UA77441C2 - 4,5-dihydro-1h-pyrazole derivatives as potent cb1 receptor antagonists, methods for their preparation (variants), intermediate, pharmaceutical composition and method for its preparation - Google Patents
4,5-dihydro-1h-pyrazole derivatives as potent cb1 receptor antagonists, methods for their preparation (variants), intermediate, pharmaceutical composition and method for its preparation Download PDFInfo
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- UA77441C2 UA77441C2 UA20040402981A UA20040402981A UA77441C2 UA 77441 C2 UA77441 C2 UA 77441C2 UA 20040402981 A UA20040402981 A UA 20040402981A UA 20040402981 A UA20040402981 A UA 20040402981A UA 77441 C2 UA77441 C2 UA 77441C2
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- phenyl
- dihydro
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203849 | 2001-09-21 | ||
| PCT/EP2002/010435 WO2003026648A1 (en) | 2001-09-21 | 2002-09-17 | 4,5-dihydro-1h-pyrazole derivatives having potent cb1-antagonistic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA77441C2 true UA77441C2 (en) | 2006-12-15 |
Family
ID=8181042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20040402981A UA77441C2 (en) | 2001-09-21 | 2002-09-17 | 4,5-dihydro-1h-pyrazole derivatives as potent cb1 receptor antagonists, methods for their preparation (variants), intermediate, pharmaceutical composition and method for its preparation |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6974810B2 (zh) |
| EP (1) | EP1429762A1 (zh) |
| JP (1) | JP4313672B2 (zh) |
| KR (1) | KR100950430B1 (zh) |
| CN (2) | CN101195604A (zh) |
| AR (1) | AR036598A1 (zh) |
| AU (1) | AU2002333853B2 (zh) |
| BR (1) | BR0208253A (zh) |
| CA (1) | CA2442245C (zh) |
| HR (1) | HRP20030913A2 (zh) |
| HU (1) | HUP0402113A3 (zh) |
| IL (2) | IL157704A0 (zh) |
| MX (1) | MXPA03009439A (zh) |
| NO (1) | NO20041170L (zh) |
| NZ (1) | NZ528280A (zh) |
| PL (1) | PL367814A1 (zh) |
| RU (1) | RU2286988C2 (zh) |
| UA (1) | UA77441C2 (zh) |
| WO (1) | WO2003026648A1 (zh) |
| ZA (1) | ZA200307218B (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1429762A1 (en) * | 2001-09-21 | 2004-06-23 | Solvay Pharmaceuticals B.V. | 4,5-dihydro-1h-pyrazole derivatives having potent cb1-antagonistic activity |
| CA2478183C (en) | 2002-03-12 | 2010-02-16 | Merck & Co. Inc. | Substituted amides |
| US7129239B2 (en) | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
| US7247628B2 (en) | 2002-12-12 | 2007-07-24 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US7329658B2 (en) | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
| US7176210B2 (en) | 2003-02-10 | 2007-02-13 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| US7141669B2 (en) | 2003-04-23 | 2006-11-28 | Pfizer Inc. | Cannabiniod receptor ligands and uses thereof |
| US7145012B2 (en) | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| US7268133B2 (en) | 2003-04-23 | 2007-09-11 | Pfizer, Inc. Patent Department | Cannabinoid receptor ligands and uses thereof |
| US7232823B2 (en) | 2003-06-09 | 2007-06-19 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
| US20050239859A2 (en) * | 2003-09-03 | 2005-10-27 | Solvay Pharmaceuticals Gmbh | Novel medical uses of 4,5-dihydro-1h-pyrazole derivatives having cb1- antagonistic activity |
| CN1956949A (zh) * | 2003-09-18 | 2007-05-02 | 默克公司 | 取代的磺酰胺 |
