MA58133B1 - Une forme cristalline d'un inhibiteur de magl - Google Patents

Une forme cristalline d'un inhibiteur de magl

Info

Publication number
MA58133B1
MA58133B1 MA58133A MA58133A MA58133B1 MA 58133 B1 MA58133 B1 MA 58133B1 MA 58133 A MA58133 A MA 58133A MA 58133 A MA58133 A MA 58133A MA 58133 B1 MA58133 B1 MA 58133B1
Authority
MA
Morocco
Prior art keywords
crystal form
magl inhibitor
magl
inhibitor
hexafluoropropan
Prior art date
Application number
MA58133A
Other languages
English (en)
Inventor
Cheryl A Grice
Todd K Jones
Kurt G Grimm
Jacqueline Lorayne Blankman
Channing Rodney Beals
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of MA58133B1 publication Critical patent/MA58133B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne l'inhibiteur magl 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluorométhyl)benzyl)pipérazine-1-carboxylate, y compris des formes cristallines et des sels et solvates pharmaceutiquement acceptables de ceux-ci.
MA58133A 2016-11-16 2017-11-15 Une forme cristalline d'un inhibiteur de magl MA58133B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662423126P 2016-11-16 2016-11-16

Publications (1)

Publication Number Publication Date
MA58133B1 true MA58133B1 (fr) 2024-02-29

Family

ID=62145805

Family Applications (2)

Application Number Title Priority Date Filing Date
MA58133A MA58133B1 (fr) 2016-11-16 2017-11-15 Une forme cristalline d'un inhibiteur de magl
MA46866A MA46866B1 (fr) 2016-11-16 2017-11-15 Une forme cristalline d'un inhibiteur de magl

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA46866A MA46866B1 (fr) 2016-11-16 2017-11-15 Une forme cristalline d'un inhibiteur de magl

Country Status (36)

Country Link
US (2) US11142517B2 (fr)
EP (2) EP3541807B1 (fr)
JP (2) JP7042548B2 (fr)
KR (1) KR102508739B1 (fr)
CN (2) CN115093382A (fr)
AU (1) AU2017361257B2 (fr)
BR (1) BR112019010003A2 (fr)
CA (1) CA3043610A1 (fr)
CL (1) CL2019001340A1 (fr)
CO (1) CO2019005045A2 (fr)
CR (1) CR20190242A (fr)
CY (1) CY1124870T1 (fr)
DK (1) DK3541807T3 (fr)
DO (1) DOP2019000120A (fr)
EA (1) EA201991086A1 (fr)
EC (1) ECSP19035171A (fr)
ES (2) ES2966939T3 (fr)
GE (1) GEP20237559B (fr)
HR (2) HRP20231697T1 (fr)
HU (2) HUE064559T2 (fr)
IL (1) IL266548A (fr)
JO (1) JOP20190109B1 (fr)
LT (1) LT3541807T (fr)
MA (2) MA58133B1 (fr)
MX (2) MX2019005767A (fr)
NI (1) NI201900053A (fr)
PE (1) PE20191239A1 (fr)
PH (1) PH12019501068A1 (fr)
PL (2) PL3964503T3 (fr)
PT (1) PT3541807T (fr)
RS (2) RS65016B1 (fr)
SI (1) SI3541807T1 (fr)
TN (1) TN2019000151A1 (fr)
UA (1) UA124585C2 (fr)
WO (1) WO2018093953A1 (fr)
ZA (1) ZA201903093B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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NZ627750A (en) 2012-01-06 2016-11-25 Abide Therapeutics Inc Carbamate compounds and of making and using same
EP3294731A4 (fr) 2015-05-11 2018-10-24 Abide Therapeutics, Inc. Procédés de traitement de l'inflammation ou de la douleur neuropathique
EP3515897B1 (fr) 2016-09-19 2021-08-18 H. Lundbeck A/S Carbamates de pipérazine comme modulateurs de magl et/ou de abhd6 et leur utilisation
JOP20190108B1 (ar) 2016-11-16 2023-09-17 H Lundbeck As تركيبات صيدلانية
LT3541807T (lt) 2016-11-16 2021-12-27 H. Lundbeck A/S Magl inhibitoriaus kristalinė forma
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
WO2018217805A1 (fr) 2017-05-23 2018-11-29 Abide Therapeutics, Inc. Inhibiteurs pyrazole de magl
ES2952332T3 (es) 2017-08-29 2023-10-30 H Lundbeck As Compuestos espirocíclicos y sus métodos de preparación y uso
AR115092A1 (es) 2018-05-15 2020-11-25 Abide Therapeutics Inc Inhibidores de magl
WO2020016710A1 (fr) * 2018-07-19 2020-01-23 Pfizer Inc. Composés spiro hétérocycliques utilisés en tant qu'inhibiteurs de magl
US20210147367A1 (en) * 2019-11-15 2021-05-20 Lundbeck La Jolla Research Center, Inc. Crystalline forms of a magl inhibitor
US11702393B2 (en) * 2020-04-21 2023-07-18 H. Lundbeck A/S Synthesis of a monoacylglycerol lipase inhibitor
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LT3541807T (lt) 2016-11-16 2021-12-27 H. Lundbeck A/S Magl inhibitoriaus kristalinė forma
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Also Published As

