ATE341552T1 - Derivate morphinähnlicher opioidverbindungen - Google Patents
Derivate morphinähnlicher opioidverbindungenInfo
- Publication number
- ATE341552T1 ATE341552T1 AT02753923T AT02753923T ATE341552T1 AT E341552 T1 ATE341552 T1 AT E341552T1 AT 02753923 T AT02753923 T AT 02753923T AT 02753923 T AT02753923 T AT 02753923T AT E341552 T1 ATE341552 T1 AT E341552T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- derivatives
- morphine
- formula
- pharmaceutically acceptable
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 102000003840 Opioid Receptors Human genes 0.000 abstract 1
- 108090000137 Opioid Receptors Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPR6938A AUPR693801A0 (en) | 2001-08-10 | 2001-08-10 | Therapeutic compounds |
AUPR9640A AUPR964001A0 (en) | 2001-12-19 | 2001-12-19 | Therapeutic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE341552T1 true ATE341552T1 (de) | 2006-10-15 |
Family
ID=25646773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02753923T ATE341552T1 (de) | 2001-08-10 | 2002-08-09 | Derivate morphinähnlicher opioidverbindungen |
Country Status (7)
Country | Link |
---|---|
US (1) | US7199129B2 (de) |
EP (1) | EP1423392B1 (de) |
JP (1) | JP2005500373A (de) |
AT (1) | ATE341552T1 (de) |
AU (1) | AU2002322169B2 (de) |
DE (1) | DE60215195T2 (de) |
WO (1) | WO2003014122A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040204862A1 (en) * | 2003-04-11 | 2004-10-14 | Wainer Irving W. | Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors |
TWI541246B (zh) | 2008-12-08 | 2016-07-11 | 歐陸斯迪公司 | 二氫羥戊甲嗎啡 |
US9193724B2 (en) | 2011-09-22 | 2015-11-24 | Merck Sharp & Dohme Corp. | Triazolopyridyl compounds as aldosterone synthase inhibitors |
EP2757884B1 (de) | 2011-09-22 | 2022-07-27 | Merck Sharp & Dohme LLC | Pyrazolopyridylverbindungen als aldosteronsynthasehemmer |
EP2757882B1 (de) | 2011-09-22 | 2020-11-04 | Merck Sharp & Dohme Corp. | Imidazopyridylverbindungen als aldosteronsynthasehemmer |
AU2013292519B2 (en) | 2012-07-19 | 2017-12-07 | Drexel University | Sigma receptor ligands for modulating cellular protein homeostasis |
GB201309654D0 (en) | 2013-05-30 | 2013-07-17 | Euro Celtique Sa | Method |
US9920836B2 (en) * | 2013-10-18 | 2018-03-20 | Kabushiki Kaisha Riken | Piston ring for internal combustion engine |
US11117870B2 (en) | 2017-11-01 | 2021-09-14 | Drexel University | Compounds, compositions, and methods for treating diseases |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3341538A (en) * | 1965-06-18 | 1967-09-12 | Geigy Chem Corp | Certain 2, 6-methano-3-benzazocines |
CA2319627A1 (en) * | 1998-01-29 | 1999-08-05 | Polychip Pharmaceuticals Pty. Ltd. | Therapeutic compounds |
JP3971299B2 (ja) | 2000-08-31 | 2007-09-05 | エフ.ホフマン−ラ ロシュ アーゲー | α−1アドレナリン作動性拮抗薬としてのキナゾリン誘導体 |
-
2002
- 2002-08-09 AT AT02753923T patent/ATE341552T1/de not_active IP Right Cessation
- 2002-08-09 JP JP2003519071A patent/JP2005500373A/ja not_active Abandoned
- 2002-08-09 WO PCT/AU2002/001088 patent/WO2003014122A1/en active IP Right Grant
- 2002-08-09 AU AU2002322169A patent/AU2002322169B2/en not_active Ceased
- 2002-08-09 DE DE60215195T patent/DE60215195T2/de not_active Expired - Fee Related
- 2002-08-09 US US10/486,536 patent/US7199129B2/en not_active Expired - Fee Related
- 2002-08-09 EP EP02753923A patent/EP1423392B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US7199129B2 (en) | 2007-04-03 |
US20040242616A1 (en) | 2004-12-02 |
JP2005500373A (ja) | 2005-01-06 |
AU2002322169B2 (en) | 2008-10-30 |
WO2003014122A1 (en) | 2003-02-20 |
EP1423392A4 (de) | 2004-11-17 |
DE60215195D1 (de) | 2006-11-16 |
EP1423392A1 (de) | 2004-06-02 |
DE60215195T2 (de) | 2007-08-23 |
EP1423392B1 (de) | 2006-10-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |