UA86094C2 - Method for the preparation of oxycodone - Google Patents
Method for the preparation of oxycodoneInfo
- Publication number
- UA86094C2 UA86094C2 UAA200702812A UAA200702812A UA86094C2 UA 86094 C2 UA86094 C2 UA 86094C2 UA A200702812 A UAA200702812 A UA A200702812A UA A200702812 A UAA200702812 A UA A200702812A UA 86094 C2 UA86094 C2 UA 86094C2
- Authority
- UA
- Ukraine
- Prior art keywords
- oxycodone
- formula
- preparation
- hydroxycodeinone
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Способ получения оксикодона формулы І путем взаимодействия тебаина формулы II или его аналога формулы III, где R представляет собой С-Салкил, алкиларил, преимущественно бензил, метоксибензил или алил, с пероксидом водорода или пероксокислоты в присутствии щавелевой кислоты в смеси с уксусной или муравьиной кислотой. Из полученного кристаллического осадка оксалата 4-гидроксикодеинона, путем добавления основы, высвобождают 14-гидроксикодеинон формулы IV, который гидрируют водородом в присутствии катализатора, с получением оксикодона формулы (І). Оксикодон превращают в гидрохлорид, который используют как активное вещество в анальгетических рецептурах.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SK321-2004A SK286087B6 (sk) | 2004-08-18 | 2004-08-18 | Spôsob prípravy oxykodonu |
Publications (1)
Publication Number | Publication Date |
---|---|
UA86094C2 true UA86094C2 (en) | 2009-03-25 |
Family
ID=34993096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200702812A UA86094C2 (en) | 2004-08-18 | 2005-08-16 | Method for the preparation of oxycodone |
Country Status (15)
Country | Link |
---|---|
US (1) | US7619087B2 (ru) |
EP (1) | EP1658293B1 (ru) |
AT (1) | ATE348102T1 (ru) |
CZ (1) | CZ2005507A3 (ru) |
DE (1) | DE602005000334T2 (ru) |
DK (1) | DK1658293T3 (ru) |
EA (1) | EA009392B1 (ru) |
ES (1) | ES2273328T3 (ru) |
NO (1) | NO20060476L (ru) |
PL (1) | PL1658293T3 (ru) |
PT (1) | PT1658293E (ru) |
SI (1) | SI1658293T1 (ru) |
SK (1) | SK286087B6 (ru) |
UA (1) | UA86094C2 (ru) |
WO (1) | WO2006019364A1 (ru) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5923827B2 (ja) * | 1981-12-16 | 1984-06-05 | フエザ−安全剃刀株式会社 | 安全かみそり刃 |
WO2007137785A2 (en) * | 2006-05-25 | 2007-12-06 | Alpharma (Bermuda) Investments Ltd | Process useful in the preparation of morphinan antagonists |
KR100780932B1 (ko) * | 2006-05-30 | 2007-11-30 | 엠텍비젼 주식회사 | 컬러 보간 방법 및 장치 |
JP2010511726A (ja) | 2006-12-04 | 2010-04-15 | ノランコ・インコーポレーテツド | 14−ヒドロキシコデイノンの濃度が低いオキシコドンの製造方法 |
WO2008070656A2 (en) * | 2006-12-04 | 2008-06-12 | Noramco, Inc | Process for reducing impurities in oxycodone base |
JP2010522189A (ja) † | 2007-03-23 | 2010-07-01 | マリンクロッド・インコーポレイテッド | オリパビンからのオキシモルホンの改善された調製 |
GB2450691A (en) * | 2007-07-02 | 2009-01-07 | Alpharma Aps | One-pot preparation of oxycodone from thebaine |
ES2586439T3 (es) * | 2008-09-18 | 2016-10-14 | Purdue Pharma Lp | Formas farmacéuticas de dosificación que comprenden poli (E-caprolactona) |
EP2377866B1 (en) | 2010-03-23 | 2014-02-26 | Siegfried AG | Preparation of low impurity opiates in a continuous flow reactor |
WO2012003468A1 (en) * | 2010-07-02 | 2012-01-05 | Johnson Matthey Public Limited Company | Process for the synthesis and purification of oxycodone |
