UA76760C2 - Пирролопиримидины в качестве ингибиторов протеинкиназы - Google Patents
Пирролопиримидины в качестве ингибиторов протеинкиназы Download PDFInfo
- Publication number
- UA76760C2 UA76760C2 UA2004010502A UA200410502A UA76760C2 UA 76760 C2 UA76760 C2 UA 76760C2 UA 2004010502 A UA2004010502 A UA 2004010502A UA 200410502 A UA200410502 A UA 200410502A UA 76760 C2 UA76760 C2 UA 76760C2
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- Prior art keywords
- alkyl
- compound according
- compound
- aryl
- substituted
- Prior art date
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- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title description 3
- 239000003909 protein kinase inhibitor Substances 0.000 title description 3
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- 230000000052 comparative effect Effects 0.000 description 32
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- ZCSHNCUQKCANBX-UHFFFAOYSA-N lithium diisopropylamide Chemical compound [Li+].CC(C)[N-]C(C)C ZCSHNCUQKCANBX-UHFFFAOYSA-N 0.000 description 6
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- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
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- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 1
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- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
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- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Изобретение раскрывает соединения формулы (І), N-оксиды, пролекарства, кислотные биоизостеры, фармацевтически приемлемые соли или сольваты таких соединений, или N-окислы, пролекарства или кислотные биоизостеры таких солей или сольватов; композиции, которые содержат такие соединения, и способы лечения, которые включают введение пациенту, который в этом нуждается, таких соединений и композиций.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0115393.1A GB0115393D0 (en) | 2001-06-23 | 2001-06-23 | Chemical compounds |
| US30167801P | 2001-06-28 | 2001-06-28 | |
| PCT/GB2002/002835 WO2003000695A1 (en) | 2001-06-23 | 2002-06-21 | Pyrrolopyrimidines as protein kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA76760C2 true UA76760C2 (ru) | 2006-09-15 |
Family
ID=9917225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2004010502A UA76760C2 (ru) | 2001-06-23 | 2002-06-21 | Пирролопиримидины в качестве ингибиторов протеинкиназы |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1404676A1 (ru) |
| JP (1) | JP4344607B2 (ru) |
| CN (1) | CN1294135C (ru) |
| AU (1) | AU2002314325B8 (ru) |
| BR (1) | BR0210652A (ru) |
| CA (1) | CA2451932C (ru) |
| CZ (1) | CZ20033443A3 (ru) |
| EA (1) | EA007415B1 (ru) |
| EC (1) | ECSP034922A (ru) |
| EE (1) | EE05432B1 (ru) |
| GB (1) | GB0115393D0 (ru) |
| HU (1) | HUP0400300A3 (ru) |
| ME (1) | MEP19308A (ru) |
| NZ (1) | NZ529766A (ru) |
| OA (1) | OA12632A (ru) |
| PL (1) | PL374096A1 (ru) |
| RS (1) | RS51698B (ru) |
| SK (1) | SK15882003A3 (ru) |
| TN (1) | TNSN03144A1 (ru) |
| TR (1) | TR200302242T2 (ru) |
| UA (1) | UA76760C2 (ru) |
| WO (1) | WO2003000695A1 (ru) |
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| GB0202679D0 (en) * | 2002-02-05 | 2002-03-20 | Glaxo Group Ltd | Novel compounds |
| AU2003265336B8 (en) | 2002-07-29 | 2009-04-23 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
| JP2007511596A (ja) * | 2003-11-17 | 2007-05-10 | ファイザー・プロダクツ・インク | 癌の治療において有用なピロロピリミジン化合物 |
| EP1689407A1 (en) * | 2003-11-25 | 2006-08-16 | Pfizer Products Inc. | Method of treatment of atherosclerosis |
| US20050250829A1 (en) * | 2004-04-23 | 2005-11-10 | Takeda San Diego, Inc. | Kinase inhibitors |
| FR2876103B1 (fr) | 2004-10-01 | 2008-02-22 | Aventis Pharma Sa | Nouveaux derives bis-azaindoles, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
| US7713973B2 (en) | 2004-10-15 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| FR2878849B1 (fr) | 2004-12-06 | 2008-09-12 | Aventis Pharma Sa | Indoles substitues, compositions les contenant, procede de fabrication et utilisation |
