UA80733C2 - Diazepinoindole derivatives as kinase inhibitors - Google Patents

Info

Publication number

UA80733C2

UA80733C2 UAA200506730A UA2005006730A UA80733C2 UA 80733 C2 UA80733 C2 UA 80733C2 UA A200506730 A UAA200506730 A UA A200506730A UA 2005006730 A UA2005006730 A UA 2005006730A UA 80733 C2 UA80733 C2 UA 80733C2

Authority

UA

Ukraine

Prior art keywords

dihydro

oxo

diazepino

indol

alkyl

Prior art date

2003-01-09

Links

• Espacenet
• Global Dossier
• Discuss

• 229940043355 kinase inhibitor Drugs 0.000 title description 3
• 239000003757 phosphotransferase inhibitor Substances 0.000 title description 2
• BSYFXFLGOGQHFU-UHFFFAOYSA-N pyrrolo[2,3-g][1,2]benzodiazepine Chemical class N1=NC=CC=C2C3=NC=CC3=CC=C21 BSYFXFLGOGQHFU-UHFFFAOYSA-N 0.000 title 1
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• 150000003839 salts Chemical class 0.000 claims abstract description 80
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• 102000001253 Protein Kinase Human genes 0.000 claims abstract description 43
• 108060006633 protein kinase Proteins 0.000 claims abstract description 42
• 239000002246 antineoplastic agent Substances 0.000 claims abstract description 37
• 229940034982 antineoplastic agent Drugs 0.000 claims abstract description 36
• 239000003795 chemical substances by application Substances 0.000 claims abstract description 33
• 230000000118 anti-neoplastic effect Effects 0.000 claims abstract description 30
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• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 15
• 230000005855 radiation Effects 0.000 claims abstract description 14
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• 125000000217 alkyl group Chemical group 0.000 claims description 192
• 239000000203 mixture Substances 0.000 claims description 119
• -1 hydrochloric acid salt Chemical class 0.000 claims description 118
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 95
• 125000000623 heterocyclic group Chemical group 0.000 claims description 69
• 125000001424 substituent group Chemical group 0.000 claims description 68
• 239000002253 acid Substances 0.000 claims description 61
• 125000001072 heteroaryl group Chemical group 0.000 claims description 57
• 125000003118 aryl group Chemical group 0.000 claims description 54
• VEXZGXHMUGYJMC-UHFFFAOYSA-N hydrochloric acid Substances Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 52
• 229910052739 hydrogen Inorganic materials 0.000 claims description 42
• LRANPJDWHYRCER-UHFFFAOYSA-N 1,2-diazepine Chemical compound N1C=CC=CC=N1 LRANPJDWHYRCER-UHFFFAOYSA-N 0.000 claims description 41
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 40
• 238000011282 treatment Methods 0.000 claims description 34
• HCUARRIEZVDMPT-UHFFFAOYSA-N Indole-2-carboxylic acid Chemical compound C1=CC=C2NC(C(=O)O)=CC2=C1 HCUARRIEZVDMPT-UHFFFAOYSA-N 0.000 claims description 30
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• CXWQAPHDSYDHBR-UHFFFAOYSA-N piperidine-4-carboxamide Chemical compound NC(=O)C1CCNCC1.NC(=O)C1CCNCC1 CXWQAPHDSYDHBR-UHFFFAOYSA-N 0.000 claims 1
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