CN104470928B (zh) | 2012-07-16 | 2017-08-11 | 罗德科技公司 | 用于改进的阿片样物质合成的方法 |
JP6236446B2 (ja) | 2012-07-16 | 2017-11-22 | ローズ テクノロジーズ | 改善されたオピオイド合成方法 |
HUE042762T2 (hu) * | 2012-08-03 | 2019-07-29 | Johnson Matthey Plc | Eljárás oxikodon elõállítására |
US10227354B2 (en) | 2013-12-18 | 2019-03-12 | Cody Laboratories, Inc. | Conversion of oxycodone base to oxycodone hydrochloride |
US9062062B1 (en) | 2013-12-18 | 2015-06-23 | Cody Laboratories, Inc. | Synthesis of oxycodone hydrochloride |
US8846923B1 (en) | 2013-12-18 | 2014-09-30 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
WO2015095585A2 (en) * | 2013-12-18 | 2015-06-25 | Cody Laboratories, Inc. | Sysnthesis of oxycodone hydrochloride |
KR101868724B1 (ko) | 2014-01-15 | 2018-06-18 | 로드스 테크놀로지즈 | 개선된 옥시모르폰 합성을 위한 방법 |
CN106029670A (zh) | 2014-01-15 | 2016-10-12 | 罗德科技公司 | 改进的羟考酮合成的方法 |
US20160052932A1 (en) * | 2014-08-25 | 2016-02-25 | Johnson Matthey Public Limited Company | Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone |
WO2016100113A2 (en) * | 2014-12-17 | 2016-06-23 | Siemens Healthcare Diagnostics Inc. | Conjugates for assays for oxycodone and oxymorphone |
WO2018234748A1 (en) * | 2017-06-20 | 2018-12-27 | Johnson Matthey Public Limited Company | HYDROGENATION PROCESS FOR THE PREPARATION OF OXYCODONE HYDROCHLORIDE FROM 14-HYDROXYCODEINONE |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6864370B1 (en) * | 2003-06-05 | 2005-03-08 | Zhaiwei Lin | Process for manufacturing oxycodone |
-
2004
- 2004-08-18 SK SK321-2004A patent/SK286087B6/sk not_active IP Right Cessation
-
2005
- 2005-08-09 CZ CZ20050507A patent/CZ2005507A3/cs unknown
- 2005-08-16 UA UAA200702812A patent/UA86094C2/ru unknown
- 2005-08-16 ES ES05776280T patent/ES2273328T3/es active Active
- 2005-08-16 PL PL05776280T patent/PL1658293T3/pl unknown
- 2005-08-16 EP EP05776280A patent/EP1658293B1/en active Active
- 2005-08-16 US US10/569,423 patent/US7619087B2/en not_active Expired - Fee Related
- 2005-08-16 WO PCT/SK2005/000014 patent/WO2006019364A1/en active IP Right Grant
- 2005-08-16 DK DK05776280T patent/DK1658293T3/da active
- 2005-08-16 EA EA200600129A patent/EA009392B1/ru not_active IP Right Cessation
- 2005-08-16 DE DE602005000334T patent/DE602005000334T2/de not_active Expired - Fee Related
- 2005-08-16 SI SI200530007T patent/SI1658293T1/sl unknown
- 2005-08-16 AT AT05776280T patent/ATE348102T1/de not_active IP Right Cessation
- 2005-08-16 PT PT05776280T patent/PT1658293E/pt unknown
-
2006
- 2006-01-30 NO NO20060476A patent/NO20060476L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1658293A1 (en) | 2006-05-24 |
EP1658293B1 (en) | 2006-12-13 |
NO20060476L (no) | 2006-03-14 |
US7619087B2 (en) | 2009-11-17 |
DE602005000334D1 (de) | 2007-01-25 |
EA009392B1 (ru) | 2007-12-28 |
PL1658293T3 (pl) | 2007-03-30 |
DK1658293T3 (da) | 2007-01-29 |
CZ2005507A3 (cs) | 2007-01-31 |
PT1658293E (pt) | 2007-01-31 |
ATE348102T1 (de) | 2007-01-15 |
US20070088162A1 (en) | 2007-04-19 |
SK286087B6 (sk) | 2008-03-05 |
SK3212004A3 (sk) | 2006-03-02 |
EA200600129A1 (ru) | 2006-06-30 |
ES2273328T3 (es) | 2007-05-01 |
WO2006019364A1 (en) | 2006-02-23 |
DE602005000334T2 (de) | 2007-04-12 |
SI1658293T1 (sl) | 2007-04-30 |
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