| BRPI0415851A (pt) * | 2003-10-24 | 2007-01-02 | Solvay Pharm Gmbh | utilizações médicas de compostos que apresentam atividade antagonìstica de cb1 e tratamento de combinação envolvendo os referidos compostos |
| AR046132A1 (es) * | 2003-10-24 | 2005-11-23 | Solvay Pharm Gmbh | Composicin farmaceutica que contiene al menos un compuesto con actividad de receptor de cb1, o un profarmaco , tautomero o sal del mismo, como componente activo adecuado para el tratamiento y/o profilaxis de enfermedades relacionadas con el receptor cb1 en pacientes juveniles y/o para el tratamiento |
| US20050124660A1 (en) * | 2003-10-27 | 2005-06-09 | Jochen Antel | Novel medical uses of compounds showing CB1-antagonistic activity and combination treatment involving said compounds |
| US20050143441A1 (en) * | 2003-10-27 | 2005-06-30 | Jochen Antel | Novel medical combination treatment of obesity involving 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity |
| TW200522944A (en) | 2003-12-23 | 2005-07-16 | Lilly Co Eli | CB1 modulator compounds |
| ES2311972T3 (es) * | 2004-01-30 | 2009-02-16 | Solvay Pharmaceuticals B.V. | Derivados 1,3,5-trisubstituidos de 4,5-dihidro-1h-pirazol que tienen actividad antagonista de cb1. |
| EP1734963A4 (en) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| TW200602314A (en) | 2004-05-28 | 2006-01-16 | Tanabe Seiyaku Co | A novel pyrrolidine compound and a process for preparing the same |
| EA011307B1 (ru) | 2004-07-12 | 2009-02-27 | Кадила Хелзкэр Лимитед | Трициклические производные пиразола в качестве модуляторов каннабиноидного рецептора |
| US20060025448A1 (en) | 2004-07-22 | 2006-02-02 | Cadila Healthcare Limited | Hair growth stimulators |
| JP2008517976A (ja) | 2004-10-25 | 2008-05-29 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ１カンナビノイド受容体拮抗薬及びカリウムチャンネルオープナーから成る、真性糖尿病１型、肥満及び関連症状の治療用の医薬組成物 |
| NZ555320A (en) | 2004-12-03 | 2010-11-26 | Schering Corp | Substituted piperazines as CB1 antagonists |
| AU2006253842A1 (en) | 2005-06-02 | 2006-12-07 | Glenmark Pharmaceuticals S.A. | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| US7923465B2 (en) | 2005-06-02 | 2011-04-12 | Glenmark Pharmaceuticals S.A. | Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| EP2308840A1 (en) | 2005-06-30 | 2011-04-13 | Prosidion Limited | GPCR agonists |
| EP1743890A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | 4,5-Dihydro-1H-pyrazole derivatives, their preparation and use as medicaments |
| EP1928463A2 (en) * | 2005-08-17 | 2008-06-11 | Solvay Pharmaceuticals GmbH | Method of using potassium channel inhibiting compounds |
| CA2637565A1 (en) * | 2006-01-18 | 2007-07-26 | Schering Corporation | Cannibinoid receptor modulators |
| WO2007131219A2 (en) * | 2006-05-05 | 2007-11-15 | Jenrin Discovery | Cannabinoid receptor antagonists/inverse agonists |
| US7964728B2 (en) | 2006-07-06 | 2011-06-21 | Solvay Pharmaceuticals B.V. | Azaindole derivatives with a combination of partial nicotinic acetyl-choline receptor agonism and dopamine reuptake inhibition |
| AR062907A1 (es) * | 2006-09-22 | 2008-12-17 | Solvay Pharm Bv | Derivados de sulfonilpirazol y sulfonilpirazolincarboxamidina como antagonistas de 5-ht6 |
| US7923026B2 (en) | 2006-10-20 | 2011-04-12 | Solvay Pharmaceuticals B.V. | Embedded micellar nanoparticles |
| EA026213B1 (ru) * | 2006-10-20 | 2017-03-31 | Солвей Фармасьютикалс Б.В. | Термостабильная твердая фармацевтическая композиция, содержащая наномицеллы, и способ ее получения |
