UA41937C2 - Стабільна місцеводіюча ретиноідна композиція - Google Patents

Стабільна місцеводіюча ретиноідна композиція

Info

Publication number
UA41937C2
UA41937C2 UA95125456A UA95125456A UA41937C2 UA 41937 C2 UA41937 C2 UA 41937C2 UA 95125456 A UA95125456 A UA 95125456A UA 95125456 A UA95125456 A UA 95125456A UA 41937 C2 UA41937 C2 UA 41937C2
Authority
UA
Ukraine
Prior art keywords
retinoid
containing composition
topical application
active substance
ionic surface
Prior art date
Application number
UA95125456A
Other languages
English (en)
Russian (ru)
Inventor
ВРІНГЕР Том ДЕ
Врингер Том Де
Харревейн Антон Ван
Арт Міехленбрюх
Арт Миехленбрюх
Original Assignee
Яманаухі Еуропе Б.В.
Яманаухи Эуропе Бв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8213946&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA41937(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Яманаухі Еуропе Б.В., Яманаухи Эуропе Бв filed Critical Яманаухі Еуропе Б.В.
Publication of UA41937C2 publication Critical patent/UA41937C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/90—Block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Винахід відноситься до водних фармацевтичних і косметичних композицій, що містять ретиноїд, для місцевого застосування на шкірі. Композиція для місцевого застосування на шкірі містить 0,001-0,5 мас.% ретиноїду у водному носії, причому вказаний водний носій додатково містить гелеутворювач, буфер для підтримання рН композиції в межах 3-7, антиоксидант і 0,5-20 мас.% принаймні однієї неіонної поверхнево-активної речовини. Неіонну поверхнево-активну речовину, що запобігає кристалізації і стабілізує зазначений ретиноїд вибирають з поліоксиетиленових моноефірів насиченого спирту, тріефірів поліоксиетиленгліцерину і насиченої кислоти, етиленоксид/пропіленоксид-блок-сополімерів.
UA95125456A 1993-07-01 1994-07-01 Стабільна місцеводіюча ретиноідна композиція UA41937C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93201931 1993-07-01
PCT/NL1994/000151 WO1995001160A1 (en) 1993-07-01 1994-07-01 Stable topical retinoid compositions

Publications (1)

Publication Number Publication Date
UA41937C2 true UA41937C2 (uk) 2001-10-15

Family

ID=8213946

Family Applications (1)

Application Number Title Priority Date Filing Date
UA95125456A UA41937C2 (uk) 1993-07-01 1994-07-01 Стабільна місцеводіюча ретиноідна композиція

Country Status (23)

Country Link
US (1) US5690923A (uk)
EP (1) EP0706370B2 (uk)
JP (2) JP3947215B2 (uk)
AT (1) ATE202694T1 (uk)
AU (1) AU678039B2 (uk)
BG (1) BG61713B1 (uk)
CA (1) CA2166062C (uk)
CZ (1) CZ285679B6 (uk)
DE (1) DE69427639T3 (uk)
DK (1) DK0706370T4 (uk)
ES (1) ES2160631T5 (uk)
FI (1) FI115607B (uk)
GR (1) GR3036761T3 (uk)
HU (1) HU217869B (uk)
MD (1) MD1587C2 (uk)
NO (1) NO311066B1 (uk)
PT (1) PT706370E (uk)
RO (1) RO115109B1 (uk)
RU (1) RU2134101C1 (uk)
SI (1) SI0706370T2 (uk)
SK (1) SK279919B6 (uk)
UA (1) UA41937C2 (uk)
WO (1) WO1995001160A1 (uk)

Families Citing this family (37)

