EA201400249A1 - Ингибиторы nedd8-активирующего фермента - Google Patents

Ингибиторы nedd8-активирующего фермента

Info

Publication number
EA201400249A1
EA201400249A1 EA201400249A EA201400249A EA201400249A1 EA 201400249 A1 EA201400249 A1 EA 201400249A1 EA 201400249 A EA201400249 A EA 201400249A EA 201400249 A EA201400249 A EA 201400249A EA 201400249 A1 EA201400249 A1 EA 201400249A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nedd8
inhibitors
activating enzyme
chemicals
nae
Prior art date
Application number
EA201400249A
Other languages
English (en)
Other versions
EA031067B1 (ru
Inventor
Эшли Сью Маккаррон
Тодд Б. Селлз
Метью Стирлинг
Стефен Г. Строуд
Original Assignee
Миллениум Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Миллениум Фармасьютикалз, Инк. filed Critical Миллениум Фармасьютикалз, Инк.
Publication of EA201400249A1 publication Critical patent/EA201400249A1/ru
Publication of EA031067B1 publication Critical patent/EA031067B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Описаны химические вещества, которые представляют собой ингибиторы Nedd8-активирующего фермента (NAE), а именно соединение {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-хлор-2-метокси-2,3-дигидро-1Н-инден-1-ил]амино}пиримидин-4-ил)окси]-2-гидроксициклопентил}метил сульфамат и его фармацевтически приемлемые соли; их твердые формы и их пролекарства. Также описаны способы применения этих химических веществ для лечения расстройств, таких как рак.
EA201400249A 2011-08-24 2012-08-23 ИНГИБИТОРЫ Nedd8-АКТИВИРУЮЩЕГО ФЕРМЕНТА EA031067B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161526830P 2011-08-24 2011-08-24
PCT/US2012/052007 WO2013028832A2 (en) 2011-08-24 2012-08-23 Inhibitors of nedd8-activating enzyme

Publications (2)

Publication Number Publication Date
EA201400249A1 true EA201400249A1 (ru) 2014-05-30
EA031067B1 EA031067B1 (ru) 2018-11-30

Family

ID=47747080

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400249A EA031067B1 (ru) 2011-08-24 2012-08-23 ИНГИБИТОРЫ Nedd8-АКТИВИРУЮЩЕГО ФЕРМЕНТА

Country Status (28)

Country Link
US (3) US8809356B2 (ru)
EP (2) EP2748168A4 (ru)
JP (1) JP6038150B2 (ru)
KR (1) KR20140054288A (ru)
CN (1) CN103889988B (ru)
AR (1) AR087672A1 (ru)
AU (1) AU2012298813B2 (ru)
BR (1) BR112014004239A2 (ru)
CA (1) CA2846231C (ru)
CL (1) CL2014000441A1 (ru)
CO (1) CO6900148A2 (ru)
CR (1) CR20140128A (ru)
DO (1) DOP2014000037A (ru)
EA (1) EA031067B1 (ru)
EC (1) ECSP14013263A (ru)
GE (1) GEP201606522B (ru)
HK (1) HK1199252A1 (ru)
IL (1) IL231069B (ru)
MA (1) MA35439B1 (ru)
MX (1) MX2014002015A (ru)
MY (1) MY166889A (ru)
PE (1) PE20141146A1 (ru)
SG (2) SG11201400102WA (ru)
TN (1) TN2014000080A1 (ru)
TW (1) TWI577667B (ru)
UA (1) UA114894C2 (ru)
UY (1) UY34292A (ru)
WO (1) WO2013028832A2 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
US8809356B2 (en) * 2011-08-24 2014-08-19 Millennium Pharmaceuticals, Inc. Inhibitors of NEDD8-activating enzyme
KR20140123104A (ko) 2012-02-17 2014-10-21 밀레니엄 파머슈티컬스 인코퍼레이티드 유비퀴틴 활성화 효소의 피라졸로피리미디닐 억제제
WO2014022744A1 (en) 2012-08-03 2014-02-06 Millennium Pharmaceuticals, Inc. INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF Uba6
EP2764866A1 (en) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
CA2916468C (en) * 2013-07-02 2019-07-23 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of sumo activating enzyme
CN103948590A (zh) * 2014-05-22 2014-07-30 中国药科大学 Nedd8激活酶抑制剂及其医药用途
HUE045748T2 (hu) 2014-07-01 2020-01-28 Millennium Pharm Inc Heteroaril vegyületek mint SUMO aktiváló enzimek inhibitorai
WO2017183927A1 (ko) * 2016-04-20 2017-10-26 한국화학연구원 신규한 헤테로고리 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
WO2018213258A1 (en) * 2017-05-15 2018-11-22 Millennium Pharmaceuticals, Inc. Treatment of merlin-deficient tumors using nae inhibitors
WO2023025668A1 (en) 2021-08-25 2023-03-02 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Methods for the generation of stem cell memory t cells for adoptive t cell therapy

