UA65542C2 - Спосіб пригнічення надлишкового продукування фактора некрозу пухлин альфа , спосіб полегшення шкідливих ефектів надлишкового продукування фактора некрозу пухлин альфа та спосіб лікування запального стану або захворювання, пов'язаного з фактором некрозу пухлин. - Google Patents
Спосіб пригнічення надлишкового продукування фактора некрозу пухлин альфа , спосіб полегшення шкідливих ефектів надлишкового продукування фактора некрозу пухлин альфа та спосіб лікування запального стану або захворювання, пов'язаного з фактором некрозу пухлин. Download PDFInfo
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- UA65542C2 UA65542C2 UA99010342A UA99010342A UA65542C2 UA 65542 C2 UA65542 C2 UA 65542C2 UA 99010342 A UA99010342 A UA 99010342A UA 99010342 A UA99010342 A UA 99010342A UA 65542 C2 UA65542 C2 UA 65542C2
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- Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
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- Immunology (AREA)
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- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2040696P | 1996-06-25 | 1996-06-25 | |
| PCT/US1997/010898 WO1997049406A1 (en) | 1996-06-25 | 1997-06-24 | Use of k-252a derivative for the treatment of peripheral or central nerve disorders, and cytokine overproduction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA65542C2 true UA65542C2 (uk) | 2004-04-15 |
Family
ID=21798468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA99010342A UA65542C2 (uk) | 1996-06-25 | 1997-06-24 | Спосіб пригнічення надлишкового продукування фактора некрозу пухлин альфа , спосіб полегшення шкідливих ефектів надлишкового продукування фактора некрозу пухлин альфа та спосіб лікування запального стану або захворювання, пов'язаного з фактором некрозу пухлин. |
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| US (1) | US6184217B1 (ja) |
| EP (1) | EP0912184B1 (ja) |
| JP (2) | JP2000514420A (ja) |
| CN (1) | CN1108799C (ja) |
| AT (1) | ATE224718T1 (ja) |
| AU (1) | AU721942B2 (ja) |
| BR (1) | BR9710693A (ja) |
| DE (1) | DE69715862T2 (ja) |
| DK (1) | DK0912184T3 (ja) |
| ES (1) | ES2184106T3 (ja) |
| HK (1) | HK1018745A1 (ja) |
| NO (1) | NO317335B1 (ja) |
| NZ (1) | NZ333441A (ja) |
| PT (1) | PT912184E (ja) |
| RU (1) | RU2183959C2 (ja) |
| UA (1) | UA65542C2 (ja) |
| WO (1) | WO1997049406A1 (ja) |
Families Citing this family (25)
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| US6127401A (en) * | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
| US6200968B1 (en) * | 1998-08-06 | 2001-03-13 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| ATE361752T1 (de) | 1998-09-25 | 2007-06-15 | Cephalon Inc | Methoden zur prophylaxe und behandlung von schäden der wahrnehmungshärchenzellen und der cochlearen neuronen |
| NZ511084A (en) | 1998-10-13 | 2004-01-30 | Kyowa Hakko Kogyo Kk | An agent for treating ophthalmopathy |
| JP2000290184A (ja) * | 1999-04-01 | 2000-10-17 | Kyowa Hakko Kogyo Co Ltd | 経鼻投与製剤 |
| CA2396165C (en) * | 2000-01-14 | 2011-01-04 | John F. Hunt | Airway alkalinization as therapy for airway diseases |
| WO2001085151A2 (en) * | 2000-05-08 | 2001-11-15 | Psoriasis Research Institute | Chimeric animal model and treatment of psoriasis |
| US7129250B2 (en) | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| AR035971A1 (es) | 2001-05-16 | 2004-07-28 | Cephalon Inc | Metodos para el tratamiento y la prevencion del dolor |
