UA114894C2 - Інгібітори nedd8-активуючого ферменту - Google Patents

Info

Publication number

UA114894C2

UA114894C2 UAA201402893A UAA201402893A UA114894C2 UA 114894 C2 UA114894 C2 UA 114894C2 UA A201402893 A UAA201402893 A UA A201402893A UA A201402893 A UAA201402893 A UA A201402893A UA 114894 C2 UA114894 C2 UA 114894C2

Authority

UA

Ukraine

Prior art keywords

crystalline form

dihydro

inden

oxy

methoxy

Prior art date

2011-08-24

Links

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• 239000003112 inhibitor Substances 0.000 title abstract description 21
• 102000038427 NEDD8-activating enzyme E1 Human genes 0.000 title abstract 3
• 108091007790 NEDD8-activating enzyme E1 Proteins 0.000 title abstract 3
• 150000001875 compounds Chemical class 0.000 claims abstract description 105
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• -1 pyrimidine-4-yl Chemical group 0.000 claims description 115
• 239000000203 mixture Substances 0.000 claims description 103
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 74
• 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims description 68
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 39
• 239000000843 powder Substances 0.000 claims description 21
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• QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical group N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 14
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• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 5
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