UA72182C2 - Oral delayed immediate release formulation and method for its manufacture - Google Patents
Oral delayed immediate release formulation and method for its manufacture Download PDFInfo
- Publication number
- UA72182C2 UA72182C2 UA99042314A UA99042314A UA72182C2 UA 72182 C2 UA72182 C2 UA 72182C2 UA 99042314 A UA99042314 A UA 99042314A UA 99042314 A UA99042314 A UA 99042314A UA 72182 C2 UA72182 C2 UA 72182C2
- Authority
- UA
- Ukraine
- Prior art keywords
- immediate
- core
- oral
- coating
- delayed
- Prior art date
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Classifications
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96202651 | 1996-09-23 | ||
| PCT/EP1997/005234 WO1998013029A1 (en) | 1996-09-23 | 1997-09-18 | Oral delayed immediate release formulation and method of preparation therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA72182C2 true UA72182C2 (en) | 2005-02-15 |
Family
ID=8224414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA99042314A UA72182C2 (en) | 1996-09-23 | 1997-09-18 | Oral delayed immediate release formulation and method for its manufacture |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6183780B1 (ar) |
| EP (1) | EP0939623B1 (ar) |
| JP (1) | JP4947824B2 (ar) |
| KR (1) | KR100501966B1 (ar) |
| CN (1) | CN1161110C (ar) |
| AT (1) | ATE213627T1 (ar) |
| AU (1) | AU717711B2 (ar) |
| BR (1) | BR9711303A (ar) |
| CA (1) | CA2263921C (ar) |
| CZ (1) | CZ294641B6 (ar) |
| DE (1) | DE69710756T2 (ar) |
| DK (1) | DK0939623T3 (ar) |
| DZ (1) | DZ2314A1 (ar) |
| ES (1) | ES2172003T3 (ar) |
| HK (1) | HK1019852A1 (ar) |
| HR (1) | HRP970493A2 (ar) |
| HU (1) | HU226693B1 (ar) |
| ID (1) | ID22039A (ar) |
| IL (1) | IL128565A (ar) |
| JO (1) | JO2066B1 (ar) |
| NO (1) | NO325763B1 (ar) |
| NZ (1) | NZ334463A (ar) |
| PL (1) | PL189016B1 (ar) |
| PT (1) | PT939623E (ar) |
| RU (1) | RU2193395C2 (ar) |
| SK (1) | SK284263B6 (ar) |
| TR (1) | TR199900641T2 (ar) |
| UA (1) | UA72182C2 (ar) |
| WO (1) | WO1998013029A1 (ar) |
| ZA (1) | ZA978431B (ar) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030109503A1 (en) * | 1995-06-06 | 2003-06-12 | Smithkline Beecham P.L.C. | Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics |
| IL139541A0 (en) | 1998-05-20 | 2004-02-08 | Liposome Co Inc | Novel particulate formulations |
| SE9802973D0 (sv) * | 1998-09-03 | 1998-09-03 | Astra Ab | Immediate release tablet |
| US6322819B1 (en) * | 1998-10-21 | 2001-11-27 | Shire Laboratories, Inc. | Oral pulsed dose drug delivery system |
| PL205109B1 (pl) * | 1998-11-02 | 2010-03-31 | Elan Pharma Int Ltd | Wielocząstkowa kompozycja metylofenidatu o modyfikowanym uwalnianiu i jej zastosowanie |
| US6294199B1 (en) | 1999-04-13 | 2001-09-25 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising administering amoxycillin |
| US6878386B1 (en) | 1999-04-13 | 2005-04-12 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate |
| US7250176B1 (en) | 1999-04-13 | 2007-07-31 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection |
| IE990406A1 (en) * | 1999-05-20 | 2000-12-27 | Elan Corp Plc | Multiparticulate controlled release selective serotonin reuptake inhibitor formulations. |
| EP1064937A1 (en) * | 1999-06-28 | 2001-01-03 | Sanofi-Synthelabo | Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof |
| EP1074249A1 (en) * | 1999-07-27 | 2001-02-07 | Jagotec Ag | A pharmaceutical tablet system for releasing at least one active substance during a release period subsequent to a no-release period |