| WO2006135915A2 (en) | 2005-06-13 | 2006-12-21 | Rigel Pharmaceuticals, Inc. | Methods and compositions for treating degenerative bone disorders |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
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| MX2009003793A (es) | 2006-10-09 | 2009-12-14 | Takeda Pharmaceutical | Inhibidores de cinasa. |
| EP2173752B2 (en) | 2007-06-13 | 2022-07-13 | Incyte Holdings Corporation | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| AU2009211004C1 (en) | 2008-01-11 | 2013-08-01 | Natco Pharma Limited | Novel pyrazolo [3, 4 -d] pyrimidine derivatives as anti -cancer agents |
| WO2009152133A1 (en) | 2008-06-10 | 2009-12-17 | Abbott Laboratories | Novel tricyclic compounds |
| TWI484962B (zh) | 2009-05-22 | 2015-05-21 | Incyte Corp | 作為ｊａｋ抑制劑之３－〔４－（７ｈ－吡咯并〔２，３－ｄ〕嘧啶－４－基）－１ｈ－吡唑－１－基〕辛烷或庚腈 |
| US8716303B2 (en) | 2009-05-22 | 2014-05-06 | Incyte Corporation | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| WO2011018894A1 (en) * | 2009-08-10 | 2011-02-17 | Raqualia Pharma Inc. | Pyrrolopyrimidine derivatives as potassium channel modulators |
| US9249145B2 (en) | 2009-09-01 | 2016-02-02 | Incyte Holdings Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| US9029359B2 (en) | 2009-09-04 | 2015-05-12 | Biogen Idec Ma, Inc. | Heteroaryl Btk inhibitors |
| SI2506716T1 (sl) | 2009-12-01 | 2017-10-30 | Abb Vie Inc. | Nove triciklične spojine |
| KR102354472B1 (ko) | 2010-03-10 | 2022-01-21 | 인사이트 홀딩스 코포레이션 | Ｊａｋ１ 저해제로서의 피페리딘４일 아제티딘 유도체 |
| EP2574168B9 (en) | 2010-05-21 | 2016-10-05 | Incyte Holdings Corporation | Topical formulation for a jak inhibitor |
| WO2012068450A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| JP5917544B2 (ja) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｊａｋ阻害剤としての複素環置換ピロロピリジンおよびピロロピリミジン |
| CN103476776B (zh) * | 2011-01-07 | 2016-09-28 | 北京赛林泰医药技术有限公司 | 作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物 |
| CN102093364B (zh) | 2011-01-07 | 2015-01-28 | 北京赛林泰医药技术有限公司 | 作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物 |
| JP5876146B2 (ja) | 2011-06-20 | 2016-03-02 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｊａｋ阻害剤としてのアゼチジニルフェニル、ピリジル、またはピラジニルカルボキサミド誘導体 |
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| PT888349E (pt) * | 1996-01-23 | 2002-10-31 | Novartis Ag | Pirrolopirimidinas e processos para a sua preparacao |
| IL129825A0 (en) * | 1996-11-27 | 2000-02-29 | Pfizer | Fused bicyclic pyrimidine derivatives |
| PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| CZ20004727A3 (cs) * | 1998-06-19 | 2002-03-13 | Pfizer Products Inc. | Deriváty pyrrolo[2,3-d] pyrimidinu |
| TR200101395T2 (tr) * | 1998-09-18 | 2001-11-21 | Basf Ag. | Kinaz engelleyiciler olarak 4-Aminopyrrolopyrimidin'ler |
| MXPA02005675A (es) * | 1999-12-10 | 2002-09-02 | Pfizer Prod Inc | Compuestos de pirrolo(2,3-d)pirimidina. |
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| RS99203A (en) | 2006-12-15 |
| CA2451932C (en) | 2009-12-29 |
| AU2002314325B2 (en) | 2009-01-08 |
| JP2005508300A (ja) | 2005-03-31 |
| RS51698B (en) | 2011-10-31 |
| CN1294135C (zh) | 2007-01-10 |
| TR200302242T2 (tr) | 2004-12-21 |
| ECSP034922A (es) | 2004-04-28 |
| WO2003000695A1 (en) | 2003-01-03 |
| EA007415B1 (ru) | 2006-10-27 |
| NZ529766A (en) | 2008-11-28 |
| EE05432B1 (et) | 2011-06-15 |
| HUP0400300A2 (en) | 2007-08-28 |
| EP1404676A1 (en) | 2004-04-07 |
| SK15882003A3 (sk) | 2004-07-07 |
| BR0210652A (pt) | 2004-08-10 |
| JP4344607B2 (ja) | 2009-10-14 |
| HUP0400300A3 (en) | 2010-12-28 |
| CZ20033443A3 (en) | 2004-03-17 |
| EE200400003A (et) | 2004-02-16 |
| EA200400073A1 (ru) | 2004-08-26 |
| CN1518552A (zh) | 2004-08-04 |
| PL374096A1 (en) | 2005-09-19 |
| AU2002314325B8 (en) | 2009-01-29 |
| GB0115393D0 (en) | 2001-08-15 |
| MEP19308A (en) | 2010-06-10 |
| WO2003000695A8 (en) | 2004-03-11 |
| OA12632A (en) | 2006-06-14 |
| CA2451932A1 (en) | 2003-01-03 |
| TNSN03144A1 (en) | 2005-12-23 |
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