UA72248C2 - Dosage form containing phosphodiesterase inhibitor and method for treating sexual dysfunction - Google Patents
Dosage form containing phosphodiesterase inhibitor and method for treating sexual dysfunction Download PDFInfo
- Publication number
- UA72248C2 UA72248C2 UA2001118182A UA2001118182A UA72248C2 UA 72248 C2 UA72248 C2 UA 72248C2 UA 2001118182 A UA2001118182 A UA 2001118182A UA 2001118182 A UA2001118182 A UA 2001118182A UA 72248 C2 UA72248 C2 UA 72248C2
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- UA
- Ukraine
- Prior art keywords
- compound
- dosage form
- buffer
- pde5
- inhibitor
- Prior art date
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- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 125000005498 phthalate group Chemical group 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000035946 sexual desire Effects 0.000 description 1
- 229960003310 sildenafil Drugs 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 239000011537 solubilization buffer Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
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- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13203699P | 1999-04-30 | 1999-04-30 | |
| PCT/US2000/011129 WO2000066099A2 (en) | 1999-04-30 | 2000-04-26 | Compositions comprising phosphodiesterase inhabitors for the treatment of sexual disfunction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA72248C2 true UA72248C2 (en) | 2005-02-15 |
Family
ID=22452153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2001118182A UA72248C2 (en) | 1999-04-30 | 2000-04-26 | Dosage form containing phosphodiesterase inhibitor and method for treating sexual dysfunction |
Country Status (47)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060093355A (ko) * | 1999-08-03 | 2006-08-24 | 릴리 아이코스 엘엘씨 | 베타-카르볼린 약학 조성물 |
| DE10010612A1 (de) * | 2000-03-03 | 2001-09-27 | Merck Patent Gmbh | Verwendung von PDE V-Inhibitoren |
| US20030153575A1 (en) * | 2000-06-08 | 2003-08-14 | Orme Mark W. | Tetracyclic diketopiperazine compounds as pdev inhibitors |
| AU2001271948A1 (en) * | 2000-08-02 | 2002-02-13 | Lilly Icos Llc | Fused heterocyclic derivatives as phosphodiesterase inhibitors |
| MXPA03011080A (es) * | 2001-06-05 | 2004-07-08 | Lilly Icos Llc | Compuestos tetraciclicos como inhibidores de pde5. |
| GB0129274D0 (en) * | 2001-12-06 | 2002-01-23 | Pfizer Ltd | Novel kit |
| US20060205733A1 (en) * | 2004-08-26 | 2006-09-14 | Encysive Pharmaceuticals | Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof |
| WO2007112272A2 (en) | 2006-03-28 | 2007-10-04 | Javelin Pharmaceuticals, Inc. | Formulations of low dose diclofenac and beta-cyclodextrin |
| US7495024B2 (en) | 2006-08-07 | 2009-02-24 | Via Pharmaceuticals, Inc. | Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque |
| DE102007028869A1 (de) | 2007-06-22 | 2008-12-24 | Ratiopharm Gmbh | Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil |
| DE102009033396A1 (de) | 2009-07-16 | 2011-01-20 | Ratiopharm Gmbh | Wässrige Lösung und gelatinierte Zusammensetzung umfassend einen Phosphodiesterase-5-Inhibitor sowie diesbezügliche Verfahren und Verwendung |
| US20110136815A1 (en) | 2009-12-08 | 2011-06-09 | Horst Zerbe | Solid oral film dosage forms and methods for making same |
| US10610528B2 (en) | 2009-12-08 | 2020-04-07 | Intelgenx Corp. | Solid oral film dosage forms and methods for making same |
| US20110263606A1 (en) * | 2010-04-26 | 2011-10-27 | Horst Zerbe | Solid oral dosage forms comprising tadalafil |
| WO2012107541A1 (en) | 2011-02-10 | 2012-08-16 | Synthon Bv | Pharmaceutical composition comprising tadalafil and a cyclodextrin |
| EP2672959A1 (de) | 2011-02-10 | 2013-12-18 | Synthon BV | Granulierte zusammensetzung mit tadalafil und einem sprengmittel |
