UA41952C2 - Похідні аміну, фармацевтична композиція на їх основі та спосіб лікування психозів і шизофренії - Google Patents

Похідні аміну, фармацевтична композиція на їх основі та спосіб лікування психозів і шизофренії

Info

Publication number
UA41952C2
UA41952C2 UA96041333A UA96041333A UA41952C2 UA 41952 C2 UA41952 C2 UA 41952C2 UA 96041333 A UA96041333 A UA 96041333A UA 96041333 A UA96041333 A UA 96041333A UA 41952 C2 UA41952 C2 UA 41952C2
Authority
UA
Ukraine
Prior art keywords
atoms
carbon
psycosis
schizophrenia
treatment
Prior art date
Application number
UA96041333A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Франк Керріган
Франк Керриган
Девід Джон Хіл
Дэвид Джон ХИЛ
Кіт Франк Мартін
Кеит Франк Мартин
Original Assignee
Кноль Акцієнгезельшафт
Кноль Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кноль Акцієнгезельшафт, Кноль Акциенгезельшафт filed Critical Кноль Акцієнгезельшафт
Publication of UA41952C2 publication Critical patent/UA41952C2/uk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/161,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/201,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
UA96041333A 1993-09-06 1994-09-01 Похідні аміну, фармацевтична композиція на їх основі та спосіб лікування психозів і шизофренії UA41952C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939318431A GB9318431D0 (en) 1993-09-06 1993-09-06 Therapeutic agents
PCT/EP1994/002904 WO1995007274A1 (en) 1993-09-06 1994-09-01 Bicyclic aromatic compounds as therapeutic agents

Publications (1)

Publication Number Publication Date
UA41952C2 true UA41952C2 (uk) 2001-10-15

Family

ID=10741568

Family Applications (1)

Application Number Title Priority Date Filing Date
UA96041333A UA41952C2 (uk) 1993-09-06 1994-09-01 Похідні аміну, фармацевтична композиція на їх основі та спосіб лікування психозів і шизофренії

Country Status (31)

