RU2290206C2 - Применение перфторалкилсодержащих комплексов металлов в качестве контрастных веществ в магнитно-резонансной томографии для визуализации бляшек, опухолей и некрозов - Google Patents

Применение перфторалкилсодержащих комплексов металлов в качестве контрастных веществ в магнитно-резонансной томографии для визуализации бляшек, опухолей и некрозов Download PDF

Info

Publication number
RU2290206C2
RU2290206C2 RU2003105810/15A RU2003105810A RU2290206C2 RU 2290206 C2 RU2290206 C2 RU 2290206C2 RU 2003105810/15 A RU2003105810/15 A RU 2003105810/15A RU 2003105810 A RU2003105810 A RU 2003105810A RU 2290206 C2 RU2290206 C2 RU 2290206C2
Authority
RU
Russia
Prior art keywords
mmol
acid
stirred
hours
residue
Prior art date
Application number
RU2003105810/15A
Other languages
English (en)
Russian (ru)
Other versions
RU2003105810A (ru
Inventor
Иоганнес ПЛАТЦЕК (DE)
Иоганнес Платцек
Петер МАРЕСКИ (DE)
Петер МАРЕСКИ
Ульрих НИДБАЛЛА (DE)
Ульрих НИДБАЛЛА
Бернд РАДЮХЕЛЬ (DE)
Бернд РАДЮХЕЛЬ
Ханнс-Йоахим ВАЙНМАНН (DE)
Ханнс-Йоахим ВАЙНМАНН
Бернд МИССЕЛЬВИТЦ (DE)
Бернд МИССЕЛЬВИТЦ
Original Assignee
Шеринг Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10040380A external-priority patent/DE10040380B4/de
Application filed by Шеринг Акциенгезельшафт filed Critical Шеринг Акциенгезельшафт
Publication of RU2003105810A publication Critical patent/RU2003105810A/ru
Application granted granted Critical
Publication of RU2290206C2 publication Critical patent/RU2290206C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
RU2003105810/15A 2000-08-11 2001-07-23 Применение перфторалкилсодержащих комплексов металлов в качестве контрастных веществ в магнитно-резонансной томографии для визуализации бляшек, опухолей и некрозов RU2290206C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10040380.8 2000-08-11
DE10040380A DE10040380B4 (de) 2000-08-11 2000-08-11 Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques

Publications (2)

Publication Number Publication Date
RU2003105810A RU2003105810A (ru) 2004-09-10
RU2290206C2 true RU2290206C2 (ru) 2006-12-27

Family

ID=7652860

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003105810/15A RU2290206C2 (ru) 2000-08-11 2001-07-23 Применение перфторалкилсодержащих комплексов металлов в качестве контрастных веществ в магнитно-резонансной томографии для визуализации бляшек, опухолей и некрозов

Country Status (26)

Country Link
EP (1) EP1307236A2 (sh)
JP (1) JP2004506025A (sh)
KR (1) KR20030022387A (sh)
CN (1) CN1469757A (sh)
AR (1) AR034139A1 (sh)
AU (2) AU7754901A (sh)
BG (1) BG107542A (sh)
BR (1) BR0113188A (sh)
CA (1) CA2419223A1 (sh)
CZ (1) CZ2003392A3 (sh)
DE (1) DE10066210B4 (sh)
EE (1) EE200300061A (sh)
HR (1) HRP20030173A2 (sh)
HU (1) HUP0300736A3 (sh)
IL (1) IL154385A0 (sh)
MX (1) MXPA03001287A (sh)
NO (1) NO20030604L (sh)
NZ (1) NZ523932A (sh)
PL (1) PL365596A1 (sh)
RU (1) RU2290206C2 (sh)
SK (1) SK1572003A3 (sh)
TW (1) TWI296931B (sh)
UA (1) UA82642C2 (sh)
WO (1) WO2002013874A2 (sh)
YU (1) YU10603A (sh)
ZA (1) ZA200301949B (sh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10231799B4 (de) * 2002-07-10 2006-10-05 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
US7344704B2 (en) 2002-07-10 2008-03-18 Schering Ag Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
DE102005008309A1 (de) * 2005-02-17 2006-08-24 Schering Ag Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone
DE102006021495A1 (de) * 2006-05-09 2007-11-15 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
US7887835B2 (en) * 2006-09-19 2011-02-15 Fujifilm Corporation Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound
DE102006049821A1 (de) * 2006-10-18 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
DE102007015598A1 (de) * 2007-03-29 2008-10-02 Heinrich-Heine-Universität Düsseldorf Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren
JP2011190183A (ja) * 2010-03-11 2011-09-29 Noguchi Institute フルオラス化糖結合型クラウンエーテル誘導体
US9976072B2 (en) 2014-03-26 2018-05-22 Chevron U.S.A. Inc. Multicarboxylate compositions and method of making the same
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
US11104639B2 (en) 2016-09-14 2021-08-31 Daikin Industries, Ltd. Branched fluorine-containing compound
JP7034160B2 (ja) 2016-11-28 2022-03-11 バイエル・ファルマ・アクティエンゲゼルシャフト 磁気共鳴画像法に使用するための高緩和度ガドリニウムキレート化合物
PE20211471A1 (es) 2018-11-23 2021-08-05 Bayer Ag Formulacion de medios de contraste y proceso para prepararlos
CN109867635A (zh) * 2019-02-14 2019-06-11 华东师范大学 一种t1型胶束磁共振成像造影剂及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
JPH10112939A (ja) * 1996-10-07 1998-04-28 Nec Corp 電源切替回路
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis

Also Published As

Publication number Publication date
IL154385A0 (en) 2003-09-17
DE10066210B4 (de) 2008-02-28
SK1572003A3 (en) 2003-10-07
HUP0300736A3 (en) 2010-01-28
MXPA03001287A (es) 2003-10-06
BG107542A (bg) 2003-09-30
JP2004506025A (ja) 2004-02-26
HUP0300736A2 (hu) 2003-09-29
TWI296931B (en) 2008-05-21
CZ2003392A3 (cs) 2003-09-17
CN1469757A (zh) 2004-01-21
WO2002013874A2 (de) 2002-02-21
BR0113188A (pt) 2003-06-24
NO20030604D0 (no) 2003-02-07
NO20030604L (no) 2003-04-11
NZ523932A (en) 2007-07-27
EP1307236A2 (de) 2003-05-07
AR034139A1 (es) 2004-02-04
CA2419223A1 (en) 2003-02-11
ZA200301949B (en) 2004-12-14
HRP20030173A2 (en) 2005-04-30
KR20030022387A (ko) 2003-03-15
AU2001277549B2 (en) 2007-02-08
WO2002013874A8 (de) 2002-06-13
EE200300061A (et) 2004-12-15
UA82642C2 (uk) 2008-05-12
AU7754901A (en) 2002-02-25
YU10603A (sh) 2006-05-25
PL365596A1 (en) 2005-01-10

Similar Documents

Publication Publication Date Title
RU2290206C2 (ru) Применение перфторалкилсодержащих комплексов металлов в качестве контрастных веществ в магнитно-резонансной томографии для визуализации бляшек, опухолей и некрозов
RU2280644C2 (ru) Перфторалкилсодержащие комплексы с остатками сахаров, способы их получения
US6818203B2 (en) Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
DE19948651B4 (de) Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung
US20090297454A1 (en) Perfluoroalkyl-Containing Complexes, Process For Their Production As Well As Their Use
BRPI0613407A2 (pt) Complexos contendo perfluoralquila, bem como composição farmacêutica, uso e processos de preparação dos mesmos
RU2289579C2 (ru) Перфторалкилсодержащие коплексы с полярными остатками, способ их получения, фармацевтическое средство
US6641797B2 (en) Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use
ZA200108575B (en) Perfluoroalkylamide, the production thereof and the use thereof in diagnostics.
CA2676313A1 (en) Novel cascade polymer complexes, processes for their preparation and pharmaceutical compositions comprising them
US6068831A (en) Pseudopolyrotaxanes
US6113880A (en) Polyrotaxane derivatives for x-ray and nuclear magnetic resonance imaging
US6461587B1 (en) Perfluoroalkylamides, their production and their use in diagnosis
JP2010506862A (ja) 過弗素化されたｐｅｇ基を有する金属キレート類、それらの製剤方法、及びそれらの使用
DE10040380A1 (de) Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques, Tumoren und Nekrosen

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20090724