KR101144600B1 - 일라프라졸의 결정형 ａ, ｂ의 제조방법 및 이들 결정형의 변환방법 - Google Patents

일라프라졸의 결정형 ａ, ｂ의 제조방법 및 이들 결정형의 변환방법 Download PDF

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KR101144600B1
KR101144600B1 KR1020090121209A KR20090121209A KR101144600B1 KR 101144600 B1 KR101144600 B1 KR 101144600B1 KR 1020090121209 A KR1020090121209 A KR 1020090121209A KR 20090121209 A KR20090121209 A KR 20090121209A KR 101144600 B1 KR101144600 B1 KR 101144600B1
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South Korea
Prior art keywords
ilaprazole
acid
crystalline form
inorganic salt
preparing
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KR1020090121209A
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English (en)
Korean (ko)
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KR20110064545A (ko
Inventor
김동연
신재수
이준연
조귀형
박성태
김정우
남상돈
김희연
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일양약품주식회사
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Priority to KR1020090121209A priority Critical patent/KR101144600B1/ko
Application filed by 일양약품주식회사 filed Critical 일양약품주식회사
Priority to PCT/KR2010/008767 priority patent/WO2011071314A2/en
Priority to BR112012012212A priority patent/BR112012012212A2/pt
Priority to EA201200716A priority patent/EA019058B1/ru
Priority to IN3176DEN2012 priority patent/IN2012DN03176A/en
Priority to UAA201207006A priority patent/UA102787C2/ru
Publication of KR20110064545A publication Critical patent/KR20110064545A/ko
Application granted granted Critical
Publication of KR101144600B1 publication Critical patent/KR101144600B1/ko
Priority to CO12097489A priority patent/CO6541539A2/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
KR1020090121209A 2009-12-08 2009-12-08 일라프라졸의 결정형 ａ, ｂ의 제조방법 및 이들 결정형의 변환방법 Active KR101144600B1 (ko)

Priority Applications (7)

Application Number Priority Date Filing Date Title
KR1020090121209A KR101144600B1 (ko) 2009-12-08 2009-12-08 일라프라졸의 결정형 ａ, ｂ의 제조방법 및 이들 결정형의 변환방법
BR112012012212A BR112012012212A2 (pt) 2009-12-08 2010-12-08 processos de preparo de formas cristalinas a e b de ilaprazol e processo para conversão das formas cristalinas
EA201200716A EA019058B1 (ru) 2009-12-08 2010-12-08 Способ получения кристаллических форм а и в илапразола и способ превращения указанных кристаллических форм
IN3176DEN2012 IN2012DN03176A (enrdf_load_stackoverflow) 2009-12-08 2010-12-08
PCT/KR2010/008767 WO2011071314A2 (en) 2009-12-08 2010-12-08 Processes for preparing crystalline forms a and b of ilaprazole and process for converting the crystalline forms
UAA201207006A UA102787C2 (ru) 2009-12-08 2010-12-08 Способ приготовления кристаллических форм а и в илапразола и способ преобразования кристаллических форм
CO12097489A CO6541539A2 (es) 2009-12-08 2012-06-08 Procesos para preparar las formas cristalinas a y b de ilaprazol y proceso para convertir las formas cristalinas

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020090121209A KR101144600B1 (ko) 2009-12-08 2009-12-08 일라프라졸의 결정형 ａ, ｂ의 제조방법 및 이들 결정형의 변환방법

Publications (2)

Publication Number Publication Date
KR20110064545A KR20110064545A (ko) 2011-06-15
KR101144600B1 true KR101144600B1 (ko) 2012-05-16

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KR1020090121209A Active KR101144600B1 (ko) 2009-12-08 2009-12-08 일라프라졸의 결정형 ａ, ｂ의 제조방법 및 이들 결정형의 변환방법

Country Status (7)