| US6541001B1 (en) | 1999-08-24 | 2003-04-01 | Teva Pharmaceutical Industries, Ltd. | Vaccine composition and method of using the same |
| US6592869B2 (en) | 1999-08-24 | 2003-07-15 | Teva Pharmaceutical Industries, Ltd. | Vaccine composition and method of using the same |
| US6485746B1 (en) | 2000-08-25 | 2002-11-26 | Neurocrine Biosciences, Inc. | Controlled-release sedative-hypnotic compositions and methods related thereto |
| PT1206248E (pt) * | 1999-08-26 | 2003-11-28 | Neurocrine Biosciences Inc | Composicoes sedativo-hipnoticas de libertacao controlada e metodos relacionados com os mesmos |
| DE10012555A1 (de) * | 2000-03-15 | 2001-09-20 | Merck Patent Gmbh | Glucocorticoide in einer Modified Release-Formulierung |
| US6720005B1 (en) * | 2000-07-07 | 2004-04-13 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Coated, platform-generating tablet |
| US6756057B2 (en) | 2000-10-12 | 2004-06-29 | Beecham Pharmaceuticals (Pte) Limited | Amoxicillin and potassium clavulanate dosage form |
| EP1330236A2 (en) | 2000-10-12 | 2003-07-30 | Beecham Pharmaceuticals (Pte) Limited | Formulation containing amoxicillin |
| US6913768B2 (en) * | 2002-09-24 | 2005-07-05 | Shire Laboratories, Inc. | Sustained release delivery of amphetamine salts |
| US20080220074A1 (en) * | 2002-10-04 | 2008-09-11 | Elan Corporation Plc | Gamma radiation sterilized nanoparticulate docetaxel compositions and methods of making same |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| ATE445393T1 (de) * | 2003-04-24 | 2009-10-15 | Jagotec Ag | Tablette mit gefärbtem kern |
| ATE512659T1 (de) | 2003-04-24 | 2011-07-15 | Jagotec Ag | Tablette mit verzögerter wirkstofffreigabe und bestimmter formgeometrie |
| ES2336913T3 (es) * | 2003-08-08 | 2010-04-19 | Biovail Laboratories International Srl | Comprimido de liberacion modificada de hidrocloruro de bupropion. |
| EP1682537B1 (en) | 2003-11-05 | 2012-03-28 | SARcode Bioscience Inc. | Modulators of cellular adhesion |
| DE602005025755D1 (de) * | 2004-06-04 | 2011-02-17 | Teva Pharma | Irbesartan enthaltende pharmazeutische zusammensetzung |
| DE102004043863A1 (de) | 2004-09-10 | 2006-03-16 | Nitec Pharma Ag | Tabletten mit orts- und zeitgesteuerter Wirkstofffreisetzung im Gastrointestinum |
| GB0423964D0 (en) * | 2004-10-28 | 2004-12-01 | Jagotec Ag | Dosage form |
| WO2006063078A2 (en) * | 2004-12-08 | 2006-06-15 | Elan Corporation, Plc | Topiramate pharmaceuticals composition |
| AU2006235483B2 (en) * | 2005-04-12 | 2010-11-25 | Elan Pharma International Limited | Controlled release compositions comprising a cephalosporin for the treatment of a bacterial infection |
| DK2444079T3 (en) | 2005-05-17 | 2017-01-30 | Sarcode Bioscience Inc | Compositions and Methods for the Treatment of Eye Diseases |
| WO2007037790A2 (en) * | 2005-06-08 | 2007-04-05 | Elan Corporation, Plc | Modified release famciclovir compositions |
| DK1916995T4 (da) | 2005-07-29 | 2022-10-03 | Stichting Groningen Centre For Drug Res | Ph-styret, pulserende indgivelsessystem, fremgangsmåder til fremstilling og anvendelse deraf |
| US20070036859A1 (en) * | 2005-08-11 | 2007-02-15 | Perry Ronald L | Sustained release antihistamine and decongestant composition |
| TWI274889B (en) * | 2005-10-06 | 2007-03-01 | Elan Microelectronics Corp | Resistive touch screen measurement system |
| US8187633B2 (en) * | 2005-11-03 | 2012-05-29 | Sun Pharma Advanced Research Company Limited | Controlled release coated tablets having prolonged gastric retention |
