UA102787C2 - Способ приготовления кристаллических форм а и в илапразола и способ преобразования кристаллических форм - Google Patents
Способ приготовления кристаллических форм а и в илапразола и способ преобразования кристаллических формInfo
- Publication number
- UA102787C2 UA102787C2 UAA201207006A UAA201207006A UA102787C2 UA 102787 C2 UA102787 C2 UA 102787C2 UA A201207006 A UAA201207006 A UA A201207006A UA A201207006 A UAA201207006 A UA A201207006A UA 102787 C2 UA102787 C2 UA 102787C2
- Authority
- UA
- Ukraine
- Prior art keywords
- ilaprazole
- crystalline forms
- preparing
- conversion
- crystalline form
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- HRRXCXABAPSOCP-UHFFFAOYSA-N ilaprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC(=CC=C3N=2)N2C=CC=C2)=C1C HRRXCXABAPSOCP-UHFFFAOYSA-N 0.000 title abstract 5
- 229950008491 ilaprazole Drugs 0.000 title abstract 5
- 238000006243 chemical reaction Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 229910017053 inorganic salt Inorganic materials 0.000 abstract 2
- 239000012046 mixed solvent Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020090121209A KR101144600B1 (ko) | 2009-12-08 | 2009-12-08 | 일라프라졸의 결정형 ａ, ｂ의 제조방법 및 이들 결정형의 변환방법 |
| PCT/KR2010/008767 WO2011071314A2 (en) | 2009-12-08 | 2010-12-08 | Processes for preparing crystalline forms a and b of ilaprazole and process for converting the crystalline forms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA102787C2 true UA102787C2 (ru) | 2013-08-12 |
Family
ID=44146052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201207006A UA102787C2 (ru) | 2009-12-08 | 2010-12-08 | Способ приготовления кристаллических форм а и в илапразола и способ преобразования кристаллических форм |
Country Status (7)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103204843B (zh) * | 2012-01-13 | 2014-12-31 | 丽珠医药集团股份有限公司 | 结晶型艾普拉唑钠乙醇化物及其制备方法 |
| CN103204842B (zh) * | 2012-01-13 | 2014-10-15 | 丽珠医药集团股份有限公司 | 结晶型艾普拉唑钠水合物及其制备方法 |
| WO2013114232A1 (en) | 2012-02-02 | 2013-08-08 | Lupin Limited | Process for preparation of crystalline form l of ilaprazole |
| CN102746275B (zh) * | 2012-06-21 | 2014-07-16 | 丽珠医药集团股份有限公司 | 结晶型艾普拉唑钠及其制备方法 |
| CN102746276B (zh) * | 2012-06-21 | 2014-07-02 | 丽珠医药集团股份有限公司 | 一种艾普拉唑钠晶型及其制备方法 |
| CN102746277B (zh) * | 2012-06-21 | 2014-05-14 | 丽珠医药集团股份有限公司 | 一种结晶形式的艾普拉唑钠及其制备方法 |
| CN113045544A (zh) * | 2014-09-04 | 2021-06-29 | 江苏奥赛康药业有限公司 | 艾普拉唑钠化合物及其药物组合物 |
| CN115403560B (zh) * | 2017-11-06 | 2024-09-03 | 丽珠医药集团股份有限公司 | 一种艾普拉唑镁晶型及其制备方法 |
| KR102027388B1 (ko) * | 2017-11-15 | 2019-10-01 | 주식회사 다산제약 | 고순도 일라프라졸 결정형 b의 제조방법 |
| CN111187255B (zh) * | 2020-01-13 | 2021-07-20 | 丽珠医药集团股份有限公司 | 右旋艾普拉唑钾盐的制备方法和右旋艾普拉唑的制备方法 |
| KR20220065235A (ko) | 2020-11-13 | 2022-05-20 | 주식회사 파마코스텍 | 일라프라졸 혼형 결정의 신규한 제조방법 |
| KR102250509B1 (ko) * | 2020-12-09 | 2021-05-11 | 유니셀랩 주식회사 | 새로운 일라프라졸/자일리톨 공결정 |
| KR20210019469A (ko) | 2021-02-02 | 2021-02-22 | 주식회사 파마코스텍 | 일라프라졸 나트륨 결정형 및 신규한 제조방법 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5315254B2 (ja) * | 2006-12-29 | 2013-10-16 | イル ヤン ファーマスーティカル カンパニー リミテッド | 溶媒和物化されたイラプラゾールの結晶形 |
| WO2008083319A1 (en) * | 2006-12-29 | 2008-07-10 | Il Yang Pharmaceutical Company, Ltd. | Solid state forms of enantiopure ilaprazole |
-
2009
- 2009-12-08 KR KR1020090121209A patent/KR101144600B1/ko active Active
-
2010
- 2010-12-08 BR BR112012012212A patent/BR112012012212A2/pt not_active Application Discontinuation
- 2010-12-08 IN IN3176DEN2012 patent/IN2012DN03176A/en unknown
- 2010-12-08 WO PCT/KR2010/008767 patent/WO2011071314A2/en active Application Filing
- 2010-12-08 UA UAA201207006A patent/UA102787C2/ru unknown
- 2010-12-08 EA EA201200716A patent/EA019058B1/ru not_active IP Right Cessation
-
2012
- 2012-06-08 CO CO12097489A patent/CO6541539A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012012212A2 (pt) | 2015-09-08 |
| IN2012DN03176A (enrdf_load_stackoverflow) | 2015-09-25 |
| CO6541539A2 (es) | 2012-10-16 |
| EA201200716A1 (ru) | 2012-10-30 |
| KR20110064545A (ko) | 2011-06-15 |
| KR101144600B1 (ko) | 2012-05-16 |
| WO2011071314A3 (en) | 2011-11-10 |
| WO2011071314A2 (en) | 2011-06-16 |
| EA019058B1 (ru) | 2013-12-30 |
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