DK200000677A - Fabrikerede artikler - Google Patents

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Publication number
DK200000677A
DK200000677A DK200000677A DKPA200000677A DK200000677A DK 200000677 A DK200000677 A DK 200000677A DK 200000677 A DK200000677 A DK 200000677A DK PA200000677 A DKPA200000677 A DK PA200000677A DK 200000677 A DK200000677 A DK 200000677A
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DK
Denmark
Prior art keywords
treatment
sexual dysfunction
pde5
pde5 inhibitor
patient
Prior art date
Application number
DK200000677A
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English (en)
Inventor
Jeffrey Thomas Emmick
Ferguson Kenneth Michael
William Ernest Pullman
John Steven Whitaker
Original Assignee
Lilly Icos Llc A Delaware Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22452153&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK200000677(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Icos Llc A Delaware Ltd filed Critical Lilly Icos Llc A Delaware Ltd
Publication of DK200000677A publication Critical patent/DK200000677A/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Glass Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)

Description

Patentkrav. 1. Fabrikeret artikel til medicinsk brug ved behandling af mennesker omfattende: (a) en oral dosisform omfattende ca. 1 til ca. 20 mg af en selektiv PDE5-inhibitor, som besidder (i) mindst eh 100 ganges forskel mellem IC50-værdierne for inhibering af PDE5 i forhold til PDE6, (ii) mindst en 1000 ganges forskel imellem IC5o-værdieme for inhibering af PDE5 i forhold til PDE1c, (iii) en IC50 mindre end 10 nM, og (iv) tilstrækkelig biotilgængelighed til at være effektiv i orale enhedsdoser på ca. 1 til ca. 20 mg; (b) et pakkeindlæg, som angiver, at PDE5-inhibitoren er nyttig ved behandling af seksuel dysfunktion i en patient, som har behov derfor, og at det er fri for kontraindikationer i forbindelse med indgivelse af organiske nitrater; og (c) en beholder. 2. Fabrikeret artikel til medicinsk brug ved behandling af mennesker omfattende: (a) en oral dosisform omfattende ca. 1 til ca. 20 mg af selektiv PDE5-inhibitor , som besidder (i) en mindst 100 ganges forskel imellem IC50-værdierne for inhibering af PDE5 i forhold til PDE6, (ii) en mindst 1000 ganges forskel imellem IC50-værdierne for inhibering af PDE5 i forhold til PDE1c, (iii) en IC50 mindre end 10 nM, og (iv) en tilstrækkelig biotilgængelighed til at være orale enhedsdoser på ca. 1 til ca. 20 mg (b) et pakkeindlæg, som angiver, at PDE5-inhibitoren er nyttig ved behandlingen af seksuel dysfunktion i en patient, som har behov derfor, og som anvender et organisk nitrat; og (c) en beholder. 3. Fabrikeret artikel til medicinsk brug ved behandling af mennesker omfattende: (a) en oral dosisform omfattnede ca. 1 til ca. 20 mg af en selektiv PDE5 inhinbitor, som besidder (i) mindst en 100 ganges forskel imellem IC50-værdierne for inhibering af PDE5 i forhold til PDE6, (ii) mindst en 1000 ganges forskel imellem IC50-værdierne for inhibering af PDE5 i forhold til PDE1c, (iii) en IC50 mindre end 10 nM, og (iv) en tilstrækkelig biotilgængelighed til at være effektiv i orale enhedsdoser på ca. 1 til ca. 20 mg; (b) et pakkeindlæg, der angiver, at PDE5-inhibitoren er nyttig ved behandlingen af seksuel dysfunktion i en patient, som har behov derfor, og som lider af en tilstand udvalgt fra gruppen bestående af en nethindesygdom, tilbøjelighed til rødmen, tilbøjelighed til synsforstyrrelser, klasse 1 kongestiv hjertestop, et myo-kardieinfarkt 90 dage eller mere før igangsættelsen af den seksuelle dysfunktionbehandling, og kombinationer af disse; og (c) en beholder. 4. Artikel ifølge krav 3, hvori nethindesygdommen er diabetisk retinopati eller Retinitis pigmentosa. 5. Artikel ifølge krav 3, hvori omtalte pakkeindlæg beskriver, at rødmen forekommer hos mindre end 2% af behandlede patienter. 6. Artikel ifølge krav 1 til 5, hvori den orale dosisform omfatter ca. 5 mg, ca. 10 mg eller ca. 20 mg af en selektiv PDE5-inhibitor. 7. Artikel ifølge krav 1 til 6, hvori pakkeindlægget beskriver en maksimal dosis af den selektive PDE5-inhibitor på ca. 20 mg pr. 24 timer. 8. Artikel ifølge krav 1 til 7, hvori den selektive PDE5-inhibitor har strukturen
Figure DK200000677AD00051
9. Fabrikeret artikel som i al væsentlighed tidligere beskrevet i denne specifikation. 10. Anvendelse af en selektiv PDE5-inhibitor til fremstilling af et medikament til behandling af seksuel dysfunktion i en patient, der behandles med et organisk nitrat. 11. Anvendelse af en selektiv PDE5-inhibitor til fremstilling af et medikament til behandling af seksuel dysfunktion i en patient, der har tilbøjelighed til synsforstyrrelser, tilbøjelighed til rødmen, lider af en nethindesygdom, lider af klasse 1 kongestiv hjertestop, eller som led af myocardieinfarkt 90 dage eller mere før igangsættelsen af behandlingen af seksuel dysfunktion. 12. Farmaceutisk formulering tilpasset til behandlingen af seksuel dysfunktion i en patient, der behandles med et organisk nitrat, der som aktiv ingrediens omfatter en selektiv PDE5-inhibitor, således som de tidligere heri beskrevne. 13. Farmaceutisk formulering tilpasset til behandlingen af seksuel dysfunktion i en patient, der har tilbøjelighed til rødmen, der som aktiv ingrediens omfatter en selektiv PDE5-inhibitor, således som de tidligere heri beskrevne. 14. Farmaceutisk formulering tilpasset til behandlingen af seksuel dysfunktion i en patient, der lider af en nethindesygdom, der som aktiv ingrediens omfatter en selektiv PDE5-inhibitor, således som de tidligere heri beskrevne. 15. Farmaceutisk formulering tilpasset til behandlingen af seksuel dysfunktion i en patient, der lider af klasse 1 kongestiv hjertestop eller led af et myocardieinfarkt 90 dage eller mere før påbegyndelsen af behandlingen af seksuel dysfunktion, der som aktiv ingrediens omfatter en selektiv PDE5-inhibitor som tidligere heri beskrevet. 16. Fremgangsmåde til behandling af seksuel dysfunktion omfattende anvendelse af en fabrikeret artikel ifølge krav 1 til 8.
DK200000677A 1999-04-30 2000-04-26 Fabrikerede artikler DK200000677A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13203699P 1999-04-30 1999-04-30