Publication number Publication date
DOP2019000120A (es) 2019-09-30
PL3964503T3 (pl) 2024-04-02
LT3541807T (lt) 2021-12-27
GEP20237559B (en) 2023-10-25
JOP20190109B1 (ar) 2022-09-15
HUE064559T2 (hu) 2024-03-28
WO2018093953A1 (fr) 2018-05-24
US20200190063A1 (en) 2020-06-18
CN110291083A (zh) 2019-09-27
MA46866B1 (fr) 2021-11-30
EP3964503A1 (fr) 2022-03-09
PE20191239A1 (es) 2019-09-16
US11993588B2 (en) 2024-05-28
MX2022000249A (es) 2022-02-03
MX2019005767A (es) 2019-12-05
AU2017361257A1 (en) 2019-05-30
MA46866A (fr) 2021-06-02
TN2019000151A1 (en) 2020-10-05
UA124585C2 (uk) 2021-10-13
JP7042548B2 (ja) 2022-03-28
EP3964503B1 (fr) 2023-11-08
CN115093382A (zh) 2022-09-23
ES2900016T3 (es) 2022-03-15
JP2022084717A (ja) 2022-06-07
PT3541807T (pt) 2021-12-09
KR20190077561A (ko) 2019-07-03
RS65016B1 (sr) 2024-01-31
KR102508739B1 (ko) 2023-03-09
IL266548A (en) 2019-07-31
PL3541807T3 (pl) 2022-01-17
BR112019010003A2 (pt) 2019-08-20
CO2019005045A2 (es) 2019-05-31
HRP20211863T1 (hr) 2022-03-04
EP3541807B1 (fr) 2021-09-29
EP3541807A1 (fr) 2019-09-25
EA201991086A1 (ru) 2019-11-29
JP2019537596A (ja) 2019-12-26
US11142517B2 (en) 2021-10-12
PH12019501068A1 (en) 2019-08-19
RS62665B1 (sr) 2021-12-31
HUE056973T2 (hu) 2022-04-28
ES2966939T3 (es) 2024-04-25
EP3541807A4 (fr) 2020-04-22
EP3964503C0 (fr) 2023-11-08
DK3541807T3 (da) 2021-12-06
CL2019001340A1 (es) 2019-10-04
AU2017361257B2 (en) 2022-02-10
HRP20231697T1 (hr) 2024-03-15
NI201900053A (es) 2019-10-30
CN110291083B (zh) 2022-06-17
CY1124870T1 (el) 2022-11-25
US20220235037A1 (en) 2022-07-28
ECSP19035171A (es) 2019-05-31
RU2019116689A (ru) 2020-12-17
NZ753241A (en) 2021-06-25
RU2019116689A3 (fr) 2021-02-26
CR20190242A (es) 2019-07-09
JOP20190109A1 (ar) 2019-05-09
JP7350117B2 (ja) 2023-09-25
SI3541807T1 (sl) 2022-01-31
CA3043610A1 (fr) 2018-05-24
ZA201903093B (en) 2020-11-25

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