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RU2134101C1 (ru) * 1993-07-01 1999-08-10 Яманаухи Эуропе Б.В. Стабильные местнодействующие ретиноидные композиции
EP0974364A4 (en) * 1996-10-25 2000-12-20 Yoshitomi Pharmaceutical METHOD FOR PREVENTING THE PREPARATION OF MEDICINAL PRODUCTS
DE19903729A1 (de) * 1999-01-30 2000-08-03 Beiersdorf Ag Verwendung von oberflächenaktiven Citronensäureestern zur Stabilisierung von Retinoiden, synergistische Gemische aus Retinoiden und oberflächenaktiven Substanzen sowie kosmetische und dermatologische Zubereitungen mit einem Gehalt an solchen Gemischen
CN1379662A (zh) * 1999-08-20 2002-11-13 荷兰联合利华有限公司 减轻弱羧酸对皮肤的刺激的皮肤化妆品组合物
DE10025756C2 (de) * 2000-05-25 2003-02-20 Cognis Deutschland Gmbh Lösungsvermittler
US6387383B1 (en) 2000-08-03 2002-05-14 Dow Pharmaceutical Sciences Topical low-viscosity gel composition
US20060189552A1 (en) * 2000-12-12 2006-08-24 Mohan Vishnupad Dispenser for dispensing three or more actives
US7060732B2 (en) * 2000-12-12 2006-06-13 Imaginative Research Associates, Inc. Antibiotic/benzoyl peroxide dispenser
US20110142922A1 (en) * 2002-04-30 2011-06-16 Ferndale Ip, Inc. Stabilized composition and method for dermatological treatment
US20030215493A1 (en) * 2002-04-30 2003-11-20 Patel Pravin M. Composition and method for dermatological treatment
US7939489B2 (en) * 2002-12-23 2011-05-10 Avon Products, Inc. Oil absorbent topical compositions and methods for using same
AU2004206769B2 (en) 2003-01-24 2009-11-26 Stiefel Research Australia Pty Ltd Clindamycin phosphate foam
US20060014834A1 (en) * 2004-05-11 2006-01-19 Mohan Vishnupad Retinoid solutions and formulations made therefrom
US7662855B2 (en) * 2004-05-11 2010-02-16 Imaginative Research Associates, Inc. Retinoid solutions and formulations made therefrom
WO2006053006A2 (en) * 2004-11-09 2006-05-18 Imaginative Research Associates, Inc. Retinoid solutions and formulations made therefrom
EP1814560A2 (en) * 2004-11-19 2007-08-08 Aventis Pharmaceuticals, Inc. Antibiotic compounds, compositions and medical uses
WO2006089070A2 (en) * 2005-02-17 2006-08-24 Connetics Corporation Acne gel
AR054805A1 (es) * 2005-06-29 2007-07-18 Stiefel Laboratories Composiciones topicas para el tratamiento de la piel
US9107844B2 (en) * 2006-02-03 2015-08-18 Stiefel Laboratories Inc. Topical skin treating compositions
AU2006339842B2 (en) * 2006-03-08 2012-06-07 Nihon Nohyaku Co., Ltd. Pharmaceutical composition for external use
AU2006339841B2 (en) * 2006-03-08 2012-08-30 Nihon Nohyaku Co., Ltd. Pharmaceutical composition for external use
BRPI0709674A2 (pt) 2006-03-31 2011-12-06 Stiefel Res Australia Pty Ltd gel de suspensão espumante
US20080287373A1 (en) * 2007-05-17 2008-11-20 Popp Karl F Topical skin treating kits
CN101790364B (zh) * 2007-06-21 2013-07-24 陶氏环球技术公司 用于个人护理组合物中的疏水组分的稳定剂
JP5529539B2 (ja) 2007-09-05 2014-06-25 株式会社ポーラファルマ 医薬組成物
EP2191827B1 (en) 2007-09-05 2013-10-30 Pola Pharma Inc. Antifungal composition
WO2009031644A1 (ja) * 2007-09-05 2009-03-12 Pola Pharma Inc. 抗真菌医薬組成物
US20090131521A1 (en) * 2007-10-18 2009-05-21 Wortzman Mitchell S Aqueous retinoid and benzoyl peroxide gel
FR2939683B1 (fr) * 2008-12-17 2012-04-20 Oreal Composition cosmetique comprenant un polyester sulfonique ramifie et un tensioactif particulier et utilisations en coiffage
US9050271B2 (en) 2009-04-09 2015-06-09 Pola Pharma Inc. Antimycotic pharmaceutical composition
WO2010117089A2 (en) 2009-04-09 2010-10-14 Pola Pharma Inc. Antimycotic pharmaceutical composition
EP2470178B1 (en) 2009-08-25 2018-10-17 Pola Pharma Inc. Antimycotic pharmaceutical composition
US11071878B2 (en) * 2009-12-31 2021-07-27 Sol-Gel Technologies Ltd. Core stabilized microcapsules, method of their preparation and uses thereof
JP5865623B2 (ja) * 2011-08-01 2016-02-17 昭和電工株式会社 皮膚外用剤およびその製造方法
JP5865624B2 (ja) * 2011-08-01 2016-02-17 昭和電工株式会社 皮膚外用剤およびその製造方法
FR2991175B1 (fr) * 2012-06-01 2014-12-19 Galderma Res & Dev Compositions pharmaceutiques topiques de type emulsion h/e contenant un retinoide
MD4479C1 (ro) * 2015-02-12 2017-12-31 Валериу НИКУШОР Compoziţie de erbicide şi procedeu de combatere a buruienilor şi ierburilor în culturile de sfeclă de zahăr cu utilizarea acesteia