Publications (1)

Publication Number Publication Date
DK200000677A true DK200000677A (da) 2000-10-31

Family

ID=22452153

Family Applications (2)

Application Number Title Priority Date Filing Date
DK00926367T DK1173181T6 (da) 1999-04-30 2000-04-26 Sammensætning omfattende inhibitorer for phosphodiesterase til behandling af seksuel dysfunktion
DK200000677A DK200000677A (da) 1999-04-30 2000-04-26 Fabrikerede artikler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK00926367T DK1173181T6 (da) 1999-04-30 2000-04-26 Sammensætning omfattende inhibitorer for phosphodiesterase til behandling af seksuel dysfunktion

Country Status (47)

Country Link
EP (2) EP1173181B3 (da)
JP (2) JP4975214B2 (da)
KR (2) KR20010020779A (da)
CN (2) CN1292264A (da)
AT (1) ATE251908T1 (da)
AU (3) AU769946C (da)
BE (1) BE1012957A5 (da)
BR (2) BR0010181A (da)
CA (2) CA2371684C (da)
CH (2) CH1173181H1 (da)
CO (1) CO5170493A1 (da)
CZ (1) CZ296534B6 (da)
DE (3) DE10021266A1 (da)
DK (2) DK1173181T6 (da)
DZ (1) DZ3171A1 (da)
EA (2) EA005416B1 (da)
ES (2) ES2187234A1 (da)
FI (1) FI20000976A7 (da)
FR (1) FR2795646B1 (da)
GB (1) GB2351663A (da)
GR (1) GR1003575B (da)
HK (1) HK1041204B (da)
HR (2) HRP20010778B1 (da)
HU (2) HUP0001632A3 (da)
ID (1) ID25704A (da)
IE (1) IE20000315A1 (da)
IL (3) IL135817A0 (da)
IT (1) ITMI20000922A1 (da)
LT (1) LT4758B (da)
LU (1) LU90569B1 (da)
LV (1) LV12560B (da)
MX (2) MXPA00003997A (da)
NL (1) NL1015027C2 (da)
NO (2) NO20002097L (da)
NZ (2) NZ504163A (da)
PE (1) PE20010071A1 (da)
PL (2) PL339897A1 (da)
PT (2) PT102457A (da)
SE (1) SE0001518L (da)
SG (1) SG98384A1 (da)
SI (2) SI1173181T1 (da)
SK (1) SK285415B6 (da)
SV (1) SV2002000055A (da)
TR (1) TR200001132A2 (da)
UA (1) UA72248C2 (da)
WO (1) WO2000066099A2 (da)
ZA (2) ZA200002058B (da)

