UA124585C2 - Кристалічні форми інгібітора magl - Google Patents

Кристалічні форми інгібітора magl Download PDF

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Publication number
UA124585C2
UA124585C2 UAA201905624A UAA201905624A UA124585C2 UA 124585 C2 UA124585 C2 UA 124585C2 UA A201905624 A UAA201905624 A UA A201905624A UA A201905624 A UAA201905624 A UA A201905624A UA 124585 C2 UA124585 C2 UA 124585C2
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UA
Ukraine
Prior art keywords
compound
theta
crystalline
patient
piperazine
Prior art date
Application number
UAA201905624A
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English (en)
Ukrainian (uk)
Inventor
Шеріл А. Гріс
Шерил А. Грис
Тодд К. Джонс
Курт Г. Грімм
Курт Г. Гримм
Жаклін Лорейн Бланкман
Жаклин Лорейн Бланкман
Ченнінг Родні Білс
Ченнинг Родни Билс
Original Assignee
Лундбек Ла Джолла Ресеарч Центер, Інк.
Лундбек Ла Джолла Ресеарч Центер, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Лундбек Ла Джолла Ресеарч Центер, Інк., Лундбек Ла Джолла Ресеарч Центер, Инк. filed Critical Лундбек Ла Джолла Ресеарч Центер, Інк.
Publication of UA124585C2 publication Critical patent/UA124585C2/uk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205Radicals derived from carbonic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13Dicarboxylic acids
    • C07C57/15Fumaric acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
UAA201905624A 2016-11-16 2017-11-15 Кристалічні форми інгібітора magl UA124585C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662423126P 2016-11-16 2016-11-16
PCT/US2017/061875 WO2018093953A1 (en) 2016-11-16 2017-11-15 Crystalline forms of a magl inhibitor

Publications (1)

Publication Number Publication Date
UA124585C2 true UA124585C2 (uk) 2021-10-13

Family

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Application Number Title Priority Date Filing Date
UAA201905624A UA124585C2 (uk) 2016-11-16 2017-11-15 Кристалічні форми інгібітора magl

Country Status (38)

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EP (2) EP3964503B1 (enExample)
JP (2) JP7042548B2 (enExample)
KR (1) KR102508739B1 (enExample)
CN (2) CN110291083B (enExample)
AU (1) AU2017361257B2 (enExample)
BR (1) BR112019010003A2 (enExample)
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SI (1) SI3541807T1 (enExample)
SM (2) SMT202100675T1 (enExample)
TN (1) TN2019000151A1 (enExample)
UA (1) UA124585C2 (enExample)
WO (1) WO2018093953A1 (enExample)
ZA (1) ZA201903093B (enExample)

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MX2022013224A (es) * 2020-04-21 2022-11-14 H Lundbeck As Sintesis de un inhibidor de la monoacilglicerol lipasa.
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JOP20190105A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
MA58133B1 (fr) 2016-11-16 2024-02-29 H Lundbeck As Une forme cristalline d'un inhibiteur de magl

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Publication number Publication date
CA3043610A1 (en) 2018-05-24
AU2017361257A1 (en) 2019-05-30
PH12019501068A1 (en) 2019-08-19
CL2019001340A1 (es) 2019-10-04
RS65016B1 (sr) 2024-01-31
SI3541807T1 (sl) 2022-01-31
DOP2019000120A (es) 2019-09-30
CY1124870T1 (el) 2022-11-25
EP3541807B1 (en) 2021-09-29
PL3541807T3 (pl) 2022-01-17
IL266548A (en) 2019-07-31
CR20190242A (es) 2019-07-09
JOP20190109B1 (ar) 2022-09-15
SMT202300494T1 (it) 2024-01-10
PL3964503T3 (pl) 2024-04-02
CN115093382A (zh) 2022-09-23
MX2019005767A (es) 2019-12-05
WO2018093953A1 (en) 2018-05-24
RU2019116689A (ru) 2020-12-17
HUE064559T2 (hu) 2024-03-28
US11142517B2 (en) 2021-10-12
HRP20211863T1 (hr) 2022-03-04
JP7350117B2 (ja) 2023-09-25
PT3541807T (pt) 2021-12-09
CO2019005045A2 (es) 2019-05-31
ES2900016T3 (es) 2022-03-15
US20220235037A1 (en) 2022-07-28
BR112019010003A2 (pt) 2019-08-20
DK3541807T3 (da) 2021-12-06
EP3541807A4 (en) 2020-04-22
HRP20231697T1 (hr) 2024-03-15
EP3964503B1 (en) 2023-11-08
MA46866B1 (fr) 2021-11-30
MA46866A (fr) 2021-06-02
EP3964503C0 (en) 2023-11-08
ES2966939T3 (es) 2024-04-25
KR102508739B1 (ko) 2023-03-09
CN110291083B (zh) 2022-06-17
US20200190063A1 (en) 2020-06-18
JP7042548B2 (ja) 2022-03-28
EP3964503A1 (en) 2022-03-09
LT3541807T (lt) 2021-12-27
NI201900053A (es) 2019-10-30
KR20190077561A (ko) 2019-07-03
MX389459B (es) 2025-03-20
RS62665B1 (sr) 2021-12-31
ECSP19035171A (es) 2019-05-31
ZA201903093B (en) 2020-11-25
MY199386A (en) 2023-10-25
PE20191239A1 (es) 2019-09-16
JOP20190109A1 (ar) 2019-05-09
JP2022084717A (ja) 2022-06-07
EP3541807A1 (en) 2019-09-25
AU2017361257B2 (en) 2022-02-10
US11993588B2 (en) 2024-05-28
SMT202100675T1 (it) 2022-01-10
HUE056973T2 (hu) 2022-04-28
MA58133B1 (fr) 2024-02-29
MX2022000249A (es) 2022-02-03
CN110291083A (zh) 2019-09-27
GEP20237559B (en) 2023-10-25
RU2019116689A3 (enExample) 2021-02-26
EA201991086A1 (ru) 2019-11-29
TN2019000151A1 (en) 2020-10-05
NZ753241A (en) 2021-06-25
JP2019537596A (ja) 2019-12-26

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