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194446A (en) 1989-06-12 1993-03-16 A. H. Robins Company, Incorporated Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals
AU6500696A (en) 1995-07-28 1997-02-26 Cubist Pharmaceuticals, Inc. Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents
WO2004043955A1 (en) 2002-11-13 2004-05-27 Rigel Pharmaceuticals, Inc. Rhodanine derivatives and pharmaceutical compositions containing them
WO2005037845A1 (en) 2003-10-17 2005-04-28 Rigel Pharmaceuticals, Inc. Benzothiazole and thiazole[5,5-b] pyridine compositions and their use as ubiquitin ligase inhibitors
US20050282818A1 (en) 2004-06-22 2005-12-22 Rigel Pharmaceuticals, Inc. Ubiquitin ligase inhibitors
WO2006084281A1 (en) 2005-02-04 2006-08-10 Millennium Pharmaceuticals, Inc. Inhibitors of e1 activating enzymes
DK1989206T3 (da) * 2006-02-02 2012-10-08 Millennium Pharm Inc E1-aktiveringsenzymhæmmere
US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
ME02789B (me) 2006-08-08 2011-06-30 Millennium Pharm Inc Jedinjenja heteroarila korisna kao inhibitori e1 aktivirajućih enzima
US9187482B2 (en) * 2009-05-14 2015-11-17 Millennium Pharmaceuticals, Inc. Hydrochloride salt of((1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate
US8809356B2 (en) * 2011-08-24 2014-08-19 Millennium Pharmaceuticals, Inc. Inhibitors of NEDD8-activating enzyme
CN104245699B (zh) * 2011-11-03 2017-06-27 米伦纽姆医药公司 Nedd8‑活化酶抑制剂和低甲基化剂的投与

Also Published As

Publication number Publication date
TN2014000080A1 (en) 2015-07-01
BR112014004239A2 (pt) 2017-03-21
CA2846231A1 (en) 2013-02-28
HK1199252A1 (en) 2015-06-26
EP2748168A2 (en) 2014-07-02
CR20140128A (es) 2014-05-15
ECSP14013263A (es) 2014-04-30
MA35439B1 (fr) 2014-09-01
CN103889988B (zh) 2018-05-04
AU2012298813B2 (en) 2016-07-28
SG10201601023UA (en) 2016-03-30
US20150011572A1 (en) 2015-01-08
MY166889A (en) 2018-07-24
CN103889988A (zh) 2014-06-25
IL231069A0 (en) 2014-03-31
CO6900148A2 (es) 2014-03-20
AU2012298813A1 (en) 2013-05-02
GEP201606522B (en) 2016-08-10
KR20140054288A (ko) 2014-05-08
WO2013028832A2 (en) 2013-02-28
TWI577667B (zh) 2017-04-11
EP2748168A4 (en) 2015-04-22
PE20141146A1 (es) 2014-09-21
WO2013028832A3 (en) 2013-05-02
DOP2014000037A (es) 2014-04-15
EP3323414A1 (en) 2018-05-23
NZ622220A (en) 2016-04-29
MX2014002015A (es) 2014-03-27
UA114894C2 (uk) 2017-08-28
CL2014000441A1 (es) 2014-09-26
CA2846231C (en) 2017-06-20
IL231069B (en) 2018-02-28
JP2014524476A (ja) 2014-09-22
US20130150388A1 (en) 2013-06-13
UY34292A (es) 2013-04-05
JP6038150B2 (ja) 2016-12-07
US20180290983A1 (en) 2018-10-11
SG11201400102WA (en) 2014-03-28
TW201313689A (zh) 2013-04-01
EA031067B1 (ru) 2018-11-30
US8809356B2 (en) 2014-08-19
AR087672A1 (es) 2014-04-09
US9850214B2 (en) 2017-12-26

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU