EA201170034A1 - Фторзамещенные производные 3,4-диарил-4,5-дигидро-1h-пиразол-1-карбоксамидина, имеющие активность антагониста cb - Google Patents

Фторзамещенные производные 3,4-диарил-4,5-дигидро-1h-пиразол-1-карбоксамидина, имеющие активность антагониста cb

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Publication number
EA201170034A1
EA201170034A1 EA201170034A EA201170034A EA201170034A1 EA 201170034 A1 EA201170034 A1 EA 201170034A1 EA 201170034 A EA201170034 A EA 201170034A EA 201170034 A EA201170034 A EA 201170034A EA 201170034 A1 EA201170034 A1 EA 201170034A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carboxamidine
dihydro
compounds
diaril
pyrazol
Prior art date
Application number
EA201170034A
Other languages
English (en)
Inventor
Йозефус Х. М. Ланге
Ван Бернард Й. Влиет
Original Assignee
Эбботт Хелткэа Продактс Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эбботт Хелткэа Продактс Б.В. filed Critical Эбботт Хелткэа Продактс Б.В.
Publication of EA201170034A1 publication Critical patent/EA201170034A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к фторированным производным 3,4-диарил-4,5-дигидро-1Н-пиразол-1-карбоксамидина в качестве антагонистов каннабиноидных рецепторов CB, способам получения этих соединений, новым промежуточным соединениям, пригодным для синтеза указанных соединений, способам получения этих промежуточных соединений, фармацевтическим композициям, содержащим одно или более из этих производных дигидропиразола в качестве активного ингредиента, а также к применению этих фармацевтических композиций для лечения ожирения и сердечно-сосудистых расстройств, связанных с ожирением, лекарственной зависимости, когнитивных дефицитов, фиброза печени и воспалительных расстройств. Соединения имеют общую формулу (I), где символы имеют значения, данные в описании.
EA201170034A 2008-06-16 2009-06-15 Фторзамещенные производные 3,4-диарил-4,5-дигидро-1h-пиразол-1-карбоксамидина, имеющие активность антагониста cb EA201170034A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6171608P 2008-06-16 2008-06-16
EP08158309 2008-06-16
PCT/EP2009/057323 WO2010003760A2 (en) 2008-06-16 2009-06-15 Fluoro-substituted 3,4-diaryl-4,5-dihydro-1h-pyrazole-1-carboxamidine derivatives having cb1-antagonistic activity

Publications (1)

Publication Number Publication Date
EA201170034A1 true EA201170034A1 (ru) 2011-08-30

Family

ID=39869924

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170034A EA201170034A1 (ru) 2008-06-16 2009-06-15 Фторзамещенные производные 3,4-диарил-4,5-дигидро-1h-пиразол-1-карбоксамидина, имеющие активность антагониста cb

Country Status (14)

Country Link
US (1) US20110172274A1 (ru)
EP (1) EP2315762A2 (ru)
JP (1) JP2011524351A (ru)
KR (1) KR20110023887A (ru)
CN (1) CN102164910A (ru)
AR (1) AR071995A1 (ru)
AU (1) AU2009268271A1 (ru)
BR (1) BRPI0915083A2 (ru)
CA (1) CA2727146A1 (ru)
EA (1) EA201170034A1 (ru)
IL (1) IL209403A0 (ru)
MX (1) MX2010013909A (ru)
TW (1) TW201008924A (ru)
WO (1) WO2010003760A2 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10602642B2 (en) 2013-12-11 2020-03-24 Asia Vital Components Co., Ltd. Back cover unit applied to portable device and having heat conduction function

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03009439A (es) * 2001-09-21 2004-02-12 Solvay Pharm Bv Derivados de 4,5-dihidro-1h-pirazol que tienen una potente actividad antagonistica de cb1.

Also Published As

Publication number Publication date
MX2010013909A (es) 2011-02-15
AR071995A1 (es) 2010-07-28
JP2011524351A (ja) 2011-09-01
AU2009268271A1 (en) 2010-01-14
CA2727146A1 (en) 2010-01-14
TW201008924A (en) 2010-03-01
KR20110023887A (ko) 2011-03-08
CN102164910A (zh) 2011-08-24
WO2010003760A3 (en) 2011-07-21
WO2010003760A2 (en) 2010-01-14
EP2315762A2 (en) 2011-05-04
BRPI0915083A2 (pt) 2015-10-27
US20110172274A1 (en) 2011-07-14
IL209403A0 (en) 2011-01-31

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