| ATE431157T1 (de) * | 2002-12-23 | 2009-05-15 | Rinat Neuroscience Corp | Verfahren zur behandlung von durch taxol induzierter sensorischer neuropathie |
| WO2004085648A2 (en) | 2003-03-19 | 2004-10-07 | Biogen Idec Ma Inc. | Nogo receptor binding protein |
| WO2004084836A2 (en) * | 2003-03-20 | 2004-10-07 | Rinat Neuroscience Corp. | Methods for treating taxol-induced gut disorder |
| TWI324604B (en) * | 2003-06-18 | 2010-05-11 | Novartis Ag | New use of staurosporine derivatives |
| US20060014165A1 (en) * | 2003-07-14 | 2006-01-19 | Decode Genetics Ehf. | Methods of diagnosis and treatment for asthma and other respiratory diseases based on haplotype association |
| AU2004257748B2 (en) * | 2003-07-14 | 2008-10-30 | Decode Genetics Ehf. | Method of diagnosis and treatment for asthma based on haplotype association |
| US20060210553A1 (en) * | 2003-07-23 | 2006-09-21 | Creabilis Therapeutics S.R.L. | Topical use of tyrosine kinase inhibitors of microbial origin to prevent and treat skin disorders characterised by excesssive cell proliferation |
| EP1720891B1 (en) | 2004-02-27 | 2012-11-07 | Cephalon, Inc. | Crystalline forms of a pharmaceutical compound |
| PT1776136E (pt) | 2004-06-24 | 2012-12-05 | Biogen Idec Inc | Tratamento de estados que envolvem desmielinização |
| MX2007001155A (es) * | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
| AR054260A1 (es) * | 2005-04-26 | 2007-06-13 | Rinat Neuroscience Corp | Metodos de tratamiento de enfermedades de la neurona motora inferior y composiciones utilizadas en los mismos |
| CN101495509B (zh) | 2005-07-08 | 2015-04-22 | 比奥根艾迪克Ma公司 | Sp35抗体及其用途 |
| US8642040B2 (en) | 2006-07-24 | 2014-02-04 | Biogen Idec Ma Inc. | Methods for promoting myelination, neuronal survival and oligodendrocyte differentiation via administration of Sp35 or TrkA antagonists |
| US8058406B2 (en) | 2008-07-09 | 2011-11-15 | Biogen Idec Ma Inc. | Composition comprising antibodies to LINGO or fragments thereof |
| CA2873623C (en) | 2012-05-14 | 2021-11-09 | Biogen Idec Ma Inc. | Lingo-2 antagonists for treatment of conditions involving motor neurons |
| CA2973266A1 (en) | 2015-01-08 | 2016-07-14 | Biogen Ma Inc. | Lingo-1 antagonists and uses for treatment of demyelinating disorders |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS6041489A (ja) * | 1983-08-12 | 1985-03-05 | Kyowa Hakko Kogyo Co Ltd | 新規生理活性物質ｋ―２５２ |
| US4554402A (en) | 1983-12-23 | 1985-11-19 | Aluminum Company Of America | Vibration damper for overhead conductor |
| JPS62120388A (ja) | 1985-11-19 | 1987-06-01 | Meiji Seika Kaisha Ltd | Ｓｆ−２３７０物質ハロゲン化誘導体とその製造法 |
| JPS62155284A (ja) | 1985-12-27 | 1987-07-10 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質ｋ−２５２の誘導体 |
| JPS62155285A (ja) | 1985-12-27 | 1987-07-10 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質ｋ−２５２の誘導体 |
| JPS62220196A (ja) | 1986-03-20 | 1987-09-28 | Kyowa Hakko Kogyo Co Ltd | 新規物質ｕｃｎ―０１ |
| US4816450A (en) | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
| JPH0826036B2 (ja) | 1987-01-22 | 1996-03-13 | 協和醗酵工業株式会社 | 生理活性物質ｋ−２５２の誘導体 |
| US4735939A (en) | 1987-02-27 | 1988-04-05 | The Dow Chemical Company | Insecticidal activity of staurosporine |
| US4923986A (en) | 1987-03-09 | 1990-05-08 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of physiologically active substance K-252 |
| IL86632A0 (en) | 1987-06-15 | 1988-11-30 | Ciba Geigy Ag | Derivatives substituted at methyl-amino nitrogen |
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| JPH07113027B2 (ja) | 1987-12-24 | 1995-12-06 | 協和醗酵工業株式会社 | Ｋ−２５２誘導体 |
