UA63990C2 - Новые сульфонамидные производные как ингибиторы рассасывания костной ткани и ингибиторы адгезии клеток - Google Patents
Новые сульфонамидные производные как ингибиторы рассасывания костной ткани и ингибиторы адгезии клеток Download PDFInfo
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- UA63990C2 UA63990C2 UA2000084983A UA200084983A UA63990C2 UA 63990 C2 UA63990 C2 UA 63990C2 UA 2000084983 A UA2000084983 A UA 2000084983A UA 200084983 A UA200084983 A UA 200084983A UA 63990 C2 UA63990 C2 UA 63990C2
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- Prior art keywords
- alkyl
- aryl
- compounds
- formula
- heteroaryl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract
Настоящее изобретение касается сульфонамидных производных формулы І, в которой R1, R2, R4, R5 и R6 имеют значения, указанные в формуле изобретения, их солей, которые физиологически переносятся, и их предшественников. Соединения формулы І являются ценными фармацевтически активными соединениями. Они представляют собой антагонисты рецептора витронектина и ингибиторы адгезии клеток, а также препятствуют рассасыванию костной ткани остеокластами. В частности, они пригодны для терапии и профилактики заболеваний, по крайней мере, частично обусловленных нежелательной степенью рассасывания костной ткани, например остеопороза. Изобретение, кроме того, касается способов получения соединений формулы І, их использования, в частности, как фармацевтически активных ингредиентов, и фармацевтических препаратов, которые содержат их. І
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1248998A | 1998-01-23 | 1998-01-23 | |
| PCT/EP1999/000242 WO1999037621A1 (en) | 1998-01-23 | 1999-01-16 | Novel sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA63990C2 true UA63990C2 (ru) | 2004-02-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| UA2000084983A UA63990C2 (ru) | 1998-01-23 | 1999-01-16 | Новые сульфонамидные производные как ингибиторы рассасывания костной ткани и ингибиторы адгезии клеток |
Country Status (25)
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| JP (1) | JP2002501054A (ru) |
| KR (1) | KR20010034319A (ru) |
| CN (1) | CN1177832C (ru) |
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| HR (1) | HRP20000493A2 (ru) |
| HU (1) | HUP0100520A3 (ru) |
| ID (1) | ID26219A (ru) |
| IL (1) | IL137423A0 (ru) |
| NO (1) | NO318795B1 (ru) |
| NZ (1) | NZ505613A (ru) |
| PL (1) | PL341871A1 (ru) |
| SK (1) | SK10632000A3 (ru) |
| TR (1) | TR200002160T2 (ru) |
| TW (1) | TWI247742B (ru) |
| UA (1) | UA63990C2 (ru) |
| WO (1) | WO1999037621A1 (ru) |
| YU (1) | YU47200A (ru) |
| ZA (1) | ZA99476B (ru) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000006169A1 (en) * | 1998-07-29 | 2000-02-10 | Merck & Co., Inc. | Integrin receptor antagonists |
| EP1028114A1 (en) | 1999-02-13 | 2000-08-16 | Aventis Pharma Deutschland GmbH | Novel guanidine derivatives as inhibitors of cell adhesion |
| EP1065208A1 (en) * | 1999-07-02 | 2001-01-03 | Aventis Pharma Deutschland GmbH | Substituted purine derivatives as inhibitors of cell adhesion |
| EP1065207A1 (en) | 1999-07-02 | 2001-01-03 | Aventis Pharma Deutschland GmbH | Naphthyridine derivatives, processes for their preparation, their use, and pharmaceutical compositions comprising them |
| EP1070707A1 (en) * | 1999-07-21 | 2001-01-24 | Aventis Pharma Deutschland GmbH | 1,4,5,6-tetrahydropyrimidine derivative as a vitronectin inhibitor |
