TWI865615B - 掩蓋了令人不快的味道的顆粒劑及其製造方法 - Google Patents

掩蓋了令人不快的味道的顆粒劑及其製造方法 Download PDF

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Publication number
TWI865615B
TWI865615B TW109133372A TW109133372A TWI865615B TW I865615 B TWI865615 B TW I865615B TW 109133372 A TW109133372 A TW 109133372A TW 109133372 A TW109133372 A TW 109133372A TW I865615 B TWI865615 B TW I865615B
Authority
TW
Taiwan
Prior art keywords
active ingredient
particles
manufacturing
unpleasant taste
granule
Prior art date
Application number
TW109133372A
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English (en)
Chinese (zh)
Other versions
TW202128143A (zh
Inventor
野村達雄
安澤亨
Original Assignee
日商耐貝醫藥股份有限公司
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Application filed by 日商耐貝醫藥股份有限公司 filed Critical 日商耐貝醫藥股份有限公司
Publication of TW202128143A publication Critical patent/TW202128143A/zh
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Publication of TWI865615B publication Critical patent/TWI865615B/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW109133372A 2019-09-25 2020-09-25 掩蓋了令人不快的味道的顆粒劑及其製造方法 TWI865615B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019173744 2019-09-25
JPJP2019-173744 2019-09-25

Publications (2)

Publication Number Publication Date
TW202128143A TW202128143A (zh) 2021-08-01
TWI865615B true TWI865615B (zh) 2024-12-11

Family

ID=75164923

Family Applications (1)

Application Number Title Priority Date Filing Date
TW109133372A TWI865615B (zh) 2019-09-25 2020-09-25 掩蓋了令人不快的味道的顆粒劑及其製造方法

Country Status (8)

Country Link
US (1) US20230016901A1 (https=)
EP (1) EP4035733A4 (https=)
JP (3) JP6905781B1 (https=)
CN (1) CN114340601A (https=)
AU (1) AU2020352037A1 (https=)
CA (1) CA3153004A1 (https=)
TW (1) TWI865615B (https=)
WO (1) WO2021060304A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230016901A1 (en) * 2019-09-25 2023-01-19 Nobelpharma Co., Ltd. Granule in which unpleasant taste is masked and method for producing granule
TR2022010921A2 (tr) * 2022-07-01 2024-01-22 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Tadı maskelenmiş bir çinko katı bileşimi.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101495097A (zh) * 2006-07-26 2009-07-29 旭化成化学株式会社 球形素颗粒及其制造方法
US20120189696A1 (en) * 2009-10-09 2012-07-26 Asahi Kasei Chemicals Corporation Coating film, and granules and tablets each utilizing same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2542122B2 (ja) * 1990-04-18 1996-10-09 旭化成工業株式会社 球状核、球形顆粒およびその製造方法
JP3985907B2 (ja) 1996-01-18 2007-10-03 旭化成ケミカルズ株式会社 フィルムコーティング粒剤の製造方法
JP2000053563A (ja) 1998-08-07 2000-02-22 Bayer Yakuhin Ltd 苦味がマスクされた速放性細粒剤
JP3981134B2 (ja) * 2003-10-29 2007-09-26 塩野義製薬株式会社 不快味を改善した被覆製剤の製造方法
DK1884242T3 (da) * 2005-05-26 2013-05-06 Dainippon Sumitomo Pharma Co Farmaceutisk sammensætning omfattende lurasidon
JP2007031292A (ja) * 2005-07-22 2007-02-08 Hamari Chemicals Ltd 亜鉛化合物含有組成物およびその製造方法
JP2008081448A (ja) 2006-09-28 2008-04-10 Kowa Pharmaceutical Co Ltd 酒石酸ゾルピデムの苦味マスキング速放性粒子
CN102958515A (zh) * 2009-12-02 2013-03-06 阿普塔利斯制药有限公司 非索非那定微胶囊及含有非索非那定微胶囊的组合物
CN102018658B (zh) * 2010-07-16 2014-03-12 钟术光 一种控释制剂及其制备方法
CN103096880B (zh) * 2010-09-13 2016-08-24 大鹏药品工业株式会社 不愉快味道被掩蔽的含药膜包覆的颗粒
US20230016901A1 (en) * 2019-09-25 2023-01-19 Nobelpharma Co., Ltd. Granule in which unpleasant taste is masked and method for producing granule

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101495097A (zh) * 2006-07-26 2009-07-29 旭化成化学株式会社 球形素颗粒及其制造方法
US20120189696A1 (en) * 2009-10-09 2012-07-26 Asahi Kasei Chemicals Corporation Coating film, and granules and tablets each utilizing same

Also Published As

Publication number Publication date
AU2020352037A1 (en) 2022-04-21
WO2021060304A1 (ja) 2021-04-01
TW202128143A (zh) 2021-08-01
JP6905781B1 (ja) 2021-07-21
CN114340601A (zh) 2022-04-12
CA3153004A1 (en) 2021-04-01
EP4035733A4 (en) 2024-01-10
EP4035733A1 (en) 2022-08-03
JP2025107467A (ja) 2025-07-17
US20230016901A1 (en) 2023-01-19
JPWO2021060304A1 (ja) 2021-10-07
JP7715378B2 (ja) 2025-07-30
JP2021138775A (ja) 2021-09-16

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