UA73071C2 - Improved method for processing activated protein c - Google Patents
Improved method for processing activated protein c Download PDFInfo
- Publication number
- UA73071C2 UA73071C2 UA99105788A UA99105788A UA73071C2 UA 73071 C2 UA73071 C2 UA 73071C2 UA 99105788 A UA99105788 A UA 99105788A UA 99105788 A UA99105788 A UA 99105788A UA 73071 C2 UA73071 C2 UA 73071C2
- Authority
- UA
- Ukraine
- Prior art keywords
- activated protein
- protein
- des
- buffer
- mentioned
- Prior art date
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4866—Protein C (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4525597P | 1997-04-28 | 1997-04-28 | |
| PCT/US1998/008384 WO1998048822A1 (en) | 1997-04-28 | 1998-04-24 | Improved methods for processing activated protein c |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA73071C2 true UA73071C2 (en) | 2005-06-15 |
Family
ID=21936854
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA99105788A UA73071C2 (en) | 1997-04-28 | 1998-04-24 | Improved method for processing activated protein c |
| UA99105884A UA55448C2 (uk) | 1997-04-28 | 1998-04-24 | Стійка ліофілізована лікарська форма з активованим білком с (варіанти) та виріб, який її містить |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA99105884A UA55448C2 (uk) | 1997-04-28 | 1998-04-24 | Стійка ліофілізована лікарська форма з активованим білком с (варіанти) та виріб, який її містить |
Country Status (35)
| Country | Link |
|---|---|
| US (4) | US6162629A (hu) |
| EP (2) | EP0875563A3 (hu) |
| JP (2) | JP4383546B2 (hu) |
| KR (2) | KR100564189B1 (hu) |
| CN (2) | CN1235638C (hu) |
| AR (2) | AR012010A1 (hu) |
| AT (1) | ATE285788T1 (hu) |
| AU (2) | AU740753C (hu) |
| BR (2) | BR9809292A (hu) |
| CA (2) | CA2288143C (hu) |
| CO (2) | CO4940438A1 (hu) |
| CZ (1) | CZ298429B6 (hu) |
| DE (1) | DE69828330T2 (hu) |
| DK (1) | DK0875252T3 (hu) |
| EA (2) | EA004881B1 (hu) |
| EG (1) | EG23685A (hu) |
| ES (1) | ES2234072T3 (hu) |
| HK (1) | HK1016472A1 (hu) |
| HU (2) | HUP0003401A3 (hu) |
| ID (2) | ID22933A (hu) |
| IL (2) | IL132502A0 (hu) |
| IN (2) | IN187157B (hu) |
| MY (2) | MY120984A (hu) |
| NO (2) | NO995134L (hu) |
| NZ (2) | NZ500346A (hu) |
| PE (2) | PE84799A1 (hu) |
| PL (2) | PL195090B1 (hu) |
| PT (1) | PT875252E (hu) |
| SI (1) | SI0875252T1 (hu) |
| SV (2) | SV1998000050A (hu) |
| TR (2) | TR199902529T2 (hu) |
| TW (2) | TWI242443B (hu) |
| UA (2) | UA73071C2 (hu) |
| WO (2) | WO1998048818A1 (hu) |
| ZA (2) | ZA983497B (hu) |
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| ID22933A (id) | 1997-04-28 | 1999-12-16 | Lilly Co Eli | Fomulasi protien c terakivasi |
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| HUP0001237A3 (en) * | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
| US6815533B1 (en) | 1998-07-31 | 2004-11-09 | Eli Lilly And Company | Cryogranulation of activated protein C |
| CA2351067A1 (en) * | 1998-11-13 | 2000-05-25 | Eli Lilly And Company | Method of treating heparin-induced thrombocytopenia |
| EP1131091B1 (en) * | 1998-11-20 | 2003-04-02 | Eli Lilly And Company | Treatment of viral hemorrhagic fever with protein c |
| CN1326357A (zh) * | 1998-11-23 | 2001-12-12 | 伊莱利利公司 | 治疗镰刀形红细胞贫血病及地中海贫血病的方法 |
| EP1137432B1 (en) * | 1998-12-10 | 2004-04-14 | Eli Lilly And Company | Use of protein c for the treatment of thrombocytopenic purpura and hemolytic uremic syndrome |
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| US20030073636A1 (en) * | 2001-09-19 | 2003-04-17 | Oklahoma Medical Research Foundation | Method of treating diabetes |
| WO2003024398A2 (en) | 2001-09-19 | 2003-03-27 | Oklahoma Medical Research Foundation | Treatment of sepsis with tafi |
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| EP1517698B2 (en) | 2002-06-21 | 2017-12-06 | Novo Nordisk Health Care AG | STABILISED SOLID COMPOSITIONS OF FACTOR VIIa POLYPEPTIDES |
| RU2329823C2 (ru) * | 2002-10-29 | 2008-07-27 | Алза Корпорейшн | Стабилизированные твердые полипептидные частицы |
| US20070142272A1 (en) * | 2003-01-24 | 2007-06-21 | Zlokovic Berislav V | Neuroprotective activity of activated protein c independent of its anticoagulant activity |
| US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| JP4658041B2 (ja) * | 2003-06-25 | 2011-03-23 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Ｖｉｉ因子ポリペプチドの液体組成物 |
| EP1729791A2 (en) * | 2004-03-17 | 2006-12-13 | Chiron Corporation | Treatment of severe community-acquired pneumonia by admistration of tissue factor pathway inhibitor (tfpi) |
| WO2006014839A2 (en) * | 2004-07-23 | 2006-02-09 | The University Of Rochester | Activated protein c inhibits undesirable effects of plasminogen activator in the brain |
| EP1913155A4 (en) * | 2005-06-23 | 2009-08-12 | Univ British Columbia | COAGULATION FACTOR III POLYMORPHISMS ASSOCIATED WITH PREDICTION RELATING TO THE RESULTS AND RESPONSE OF A SUBJECT TO THERAPY |
