PE20141146A1 - Inhibidores de la enzima activadora de nedd8 - Google Patents

Inhibidores de la enzima activadora de nedd8

Info

Publication number
PE20141146A1
PE20141146A1 PE2014000250A PE2014000250A PE20141146A1 PE 20141146 A1 PE20141146 A1 PE 20141146A1 PE 2014000250 A PE2014000250 A PE 2014000250A PE 2014000250 A PE2014000250 A PE 2014000250A PE 20141146 A1 PE20141146 A1 PE 20141146A1
Authority
PE
Peru
Prior art keywords
enzyme inhibitors
activating enzyme
nedd8 activating
refers
nedd8
Prior art date
Application number
PE2014000250A
Other languages
English (en)
Inventor
Ashley Sue Mccarron
Todd B Sells
Matthew Stirling
Stephen G Stroud
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of PE20141146A1 publication Critical patent/PE20141146A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE AL COMPUESTO SULFAMATO DE {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-CLORO-2-METOXI-2,3-DIHIDRO-1H-INDEN-1-IL]AMINO}PIRIMIDIN-4-IL)OXI]-2-HIDROXICICLOPENTIL}METILO, QUE SE CARACTERIZA POR UN PATRON DE DIFRACCION DE RAYOS X EN POLVO (XRPD) QUE TIENE PICOS EN EL ANGULO 2 THETA DE 4.5�, 15.2�, 21.3�, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE ES UTIL PARA EL TRATAMIENTO DE CANCER.
PE2014000250A 2011-08-24 2012-08-23 Inhibidores de la enzima activadora de nedd8 PE20141146A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161526830P 2011-08-24 2011-08-24

Publications (1)

Publication Number Publication Date
PE20141146A1 true PE20141146A1 (es) 2014-09-21

Family

ID=47747080

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014000250A PE20141146A1 (es) 2011-08-24 2012-08-23 Inhibidores de la enzima activadora de nedd8

Country Status (28)

Country Link
US (3) US8809356B2 (es)
EP (2) EP2748168A4 (es)
JP (1) JP6038150B2 (es)
KR (1) KR20140054288A (es)
CN (1) CN103889988B (es)
AR (1) AR087672A1 (es)
AU (1) AU2012298813B2 (es)
BR (1) BR112014004239A2 (es)
CA (1) CA2846231C (es)
CL (1) CL2014000441A1 (es)
CO (1) CO6900148A2 (es)
CR (1) CR20140128A (es)
DO (1) DOP2014000037A (es)
EA (1) EA031067B1 (es)
EC (1) ECSP14013263A (es)
GE (1) GEP201606522B (es)
HK (1) HK1199252A1 (es)
IL (1) IL231069B (es)
MA (1) MA35439B1 (es)
MX (1) MX2014002015A (es)
MY (1) MY166889A (es)
PE (1) PE20141146A1 (es)
SG (2) SG10201601023UA (es)
TN (1) TN2014000080A1 (es)
TW (1) TWI577667B (es)
UA (1) UA114894C2 (es)
UY (1) UY34292A (es)
WO (1) WO2013028832A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
WO2013028832A2 (en) * 2011-08-24 2013-02-28 Millennium Pharmaceuticals, Inc. Inhibitors of nedd8-activating enzyme
MX352963B (es) 2012-02-17 2017-12-15 Millennium Pharm Inc Inhibidores de pirazolopirimidinilo en enzima activadora de ubiquitina.
JP2015524442A (ja) 2012-08-03 2015-08-24 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｕｂａ６のインドール置換ピロロピリミジニル阻害剤
EP2764866A1 (en) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
CA2916468C (en) 2013-07-02 2019-07-23 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of sumo activating enzyme
CN103948590A (zh) * 2014-05-22 2014-07-30 中国药科大学 Nedd8激活酶抑制剂及其医药用途
BR112016030787B1 (pt) * 2014-07-01 2022-12-20 Takeda Pharmaceutical Company Limited Entidade química, composição farmacêutica e seu uso
WO2017183927A1 (ko) * 2016-04-20 2017-10-26 한국화학연구원 신규한 헤테로고리 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
WO2018213258A1 (en) * 2017-05-15 2018-11-22 Millennium Pharmaceuticals, Inc. Treatment of merlin-deficient tumors using nae inhibitors
WO2023025668A1 (en) 2021-08-25 2023-03-02 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Methods for the generation of stem cell memory t cells for adoptive t cell therapy

