UA82642C2 - Застосування перфторалкілвмісних комплексів металів як контрастних речовин в магнітно-резонансній томографії для візуалізації бляшок, пухлин і некрозів - Google Patents
Застосування перфторалкілвмісних комплексів металів як контрастних речовин в магнітно-резонансній томографії для візуалізації бляшок, пухлин і некрозів Download PDFInfo
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- UA82642C2 UA82642C2 UA2003032067A UA2003032067A UA82642C2 UA 82642 C2 UA82642 C2 UA 82642C2 UA 2003032067 A UA2003032067 A UA 2003032067A UA 2003032067 A UA2003032067 A UA 2003032067A UA 82642 C2 UA82642 C2 UA 82642C2
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- 229910052808 lithium carbonate Inorganic materials 0.000 description 1
- IOEDDFFKYCBADJ-UHFFFAOYSA-M lithium;4-methylbenzenesulfonate Chemical compound [Li+].CC1=CC=C(S([O-])(=O)=O)C=C1 IOEDDFFKYCBADJ-UHFFFAOYSA-M 0.000 description 1
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- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- BLQJIBCZHWBKSL-UHFFFAOYSA-L magnesium iodide Chemical compound [Mg+2].[I-].[I-] BLQJIBCZHWBKSL-UHFFFAOYSA-L 0.000 description 1
- 229910001641 magnesium iodide Inorganic materials 0.000 description 1
- IPFASKMZBDWRNG-UHFFFAOYSA-N manganese 5,10,15,20-tetraphenyl-21,23-dihydroporphyrin Chemical compound [Mn].c1cc2nc1c(-c1ccccc1)c1ccc([nH]1)c(-c1ccccc1)c1ccc(n1)c(-c1ccccc1)c1ccc([nH]1)c2-c1ccccc1 IPFASKMZBDWRNG-UHFFFAOYSA-N 0.000 description 1
- 239000011656 manganese carbonate Substances 0.000 description 1
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- BZLVMXJERCGZMT-UHFFFAOYSA-N methyl tert-butyl ether Substances COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 1
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- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- NCAIGTHBQTXTLR-UHFFFAOYSA-N phentermine hydrochloride Chemical compound [Cl-].CC(C)([NH3+])CC1=CC=CC=C1 NCAIGTHBQTXTLR-UHFFFAOYSA-N 0.000 description 1
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- 229920001184 polypeptide Polymers 0.000 description 1
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- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- ZDYVRSLAEXCVBX-UHFFFAOYSA-N pyridinium p-toluenesulfonate Chemical compound C1=CC=[NH+]C=C1.CC1=CC=C(S([O-])(=O)=O)C=C1 ZDYVRSLAEXCVBX-UHFFFAOYSA-N 0.000 description 1
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
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- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- KVCGISUBCHHTDD-UHFFFAOYSA-M sodium;4-methylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1 KVCGISUBCHHTDD-UHFFFAOYSA-M 0.000 description 1
- KKVTYAVXTDIPAP-UHFFFAOYSA-M sodium;methanesulfonate Chemical compound [Na+].CS([O-])(=O)=O KKVTYAVXTDIPAP-UHFFFAOYSA-M 0.000 description 1
- SETMGIIITGNLAS-UHFFFAOYSA-N spizofurone Chemical compound O=C1C2=CC(C(=O)C)=CC=C2OC21CC2 SETMGIIITGNLAS-UHFFFAOYSA-N 0.000 description 1
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- 150000005621 tetraalkylammonium salts Chemical class 0.000 description 1
- DZLFLBLQUQXARW-UHFFFAOYSA-N tetrabutylammonium Chemical compound CCCC[N+](CCCC)(CCCC)CCCC DZLFLBLQUQXARW-UHFFFAOYSA-N 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
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- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
- 125000005208 trialkylammonium group Chemical group 0.000 description 1
