UA75864C2 - Prolactin-inhibiting agent - Google Patents
Prolactin-inhibiting agent Download PDFInfo
- Publication number
- UA75864C2 UA75864C2 UA2001053311A UA2001053311A UA75864C2 UA 75864 C2 UA75864 C2 UA 75864C2 UA 2001053311 A UA2001053311 A UA 2001053311A UA 2001053311 A UA2001053311 A UA 2001053311A UA 75864 C2 UA75864 C2 UA 75864C2
- Authority
- UA
- Ukraine
- Prior art keywords
- medicinal product
- ring
- reducing
- prolactin levels
- compound
- Prior art date
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- PLAPMLGJVGLZOV-VPRICQMDSA-N orientin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=C(O)C2=C1OC(C=1C=C(O)C(O)=CC=1)=CC2=O PLAPMLGJVGLZOV-VPRICQMDSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 210000003635 pituitary gland Anatomy 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 229930006696 sabinene Natural products 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 229930004725 sesquiterpene Natural products 0.000 description 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000009331 sowing Methods 0.000 description 1
- FRMCCTDTYSRUBE-BGPZULBFSA-N spathulenol Chemical compound C1CC(=C)[C@@H]2CC[C@](C)(O)[C@H]2[C@@H]2C(C)(C)[C@@H]21 FRMCCTDTYSRUBE-BGPZULBFSA-N 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- SGEWCQFRYRRZDC-VPRICQMDSA-N vitexin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=C(O)C2=C1OC(C=1C=CC(O)=CC=1)=CC2=O SGEWCQFRYRRZDC-VPRICQMDSA-N 0.000 description 1
- PZKISQRTNNHUGF-UHFFFAOYSA-N vitexine Natural products OC1C(O)C(O)C(CO)OC1OC1=C(O)C=C(O)C2=C1OC(C=1C=CC(O)=CC=1)=CC2=O PZKISQRTNNHUGF-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- DTOSIQBPPRVQHS-UHFFFAOYSA-N α-Linolenic acid Chemical compound CCC=CCC=CCC=CCCCCCCCC(O)=O DTOSIQBPPRVQHS-UHFFFAOYSA-N 0.000 description 1
- NPNUFJAVOOONJE-ZIAGYGMSSA-N β-(E)-Caryophyllene Chemical compound C1CC(C)=CCCC(=C)[C@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-ZIAGYGMSSA-N 0.000 description 1
- LFJQCDVYDGGFCH-UHFFFAOYSA-N β-phellandrene Chemical compound CC(C)C1CCC(=C)C=C1 LFJQCDVYDGGFCH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/05—Alcohols containing rings other than six-membered aromatic rings
- C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
- C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
- C07C35/36—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.4.0) system, e.g. naphols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fats And Perfumes (AREA)
- Furan Compounds (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19853476A DE19853476A1 (de) | 1998-11-19 | 1998-11-19 | Prolaktin-senkendes Mittel |
PCT/EP1999/008507 WO2000030623A2 (de) | 1998-11-19 | 1999-11-05 | Prolaktin-senkendes mittel |
Publications (1)
Publication Number | Publication Date |
---|---|
UA75864C2 true UA75864C2 (en) | 2006-06-15 |
Family
ID=7888392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA2001053311A UA75864C2 (en) | 1998-11-19 | 1999-05-11 | Prolactin-inhibiting agent |
Country Status (14)
Country | Link |
---|---|
US (2) | US6635672B1 (zh) |
EP (1) | EP1131061B1 (zh) |
JP (1) | JP4290889B2 (zh) |
KR (1) | KR100609765B1 (zh) |
CN (1) | CN1172664C (zh) |
AT (1) | ATE296623T1 (zh) |
BR (1) | BR9915514A (zh) |
DE (2) | DE19853476A1 (zh) |
EA (1) | EA004588B1 (zh) |
ES (1) | ES2241373T3 (zh) |
HK (1) | HK1037523A1 (zh) |
PT (1) | PT1131061E (zh) |
UA (1) | UA75864C2 (zh) |