Country Link
US (1) US5767116A (cs)
EP (1) EP0717739B1 (cs)
JP (1) JPH09502431A (cs)
KR (1) KR100325964B1 (cs)
CN (1) CN1052723C (cs)
AT (1) ATE191214T1 (cs)
AU (1) AU689802B2 (cs)
BG (1) BG63272B1 (cs)
BR (1) BR9407413A (cs)
CA (1) CA2170056A1 (cs)
CZ (1) CZ61496A3 (cs)
DE (1) DE69423767T2 (cs)
DK (1) DK0717739T3 (cs)
ES (1) ES2144528T3 (cs)
FI (1) FI961016A0 (cs)
GB (1) GB9318431D0 (cs)
GR (1) GR3033575T3 (cs)
HU (1) HUT75875A (cs)
IL (1) IL110844A (cs)
NO (1) NO308536B1 (cs)
NZ (1) NZ273581A (cs)
PL (1) PL178270B1 (cs)
PT (1) PT717739E (cs)
RO (1) RO116811B1 (cs)
RU (1) RU2136680C1 (cs)
SI (1) SI9420058B (cs)
SK (1) SK27196A3 (cs)
TW (1) TW311137B (cs)
UA (1) UA41952C2 (cs)
WO (1) WO1995007274A1 (cs)
ZA (1) ZA946798B (cs)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9514380D0 (en) * 1995-07-13 1995-09-13 Knoll Ag Therapeutic agents
FR2738823B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 3-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)-3,4-dihydroquinolein-2(1h)-one,leur preparation et leur application en therapeutique
GB9526495D0 (en) * 1995-12-23 1996-02-28 Knoll Ag Therapeutic agents
DE19624154A1 (de) 1996-06-18 1998-01-08 Hoechst Ag Ringannelierte Dihydropyrane, Verfahren zur Herstellung sowie deren Verwendung
GB9627005D0 (en) 1996-12-27 1997-02-12 Knoll Ag Therapeutic agents
GB9627006D0 (en) * 1996-12-27 1997-02-12 Knoll Ag Therapeutic agents
FR2760014B1 (fr) * 1997-02-27 1999-04-09 Adir Nouveaux composes de 2-amino indane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9704948D0 (en) 1997-03-11 1997-04-30 Knoll Ag Therapeutic agents
FR2761358B1 (fr) * 1997-03-27 1999-05-07 Adir Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6077850A (en) * 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
US6034256A (en) 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
GB9811879D0 (en) * 1998-06-03 1998-07-29 Knoll Ag Therapeutic agents
FR2780057B1 (fr) * 1998-06-18 2002-09-13 Sanofi Sa Phenoxypropanolamines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2782515B1 (fr) * 1998-08-21 2000-09-22 Adir NOUVEAUX DERIVES DE L'INDANE-1-Ol, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
GB9915616D0 (en) * 1999-07-05 1999-09-01 Knoll Ag Therapeutic agents
GB0007376D0 (en) * 2000-03-28 2000-05-17 Knoll Ag Therapeutic agents
US6458804B1 (en) 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6656951B2 (en) * 2001-04-24 2003-12-02 Wyeth 8-aza-bicyclo[3.2.1]octan-3-ol derivatives of 2,3-dihydro-1,4-benzodioxan as 5-HT1A antagonists
US6656950B2 (en) * 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
DE10120619A1 (de) * 2001-04-26 2002-10-31 Merck Patent Gmbh 2-(5-(4-Fluorphenyl)-3-pyridylmethylaminomethyl-chroman
WO2002088129A1 (en) * 2001-04-26 2002-11-07 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
WO2003031439A1 (en) * 2001-10-05 2003-04-17 Wyeth Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole
US6939877B2 (en) 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
US6911445B2 (en) * 2002-09-12 2005-06-28 Wyeth Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
US7153849B2 (en) * 2002-09-12 2006-12-26 Wyeth Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans
US6800637B2 (en) * 2002-09-12 2004-10-05 Wyeth Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
FR2884251B1 (fr) * 2005-04-08 2007-07-13 Servier Lab Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
RU2419610C2 (ru) 2005-05-26 2011-05-27 Ньюрон Системз, Инк. Композиции и способы лечения заболевания сетчатки
TWI457122B (zh) * 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3-二氫苯並[1,4]戴奧辛-2-基甲基衍生物
JP5885670B2 (ja) 2009-12-11 2016-03-15 アルデイラ セラピューティクス, インコーポレイテッド 黄斑変性の処置のための組成物および方法
KR102435676B1 (ko) 2013-01-23 2022-08-24 알데이라 테라퓨틱스, 아이엔씨. 독성 알데히드 관련된 질병 및 치료
JP2019519582A (ja) 2016-06-29 2019-07-11 オリオン コーポレーション ベンゾジオキサン誘導体およびその医薬用途
JP2021533154A (ja) 2018-08-06 2021-12-02 アルデイラ セラピューティクス, インコーポレイテッド 多形化合物およびその使用
CA3137301A1 (en) 2019-05-02 2020-11-05 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
WO2020223717A1 (en) 2019-05-02 2020-11-05 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
WO2021231792A1 (en) 2020-05-13 2021-11-18 Aldeyra Therapeutics, Inc. Pharmaceutical formulations and uses thereof
MX2023014509A (es) * 2021-07-02 2024-01-26 Aldeyra Therapeutics Inc Compuestos atrapadores de aldehidos heterociclicos y usos de los mismos.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684739A (en) * 1980-12-15 1987-08-04 Mitsubishi Chemical Industries Limited Alkylenedioxybenzene derivatives and acid addition salts thereof
JPS58154574A (ja) * 1982-03-09 1983-09-14 Mitsubishi Chem Ind Ltd アルキレンジオキシベンゼン誘導体およびその酸付加塩
US4569933A (en) * 1984-04-13 1986-02-11 Cornu Pierre Jean Antihypertensive substituted derivatives of 2,5-diamino 1,4-diazole
CA1260474A (en) * 1984-12-03 1989-09-26 Raymond A. Stokbroekx Benzoxazol- and benzothiazolamine derivatives
US4749702A (en) * 1985-04-15 1988-06-07 Janssen Pharmaceutica N. V. Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
DE3901814A1 (de) * 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
FR2658823B1 (fr) * 1990-02-27 1992-04-30 Adir Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent .
US5182292A (en) * 1991-06-21 1993-01-26 American Home Products Corporation Psychotropic piperidinylmethyl benzodioxans
FR2681325B1 (fr) * 1991-09-16 1993-12-17 Fabre Medicament Pierre Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
SI9300097B (en) * 1992-02-27 2001-12-31 Janssen Pharmaceutica Nv (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines

Also Published As

Publication number Publication date
NO960888L (no) 1996-03-05
NO308536B1 (no) 2000-09-25
CN1052723C (zh) 2000-05-24
NZ273581A (en) 1998-05-27
US5767116A (en) 1998-06-16
AU689802B2 (en) 1998-04-09
RO116811B1 (ro) 2001-06-29
HU9600552D0 (en) 1996-05-28
SK27196A3 (en) 1996-10-02
DE69423767T2 (de) 2000-07-20
EP0717739A1 (en) 1996-06-26
DE69423767D1 (de) 2000-05-04
EP0717739B1 (en) 2000-03-29
KR100325964B1 (ko) 2002-07-27
RU2136680C1 (ru) 1999-09-10
BR9407413A (pt) 1996-11-12
CZ61496A3 (en) 1996-09-11
TW311137B (cs) 1997-07-21
GB9318431D0 (en) 1993-10-20
FI961016A (fi) 1996-03-05
NO960888D0 (no) 1996-03-05
ATE191214T1 (de) 2000-04-15
PL178270B1 (pl) 2000-03-31
SI9420058A (en) 1996-12-31
ZA946798B (en) 1995-04-06
CA2170056A1 (en) 1995-03-16
GR3033575T3 (en) 2000-09-29
IL110844A (en) 1999-10-28
FI961016A0 (fi) 1996-03-05
CN1133043A (zh) 1996-10-09
JPH09502431A (ja) 1997-03-11
WO1995007274A1 (en) 1995-03-16
BG100388A (bg) 1996-07-31
PL313347A1 (en) 1996-06-24
DK0717739T3 (da) 2000-07-10
HUT75875A (en) 1997-05-28
BG63272B1 (bg) 2001-08-31
IL110844A0 (en) 1995-01-24
ES2144528T3 (es) 2000-06-16
SI9420058B (sl) 2002-02-28
PT717739E (pt) 2000-07-31
AU7692894A (en) 1995-03-27

Similar Documents

Publication Publication Date Title
UA41952C2 (uk) Похідні аміну, фармацевтична композиція на їх основі та спосіб лікування психозів і шизофренії
KR20010006390A (ko) 삼환식 화합물
HK1026700A1 (en) 1,4-Substituted cyclic amine derivatives or dihydroindole derivatives and medicament thereof.
HK1018449A1 (en) Derivatives of camptothecin for cancer treatment and its use
ES2091212T3 (es) Compuestos de xantina.
MY102908A (en) Isoxazole and furan derivatives, their preparation and use as antiviral agents.
FI943142A0 (fi) Amidi- ja ureajohdannaiset, joilla on veren korkeita kolesteroliarvoja vastustava vaikutus, niiden valmistus ja terapeuttiset käytöt
DK0488513T3 (da) Anvendelse af dioxabicyclo(3.3.0)octanderivater til fremstilling af et medikament til inhibering af cholesterolmetabolismen
NZ505103A (en) Phenylaminoalkylcarboxylic acid derivatives useful as beta 3 adrenoceptor stimulants
KR940003953A (ko) 1. 4-벤조디옥산 유도체
TW355183B (en) Substituted benzenesulfonylureas having cardiovascular activity for their preparation, and pharmaceutical compositions containing them
CO4230234A1 (es) DERIVADOS DE 6-(HIDROXIFENIL)SULFONIL-BENZO[b]PIRANO, COMPO- SICIONES QUE CONTIENEN TALES DERIVADOS, USOS DE LOS MISMOS, PROCEDIMIENTOS DE PREPARACION E INTERMEDIOS EMPLEADOS EN LA PREPARACION DE TALES DERIVADOS
ES8404311A1 (es) Un procedimiento para la preparacion de derivados de etanolamina.
EP0335979A4 (en) Thienopyrimidine derivatives
EP0470686A3 (en) (benzhydryloxyethylpiperidyl)aliphatic acid derivatives and their use in the treatment of allergies and asthma
IE901314L (en) 2- substituted-n,n'-di(trimethoxybenzoyl)piperazines
UA66888C2 (uk) 3-тетрагідропіридин-4-іл індоли, спосіб їх отримання та спосіб лікування психічних розладів
KR960003719A (ko) 녹내장 치료제 및 안압 강하제
EP0251574A3 (en) Antifungal derivatives of n-(6,6-dimethyl-2-hepten-4-ynyl)-1-naphthalenemethanamine and method of using same
TW225989B (cs)
GR3017801T3 (en) Flavone derivatives.
ZA905650B (en) Method of treating diabetes mellitus
EP0272330A4 (en) 1,1,2-TRIARYL-1-BUTENE DERIVATIVES.
KR890014515A (ko) 트리사이클릭 아민 유도체
NZ304988A (en) 1-omega-(3,4-dihydro-2-naphthalenyl)alkyl] cyclic amine derivatives and their use