| DK2049123T4 (en) | 2006-08-03 | 2016-11-28 | Horizon Pharma Ag | LATE discharge-glucocorticoid treatment of rheumatoid ILLNESS |
| US20080081067A1 (en) * | 2006-10-03 | 2008-04-03 | Gupta Manishkumar | Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| WO2009021127A2 (en) * | 2007-08-07 | 2009-02-12 | Neurogen Corporation | Controlled released compositions |
| US20090155176A1 (en) | 2007-10-19 | 2009-06-18 | Sarcode Corporation | Compositions and methods for treatment of diabetic retinopathy |
| US8080562B2 (en) | 2008-04-15 | 2011-12-20 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| EP2391369A1 (en) * | 2009-01-26 | 2011-12-07 | Nitec Pharma AG | Delayed-release glucocorticoid treatment of asthma |
| NZ582836A (en) * | 2009-01-30 | 2011-06-30 | Nitec Pharma Ag | Delayed-release glucocorticoid treatment of rheumatoid arthritis by improving signs and symptoms, showing major or complete clinical response and by preventing from joint damage |
| US8378105B2 (en) | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| EP2314296A1 (en) * | 2009-10-22 | 2011-04-27 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Orally Disintegrating Tablets of Betahistine |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| WO2012071220A1 (en) * | 2010-11-23 | 2012-05-31 | Transcept Pharmaceuticals, Inc. | Compositions and methods for once-daily administration of a trilayer osmotic tablet |
| RU2453308C1 (ru) * | 2010-12-20 | 2012-06-20 | Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ ФЕДЕРАЛЬНОГО АГЕНТСТВА ПО ЗДРАВООХРАНЕНИЮ И СОЦИАЛЬНОМУ РАЗВИТИЮ" | Драже с оксиметилурацилом и мебеверина гидрохлоридом для лечения функциональных заболеваний желудочно-кишечного тракта |
| KR102258769B1 (ko) * | 2011-10-14 | 2021-06-01 | 지엘팜텍주식회사 | 장용소화효소제 및 그 제조방법 |
| DE102012105528A1 (de) | 2012-06-25 | 2014-01-02 | Hennig Arzneimittel Gmbh & Co. Kg | Arzneiform zur Freisetzung von Wirkstoffen |
| KR102157608B1 (ko) | 2012-07-25 | 2020-09-18 | 에스에이알코드 바이오사이언스 인코포레이티드 | Lfa-1 저해제 및 그의 다형체 |
| US9545446B2 (en) | 2013-02-25 | 2017-01-17 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| US20160220630A1 (en) | 2013-10-10 | 2016-08-04 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions |
| KR102207539B1 (ko) * | 2015-06-30 | 2021-01-26 | 네우라드 리미티드 | 신규한 호흡 제어 조절 화합물, 및 그의 제조 및 사용 방법 |
| US10653744B2 (en) | 2016-01-11 | 2020-05-19 | Bausch Health Ireland Limited | Formulations and methods for treating ulcerative colitis |
| CN108836948B (zh) * | 2018-06-11 | 2024-04-12 | 宁波西敦医药包衣科技有限公司 | 一种利用包衣技术实现营养素可控制释放的产品 |
| RU2695135C1 (ru) * | 2018-07-11 | 2019-07-22 | Федеральное государственное унитарное предприятие "Научно-исследовательский институт гигиены, профпатологии и экологии человека" Федерального медико-биологического агентства | Двухуровневая микрогранулированная форма терапевтического пептида для перорального применения и способ ее получения |
| CN110403912A (zh) * | 2019-09-04 | 2019-11-05 | 西安科力康医药科技有限公司 | 缓控释包衣粉 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH666405A5 (de) * | 1985-06-24 | 1988-07-29 | Ciba Geigy Ag | Feste, haltbare darreichungsformen mit elastischem filmueberzug. |
| GB8524001D0 (en) * | 1985-09-30 | 1985-11-06 | Glaxo Group Ltd | Pharmaceutical composition |
| US5122384A (en) * | 1989-05-05 | 1992-06-16 | Kv Pharmaceutical Company | Oral once-per-day organic nitrate formulation which does not induce tolerance |
| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5032405A (en) * | 1989-09-27 | 1991-07-16 | Warner-Lambert Company | Oral pharmaceutical composition for acid sensitive proteinaceous agents |
| FR2655266B1 (fr) * | 1989-12-05 | 1992-04-03 | Smith Kline French Lab | Compositions pharmaceutiques a base de cimetidine. |
| US5229131A (en) * | 1990-02-05 | 1993-07-20 | University Of Michigan | Pulsatile drug delivery system |
| US5158777A (en) * | 1990-02-16 | 1992-10-27 | E. R. Squibb & Sons, Inc. | Captopril formulation providing increased duration of activity |
| GB9104854D0 (en) * | 1991-03-07 | 1991-04-17 | Reckitt & Colmann Prod Ltd | Sustained release compositions |
| US5286497A (en) | 1991-05-20 | 1994-02-15 | Carderm Capital L.P. | Diltiazem formulation |
| WO1993019741A1 (en) * | 1992-03-31 | 1993-10-14 | Benzon Pharma A/S | A pharmaceutical formulation |
| US5500227A (en) * | 1993-11-23 | 1996-03-19 | Euro-Celtique, S.A. | Immediate release tablet cores of insoluble drugs having sustained-release coating |
| DK0758244T4 (da) * | 1994-05-06 | 2008-06-16 | Pfizer | Doseringsformer af azithromycin med styret frigivelse |
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1997
- 1997-09-16 HR HR96202651,4A patent/HRP970493A2/hr not_active Application Discontinuation
- 1997-09-18 SK SK376-99A patent/SK284263B6/sk not_active IP Right Cessation
- 1997-09-18 EP EP97943895A patent/EP0939623B1/en not_active Expired - Lifetime
- 1997-09-18 RU RU99108461/14A patent/RU2193395C2/ru not_active IP Right Cessation
- 1997-09-18 WO PCT/EP1997/005234 patent/WO1998013029A1/en active IP Right Grant
- 1997-09-18 KR KR10-1999-7002380A patent/KR100501966B1/ko not_active IP Right Cessation
- 1997-09-18 PT PT97943895T patent/PT939623E/pt unknown
- 1997-09-18 CN CNB971981671A patent/CN1161110C/zh not_active Expired - Fee Related
- 1997-09-18 ID IDW990114A patent/ID22039A/id unknown
- 1997-09-18 DK DK97943895T patent/DK0939623T3/da active
- 1997-09-18 PL PL97332245A patent/PL189016B1/pl not_active IP Right Cessation
- 1997-09-18 CA CA002263921A patent/CA2263921C/en not_active Expired - Fee Related
- 1997-09-18 BR BR9711303A patent/BR9711303A/pt not_active Application Discontinuation
- 1997-09-18 ZA ZA9708431A patent/ZA978431B/xx unknown
- 1997-09-18 TR TR1999/00641T patent/TR199900641T2/xx unknown
- 1997-09-18 JP JP51526398A patent/JP4947824B2/ja not_active Expired - Fee Related
- 1997-09-18 AT AT97943895T patent/ATE213627T1/de active
- 1997-09-18 HU HU9904121A patent/HU226693B1/hu not_active IP Right Cessation
- 1997-09-18 UA UA99042314A patent/UA72182C2/uk unknown
- 1997-09-18 NZ NZ334463A patent/NZ334463A/xx not_active IP Right Cessation
- 1997-09-18 IL IL12856597A patent/IL128565A/xx not_active IP Right Cessation
- 1997-09-18 CZ CZ1999995A patent/CZ294641B6/cs not_active IP Right Cessation
- 1997-09-18 ES ES97943895T patent/ES2172003T3/es not_active Expired - Lifetime
- 1997-09-18 AU AU45570/97A patent/AU717711B2/en not_active Ceased
- 1997-09-18 DE DE69710756T patent/DE69710756T2/de not_active Expired - Lifetime
- 1997-09-19 US US08/934,196 patent/US6183780B1/en not_active Expired - Lifetime
- 1997-09-21 JO JO19972066A patent/JO2066B1/ar active
- 1997-09-22 DZ DZ970164A patent/DZ2314A1/xx active
-
1999
- 1999-03-22 NO NO19991385A patent/NO325763B1/no not_active IP Right Cessation
- 1999-10-15 HK HK99104576A patent/HK1019852A1/xx not_active IP Right Cessation
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