AR071995A1 - Derivados de 3,4-diaril-4,5-dihidro-1h-pirazol-1-carboxamidina sustituidos con fluor que tienen actividad antagonista cb1, procesos de preparacion y composiciones farmaceuticas que los contienen - Google Patents
Derivados de 3,4-diaril-4,5-dihidro-1h-pirazol-1-carboxamidina sustituidos con fluor que tienen actividad antagonista cb1, procesos de preparacion y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR071995A1 AR071995A1 ARP090101988A ARP090101988A AR071995A1 AR 071995 A1 AR071995 A1 AR 071995A1 AR P090101988 A ARP090101988 A AR P090101988A AR P090101988 A ARP090101988 A AR P090101988A AR 071995 A1 AR071995 A1 AR 071995A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- formula
- pharmaceutical compositions
- derivatives
- carboxamidine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se refiere a derivados de 3,4-diaril-4,5-dihidro-1H-pirazol-1-carboxamidina fluorados como antagonistas de receptores CB1 cannabinoides, metodos para preparar estos compuestos intermediarios utiles para la s¡ntesis de dichos compuestos, metodos para la preparacion de estos intermediarios, composiciones farmaceuticas que contienen uno o m s de estos derivados de dihidropirazol como ingrediente activo, as¡ como el uso de estas composiciones farmaceuticas para el tratamiento de obesidad y trastornos cardiovasculares relacionados con la obesidad, adiccion a drogas, deficit de cognicion, fibrosis hep tica y trastornos inflamatorios. Reivindicacion 1: Un compuesto de la formula (1) o un tautomero, estereoisomero, N-oxido o una sal farmacologicamente aceptable, de cualquiera de los anteriores, en donde: n es 1 o 2, cuando n = 1, R1 es elegido de F o CF3, en cualquiera de las posiciones 3- o 4- del anillo de piperidina, cuando n = 2, R1 es F, ambos en las posiciones 3- o 4-, o uno en la posicion 3- y el segundo en la posicion 4- o en la posicion 5-, R2 es elegido de H o alquilo C1-3, R3 es elegido de H o metilo. Reivindicacion 7: Un compuesto de formula (7) en donde R1 y n tienen los significados dados en la reivindicacion 1, siendo tales compuestos utiles en la preparacion de compuestos de la formula (1). Reivindicacion 8: Un compuesto de formula (8) en donde R1 y n tienen los significados dados en la reivindicacion 1, siendo tales compuestos utiles en la preparacion de compuestos de la formula (1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08158309 | 2008-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071995A1 true AR071995A1 (es) | 2010-07-28 |
Family
ID=39869924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101988A AR071995A1 (es) | 2008-06-16 | 2009-06-03 | Derivados de 3,4-diaril-4,5-dihidro-1h-pirazol-1-carboxamidina sustituidos con fluor que tienen actividad antagonista cb1, procesos de preparacion y composiciones farmaceuticas que los contienen |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20110172274A1 (es) |
| EP (1) | EP2315762A2 (es) |
| JP (1) | JP2011524351A (es) |
| KR (1) | KR20110023887A (es) |
| CN (1) | CN102164910A (es) |
| AR (1) | AR071995A1 (es) |
| AU (1) | AU2009268271A1 (es) |
| BR (1) | BRPI0915083A2 (es) |
| CA (1) | CA2727146A1 (es) |
| EA (1) | EA201170034A1 (es) |
| IL (1) | IL209403A0 (es) |
| MX (1) | MX2010013909A (es) |
| TW (1) | TW201008924A (es) |
| WO (1) | WO2010003760A2 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10602642B2 (en) | 2013-12-11 | 2020-03-24 | Asia Vital Components Co., Ltd. | Back cover unit applied to portable device and having heat conduction function |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03009439A (es) * | 2001-09-21 | 2004-02-12 | Solvay Pharm Bv | Derivados de 4,5-dihidro-1h-pirazol que tienen una potente actividad antagonistica de cb1. |
-
2009
- 2009-06-03 AR ARP090101988A patent/AR071995A1/es unknown
- 2009-06-12 TW TW098119716A patent/TW201008924A/zh unknown
- 2009-06-15 WO PCT/EP2009/057323 patent/WO2010003760A2/en active Application Filing
- 2009-06-15 EP EP09779743A patent/EP2315762A2/en not_active Withdrawn
- 2009-06-15 KR KR1020117001125A patent/KR20110023887A/ko not_active Application Discontinuation
- 2009-06-15 US US12/999,494 patent/US20110172274A1/en not_active Abandoned
- 2009-06-15 BR BRPI0915083A patent/BRPI0915083A2/pt not_active Application Discontinuation
- 2009-06-15 MX MX2010013909A patent/MX2010013909A/es not_active Application Discontinuation
- 2009-06-15 JP JP2011513000A patent/JP2011524351A/ja active Pending
- 2009-06-15 EA EA201170034A patent/EA201170034A1/ru unknown
- 2009-06-15 CA CA2727146A patent/CA2727146A1/en not_active Abandoned
- 2009-06-15 CN CN2009801228101A patent/CN102164910A/zh active Pending
- 2009-06-15 AU AU2009268271A patent/AU2009268271A1/en not_active Abandoned
-
2010
- 2010-11-18 IL IL209403A patent/IL209403A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2010013909A (es) | 2011-02-15 |
| JP2011524351A (ja) | 2011-09-01 |
| EA201170034A1 (ru) | 2011-08-30 |
| AU2009268271A1 (en) | 2010-01-14 |
| CA2727146A1 (en) | 2010-01-14 |
| TW201008924A (en) | 2010-03-01 |
| KR20110023887A (ko) | 2011-03-08 |
| CN102164910A (zh) | 2011-08-24 |
| WO2010003760A3 (en) | 2011-07-21 |
| WO2010003760A2 (en) | 2010-01-14 |
| EP2315762A2 (en) | 2011-05-04 |
| BRPI0915083A2 (pt) | 2015-10-27 |
| US20110172274A1 (en) | 2011-07-14 |
| IL209403A0 (en) | 2011-01-31 |
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| AR071995A1 (es) | Derivados de 3,4-diaril-4,5-dihidro-1h-pirazol-1-carboxamidina sustituidos con fluor que tienen actividad antagonista cb1, procesos de preparacion y composiciones farmaceuticas que los contienen | |
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| Date | Code | Title | Description |
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| FB | Suspension of granting procedure |