Country Link
KR (1) KR101144600B1 (enrdf_load_stackoverflow)
BR (1) BR112012012212A2 (enrdf_load_stackoverflow)
CO (1) CO6541539A2 (enrdf_load_stackoverflow)
EA (1) EA019058B1 (enrdf_load_stackoverflow)
IN (1) IN2012DN03176A (enrdf_load_stackoverflow)
UA (1) UA102787C2 (enrdf_load_stackoverflow)
WO (1) WO2011071314A2 (enrdf_load_stackoverflow)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190055481A (ko) 2017-11-15 2019-05-23 주식회사 다산제약 고순도 일라프라졸 결정형 b의 제조방법
KR20210019469A (ko) 2021-02-02 2021-02-22 주식회사 파마코스텍 일라프라졸 나트륨 결정형 및 신규한 제조방법
KR102250509B1 (ko) * 2020-12-09 2021-05-11 유니셀랩 주식회사 새로운 일라프라졸/자일리톨 공결정
KR20220065235A (ko) 2020-11-13 2022-05-20 주식회사 파마코스텍 일라프라졸 혼형 결정의 신규한 제조방법

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103204842B (zh) * 2012-01-13 2014-10-15 丽珠医药集团股份有限公司 结晶型艾普拉唑钠水合物及其制备方法
CN103204843B (zh) * 2012-01-13 2014-12-31 丽珠医药集团股份有限公司 结晶型艾普拉唑钠乙醇化物及其制备方法
WO2013114232A1 (en) 2012-02-02 2013-08-08 Lupin Limited Process for preparation of crystalline form l of ilaprazole
CN102746276B (zh) * 2012-06-21 2014-07-02 丽珠医药集团股份有限公司 一种艾普拉唑钠晶型及其制备方法
CN102746275B (zh) * 2012-06-21 2014-07-16 丽珠医药集团股份有限公司 结晶型艾普拉唑钠及其制备方法
CN102746277B (zh) * 2012-06-21 2014-05-14 丽珠医药集团股份有限公司 一种结晶形式的艾普拉唑钠及其制备方法
CN105461692A (zh) * 2014-09-04 2016-04-06 江苏奥赛康药业股份有限公司 艾普拉唑钠化合物及其药物组合物
CN115403560B (zh) * 2017-11-06 2024-09-03 丽珠医药集团股份有限公司 一种艾普拉唑镁晶型及其制备方法
CN111187255B (zh) * 2020-01-13 2021-07-20 丽珠医药集团股份有限公司 右旋艾普拉唑钾盐的制备方法和右旋艾普拉唑的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090086615A (ko) * 2006-12-29 2009-08-13 일양약품주식회사 라세믹 일라프라졸의 고체상 형태

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080200515A1 (en) * 2006-12-29 2008-08-21 Tap Pharmaceutical Products Inc. Solid state forms of enantiopure ilaprazole

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090086615A (ko) * 2006-12-29 2009-08-13 일양약품주식회사 라세믹 일라프라졸의 고체상 형태

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190055481A (ko) 2017-11-15 2019-05-23 주식회사 다산제약 고순도 일라프라졸 결정형 b의 제조방법
KR20220065235A (ko) 2020-11-13 2022-05-20 주식회사 파마코스텍 일라프라졸 혼형 결정의 신규한 제조방법
KR102250509B1 (ko) * 2020-12-09 2021-05-11 유니셀랩 주식회사 새로운 일라프라졸/자일리톨 공결정
KR20210019469A (ko) 2021-02-02 2021-02-22 주식회사 파마코스텍 일라프라졸 나트륨 결정형 및 신규한 제조방법

Also Published As

Publication number Publication date
KR20110064545A (ko) 2011-06-15
UA102787C2 (ru) 2013-08-12
EA019058B1 (ru) 2013-12-30
WO2011071314A2 (en) 2011-06-16
EA201200716A1 (ru) 2012-10-30
BR112012012212A2 (pt) 2015-09-08
IN2012DN03176A (enrdf_load_stackoverflow) 2015-09-25
CO6541539A2 (es) 2012-10-16
WO2011071314A3 (en) 2011-11-10

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