| WO2012107092A1 (en) | 2011-02-10 | 2012-08-16 | Synthon Bv | Pharmaceutical composition comprising tadalafil and a cyclodextrin |
| KR102239291B1 (ko) | 2013-06-28 | 2021-04-14 | 한미약품 주식회사 | 타다라필 또는 이의 약학적으로 허용가능한 염을 포함하는 저작정 제제 |
| KR101663238B1 (ko) | 2013-11-15 | 2016-10-14 | 한미약품 주식회사 | 타다라필 및 암로디핀을 포함하는 복합 고형 제제 |
| KR102646431B1 (ko) | 2017-09-29 | 2024-03-12 | 한미약품 주식회사 | 생산성 및 균일성이 개선된 타다라필을 함유하는 고형제제 및 그 제조방법 |
| JP7312198B2 (ja) * | 2018-02-07 | 2023-07-20 | スマヴァ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 医薬製剤、医薬製剤の製造方法、およびそれを含む医薬品 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9301192D0 (en) * | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
| GB9514465D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| GB9401090D0 (en) * | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
| GB9423911D0 (en) * | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
| GB9511220D0 (en) * | 1995-06-02 | 1995-07-26 | Glaxo Group Ltd | Solid dispersions |
| GB9514473D0 (en) * | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| GB9514464D0 (en) * | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Medicaments |
| JP3418405B2 (ja) | 1996-05-10 | 2003-06-23 | アイコス コーポレイション | カルボリン誘導体 |
| PL336586A1 (en) * | 1997-04-25 | 2000-07-03 | Pfizer | Pyrazoylpyrimidinones inhibiting the cyclic guanosine 3',5'-monophosphate phosphodiesterase of type 5 (cgmp pde5) for treating sexual disorders |
| WO1999059584A1 (en) * | 1998-05-20 | 1999-11-25 | Schering Corporation | Combination of phentolamine and cyclic gmp phosphodiesterase inhibitors for the treatment of sexual dysfunction |
| JP2002524564A (ja) | 1998-09-16 | 2002-08-06 | アイコス コーポレイション | ｃＧＭＰホスホジエステラーゼ阻害剤としてのカルボリン誘導体 |
| EP1120120A4 (de) * | 1998-10-05 | 2009-04-29 | Eisai R&D Man Co Ltd | Tableten die sich unmittelbar in der mundhöhle auflösen |
| AU3724400A (en) * | 1999-03-08 | 2000-09-28 | Merck & Co., Inc. | Methods and compositions for treating erectile dysfunction |
| US6451807B1 (en) * | 1999-04-30 | 2002-09-17 | Lilly Icos, Llc. | Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor |
| AU4663100A (en) * | 1999-04-30 | 2000-11-17 | Lilly Icos Llc | Treatment of female arousal disorder |
-
2000
- 2000-04-25 HU HU0001632A patent/HUP0001632A3/hu unknown
- 2000-04-25 ES ES200001055A patent/ES2187234A1/es not_active Withdrawn
- 2000-04-25 MX MXPA00003997A patent/MXPA00003997A/es unknown
- 2000-04-25 NO NO20002097A patent/NO20002097L/no not_active Application Discontinuation
- 2000-04-25 IL IL13581700A patent/IL135817A0/xx unknown
- 2000-04-25 SV SV2000000055A patent/SV2002000055A/es not_active Application Discontinuation
- 2000-04-26 GB GB0010199A patent/GB2351663A/en not_active Withdrawn
- 2000-04-26 KR KR1020000022108A patent/KR20010020779A/ko not_active Application Discontinuation
- 2000-04-26 BE BE2000/0295A patent/BE1012957A5/fr not_active IP Right Cessation
- 2000-04-26 AT AT00926367T patent/ATE251908T1/de active
- 2000-04-26 IT IT2000MI000922A patent/ITMI20000922A1/it unknown
- 2000-04-26 ZA ZA200002058A patent/ZA200002058B/xx unknown
- 2000-04-26 IE IE20000315A patent/IE20000315A1/en not_active IP Right Cessation
- 2000-04-26 CA CA002307101A patent/CA2307101C/en not_active Expired - Fee Related
- 2000-04-26 LV LVP-00-56A patent/LV12560B/en unknown
- 2000-04-26 ES ES00926367.4T patent/ES2208317T7/es active Active
- 2000-04-26 DE DE10021266A patent/DE10021266A1/de not_active Withdrawn
- 2000-04-26 AU AU30129/00A patent/AU3012900A/en not_active Abandoned
- 2000-04-26 NZ NZ514882A patent/NZ514882A/en not_active IP Right Cessation
- 2000-04-26 UA UA2001118182A patent/UA72248C2/uk unknown
- 2000-04-26 LU LU90569A patent/LU90569B1/fr active
- 2000-04-26 AU AU44908/00A patent/AU769946C/en not_active Expired
- 2000-04-26 SE SE0001518A patent/SE0001518L/xx not_active Application Discontinuation