| JP2766360B2 (ja) | 1988-02-04 | 1998-06-18 | 協和醗酵工業株式会社 | スタウロスポリン誘導体 |
| DE3835842A1 (de) | 1988-10-21 | 1990-04-26 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| DE3924538A1 (de) | 1989-07-25 | 1991-01-31 | Goedecke Ag | Indolocarbazol und dessen verwendung |
| WO1991009034A1 (en) | 1989-12-14 | 1991-06-27 | Schering Corporation | Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856 |
| JPH0586068A (ja) | 1991-03-04 | 1993-04-06 | Rikagaku Kenkyusho | 新規抗生物質ｒｋ−１４０９、その製造法並びに抗腫瘍剤及び抗炎症剤 |
| JPH07505124A (ja) | 1991-11-08 | 1995-06-08 | ザ ユニバーシティ オブ サザン カリフォルニア | ニューロトロフィン活性増強のためのｋ−２５２化合物を含む組成物 |
| JP2593021B2 (ja) | 1991-12-13 | 1997-03-19 | 伊藤ハム株式会社 | ウシ胚の性の識別方法 |
| US6271242B1 (en) | 1992-02-10 | 2001-08-07 | Bristol-Myers Squibb Co. | Method for treating cancer using a tyrosine protein kinase inhibitor |
| JPH05247055A (ja) | 1992-03-03 | 1993-09-24 | Meiji Seika Kaisha Ltd | スタウロスポリン誘導体及びそれを含有する抗腫瘍効果増強剤 |
| EP0575955B1 (en) | 1992-06-22 | 1999-09-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing staurosporine derivatives |
| JPH0673063A (ja) | 1992-06-22 | 1994-03-15 | Kyowa Hakko Kogyo Co Ltd | Ｕｃｎ−０１誘導体 |
| US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
| US5621100A (en) | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
| GB9215921D0 (en) * | 1992-07-27 | 1992-09-09 | Wellcome Found | Anti-inflammatory compounds |
| JP3344586B2 (ja) | 1993-05-28 | 2002-11-11 | セファロン，インコーポレイテッド | インドロカルバゾール誘導体を含有する前立腺病理疾患の治療剤 |
| EP0703917A1 (en) | 1993-06-17 | 1996-04-03 | Novartis AG | Indolocarbazole compound useful as proteinkinase c inhibitor |
| WO1995022331A1 (en) | 1994-02-18 | 1995-08-24 | Cephalon, Inc. | Aqueous indolocarbazole solutions |
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- 1997-06-24 WO PCT/US1997/010898 patent/WO1997049406A1/en active IP Right Grant
- 1997-06-24 UA UA99010342A patent/UA65542C2/uk unknown
- 1997-06-24 US US08/881,679 patent/US6184217B1/en not_active Expired - Lifetime
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- 1997-06-24 JP JP10503444A patent/JP2000514420A/ja active Pending
- 1997-06-24 PT PT97930203T patent/PT912184E/pt unknown
- 1997-06-24 RU RU99101117/14A patent/RU2183959C2/ru active
- 1997-06-24 CN CN97197341A patent/CN1108799C/zh not_active Expired - Lifetime
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1998
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1999
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2008
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Also Published As
| Publication number | Publication date |
|---|---|
| PT912184E (pt) | 2002-12-31 |
| JP2008189676A (ja) | 2008-08-21 |
| DE69715862T2 (de) | 2003-04-10 |
| NZ333441A (en) | 1999-05-28 |
| DK0912184T3 (da) | 2002-11-25 |
| ATE224718T1 (de) | 2002-10-15 |
| WO1997049406A1 (en) | 1997-12-31 |
| HK1018745A1 (en) | 2000-01-07 |
| EP0912184A1 (en) | 1999-05-06 |
| NO317335B1 (no) | 2004-10-11 |
| ES2184106T3 (es) | 2003-04-01 |
| JP4767982B2 (ja) | 2011-09-07 |
| CN1108799C (zh) | 2003-05-21 |
| NO986111L (no) | 1999-02-23 |
| AU3409097A (en) | 1998-01-14 |
| EP0912184B1 (en) | 2002-09-25 |
| RU2183959C2 (ru) | 2002-06-27 |
| CN1228024A (zh) | 1999-09-08 |
| NO986111D0 (no) | 1998-12-23 |
| AU721942B2 (en) | 2000-07-20 |
| DE69715862D1 (de) | 2002-10-31 |
| US6184217B1 (en) | 2001-02-06 |
| JP2000514420A (ja) | 2000-10-31 |
| BR9710693A (pt) | 2000-01-11 |
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