| ES2386972T3 (es) * | 2006-05-31 | 2012-09-10 | Genzyme Corporation | Uso de polisacáridos para la estimulación de la actividad enzimática |
| CA2654761A1 (en) * | 2006-06-09 | 2007-12-13 | The University Of British Columbia | Interferon gamma polymorphisms as indicators of subject outcome in critically ill subjects |
| WO2008107908A1 (en) * | 2007-03-05 | 2008-09-12 | Cadila Healthcare Limited | Compositions comprising peg- interferon alpha conjugates and raffinose as cryoprotectant |
| US8168760B2 (en) | 2007-03-29 | 2012-05-01 | Abbott Laboratories | Crystalline anti-human IL-12 antibodies |
| NZ602498A (en) * | 2007-11-30 | 2014-08-29 | Abbvie Inc | Protein formulations and methods of making same |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| US20110171200A1 (en) * | 2008-01-15 | 2011-07-14 | Walley Keith R | Protein c rs2069915 as a response predictor to survival and administration of activated protein c or protein c-like compound |
| NZ592644A (en) * | 2008-11-28 | 2013-09-27 | Abbott Lab | Stable antibody compositions and methods for stabilizing same |
| WO2012068519A2 (en) | 2010-11-19 | 2012-05-24 | Sirius Genomics Inc. | Markers associated with response to activated protein c administration, and uses thereof |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| EP2834635A4 (en) | 2012-04-03 | 2015-09-02 | Smiths Medical Asd Inc | COMPOSITIONS WITH A HEPARINE ACCUMULATIVE AND METHOD THEREFOR |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| EP2869833B1 (en) | 2012-07-04 | 2018-04-04 | ZZ Biotech LLC. | Activated protein c for use in the treatment of inflammatory skin disorders |
| AU2013309506A1 (en) | 2012-09-02 | 2015-03-12 | Abbvie Inc. | Methods to control protein heterogeneity |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| AU2013381687A1 (en) | 2013-03-12 | 2015-09-24 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| WO2015157791A1 (en) | 2014-04-16 | 2015-10-22 | The University Of Sydney | Treatment of abnormal cutaneous scarring |
| US11058750B2 (en) | 2015-12-03 | 2021-07-13 | Mor Research Applications Ltd. | Compositions and methods for treatment of ocular diseases |
| EP3463308B1 (en) * | 2016-06-01 | 2021-12-01 | Servier IP UK Limited | Formulations of polyalkylene oxide-asparaginase and methods of making and using the same |
| CN108159399B (zh) * | 2017-12-29 | 2020-07-24 | 华中科技大学同济医学院附属同济医院 | 一种凝血蛋白酶aPC在防治糖尿病心肌病药物中的应用 |
| WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
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| HUP0001237A3 (en) | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
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1998
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- 1998-04-24 AU AU71618/98A patent/AU740753C/en not_active Ceased
- 1998-04-24 ID IDW991254A patent/ID23172A/id unknown
- 1998-04-24 US US09/065,872 patent/US6162629A/en not_active Expired - Lifetime
- 1998-04-24 AU AU72589/98A patent/AU743531B2/en not_active Ceased
- 1998-04-24 HU HU0003401A patent/HUP0003401A3/hu unknown
- 1998-04-24 CA CA2288143A patent/CA2288143C/en not_active Expired - Fee Related
- 1998-04-24 TR TR1999/02529T patent/TR199902529T2/xx unknown
- 1998-04-24 NZ NZ500346A patent/NZ500346A/en unknown
- 1998-04-24 UA UA99105788A patent/UA73071C2/uk unknown
- 1998-04-24 UA UA99105884A patent/UA55448C2/uk unknown
- 1998-04-24 JP JP54721998A patent/JP4383546B2/ja not_active Expired - Fee Related
- 1998-04-24 CN CNB988045672A patent/CN1235638C/zh not_active Expired - Fee Related
- 1998-04-24 CN CNB988063824A patent/CN1227025C/zh not_active Expired - Fee Related
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- 1998-04-24 ZA ZA9803497A patent/ZA983497B/xx unknown
- 1998-04-24 TR TR1999/02631T patent/TR199902631T2/xx unknown
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- 1998-04-24 IL IL13250298A patent/IL132502A0/xx unknown
- 1998-04-24 IL IL13232598A patent/IL132325A/xx not_active IP Right Cessation
- 1998-04-24 AR ARP980101908A patent/AR012010A1/es active IP Right Grant
- 1998-04-24 NZ NZ337828A patent/NZ337828A/en unknown
- 1998-04-24 KR KR1019997009835A patent/KR100564189B1/ko not_active IP Right Cessation
- 1998-04-24 PL PL98336889A patent/PL195090B1/pl not_active IP Right Cessation
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- 1998-04-24 CO CO98022605A patent/CO4940438A1/es unknown
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- 1998-04-24 CO CO98022609A patent/CO4950523A1/es unknown
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- 1998-04-24 BR BR9809292-8A patent/BR9809292A/pt not_active Application Discontinuation
- 1998-04-24 PL PL98336420A patent/PL195642B1/pl unknown
- 1998-04-24 HU HU0100284A patent/HU224826B1/hu not_active IP Right Cessation
- 1998-04-24 PE PE1998000309A patent/PE86299A1/es not_active Application Discontinuation
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- 1998-04-28 EP EP98303312A patent/EP0875563A3/en not_active Withdrawn
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