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194446A (en) 1989-06-12 1993-03-16 A. H. Robins Company, Incorporated Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals
AU6500696A (en) 1995-07-28 1997-02-26 Cubist Pharmaceuticals, Inc. Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents
US20060276520A1 (en) 2002-11-13 2006-12-07 Rigel Pharmaceuticals, Inc. Rhodanine derivatives and pharmaceutical compositions containing them
EP1680431A1 (en) 2003-10-17 2006-07-19 Rigel Pharmaceuticals, Inc. Benzothiazole and thiazole'5,5-b!pyridine compositions and their use as ubiquitin ligase inhibitors
JP2008503591A (ja) 2004-06-22 2008-02-07 ライジェル ファーマシューティカルズ， インコーポレイテッド ユビキチンリガーゼ阻害剤
RS52458B (en) 2005-02-04 2013-02-28 Millennium Pharmaceuticals Inc. E1 ENZYMING ENZYME INHIBITORS
CA2639924C (en) 2006-02-02 2017-01-10 Millennium Pharmaceuticals, Inc. Purinyl-and pyrrolo[2,3-d]pyrimidinyl cyclopentyl compounds and their use as inhibitors of e1 activating enzymes
WO2008019124A1 (en) * 2006-08-08 2008-02-14 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of e1 activating enzymes
US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
RU2562245C2 (ru) * 2009-05-14 2015-09-10 Милленниум Фармасьютикалз, Инк. ГИДРОХЛОРИД (1S,2S,4R)-4-{ 4-[(1S)-2,3-ДИГИДРО-1Н-ИНДЕН-1-ИЛАМИНО]-7Н-ПИРРОЛО [2,3-d]ПИРИМИДИН-7-ИЛ} -2-ГИДРОКСИЦИКЛОПЕНТИЛ)МЕТИЛ СУЛЬФАМАТА
WO2013028832A2 (en) * 2011-08-24 2013-02-28 Millennium Pharmaceuticals, Inc. Inhibitors of nedd8-activating enzyme
ES2668272T3 (es) * 2011-11-03 2018-05-17 Millennium Pharmaceuticals, Inc. Administración de inhibidor de enzimas que activa NEDD8 y agente de hipometilación

Also Published As

Publication number Publication date
GEP201606522B (en) 2016-08-10
EP3323414A1 (en) 2018-05-23
IL231069B (en) 2018-02-28
CO6900148A2 (es) 2014-03-20
US8809356B2 (en) 2014-08-19
US20150011572A1 (en) 2015-01-08
US20130150388A1 (en) 2013-06-13
DOP2014000037A (es) 2014-04-15
CR20140128A (es) 2014-05-15
JP6038150B2 (ja) 2016-12-07
IL231069A0 (en) 2014-03-31
HK1199252A1 (en) 2015-06-26
US9850214B2 (en) 2017-12-26
EP2748168A2 (en) 2014-07-02
CA2846231C (en) 2017-06-20
EA201400249A1 (ru) 2014-05-30
AU2012298813A1 (en) 2013-05-02
NZ622220A (en) 2016-04-29
SG10201601023UA (en) 2016-03-30
AU2012298813B2 (en) 2016-07-28
UY34292A (es) 2013-04-05
MA35439B1 (fr) 2014-09-01
KR20140054288A (ko) 2014-05-08
CN103889988A (zh) 2014-06-25
MY166889A (en) 2018-07-24
TW201313689A (zh) 2013-04-01
TWI577667B (zh) 2017-04-11
EP2748168A4 (en) 2015-04-22
AR087672A1 (es) 2014-04-09
WO2013028832A2 (en) 2013-02-28
BR112014004239A2 (pt) 2017-03-21
CL2014000441A1 (es) 2014-09-26
WO2013028832A3 (en) 2013-05-02
SG11201400102WA (en) 2014-03-28
CN103889988B (zh) 2018-05-04
TN2014000080A1 (en) 2015-07-01
ECSP14013263A (es) 2014-04-30
EA031067B1 (ru) 2018-11-30
US20180290983A1 (en) 2018-10-11
CA2846231A1 (en) 2013-02-28
JP2014524476A (ja) 2014-09-22
UA114894C2 (uk) 2017-08-28
MX2014002015A (es) 2014-03-27

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