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ES2208317T7 (es) 2015-09-15
CN1384746A (zh) 2002-12-11
MXPA00003997A (es) 2002-03-08
FR2795646B1 (fr) 2002-08-16
KR100577057B1 (ko) 2006-05-10
BR0003046A (pt) 2002-07-23
LU90569B1 (fr) 2002-02-27
GB2351663A (en) 2001-01-10
LT4758B (lt) 2001-02-26
DK1173181T3 (da) 2004-02-16
SI20361A (sl) 2001-04-30
NL1015027C2 (nl) 2001-02-14
LT2000035A (lt) 2000-11-27
SK285415B6 (sk) 2007-01-04
EP1415652A3 (en) 2004-05-12
IL146098A0 (en) 2002-07-25
ITMI20000922A1 (it) 2001-10-26
SK15632001A3 (sk) 2002-02-05
UA72248C2 (en) 2005-02-15
ID25704A (id) 2000-11-02
AU2004201988A1 (en) 2004-06-10
PT102457A (pt) 2000-11-30
NL1015027A1 (nl) 2000-10-31
PE20010071A1 (es) 2001-03-22
LV12560A (en) 2000-11-20
JP2000336043A (ja) 2000-12-05
CZ296534B6 (cs) 2006-04-12
HRP20010778B1 (en) 2005-04-30
JP4975214B2 (ja) 2012-07-11
HUP0200912A3 (en) 2003-07-28
HU0200912D0 (en) 2002-04-29
HUP0200912A2 (en) 2002-08-28
CN1292264A (zh) 2001-04-25
PT1173181E (pt) 2004-02-27
SE0001518L (sv) 2000-10-31
ITMI20000922A0 (it) 2000-04-26
FI20000976L (fi) 2000-10-30
ES2208317T3 (es) 2004-06-16
HU0001632D0 (en) 2000-06-28
FI20000976A0 (fi) 2000-04-26
NO20002097D0 (no) 2000-04-25
EA005416B1 (ru) 2005-02-24
SI1173181T1 (en) 2004-04-30
EP1173181B3 (en) 2015-03-25
ATE251908T1 (de) 2003-11-15
IL146098A (en) 2007-06-03
GR1003575B (el) 2001-05-14
MXPA01010837A (es) 2002-11-07
WO2000066099A2 (en) 2000-11-09
CN1196487C (zh) 2005-04-13
EA200101008A1 (ru) 2002-04-25
CH692478A5 (de) 2002-07-15
SG98384A1 (en) 2003-09-19
DZ3171A1 (da) 2000-11-09
PL339897A1 (en) 2000-11-06
HUP0001632A3 (en) 2001-12-28
SV2002000055A (es) 2002-07-03
ZA200002058B (en) 2000-11-02
CA2307101C (en) 2003-01-28
WO2000066099A3 (en) 2001-01-18
EA200000355A3 (ru) 2001-02-26
DE60005940D1 (de) 2003-11-20
NZ504163A (en) 2001-11-30
JP2002543116A (ja) 2002-12-17
ES2187234A1 (es) 2003-05-16
DE60005940T3 (de) 2015-08-27
AU769946B2 (en) 2004-02-12
NO322013B3 (no) 2017-11-06
CH1173181H1 (da) 2019-07-15
PL197813B1 (pl) 2008-04-30
HU230369B1 (hu) 2016-03-29
CA2371684A1 (en) 2000-11-09
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TR200001132A3 (tr) 2001-01-22
NO20002097L (no) 2001-10-26
EA200000355A2 (ru) 2000-10-30
EP1173181B1 (en) 2003-10-15
GR20000100153A (el) 2000-12-29
HRP20000243A2 (en) 2001-12-31
KR20010020779A (ko) 2001-03-15
CZ20013879A3 (cs) 2002-04-17
ZA200108900B (en) 2003-03-26
TR200001132A2 (tr) 2001-01-22
IL135817A0 (en) 2001-05-20
AU769946C (en) 2005-01-13
KR20020008396A (ko) 2002-01-30
DE60005940T2 (de) 2004-07-29
DE10021266A1 (de) 2000-11-16
IE20000315A1 (en) 2001-03-07
SE0001518D0 (sv) 2000-04-26
BE1012957A5 (fr) 2001-06-05
NO20015275D0 (no) 2001-10-29
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HK1041204B (en) 2004-03-05
DK1173181T6 (da) 2015-04-27
CA2307101A1 (en) 2000-10-30
PL352629A1 (en) 2003-08-25
DE20007861U1 (de) 2000-08-24
FR2795646A1 (fr) 2001-01-05
LV12560B (en) 2001-04-20
NZ514882A (en) 2003-08-29
HUP0001632A2 (hu) 2001-05-28
HK1041204A1 (en) 2002-07-05
HRP20010778A2 (en) 2002-12-31
EP1415652A2 (en) 2004-05-06
NO322013B1 (no) 2006-08-07
CO5170493A1 (es) 2002-06-27
AU4490800A (en) 2000-11-17
CA2371684C (en) 2007-10-23
FI20000976A7 (fi) 2000-10-30

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