| EA016507B1 (ru) | 2007-01-04 | 2012-05-30 | Прозидион Лимитед | Пиперидиновые агонисты gpcr |
| AR064735A1 (es) | 2007-01-04 | 2009-04-22 | Prosidion Ltd | Agonistas de gpcr y composicion farmaceutica en base al compuesto |
| GB0700122D0 (en) | 2007-01-04 | 2007-02-14 | Prosidion Ltd | GPCR agonists |
| PE20081849A1 (es) | 2007-01-04 | 2009-01-26 | Prosidion Ltd | Derivados de piperidin-4-il-propoxi-benzamida como agonistas de gpcr |
| EA015129B1 (ru) | 2007-01-04 | 2011-06-30 | Прозидион Лимитед | Пиперидиновые агонисты gpcr |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL158178B (nl) * | 1974-07-12 | 1978-10-16 | Philips Nv | Werkwijze ter bereiding van insekticide preparaten die een pyrazolinederivaat bevatten, aldus verkregen gevormde preparaten, en werkwijze ter bereiding van pyrazolinederivaten met insekticide werking. |
| JPH03173887A (ja) * | 1989-03-27 | 1991-07-29 | Nissan Chem Ind Ltd | スルタムスルホンアミド及び除草剤 |
| FR2692575B1 (fr) * | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| FR2789079B3 (fr) * | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
| ATE346047T1 (de) * | 2000-03-23 | 2006-12-15 | Solvay Pharm Bv | 4,5-dihydro-1h-pyrazolderivate mit cb1- antagonistischer aktivität |
| EP1429762A1 (en) * | 2001-09-21 | 2004-06-23 | Solvay Pharmaceuticals B.V. | 4,5-dihydro-1h-pyrazole derivatives having potent cb1-antagonistic activity |
| US20050143441A1 (en) | 2003-10-27 | 2005-06-30 | Jochen Antel | Novel medical combination treatment of obesity involving 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity |
| US20050124660A1 (en) | 2003-10-27 | 2005-06-09 | Jochen Antel | Novel medical uses of compounds showing CB1-antagonistic activity and combination treatment involving said compounds |
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- 2002-09-17 WO PCT/EP2002/010435 patent/WO2003026648A1/en active IP Right Grant
- 2002-09-17 IL IL15770402A patent/IL157704A0/xx unknown
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- 2002-09-17 UA UA20040402981A patent/UA77441C2/uk unknown
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- 2002-09-17 RU RU2003130268/04A patent/RU2286988C2/ru not_active IP Right Cessation
- 2002-09-17 NZ NZ528280A patent/NZ528280A/en not_active IP Right Cessation
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| NZ528280A (en) | 2005-11-25 |
| HUP0402113A3 (en) | 2012-05-29 |
| KR100950430B1 (ko) | 2010-04-02 |
| RU2286988C2 (ru) | 2006-11-10 |
| JP2005503428A (ja) | 2005-02-03 |
| CN1529595A (zh) | 2004-09-15 |
| US20070259884A1 (en) | 2007-11-08 |
| CA2442245C (en) | 2010-03-30 |
| CA2442245A1 (en) | 2003-04-03 |
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| US20040106800A1 (en) | 2004-06-03 |
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| NO20041170L (no) | 2004-06-21 |
| IL157704A0 (en) | 2004-03-28 |
| WO2003026648A1 (en) | 2003-04-03 |
| US6974810B2 (en) | 2005-12-13 |
| KR20040035845A (ko) | 2004-04-29 |
| IL157704A (en) | 2008-07-08 |
| HRP20030913A2 (en) | 2004-06-30 |
| BR0208253A (pt) | 2004-04-13 |
| CN101195604A (zh) | 2008-06-11 |
| EP1429762A1 (en) | 2004-06-23 |
| AU2002333853B2 (en) | 2006-07-13 |
| HUP0402113A2 (hu) | 2005-01-28 |
| PL367814A1 (en) | 2005-03-07 |
| MXPA03009439A (es) | 2004-02-12 |
| RU2003130268A (ru) | 2005-01-27 |
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