UA40633C2 - Фармацевтичний емульсійний склад, спосіб його одержання і спосіб зниження в короткий термін тиску крові - Google Patents

Фармацевтичний емульсійний склад, спосіб його одержання і спосіб зниження в короткий термін тиску крові

Info

Publication number
UA40633C2
UA40633C2 UA96051803A UA96051803A UA40633C2 UA 40633 C2 UA40633 C2 UA 40633C2 UA 96051803 A UA96051803 A UA 96051803A UA 96051803 A UA96051803 A UA 96051803A UA 40633 C2 UA40633 C2 UA 40633C2
Authority
UA
Ukraine
Prior art keywords
short
blood
preparation
emulsion composition
pharmaceutical emulsion
Prior art date
Application number
UA96051803A
Other languages
English (en)
Russian (ru)
Inventor
Челль АНДЕРССОН
Челль Халмар Андерссон
Ева Крістіна Бюред
Ева Кристина Бюред
Анна-Карін Ханссон
Анна-Карин Ханссон
Маргарета Норландер
Рольф Крістер Вестерлунд
Рольф Кристер Вестерлунд
Original Assignee
Астра Актієболаг
Астра АБ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астра Актієболаг, Астра АБ filed Critical Астра Актієболаг
Publication of UA40633C2 publication Critical patent/UA40633C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Даний винахід належить до емульсій нових, сильнодіючих, дуже короткої дії, антигіпертензивних антагоністів кальцію дигідропіридинового типу з високою васкулярною селективністю і до способу приготування таких емульсій. Фармацевтичний склад для зниження за короткий час кров'яного тиску для внутрішньовенного введення у вигляді емульсії містить: a) сполуку дигідропіридину короткої дії, що має період напіврозпаду в плазмі менший, ніж 30 хвилин; b) ліпідну фазу; c) емульгатор і d) воду або буфер.
UA96051803A 1993-11-12 1994-11-03 Фармацевтичний емульсійний склад, спосіб його одержання і спосіб зниження в короткий термін тиску крові UA40633C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9303744A SE9303744D0 (sv) 1993-11-12 1993-11-12 Pharmaceutical emulsion
PCT/SE1994/001032 WO1995013066A1 (en) 1993-11-12 1994-11-03 Pharmaceutical emulsion

Publications (1)

Publication Number Publication Date
UA40633C2 true UA40633C2 (uk) 2001-08-15

Family

ID=20391731

Family Applications (1)

Application Number Title Priority Date Filing Date
UA96051803A UA40633C2 (uk) 1993-11-12 1994-11-03 Фармацевтичний емульсійний склад, спосіб його одержання і спосіб зниження в короткий термін тиску крові

Country Status (31)

Country Link
US (1) US5739152A (uk)
EP (1) EP0727997B1 (uk)
JP (1) JP3759951B2 (uk)
KR (1) KR100345627B1 (uk)
CN (1) CN1072934C (uk)
AT (1) ATE213158T1 (uk)
AU (1) AU678650B2 (uk)
CA (1) CA2176360C (uk)
CZ (1) CZ290772B6 (uk)
DE (1) DE69429871T2 (uk)
DK (1) DK0727997T3 (uk)
EE (1) EE03223B1 (uk)
EG (1) EG20764A (uk)
ES (1) ES2172572T3 (uk)
FI (1) FI116999B (uk)
HK (1) HK1013261A1 (uk)
HU (1) HU223142B1 (uk)
IL (1) IL111345A (uk)
IS (1) IS2036B (uk)
MY (1) MY121201A (uk)
NO (1) NO314877B1 (uk)
NZ (1) NZ276197A (uk)
PL (1) PL181462B1 (uk)
PT (1) PT727997E (uk)
RU (1) RU2144358C1 (uk)
SA (1) SA94150314B1 (uk)
SE (1) SE9303744D0 (uk)
SK (1) SK283271B6 (uk)
UA (1) UA40633C2 (uk)
WO (1) WO1995013066A1 (uk)
ZA (1) ZA948180B (uk)