| US6849639B2 (en) | 1999-12-14 | 2005-02-01 | Amgen Inc. | Integrin inhibitors and their methods of use |
| EP1108721A1 (en) | 1999-12-15 | 2001-06-20 | Aventis Pharma Deutschland GmbH | Thienylalanine derivatives as inhibitors of cell adhesion |
| US20030199571A1 (en) * | 1999-12-24 | 2003-10-23 | Gordon Bruton | (Hetero) Bicyclymethanesulfonylamino-substituted hydroxamic acid derivatives |
| FR2808798A1 (fr) * | 2000-05-09 | 2001-11-16 | Hoechst Marion Roussel Inc | Nouveaux derives antagonistes du recepteur de la vitronectine |
| FR2847254B1 (fr) | 2002-11-19 | 2005-01-28 | Aventis Pharma Sa | Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant |
| CN1938293A (zh) * | 2004-03-24 | 2007-03-28 | 捷瑞尼股份公司 | 抑制血管发生的新化合物及其应用 |
| FR2870541B1 (fr) | 2004-05-18 | 2006-07-14 | Proskelia Sas | Derives de pyrimidines antigonistes du recepteur de la vitronectine |
| GB0412553D0 (en) * | 2004-06-04 | 2004-07-07 | Univ Aberdeen | Therapeutic agents for the treatment of bone conditions |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| FR2873585B1 (fr) * | 2004-07-27 | 2006-11-17 | Aventis Pharma Sa | Nouvelles formulations galeniques de principes actifs |
| GB0705400D0 (en) | 2007-03-21 | 2007-05-02 | Univ Aberdeen | Therapeutic compounds andm their use |
| GB0817207D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
| GB0817208D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | Therapeutic apsap compounds and their use |
| GB201311361D0 (en) | 2013-06-26 | 2013-08-14 | Pimco 2664 Ltd | Compounds and their therapeutic use |
| BR112016027778A2 (pt) | 2014-05-30 | 2017-08-15 | Pfizer | Usos de derivados de carbonitrila, sua combinação e sua composição farmacêutica |
| WO2016097001A1 (en) | 2014-12-17 | 2016-06-23 | Pimco 2664 Limited | N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzenesulfonamide compounds and their therapeutic use |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995032710A1 (en) * | 1994-05-27 | 1995-12-07 | Merck & Co., Inc. | Compounds for inhibiting osteoclast-mediated bone resorption |
| JP3895792B2 (ja) * | 1995-12-08 | 2007-03-22 | プロスケリア・エス・ア・エス | 骨形成促進剤 |
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1999
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- 1999-01-16 IL IL13742399A patent/IL137423A0/xx unknown
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Also Published As
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| AP1269A (en) | 2004-04-03 |
| HRP20000493A2 (en) | 2001-06-30 |
| KR20010034319A (ko) | 2001-04-25 |
| YU47200A (sh) | 2002-11-15 |
| HUP0100520A1 (hu) | 2001-07-30 |
| BR9907735A (pt) | 2000-10-17 |
| CA2318221A1 (en) | 1999-07-29 |
| PL341871A1 (en) | 2001-05-07 |
| TR200002160T2 (tr) | 2001-07-23 |
| HUP0100520A3 (en) | 2002-11-28 |
| EA200000785A1 (ru) | 2001-02-26 |
| EP1049677A1 (en) | 2000-11-08 |
| EA003102B1 (ru) | 2002-12-26 |
| NZ505613A (en) | 2002-11-26 |
| NO20003765L (no) | 2000-09-25 |
| ZA99476B (en) | 1999-08-05 |
| WO1999037621A1 (en) | 1999-07-29 |
| CN1177832C (zh) | 2004-12-01 |
| AU2518199A (en) | 1999-08-09 |
| AP2000001863A0 (en) | 2000-09-30 |
| AR014456A1 (es) | 2001-02-28 |
| BG104630A (en) | 2001-04-30 |
| NO318795B1 (no) | 2005-05-09 |
| ID26219A (id) | 2000-12-07 |
| TWI247742B (en) | 2006-01-21 |
| JP2002501054A (ja) | 2002-01-15 |
| NO20003765D0 (no) | 2000-07-21 |
| IL137423A0 (en) | 2001-07-24 |
| AU752882B2 (en) | 2002-10-03 |
| CN1293662A (zh) | 2001-05-02 |
| SK10632000A3 (sk) | 2001-02-12 |
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