WO (1) | WO2000030623A2 (zh) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005076748A2 (en) * | 2004-02-13 | 2005-08-25 | Janakiram Chodavarapu | Therapeutic composition and method for preparing from dodonaea sp |
CN101948453B (zh) * | 2006-05-23 | 2012-05-23 | 山东绿叶制药有限公司 | Neo-克罗烷型二萜化合物及其应用 |
EP2556829B1 (en) | 2011-08-10 | 2015-08-19 | Universität Leipzig | Bicyclic labdane diterpenes for use in the treatment of TRPC6 associated diseases |
WO2013072332A1 (en) * | 2011-11-14 | 2013-05-23 | Givaudan Sa | Methods of using antagonists of bitter taste receptors |
CN103553919B (zh) * | 2013-11-05 | 2014-12-31 | 成都中医药大学 | 一种萜类化合物及其制备方法和用途 |
CN103804330A (zh) * | 2014-02-25 | 2014-05-21 | 中国药科大学 | ent-半日花烷二萜衍生物的制备及抗肿瘤用途 |
CN105085449B (zh) * | 2014-05-13 | 2019-03-26 | 上海中医药大学 | 半日花型二萜衍生物及其制备方法和应用 |
CN106565641B (zh) * | 2016-11-14 | 2019-04-02 | 中国科学院昆明植物研究所 | 呋喃半日花烷二萜衍生物及其药物组合物和其在制药中的应用 |
EP3498306A1 (de) | 2017-12-16 | 2019-06-19 | Bionorica SE | Extrakte aus vitex agnus castus zur behandlung und diagnose von brustkrebs |
CN110305082A (zh) * | 2019-08-21 | 2019-10-08 | 成都格利普生物科技有限公司 | 采用蔓荆子提取蔓荆呋喃的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5883074A (en) | 1995-02-08 | 1999-03-16 | Microcide Pharmaceuticals, Inc. | Potentiators of antibacterial agents |
US6150381A (en) | 1998-06-09 | 2000-11-21 | R.J. Reynolds Tobacco Company | Methods of treating microbial infection and therapeutic formulations therefor |
-
1998
- 1998-11-19 DE DE19853476A patent/DE19853476A1/de not_active Ceased
-
1999
- 1999-05-11 UA UA2001053311A patent/UA75864C2/uk unknown
- 1999-11-05 JP JP2000583506A patent/JP4290889B2/ja not_active Expired - Fee Related
- 1999-11-05 EA EA200100564A patent/EA004588B1/ru not_active IP Right Cessation
- 1999-11-05 DE DE59912125T patent/DE59912125D1/de not_active Expired - Lifetime
- 1999-11-05 KR KR1020017005832A patent/KR100609765B1/ko not_active IP Right Cessation
- 1999-11-05 ES ES99972533T patent/ES2241373T3/es not_active Expired - Lifetime
- 1999-11-05 EP EP99972533A patent/EP1131061B1/de not_active Expired - Lifetime
- 1999-11-05 CN CNB998134201A patent/CN1172664C/zh not_active Expired - Fee Related
- 1999-11-05 WO PCT/EP1999/008507 patent/WO2000030623A2/de active IP Right Grant
- 1999-11-05 BR BR9915514-1A patent/BR9915514A/pt not_active Application Discontinuation
- 1999-11-05 PT PT99972533T patent/PT1131061E/pt unknown
- 1999-11-05 US US09/856,219 patent/US6635672B1/en not_active Expired - Fee Related
- 1999-11-05 AT AT99972533T patent/ATE296623T1/de active
-
2001
- 2001-10-11 HK HK01107133A patent/HK1037523A1/xx not_active IP Right Cessation
-
2003
- 2003-10-02 US US10/676,314 patent/US20040138297A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6635672B1 (en) | 2003-10-21 |
CN1326343A (zh) | 2001-12-12 |
HK1037523A1 (en) | 2002-02-15 |
DE59912125D1 (de) | 2005-07-07 |
EP1131061A1 (de) | 2001-09-12 |
EP1131061B1 (de) | 2005-06-01 |
JP4290889B2 (ja) | 2009-07-08 |
US20040138297A1 (en) | 2004-07-15 |
PT1131061E (pt) | 2005-08-31 |
EA200100564A1 (ru) | 2001-10-22 |
ES2241373T3 (es) | 2005-10-16 |
BR9915514A (pt) | 2001-08-07 |
KR100609765B1 (ko) | 2006-08-09 |
CN1172664C (zh) | 2004-10-27 |
ATE296623T1 (de) | 2005-06-15 |
WO2000030623A3 (de) | 2000-08-31 |
WO2000030623A2 (de) | 2000-06-02 |
KR20010080965A (ko) | 2001-08-25 |
JP2003521457A (ja) | 2003-07-15 |
DE19853476A1 (de) | 2000-05-31 |
EA004588B1 (ru) | 2004-06-24 |
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