccine efficiency
Prior art date
Application number
UAA200802674A
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English (en)
Ukrainian (uk)
Inventor
Эрих Хоффманн
Александр С. ЛИПАТОВ
Роберт Г. Вебстер
Ричард Дж. Вебби
Елена А. ГОВОРКОВА
Original Assignee
Ст. Джуд Чилдреньс Рисьорч Хоспител
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Application filed by Ст. Джуд Чилдреньс Рисьорч Хоспител filed Critical Ст. Джуд Чилдреньс Рисьорч Хоспител
Publication of UA94717C2 publication Critical patent/UA94717C2/ru

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A61K2039/5254—Virus avirulent or attenuated
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161—Methods of inactivation or attenuation
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    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Abstract

Изобретение относится к молекуле гемагглютинина (НА) вируса гриппа, который содержит аспарагин в аминокислотном положении, который соответствует аминокислотному положению 223 в НА Н5, где молекула НА не происходит от изолята человеческого Н5 А/НК/213/03 и где включение аспарагина в положение 223 приводит к повышенной реактивности относительно антисыворотки, полученной из организма животного, которое инфицировано вирусом гриппа или противогриппозной вакциной. Также изобретение относится к рекомбинантному вирусу гриппа, который содержит заявленную молекулу НА вируса гриппа и вакцинного вируса гриппа, который содержит заявленную рекомбинантную молекулу гемаглютинина (НА), а также изобретение относится к противогриппозной вакцине, которая содержит заявленную молекулу гемаглютинина вируса гриппа.
UAA200802674A 2005-08-04 2006-07-28 Модифицированный вирус гриппа, предназначенный для мониторинга и повышения эффективности вакцины UA94717C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70580805P 2005-08-04 2005-08-04

Publications (1)

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UA94717C2 true UA94717C2 (ru) 2011-06-10

Family

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UAA200802674A UA94717C2 (ru) 2005-08-04 2006-07-28 Модифицированный вирус гриппа, предназначенный для мониторинга и повышения эффективности вакцины

Country Status (16)

Country Link
US (4) US7871626B2 (ru)
EP (1) EP1924281B1 (ru)
JP (2) JP5395430B2 (ru)
KR (1) KR101334047B1 (ru)
CN (2) CN103172710B (ru)
AU (1) AU2006278696B2 (ru)
BR (1) BRPI0614297A2 (ru)
CA (1) CA2617483C (ru)
ES (1) ES2728791T3 (ru)
HU (1) HUE043952T2 (ru)
PL (1) PL1924281T3 (ru)
RU (3) RU2420535C2 (ru)
SG (1) SG2014007934A (ru)
UA (1) UA94717C2 (ru)
WO (1) WO2007019094A2 (ru)
ZA (1) ZA200800505B (ru)

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JP5395430B2 (ja) 2014-01-22
SG2014007934A (en) 2014-04-28
CA2617483C (en) 2016-09-27
KR101334047B1 (ko) 2013-11-29
EP1924281A4 (en) 2014-01-01
AU2006278696A8 (en) 2008-03-06
PL1924281T3 (pl) 2019-10-31
US8574592B2 (en) 2013-11-05
CN101283099A (zh) 2008-10-08
US20070031453A1 (en) 2007-02-08
US20110104202A1 (en) 2011-05-05
RU2420535C2 (ru) 2011-06-10
CN103172710A (zh) 2013-06-26
RU2011103648A (ru) 2012-08-10
BRPI0614297A2 (pt) 2011-03-22
US7871626B2 (en) 2011-01-18
US20140030702A1 (en) 2014-01-30
CN101283099B (zh) 2013-03-27
US9499850B2 (en) 2016-11-22
CA2617483A1 (en) 2007-02-15
WO2007019094A3 (en) 2007-07-12
KR20080042864A (ko) 2008-05-15
CN103172710B (zh) 2016-08-17
RU2552213C2 (ru) 2015-06-10
JP2014003982A (ja) 2014-01-16
HUE043952T2 (hu) 2019-09-30
AU2006278696B2 (en) 2012-03-15
EP1924281A2 (en) 2008-05-28
JP5745584B2 (ja) 2015-07-08
WO2007019094A2 (en) 2007-02-15
ES2728791T3 (es) 2019-10-28
EP1924281B1 (en) 2019-05-08
US20130017216A1 (en) 2013-01-17
AU2006278696A1 (en) 2007-02-15
RU2013101020A (ru) 2014-07-20
JP2009502197A (ja) 2009-01-29
US8293247B2 (en) 2012-10-23
RU2008107875A (ru) 2009-09-10
RU2480480C2 (ru) 2013-04-27
ZA200800505B (en) 2008-12-31

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