- 2000-04-26 CZ CZ20013879A patent/CZ296534B6/cs not_active IP Right Cessation
- 2000-04-26 HR HR20000243A patent/HRP20000243A2/hr not_active Application Discontinuation
- 2000-04-26 DE DE60005940.5T patent/DE60005940T3/de not_active Expired - Lifetime
- 2000-04-26 DE DE20007861U patent/DE20007861U1/de not_active Expired - Lifetime
- 2000-04-26 NL NL1015027A patent/NL1015027C2/nl not_active IP Right Cessation
- 2000-04-26 EA EA200101008A patent/EA005416B1/ru not_active IP Right Cessation
- 2000-04-26 CH CH00819/00A patent/CH692478A5/de not_active IP Right Cessation
- 2000-04-26 PL PL00339897A patent/PL339897A1/xx not_active Application Discontinuation
- 2000-04-26 FR FR0005296A patent/FR2795646B1/fr not_active Expired - Fee Related
- 2000-04-26 FI FI20000976A patent/FI20000976A/fi not_active IP Right Cessation
- 2000-04-26 EA EA200000355A patent/EA200000355A3/ru unknown
- 2000-04-26 SI SI200030225T patent/SI1173181T1/xx unknown
- 2000-04-26 ID IDP20000331D patent/ID25704A/id unknown
- 2000-04-26 NZ NZ504163A patent/NZ504163A/en unknown
- 2000-04-26 EP EP03023276A patent/EP1415652A3/de not_active Withdrawn
- 2000-04-26 CO CO00029997A patent/CO5170493A1/es not_active Application Discontinuation
- 2000-04-26 DZ DZ003171A patent/DZ3171A1/xx active
- 2000-04-26 SG SG200002287A patent/SG98384A1/en unknown
- 2000-04-26 HU HU0200912A patent/HU230369B1/hu not_active IP Right Cessation
- 2000-04-26 LT LT2000035A patent/LT4758B/lt not_active IP Right Cessation
- 2000-04-26 GR GR20000100153A patent/GR1003575B/el unknown
- 2000-04-26 JP JP2000614984A patent/JP4975214B2/ja not_active Expired - Lifetime
- 2000-04-26 PE PE2000000388A patent/PE20010071A1/es not_active Application Discontinuation
- 2000-04-26 PT PT00926367T patent/PT1173181E/pt unknown
- 2000-04-26 BR BR0003046-5A patent/BR0003046A/pt not_active IP Right Cessation
- 2000-04-26 PL PL352629A patent/PL197813B1/pl unknown
- 2000-04-26 CN CNB008097771A patent/CN1196487C/zh not_active Expired - Lifetime
- 2000-04-26 EP EP00926367.4A patent/EP1173181B3/de not_active Expired - Lifetime
- 2000-04-26 SK SK1563-2001A patent/SK285415B6/sk not_active IP Right Cessation
- 2000-04-26 WO PCT/US2000/011129 patent/WO2000066099A2/en active IP Right Grant
- 2000-04-26 DK DK00926367T patent/DK1173181T6/en active
- 2000-04-26 TR TR2000/01132A patent/TR200001132A3/tr unknown
- 2000-04-26 IL IL14609800A patent/IL146098A0/xx unknown
- 2000-04-26 CA CA002371684A patent/CA2371684C/en not_active Expired - Lifetime
- 2000-04-26 CH CH00926367.4T patent/CH1173181H1/de unknown
- 2000-04-26 CN CN00106987XA patent/CN1292264A/zh active Pending
- 2000-04-26 PT PT102457A patent/PT102457A/pt unknown
- 2000-04-26 MX MXPA01010837A patent/MXPA01010837A/es active IP Right Grant
- 2000-04-26 SI SI200000107A patent/SI20361A/sl not_active IP Right Cessation
- 2000-04-26 DK DK200000677A patent/DK200000677A/da not_active Application Discontinuation
- 2000-04-26 BR BR0010181-8A patent/BR0010181A/pt not_active Application Discontinuation
- 2000-04-26 KR KR1020017013747A patent/KR100577057B1/ko active IP Right Review Request
- 2000-04-26 JP JP2000126472A patent/JP2000336043A/ja active Pending
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2001
- 2001-10-22 IL IL146098A patent/IL146098A/en not_active IP Right Cessation
- 2001-10-23 HR HR20010778A patent/HRP20010778B1/xx not_active IP Right Cessation
- 2001-10-29 ZA ZA200108900A patent/ZA200108900B/xx unknown
- 2001-10-29 NO NO20015275A patent/NO322013B3/no not_active IP Right Cessation
-
2002
- 2002-02-26 HK HK02101474.1A patent/HK1041204B/zh not_active IP Right Cessation
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2004
- 2004-05-12 AU AU2004201988A patent/AU2004201988A1/en not_active Abandoned
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