- 125000004665 trialkylsilyl group Chemical group 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
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- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
Landscapes
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10040380A DE10040380B4 (de) | 2000-08-11 | 2000-08-11 | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques |
| PCT/EP2001/008498 WO2002013874A2 (de) | 2000-08-11 | 2001-07-23 | Verwendung von perfluoralkylhaltigen metallkomplexen als kontrastmittel im mr-imaging zur darstellung von plaques, tumoren und nekrosen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA82642C2 true UA82642C2 (uk) | 2008-05-12 |
Family
ID=7652860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2003032067A UA82642C2 (uk) | 2000-08-11 | 2001-07-23 | Застосування перфторалкілвмісних комплексів металів як контрастних речовин в магнітно-резонансній томографії для візуалізації бляшок, пухлин і некрозів |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1307236A2 (sh) |
| JP (1) | JP2004506025A (sh) |
| KR (1) | KR20030022387A (sh) |
| CN (1) | CN1469757A (sh) |
| AR (1) | AR034139A1 (sh) |
| AU (2) | AU2001277549B2 (sh) |
| BG (1) | BG107542A (sh) |
| BR (1) | BR0113188A (sh) |
| CA (1) | CA2419223A1 (sh) |
| CZ (1) | CZ2003392A3 (sh) |
| DE (1) | DE10066210B4 (sh) |
| EE (1) | EE200300061A (sh) |
| HR (1) | HRP20030173A2 (sh) |
| HU (1) | HUP0300736A3 (sh) |
| IL (1) | IL154385A0 (sh) |
| MX (1) | MXPA03001287A (sh) |
| NO (1) | NO20030604L (sh) |
| NZ (1) | NZ523932A (sh) |
| PL (1) | PL365596A1 (sh) |
| RU (1) | RU2290206C2 (sh) |
| SK (1) | SK1572003A3 (sh) |
| TW (1) | TWI296931B (sh) |
| UA (1) | UA82642C2 (sh) |
| WO (1) | WO2002013874A2 (sh) |
| YU (1) | YU10603A (sh) |
| ZA (1) | ZA200301949B (sh) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10231799B4 (de) * | 2002-07-10 | 2006-10-05 | Schering Ag | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben |
| US7344704B2 (en) | 2002-07-10 | 2008-03-18 | Schering Ag | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi |
| DE102005008309A1 (de) * | 2005-02-17 | 2006-08-24 | Schering Ag | Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone |
| DE102006021495A1 (de) * | 2006-05-09 | 2007-11-15 | Bayer Schering Pharma Ag | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit |
| US7887835B2 (en) * | 2006-09-19 | 2011-02-15 | Fujifilm Corporation | Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound |
| DE102006049821A1 (de) * | 2006-10-18 | 2008-04-24 | Bayer Schering Pharma Aktiengesellschaft | Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung |
| DE102007015598A1 (de) * | 2007-03-29 | 2008-10-02 | Heinrich-Heine-Universität Düsseldorf | Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren |
| JP2011190183A (ja) * | 2010-03-11 | 2011-09-29 | Noguchi Institute | フルオラス化糖結合型クラウンエーテル誘導体 |
| US9976072B2 (en) | 2014-03-26 | 2018-05-22 | Chevron U.S.A. Inc. | Multicarboxylate compositions and method of making the same |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| JP7037069B2 (ja) * | 2016-09-14 | 2022-03-16 | ダイキン工業株式会社 | 分枝含フッ素化合物 |
| RU2755181C2 (ru) | 2016-11-28 | 2021-09-14 | Байер Фарма Акциенгезельшафт | Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации |
| MX2021006024A (es) | 2018-11-23 | 2021-07-06 | Bayer Ag | Formulacion de medios de contraste y proceso para prepararlos. |
| CN109867635A (zh) * | 2019-02-14 | 2019-06-11 | 华东师范大学 | 一种t1型胶束磁共振成像造影剂及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19603033A1 (de) * | 1996-01-19 | 1997-07-24 | Schering Ag | Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