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FR2591105B1 (fr) * 1985-12-11 1989-03-24 Moet Hennessy Rech Composition pharmaceutique, notamment dermatologique, ou cosmetique, a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un retinoide ou un analogue structural dudit retinoide tel qu'un carotenoide.
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JP2827295B2 (ja) * 1989-07-04 1998-11-25 大正製薬株式会社 ビタミンａ類含有点眼剤
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JP3031990B2 (ja) * 1990-10-19 2000-04-10 同仁医薬化工株式会社 消炎鎮痛クリーム剤組成物
RU2134101C1 (ru) * 1993-07-01 1999-08-10 Яманаухи Эуропе Б.В. Стабильные местнодействующие ретиноидные композиции

Also Published As

Publication number Publication date
HUT74072A (en) 1996-10-28
SI0706370T1 (en) 2001-12-31
EP0706370A1 (en) 1996-04-17
CA2166062C (en) 2008-09-16
FI956204A0 (fi) 1995-12-22
JPH08512049A (ja) 1996-12-17
DE69427639T3 (de) 2005-08-04
ES2160631T5 (es) 2005-07-16
US5690923A (en) 1997-11-25
ES2160631T3 (es) 2001-11-16
CZ285679B6 (cs) 1999-10-13
AU678039B2 (en) 1997-05-15
MD1587C2 (ro) 2001-06-30
EP0706370B2 (en) 2005-01-26
CZ348395A3 (en) 1996-04-17
AU7391394A (en) 1995-01-24
NO311066B1 (no) 2001-10-08
GR3036761T3 (en) 2001-12-31
DK0706370T3 (da) 2001-09-17
ATE202694T1 (de) 2001-07-15
RU2134101C1 (ru) 1999-08-10
FI115607B (fi) 2005-06-15
NO955193L (no) 1996-02-08
JP3947215B2 (ja) 2007-07-18
BG100267A (bg) 1996-07-31
RO115109B1 (ro) 1999-11-30
BG61713B1 (bg) 1998-04-30
SK279919B6 (sk) 1999-05-07
HU9503721D0 (en) 1996-02-28
NO955193D0 (no) 1995-12-20
JP2006328089A (ja) 2006-12-07
DE69427639D1 (de) 2001-08-09
MD950443A (en) 1997-09-30
SI0706370T2 (en) 2005-06-30
PT706370E (pt) 2001-11-30
DE69427639T2 (de) 2001-10-18
CA2166062A1 (en) 1995-01-12
EP0706370B1 (en) 2001-07-04
DK0706370T4 (da) 2005-04-18
FI956204A (fi) 1995-12-22
HU217869B (hu) 2000-04-28
SK159795A3 (en) 1997-03-05
WO1995001160A1 (en) 1995-01-12
MD1587B2 (en) 2001-01-31

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