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US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
DK1079808T3 (da) * 1998-05-29 2004-06-07 Skyepharma Canada Inc Præparater med termisk beskyttede mikropartikler og fremgangsmåde til slutdampsterilisering deraf
SE9804002D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New manufacturing process
DE10036871A1 (de) 2000-07-28 2002-02-14 Pharmasol Gmbh Dispersionen zur Formulierung wenig oder schwer löslicher Wirkstoffe
CA2449856C (en) 2001-06-15 2009-03-10 Cornerstone Pharmaceuticals Pharmaceutical and diagnostic compositions containing nanoparticles useful for treating targeted tissues and cells
PL2368554T3 (pl) * 2003-04-08 2015-05-29 Progenics Pharm Inc Preparaty farmaceutyczne zawierające metylonaltrekson
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
ES2765811T5 (es) * 2007-03-29 2024-02-27 Progenics Pharm Inc Forma cristalina de bromuro de (R)-n-metilnaltrexona y sus usos
ES2540551T3 (es) * 2007-03-29 2015-07-10 Wyeth Llc Antagonistas de receptores opioides periféricos y usos de los mismos
PE20090700A1 (es) * 2007-03-29 2009-07-13 Progenics Pharm Inc Compuestos heterociclicos como antagonistas del receptor opioide periferico
WO2009099411A1 (en) 2008-02-06 2009-08-13 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
US20100113534A1 (en) 2008-08-01 2010-05-06 Rajeshwar Motheram Pharmaceutical Compositions And Methods For Producing Low Impurity Concentrations Of The Same
KR20160095206A (ko) 2008-08-01 2016-08-10 더 메디슨스 컴퍼니 약제학적 조성물 및 이를 안정화시키는 방법
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
US9034389B2 (en) 2009-03-11 2015-05-19 Stable Solutions Llc Omega-3 enriched fish oil-in-water parenteral nutrition emulsions
US8993625B2 (en) 2009-03-11 2015-03-31 Stable Solutions Llc Method of mitigating adverse drug events using omega-3 fatty acids as a parenteral therapeutic drug vehicle
WO2010107081A1 (ja) * 2009-03-19 2010-09-23 第一三共株式会社 包装により安定保存された固形製剤
CN101780036B (zh) * 2010-03-30 2011-11-16 武汉武药科技有限公司 丁酸氯维地平脂微球注射液及其制备方法
US8658676B2 (en) * 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
EP2627173B2 (en) * 2010-10-12 2018-07-04 Chiesi Farmaceutici S.p.A. Clevidipine emulsion formulations containing antimicrobial agents
CN102531998A (zh) * 2010-12-09 2012-07-04 天津药物研究院 α型多晶型丁酸氯维地平结晶、其制备方法、用途和药物组合物
CN102525918A (zh) * 2010-12-30 2012-07-04 天津药物研究院 一种丁酸氯维地平的脂肪乳注射液及其制备工艺
US20120213855A1 (en) * 2011-02-17 2012-08-23 Cima Labs Inc. Dosage forms for weakly ionizable compounds
US20150094344A1 (en) * 2011-04-01 2015-04-02 The Medicines Company Short-acting dihydropyridines (clevidipine) for use in reducing stroke damage
EP2793833B1 (en) 2011-12-20 2020-06-24 Vyome Therapeutics Limited Topical oil composition for the treatment of fungal infections
WO2014066870A1 (en) 2012-10-26 2014-05-01 The Medicines Company Methods for controlling blood pressure and reducing dyspnea in heart failure
CN103110580B (zh) * 2013-02-20 2014-09-17 北京德立福瑞医药科技有限公司 丁酸氯维地平注射剂
AU2014252157B2 (en) * 2013-04-12 2017-05-11 Vyome Therapeutics Limited Composition and formulation of antimicrobial agents, processes thereof and methods for treating microbial infections
US11737989B2 (en) 2014-05-19 2023-08-29 Chiesi Farmaceutici S.P.A. Clevidipine nanoparticles and pharmaceutical compositions thereof

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DE3315805A1 (de) * 1983-04-30 1984-11-08 Bayer Ag, 5090 Leverkusen Wirkstoffzubereitungen
DE3339236A1 (de) * 1983-10-28 1985-05-09 Bayer Ag Arzneimittelzubereitung
DE3515335C2 (de) * 1985-04-27 1995-01-26 Bayer Ag Arzneizubereitung enthaltend Dihydropyridine und Verfahren zu ihrer Herstellung
DE4217842A1 (de) * 1992-05-29 1993-12-02 Dietl Hans Calciumantagonisten enthaltende pharmazeutische Zubereitung zur intravenösen und intrakoronaren Applikation sowie Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
EE03223B1 (et) 1999-10-15
NO961898L (no) 1996-06-25
SK59796A3 (en) 1996-12-04
NO961898D0 (no) 1996-05-10
MY121201A (en) 2006-01-28
JPH09505045A (ja) 1997-05-20
FI116999B (fi) 2006-05-15
HU223142B1 (hu) 2004-03-29
CA2176360C (en) 2005-08-23
EP0727997B1 (en) 2002-02-13
AU1037195A (en) 1995-05-29
HU9601268D0 (en) 1996-07-29
NZ276197A (en) 1997-04-24
CN1136774A (zh) 1996-11-27
FI961999A (fi) 1996-05-10
ES2172572T3 (es) 2002-10-01
IS2036B (is) 2005-08-15
FI961999A0 (fi) 1996-05-10
IS4224A (is) 1995-05-13
CZ290772B6 (cs) 2002-10-16
CN1072934C (zh) 2001-10-17
PL314263A1 (en) 1996-09-02
IL111345A (en) 2000-08-31
KR100345627B1 (ko) 2003-03-15
SE9303744D0 (sv) 1993-11-12
DE69429871T2 (de) 2002-08-22
US5739152A (en) 1998-04-14
IL111345A0 (en) 1994-12-29
CA2176360A1 (en) 1995-05-18
HK1013261A1 (en) 1999-08-20
SA94150314B1 (ar) 2005-06-14
WO1995013066A1 (en) 1995-05-18
DE69429871D1 (de) 2002-03-21
CZ133896A3 (en) 1996-09-11
PL181462B1 (pl) 2001-07-31
EP0727997A1 (en) 1996-08-28
EG20764A (en) 2000-01-31
PT727997E (pt) 2002-07-31
RU2144358C1 (ru) 2000-01-20
SK283271B6 (sk) 2003-04-01
DK0727997T3 (da) 2002-04-22
AU678650B2 (en) 1997-06-05
ATE213158T1 (de) 2002-02-15
JP3759951B2 (ja) 2006-03-29
HUT74474A (en) 1996-12-30
NO314877B1 (no) 2003-06-10
ZA948180B (en) 1995-05-12

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