| JPH10112939A (ja) * | 1996-10-07 | 1998-04-28 | Nec Corp | 電源切替回路 |
| DE19729013A1 (de) * | 1997-07-03 | 1999-02-04 | Schering Ag | Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
| US6019959A (en) * | 1997-07-31 | 2000-02-01 | Schering Aktiengesellschaft | Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis |
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2000
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2001
- 2001-07-23 JP JP2002519012A patent/JP2004506025A/ja active Pending
- 2001-07-23 MX MXPA03001287A patent/MXPA03001287A/es active IP Right Grant
- 2001-07-23 EP EP01955366A patent/EP1307236A2/de not_active Withdrawn
- 2001-07-23 YU YU10603A patent/YU10603A/sh unknown
- 2001-07-23 AU AU2001277549A patent/AU2001277549B2/en not_active Ceased
- 2001-07-23 EE EEP200300061A patent/EE200300061A/xx unknown
- 2001-07-23 KR KR10-2003-7002023A patent/KR20030022387A/ko not_active IP Right Cessation
- 2001-07-23 CA CA002419223A patent/CA2419223A1/en not_active Abandoned
- 2001-07-23 UA UA2003032067A patent/UA82642C2/uk unknown
- 2001-07-23 NZ NZ523932A patent/NZ523932A/en unknown
- 2001-07-23 CZ CZ2003392A patent/CZ2003392A3/cs unknown
- 2001-07-23 AU AU7754901A patent/AU7754901A/xx active Pending
- 2001-07-23 SK SK157-2003A patent/SK1572003A3/sk not_active Application Discontinuation
- 2001-07-23 HU HU0300736A patent/HUP0300736A3/hu unknown
- 2001-07-23 CN CNA018172717A patent/CN1469757A/zh active Pending
- 2001-07-23 WO PCT/EP2001/008498 patent/WO2002013874A2/de not_active Application Discontinuation
- 2001-07-23 RU RU2003105810/15A patent/RU2290206C2/ru not_active IP Right Cessation
- 2001-07-23 IL IL15438501A patent/IL154385A0/xx unknown
- 2001-07-23 PL PL01365596A patent/PL365596A1/xx not_active Application Discontinuation
- 2001-07-23 BR BR0113188-5A patent/BR0113188A/pt not_active IP Right Cessation
- 2001-08-10 AR ARP010103833A patent/AR034139A1/es unknown
- 2001-08-10 TW TW090119643A patent/TWI296931B/zh active
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2003
- 2003-02-07 BG BG107542A patent/BG107542A/bg unknown
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- 2003-03-10 HR HR20030173A patent/HRP20030173A2/hr not_active Application Discontinuation
- 2003-03-10 ZA ZA200301949A patent/ZA200301949B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0300736A3 (en) | 2010-01-28 |
| CZ2003392A3 (cs) | 2003-09-17 |
| WO2002013874A2 (de) | 2002-02-21 |
| CA2419223A1 (en) | 2003-02-11 |
| YU10603A (sh) | 2006-05-25 |
| AU2001277549B2 (en) | 2007-02-08 |
| TWI296931B (en) | 2008-05-21 |
| CN1469757A (zh) | 2004-01-21 |
| HRP20030173A2 (en) | 2005-04-30 |
| BG107542A (bg) | 2003-09-30 |
| IL154385A0 (en) | 2003-09-17 |
| RU2290206C2 (ru) | 2006-12-27 |
| DE10066210B4 (de) | 2008-02-28 |
| NZ523932A (en) | 2007-07-27 |
| EE200300061A (et) | 2004-12-15 |
| AR034139A1 (es) | 2004-02-04 |
| AU7754901A (en) | 2002-02-25 |
| BR0113188A (pt) | 2003-06-24 |
| WO2002013874A8 (de) | 2002-06-13 |
| MXPA03001287A (es) | 2003-10-06 |
| EP1307236A2 (de) | 2003-05-07 |
| ZA200301949B (en) | 2004-12-14 |
| SK1572003A3 (en) | 2003-10-07 |
| PL365596A1 (en) | 2005-01-10 |
| NO20030604L (no) | 2003-04-11 |
| KR20030022387A (ko) | 2003-03-15 |
| HUP0300736A2 (hu) | 2003-09-29 |
| NO20030604D0 (no) | 2003-02-07 |
| JP2004506025A (ja) | 2004-02-26 |
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