UA113388C2 - ЗАСТОСУВАННЯ АНТИТІЛА ПРОТИ с-МЕТ - Google Patents

ЗАСТОСУВАННЯ АНТИТІЛА ПРОТИ с-МЕТ

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UA113388C2
UA113388C2 UAA201214956A UAA201214956A UA113388C2 UA 113388 C2 UA113388 C2 UA 113388C2 UA A201214956 A UAA201214956 A UA A201214956A UA A201214956 A UAA201214956 A UA A201214956A UA 113388 C2 UA113388 C2 UA 113388C2
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met
application
antibody against
inhibiting
monoclonal antibody
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UAA201214956A
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/72—Increased effector function due to an Fc-modification
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

Винахід належить до застосування моноклонального антитіла або його бівалентного функціонального фрагмента, здатного інгібувати димеризацію c-Met, та застосування композиції, що містить моноклональне антитіло або його бівалентний функціональний фрагмент, які здатні інгібувати димеризацію c-Met для застосування при попередженні та/або лікуванні раку, що характеризується гіперекспресією c-Met, яка є результатом генної ампліфікації c-Met, такого як рак ШКТ або нирково-клітинна карцинома.
UAA201214956A 2010-06-01 2011-01-06 ЗАСТОСУВАННЯ АНТИТІЛА ПРОТИ с-МЕТ UA113388C2 (xx)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/791,681 US8545839B2 (en) 2008-12-02 2010-06-01 Anti-c-Met antibody
PCT/EP2011/059139 WO2011151412A1 (en) 2010-06-01 2011-06-01 Novel anti-cmet antibody

Publications (1)

Publication Number Publication Date
UA113388C2 true UA113388C2 (xx) 2017-01-25

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US (4) US8545839B2 (uk)
EP (1) EP2575879B1 (uk)
JP (1) JP5973998B2 (uk)
KR (1) KR101838311B1 (uk)
CN (2) CN105688209A (uk)
AU (1) AU2011260286B2 (uk)
BR (1) BR112012030805A2 (uk)
CA (1) CA2801264C (uk)
ES (1) ES2582038T3 (uk)
HU (1) HUE029043T2 (uk)
IL (1) IL223366B (uk)
MA (1) MA34289B1 (uk)
MX (1) MX340101B (uk)
MY (1) MY163096A (uk)
NZ (1) NZ604056A (uk)
PL (1) PL2575879T3 (uk)
RU (1) RU2607377C2 (uk)
TN (1) TN2012000558A1 (uk)
UA (1) UA113388C2 (uk)
WO (1) WO2011151412A1 (uk)

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CN103002916A (zh) 2013-03-27
US20150307613A1 (en) 2015-10-29
JP5973998B2 (ja) 2016-08-23
BR112012030805A2 (pt) 2017-09-19
US20110097262A1 (en) 2011-04-28
MA34289B1 (fr) 2013-06-01
PL2575879T3 (pl) 2016-10-31
RU2607377C2 (ru) 2017-01-10
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